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Q6BQK9

- NTE1_DEBHA

UniProt

Q6BQK9 - NTE1_DEBHA

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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1270 – 12701By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi681 – 811131cNMP 1Add
BLAST
Nucleotide bindingi807 – 960154cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
Ordered Locus Names:DEHA2E04400g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome E

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15441544Lysophospholipase NTE1PRO_0000295319Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BQK9.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicBy similarityAdd
BLAST
Topological domaini59 – 7618LumenalBy similarityAdd
BLAST
Topological domaini98 – 15441447CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1237 – 1401165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1268 – 12725GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 376Poly-Ser
Compositional biasi434 – 4396Poly-Ser
Compositional biasi1092 – 10976Poly-Asp

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
InParanoidiQ6BQK9.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BQK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTIEIVSTV AEYTEIHSPV SSKFLLPSAR DSSSSISLFS AIFWFWSWLF
60 70 80 90 100
FKIMNIFLYY IPNIIVNLFS VNFQITLSLS SIVITLTGII SFCFLIVRYK
110 120 130 140 150
YLTRYSKTTK STDKPKSSNK NIDLVGSIKK NKRGDSKSTS NYLDEFLSAI
160 170 180 190 200
KVFGYLERPV FHELTRNMTT QKLSSEEILY LDEKLGFSIV VEGTIQVYTK
210 220 230 240 250
VNSVNSSTTS NSDDNELNFE KDDLLTIGDQ CYQLLNEVKS GSPLSSLMST
260 270 280 290 300
LDLFKPVDPD TMSNRLFSPF ELDSNPASNP LSPDNTGSKS FDPLSSGNFN
310 320 330 340 350
DTSLSSSDRN YPNIVARPKP IEDSNNLNTA TIAIIPYSAF QKVQSKYPKA
360 370 380 390 400
TSHIVTMVIT RLYKITMNTI HSYLGLTREI IRSEIQLNES EGAKDSLPSY
410 420 430 440 450
LYDGVIEKFY GDKNNETLLN KTAESPSVSI NKTSSSSSSL PKKSTTSLRP
460 470 480 490 500
LNRNQSSRYV VLDSRSKSTH PGDLLSSVPL SRRSDYYQTH TTIQPDPEEV
510 520 530 540 550
RSQSRTKMTS PVLPKRQISS NGGPTLKGHS SSTTKFENIR DRTFSDEREE
560 570 580 590 600
TEETSLRIAI IENIFKILGI NEVSNMIGSM SDLNSRSSSV NSSVVGLPSL
610 620 630 640 650
MNNGNESKYP NGIFDFNTGK VRYDSISSFP TSLNKGANNN LKFYDTVNQS
660 670 680 690 700
QLKDMDHEND KSSQVDINNL MFKRKSIPIQ SFESNFYDVK NEFSKHLNIK
710 720 730 740 750
YFGPNTTLVE QESFNSGLYY VIDGTLDVFY KPASKESENL TPMNKKKLYT
760 770 780 790 800
VKSGGLAGYL SSIIGVRSLV SISTPGDKGV IVAHIPKNEF SKLLDKFYFL
810 820 830 840 850
QLPVASKLKS LLSSQILTID YALEWCHIPA GDVLCSQGDL ANGFHIVLSG
860 870 880 890 900
RFRVVRYNNN KSSEVNPDDN TDIHDYNNNL IDESLSYKSR KKKDDITILG
910 920 930 940 950
EYGHGETIGE VEVLTASRRT NSLIAVRDSE TARIPRTLFE MLSLRNPSIM
960 970 980 990 1000
VKVSRIVANK MAKKDNIGIP STISSNVPLI VTNTDSHISN DYKTITILPT
1010 1020 1030 1040 1050
VSGLPVRDFA DKLVSALKNI GRNVIALDQA STLTHLGRHA FDERLAQLKL
1060 1070 1080 1090 1100
SGYFAYLEEE YQTIVYVCDT PLKSNWTSTC ISQGDCILLL ADADDDDVAT
1110 1120 1130 1140 1150
NIGEYERLLM KLKTTARTDL CLIHADKYVE PGSTSVWLKN RIWVQGHHHI
1160 1170 1180 1190 1200
QMEIARDNSV QQGQKTSIIK NIAAKISSRT NTNIKSRLEN VKTKAILSLN
1210 1220 1230 1240 1250
KFNNRLSRRT HSYKTVQAHK NDFLRLARIL SNESVGLVLG GGGSRGISHV
1260 1270 1280 1290 1300
GVVMALEKHG IPIDLIGGTS IGSFVGGLYA KDYNIVSIYG RAKRFAKRVS
1310 1320 1330 1340 1350
SWWRMVLDLT YPVTSYITGY EFNRGIWKIF GSSEIEDFWI RYFCNSTNIT
1360 1370 1380 1390 1400
NSTMDIHESG FSWRFIRASM SLAGLLPPIT YGGSMLLDGG YLDNLPVMEM
1410 1420 1430 1440 1450
KKKGAKYIIA VDVGSVDDRT PMNYGDTLSG FWVLFNRWNP FSRHPNVPNM
1460 1470 1480 1490 1500
MDIQLRLAYV ASVNALELAK KTPGVIYLRP PIDDYATLDF AKFDEIYHVG
1510 1520 1530 1540
MAYADNLLTR WEQTGKIPPI AGMIDRSRIR NGEERKSLYR RSSI
Length:1,544
Mass (Da):173,122
Last modified:December 16, 2008 - v2
Checksum:iB83771ADE5D86F30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382137 Genomic DNA. Translation: CAG87737.2.
RefSeqiXP_459511.2. XM_459511.1.

Genome annotation databases

GeneIDi2902795.
KEGGidha:DEHA2E04400g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382137 Genomic DNA. Translation: CAG87737.2 .
RefSeqi XP_459511.2. XM_459511.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BQK9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2902795.
KEGGi dha:DEHA2E04400g.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
InParanoidi Q6BQK9.
KOi K14676.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiNTE1_DEBHA
AccessioniPrimary (citable) accession number: Q6BQK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3