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Q6BRB7 (ERG6_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sterol 24-C-methyltransferase

EC=2.1.1.41
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene names
Name:ERG6
Ordered Locus Names:DEHA2D17622g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.

Catalytic activity

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathway

Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Sterol 24-C-methyltransferase
PRO_0000124792

Sequences

Sequence LengthMass (Da)Tools
Q6BRB7 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: AF0246F095D969F9

FASTA37742,950
        10         20         30         40         50         60 
MPSAVQLAEK NHEKDSKFAK ALHGESYKQT GLKALMSKAR DASEVANDGY FKHWDGGVTK 

        70         80         90        100        110        120 
EDEDKRLSDY SNLTAHYYNL VTDFYEYGWG SSFHFSRYYT GEAFRQATAR HEHFLAHKMQ 

       130        140        150        160        170        180 
INENMKVLDV GCGVGGPARE ICRFTDCSIV GLNNNDYQIE RANHYARKYK LDDKLSFVKG 

       190        200        210        220        230        240 
DFMQMDFEAE SFDAVYAIEA TVHAPVLEGV YSEIYKVLKP GGVFGVYEWV MTDKYDDENE 

       250        260        270        280        290        300 
EHRKIAYGIE VGDGIPKMYK REVAEKALKS VGFEIEYEAD LADKEDDIPW YYPLSGEWKY 

       310        320        330        340        350        360 
VQTLSDYFTI FRTSKVGRTI TTEAVGLMEK LGLAPKGSKQ VTNALEDAAV NLVEGGRQKL 

       370 
FTPMMLYVCR KPANEDI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382136 Genomic DNA. Translation: CAG87427.1.
RefSeqXP_459253.1. XM_459253.1.

3D structure databases

ProteinModelPortalQ6BRB7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.Q6BRB7.

Proteomic databases

PRIDEQ6BRB7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2901632.
KEGGdha:DEHA2D17622g.

Phylogenomic databases

eggNOGCOG0500.
KOK00559.
OMAFHFCRFS.
OrthoDBEOG7DVDMW.

Enzyme and pathway databases

UniPathwayUPA00768; UER00760.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 2 hits.
PROSITEPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameERG6_DEBHA
AccessionPrimary (citable) accession number: Q6BRB7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways