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Q6BQK9 (NTE1_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
Ordered Locus Names:DEHA2E04400g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length1544 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentEndoplasmic reticulum
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15441544Lysophospholipase NTE1
PRO_0000295319

Regions

Topological domain1 – 3737Cytoplasmic By similarity
Transmembrane38 – 5821Helical; Potential
Topological domain59 – 7618Lumenal By similarity
Transmembrane77 – 9721Helical; Potential
Topological domain98 – 15441447Cytoplasmic By similarity
Domain1237 – 1401165Patatin
Nucleotide binding681 – 811131cNMP 1
Nucleotide binding807 – 960154cNMP 2
Motif1268 – 12725GXSXG
Compositional bias32 – 376Poly-Ser
Compositional bias434 – 4396Poly-Ser
Compositional bias1092 – 10976Poly-Asp

Sites

Active site12701 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BQK9 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: B83771ADE5D86F30

FASTA1,544173,122
        10         20         30         40         50         60 
MSTIEIVSTV AEYTEIHSPV SSKFLLPSAR DSSSSISLFS AIFWFWSWLF FKIMNIFLYY 

        70         80         90        100        110        120 
IPNIIVNLFS VNFQITLSLS SIVITLTGII SFCFLIVRYK YLTRYSKTTK STDKPKSSNK 

       130        140        150        160        170        180 
NIDLVGSIKK NKRGDSKSTS NYLDEFLSAI KVFGYLERPV FHELTRNMTT QKLSSEEILY 

       190        200        210        220        230        240 
LDEKLGFSIV VEGTIQVYTK VNSVNSSTTS NSDDNELNFE KDDLLTIGDQ CYQLLNEVKS 

       250        260        270        280        290        300 
GSPLSSLMST LDLFKPVDPD TMSNRLFSPF ELDSNPASNP LSPDNTGSKS FDPLSSGNFN 

       310        320        330        340        350        360 
DTSLSSSDRN YPNIVARPKP IEDSNNLNTA TIAIIPYSAF QKVQSKYPKA TSHIVTMVIT 

       370        380        390        400        410        420 
RLYKITMNTI HSYLGLTREI IRSEIQLNES EGAKDSLPSY LYDGVIEKFY GDKNNETLLN 

       430        440        450        460        470        480 
KTAESPSVSI NKTSSSSSSL PKKSTTSLRP LNRNQSSRYV VLDSRSKSTH PGDLLSSVPL 

       490        500        510        520        530        540 
SRRSDYYQTH TTIQPDPEEV RSQSRTKMTS PVLPKRQISS NGGPTLKGHS SSTTKFENIR 

       550        560        570        580        590        600 
DRTFSDEREE TEETSLRIAI IENIFKILGI NEVSNMIGSM SDLNSRSSSV NSSVVGLPSL 

       610        620        630        640        650        660 
MNNGNESKYP NGIFDFNTGK VRYDSISSFP TSLNKGANNN LKFYDTVNQS QLKDMDHEND 

       670        680        690        700        710        720 
KSSQVDINNL MFKRKSIPIQ SFESNFYDVK NEFSKHLNIK YFGPNTTLVE QESFNSGLYY 

       730        740        750        760        770        780 
VIDGTLDVFY KPASKESENL TPMNKKKLYT VKSGGLAGYL SSIIGVRSLV SISTPGDKGV 

       790        800        810        820        830        840 
IVAHIPKNEF SKLLDKFYFL QLPVASKLKS LLSSQILTID YALEWCHIPA GDVLCSQGDL 

       850        860        870        880        890        900 
ANGFHIVLSG RFRVVRYNNN KSSEVNPDDN TDIHDYNNNL IDESLSYKSR KKKDDITILG 

       910        920        930        940        950        960 
EYGHGETIGE VEVLTASRRT NSLIAVRDSE TARIPRTLFE MLSLRNPSIM VKVSRIVANK 

       970        980        990       1000       1010       1020 
MAKKDNIGIP STISSNVPLI VTNTDSHISN DYKTITILPT VSGLPVRDFA DKLVSALKNI 

      1030       1040       1050       1060       1070       1080 
GRNVIALDQA STLTHLGRHA FDERLAQLKL SGYFAYLEEE YQTIVYVCDT PLKSNWTSTC 

      1090       1100       1110       1120       1130       1140 
ISQGDCILLL ADADDDDVAT NIGEYERLLM KLKTTARTDL CLIHADKYVE PGSTSVWLKN 

      1150       1160       1170       1180       1190       1200 
RIWVQGHHHI QMEIARDNSV QQGQKTSIIK NIAAKISSRT NTNIKSRLEN VKTKAILSLN 

      1210       1220       1230       1240       1250       1260 
KFNNRLSRRT HSYKTVQAHK NDFLRLARIL SNESVGLVLG GGGSRGISHV GVVMALEKHG 

      1270       1280       1290       1300       1310       1320 
IPIDLIGGTS IGSFVGGLYA KDYNIVSIYG RAKRFAKRVS SWWRMVLDLT YPVTSYITGY 

      1330       1340       1350       1360       1370       1380 
EFNRGIWKIF GSSEIEDFWI RYFCNSTNIT NSTMDIHESG FSWRFIRASM SLAGLLPPIT 

      1390       1400       1410       1420       1430       1440 
YGGSMLLDGG YLDNLPVMEM KKKGAKYIIA VDVGSVDDRT PMNYGDTLSG FWVLFNRWNP 

      1450       1460       1470       1480       1490       1500 
FSRHPNVPNM MDIQLRLAYV ASVNALELAK KTPGVIYLRP PIDDYATLDF AKFDEIYHVG 

      1510       1520       1530       1540 
MAYADNLLTR WEQTGKIPPI AGMIDRSRIR NGEERKSLYR RSSI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382137 Genomic DNA. Translation: CAG87737.2.
RefSeqXP_459511.2. XM_459511.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.Q6BQK9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2902795.
KEGGdha:DEHA2E04400g.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
KOK14676.
OMASPWTQTC.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_DEBHA
AccessionPrimary (citable) accession number: Q6BQK9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 16, 2008
Last modified: February 19, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families