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Q6BQK9

- NTE1_DEBHA

UniProt

Q6BQK9 - NTE1_DEBHA

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Protein

Lysophospholipase NTE1

Gene
NTE1, DEHA2E04400g
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1270 – 12701 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi681 – 811131cNMP 1Add
BLAST
Nucleotide bindingi807 – 960154cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
Ordered Locus Names:DEHA2E04400g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome E

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737Cytoplasmic By similarityAdd
BLAST
Transmembranei38 – 5821Helical; Reviewed predictionAdd
BLAST
Topological domaini59 – 7618Lumenal By similarityAdd
BLAST
Transmembranei77 – 9721Helical; Reviewed predictionAdd
BLAST
Topological domaini98 – 15441447Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15441544Lysophospholipase NTE1PRO_0000295319Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BQK9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1237 – 1401165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1268 – 12725GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 376Poly-Ser
Compositional biasi434 – 4396Poly-Ser
Compositional biasi1092 – 10976Poly-Asp

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BQK9-1 [UniParc]FASTAAdd to Basket

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MSTIEIVSTV AEYTEIHSPV SSKFLLPSAR DSSSSISLFS AIFWFWSWLF     50
FKIMNIFLYY IPNIIVNLFS VNFQITLSLS SIVITLTGII SFCFLIVRYK 100
YLTRYSKTTK STDKPKSSNK NIDLVGSIKK NKRGDSKSTS NYLDEFLSAI 150
KVFGYLERPV FHELTRNMTT QKLSSEEILY LDEKLGFSIV VEGTIQVYTK 200
VNSVNSSTTS NSDDNELNFE KDDLLTIGDQ CYQLLNEVKS GSPLSSLMST 250
LDLFKPVDPD TMSNRLFSPF ELDSNPASNP LSPDNTGSKS FDPLSSGNFN 300
DTSLSSSDRN YPNIVARPKP IEDSNNLNTA TIAIIPYSAF QKVQSKYPKA 350
TSHIVTMVIT RLYKITMNTI HSYLGLTREI IRSEIQLNES EGAKDSLPSY 400
LYDGVIEKFY GDKNNETLLN KTAESPSVSI NKTSSSSSSL PKKSTTSLRP 450
LNRNQSSRYV VLDSRSKSTH PGDLLSSVPL SRRSDYYQTH TTIQPDPEEV 500
RSQSRTKMTS PVLPKRQISS NGGPTLKGHS SSTTKFENIR DRTFSDEREE 550
TEETSLRIAI IENIFKILGI NEVSNMIGSM SDLNSRSSSV NSSVVGLPSL 600
MNNGNESKYP NGIFDFNTGK VRYDSISSFP TSLNKGANNN LKFYDTVNQS 650
QLKDMDHEND KSSQVDINNL MFKRKSIPIQ SFESNFYDVK NEFSKHLNIK 700
YFGPNTTLVE QESFNSGLYY VIDGTLDVFY KPASKESENL TPMNKKKLYT 750
VKSGGLAGYL SSIIGVRSLV SISTPGDKGV IVAHIPKNEF SKLLDKFYFL 800
QLPVASKLKS LLSSQILTID YALEWCHIPA GDVLCSQGDL ANGFHIVLSG 850
RFRVVRYNNN KSSEVNPDDN TDIHDYNNNL IDESLSYKSR KKKDDITILG 900
EYGHGETIGE VEVLTASRRT NSLIAVRDSE TARIPRTLFE MLSLRNPSIM 950
VKVSRIVANK MAKKDNIGIP STISSNVPLI VTNTDSHISN DYKTITILPT 1000
VSGLPVRDFA DKLVSALKNI GRNVIALDQA STLTHLGRHA FDERLAQLKL 1050
SGYFAYLEEE YQTIVYVCDT PLKSNWTSTC ISQGDCILLL ADADDDDVAT 1100
NIGEYERLLM KLKTTARTDL CLIHADKYVE PGSTSVWLKN RIWVQGHHHI 1150
QMEIARDNSV QQGQKTSIIK NIAAKISSRT NTNIKSRLEN VKTKAILSLN 1200
KFNNRLSRRT HSYKTVQAHK NDFLRLARIL SNESVGLVLG GGGSRGISHV 1250
GVVMALEKHG IPIDLIGGTS IGSFVGGLYA KDYNIVSIYG RAKRFAKRVS 1300
SWWRMVLDLT YPVTSYITGY EFNRGIWKIF GSSEIEDFWI RYFCNSTNIT 1350
NSTMDIHESG FSWRFIRASM SLAGLLPPIT YGGSMLLDGG YLDNLPVMEM 1400
KKKGAKYIIA VDVGSVDDRT PMNYGDTLSG FWVLFNRWNP FSRHPNVPNM 1450
MDIQLRLAYV ASVNALELAK KTPGVIYLRP PIDDYATLDF AKFDEIYHVG 1500
MAYADNLLTR WEQTGKIPPI AGMIDRSRIR NGEERKSLYR RSSI 1544
Length:1,544
Mass (Da):173,122
Last modified:December 16, 2008 - v2
Checksum:iB83771ADE5D86F30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382137 Genomic DNA. Translation: CAG87737.2.
RefSeqiXP_459511.2. XM_459511.1.

Genome annotation databases

GeneIDi2902795.
KEGGidha:DEHA2E04400g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382137 Genomic DNA. Translation: CAG87737.2 .
RefSeqi XP_459511.2. XM_459511.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BQK9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2902795.
KEGGi dha:DEHA2E04400g.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
KOi K14676.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiNTE1_DEBHA
AccessioniPrimary (citable) accession number: Q6BQK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 16, 2008
Last modified: February 19, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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