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Q6BRB7

- ERG6_DEBHA

UniProt

Q6BRB7 - ERG6_DEBHA

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Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathwayi

GO - Molecular functioni

  1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. sterol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferase (EC:2.1.1.41)
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene namesi
Name:ERG6
Ordered Locus Names:DEHA2D17622g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome D

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Sterol 24-C-methyltransferasePRO_0000124792Add
BLAST

Proteomic databases

PRIDEiQ6BRB7.

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BRB7.

Structurei

3D structure databases

ProteinModelPortaliQ6BRB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0500.
InParanoidiQ6BRB7.
KOiK00559.
OMAiFHFCRFS.
OrthoDBiEOG7DVDMW.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BRB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSAVQLAEK NHEKDSKFAK ALHGESYKQT GLKALMSKAR DASEVANDGY
60 70 80 90 100
FKHWDGGVTK EDEDKRLSDY SNLTAHYYNL VTDFYEYGWG SSFHFSRYYT
110 120 130 140 150
GEAFRQATAR HEHFLAHKMQ INENMKVLDV GCGVGGPARE ICRFTDCSIV
160 170 180 190 200
GLNNNDYQIE RANHYARKYK LDDKLSFVKG DFMQMDFEAE SFDAVYAIEA
210 220 230 240 250
TVHAPVLEGV YSEIYKVLKP GGVFGVYEWV MTDKYDDENE EHRKIAYGIE
260 270 280 290 300
VGDGIPKMYK REVAEKALKS VGFEIEYEAD LADKEDDIPW YYPLSGEWKY
310 320 330 340 350
VQTLSDYFTI FRTSKVGRTI TTEAVGLMEK LGLAPKGSKQ VTNALEDAAV
360 370
NLVEGGRQKL FTPMMLYVCR KPANEDI
Length:377
Mass (Da):42,950
Last modified:August 16, 2004 - v1
Checksum:iAF0246F095D969F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382136 Genomic DNA. Translation: CAG87427.1.
RefSeqiXP_459253.1. XM_459253.1.

Genome annotation databases

GeneIDi2901632.
KEGGidha:DEHA2D17622g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382136 Genomic DNA. Translation: CAG87427.1 .
RefSeqi XP_459253.1. XM_459253.1.

3D structure databases

ProteinModelPortali Q6BRB7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BRB7.

Proteomic databases

PRIDEi Q6BRB7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2901632.
KEGGi dha:DEHA2D17622g.

Phylogenomic databases

eggNOGi COG0500.
InParanoidi Q6BRB7.
KOi K00559.
OMAi FHFCRFS.
OrthoDBi EOG7DVDMW.

Enzyme and pathway databases

UniPathwayi UPA00768 ; UER00760 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view ]
Pfami PF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiERG6_DEBHA
AccessioniPrimary (citable) accession number: Q6BRB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3