Reviewed, UniProtKB/Swiss-Prot Q6BRB7 (ERG6_DEBHA)

Names and origin

Protein names

Recommended name:
    Sterol 24-C-methyltransferase
    EC=2.1.1.41
Alternative name(s):
    Delta(24)-sterol C-methyltransferase

Gene names

Name:	ERG6
Ordered Locus Names:	DEHA2D17622g

Organism

Debaryomyces hansenii (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

4959 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Debaryomyces

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.
Catalytic activity	S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
Pathway	Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.
Sequence similarities	Belongs to the methyltransferase superfamily. ERG6 family.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sterol 24-C-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	Sterol 24-C-methyltransferase		PRO_0000124792

Sequences

	Sequence		Length	Mass (Da)
	Q6BRB7-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: AF0246F095D969F9	FASTA	377	42,950
	10 20 30 40 50 60 MPSAVQLAEK NHEKDSKFAK ALHGESYKQT GLKALMSKAR DASEVANDGY FKHWDGGVTK 70 80 90 100 110 120 EDEDKRLSDY SNLTAHYYNL VTDFYEYGWG SSFHFSRYYT GEAFRQATAR HEHFLAHKMQ 130 140 150 160 170 180 INENMKVLDV GCGVGGPARE ICRFTDCSIV GLNNNDYQIE RANHYARKYK LDDKLSFVKG 190 200 210 220 230 240 DFMQMDFEAE SFDAVYAIEA TVHAPVLEGV YSEIYKVLKP GGVFGVYEWV MTDKYDDENE 250 260 270 280 290 300 EHRKIAYGIE VGDGIPKMYK REVAEKALKS VGFEIEYEAD LADKEDDIPW YYPLSGEWKY 310 320 330 340 350 360 VQTLSDYFTI FRTSKVGRTI TTEAVGLMEK LGLAPKGSKQ VTNALEDAAV NLVEGGRQKL 370 FTPMMLYVCR KPANEDI

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / IFO 0083 / IGC 2968 / JCM 1990.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382136 Genomic DNA. Translation: CAG87427.1.
RefSeq	XP_459253.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2901632.
KEGG	dha:DEHA0D19151g.
Phylogenomic databases
HOGENOM	Q6BRB7.
OMA	Q6BRB7. FVKGDFM.
Enzyme and pathway databases
BRENDA	2.1.1.41. 74267.
Family and domain databases
InterPro	IPR013216. Methyltransf_11. IPR013705. Sterol_MeTrfase_C. [Graphical view]
Pfam	PF08241. Methyltransf_11. 1 hit. PF08498. Sterol_MT_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERG6_DEBHA

Accession

Primary (citable) accession number: Q6BRB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	August 16, 2004
Last modified:	May 5, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)