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Q6BRN7 (DUT_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:DUT1
Ordered Locus Names:DEHA2D14982g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length160 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Subunit structure

Homotrimer By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdUMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

dUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 160160Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182932

Regions

Region79 – 813Substrate binding By similarity
Region93 – 964Substrate binding By similarity
Region154 – 1552Substrate binding By similarity

Sites

Binding site1041Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site1491Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BRN7 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: CCF54D95959E7E53

FASTA16017,004
        10         20         30         40         50         60 
MTDAEQTIKN QKTQEAEQSL RVFLRSENAT LPTRGSVLSA GYDIYASEEA VIPAQGQGLV 

        70         80         90        100        110        120 
GTDISVAVPI GTYGRVAPRS GLAVKHGIST GAGVIDADYR GEVKVVLFNH AQKDFTIQKG 

       130        140        150        160 
DRIAQLVLEK IVMADIKQIT AEELDITARG EGGFGSTGKN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382136 Genomic DNA. Translation: CAG87304.1.
RefSeqXP_459133.1. XM_459133.1.

3D structure databases

ProteinModelPortalQ6BRN7.
SMRQ6BRN7. Positions 26-139.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.Q6BRN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2901232.
KEGGdha:DEHA2D14982g.

Phylogenomic databases

eggNOGCOG0756.
KOK01520.
OMALVDTQIS.
OrthoDBEOG7T7H6C.

Enzyme and pathway databases

UniPathwayUPA00610; UER00666.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDUT_DEBHA
AccessionPrimary (citable) accession number: Q6BRN7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: August 16, 2004
Last modified: November 13, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways