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Q6BRB7

- ERG6_DEBHA

UniProt

Q6BRB7 - ERG6_DEBHA

Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

    Pathwayi

    GO - Molecular functioni

    1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sterol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00768; UER00760.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol 24-C-methyltransferase (EC:2.1.1.41)
    Alternative name(s):
    Delta(24)-sterol C-methyltransferase
    Gene namesi
    Name:ERG6
    Ordered Locus Names:DEHA2D17622g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome D

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Sterol 24-C-methyltransferasePRO_0000124792Add
    BLAST

    Proteomic databases

    PRIDEiQ6BRB7.

    Interactioni

    Protein-protein interaction databases

    STRINGi4959.Q6BRB7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6BRB7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0500.
    KOiK00559.
    OMAiFHFCRFS.
    OrthoDBiEOG7DVDMW.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view]
    PfamiPF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6BRB7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSAVQLAEK NHEKDSKFAK ALHGESYKQT GLKALMSKAR DASEVANDGY    50
    FKHWDGGVTK EDEDKRLSDY SNLTAHYYNL VTDFYEYGWG SSFHFSRYYT 100
    GEAFRQATAR HEHFLAHKMQ INENMKVLDV GCGVGGPARE ICRFTDCSIV 150
    GLNNNDYQIE RANHYARKYK LDDKLSFVKG DFMQMDFEAE SFDAVYAIEA 200
    TVHAPVLEGV YSEIYKVLKP GGVFGVYEWV MTDKYDDENE EHRKIAYGIE 250
    VGDGIPKMYK REVAEKALKS VGFEIEYEAD LADKEDDIPW YYPLSGEWKY 300
    VQTLSDYFTI FRTSKVGRTI TTEAVGLMEK LGLAPKGSKQ VTNALEDAAV 350
    NLVEGGRQKL FTPMMLYVCR KPANEDI 377
    Length:377
    Mass (Da):42,950
    Last modified:August 16, 2004 - v1
    Checksum:iAF0246F095D969F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382136 Genomic DNA. Translation: CAG87427.1.
    RefSeqiXP_459253.1. XM_459253.1.

    Genome annotation databases

    GeneIDi2901632.
    KEGGidha:DEHA2D17622g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382136 Genomic DNA. Translation: CAG87427.1 .
    RefSeqi XP_459253.1. XM_459253.1.

    3D structure databases

    ProteinModelPortali Q6BRB7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BRB7.

    Proteomic databases

    PRIDEi Q6BRB7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2901632.
    KEGGi dha:DEHA2D17622g.

    Phylogenomic databases

    eggNOGi COG0500.
    KOi K00559.
    OMAi FHFCRFS.
    OrthoDBi EOG7DVDMW.

    Enzyme and pathway databases

    UniPathwayi UPA00768 ; UER00760 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view ]
    Pfami PF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiERG6_DEBHA
    AccessioniPrimary (citable) accession number: Q6BRB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3