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Q6BQK9

- NTE1_DEBHA

UniProt

Q6BQK9 - NTE1_DEBHA

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1270 – 12701By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi681 – 811131cNMP 1Add
    BLAST
    Nucleotide bindingi807 – 960154cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    Ordered Locus Names:DEHA2E04400g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome E

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15441544Lysophospholipase NTE1PRO_0000295319Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4959.Q6BQK9.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737CytoplasmicBy similarityAdd
    BLAST
    Topological domaini59 – 7618LumenalBy similarityAdd
    BLAST
    Topological domaini98 – 15441447CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1237 – 1401165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1268 – 12725GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi32 – 376Poly-Ser
    Compositional biasi434 – 4396Poly-Ser
    Compositional biasi1092 – 10976Poly-Asp

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    KOiK14676.
    OMAiSPWTQTC.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6BQK9-1 [UniParc]FASTAAdd to Basket

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    MSTIEIVSTV AEYTEIHSPV SSKFLLPSAR DSSSSISLFS AIFWFWSWLF     50
    FKIMNIFLYY IPNIIVNLFS VNFQITLSLS SIVITLTGII SFCFLIVRYK 100
    YLTRYSKTTK STDKPKSSNK NIDLVGSIKK NKRGDSKSTS NYLDEFLSAI 150
    KVFGYLERPV FHELTRNMTT QKLSSEEILY LDEKLGFSIV VEGTIQVYTK 200
    VNSVNSSTTS NSDDNELNFE KDDLLTIGDQ CYQLLNEVKS GSPLSSLMST 250
    LDLFKPVDPD TMSNRLFSPF ELDSNPASNP LSPDNTGSKS FDPLSSGNFN 300
    DTSLSSSDRN YPNIVARPKP IEDSNNLNTA TIAIIPYSAF QKVQSKYPKA 350
    TSHIVTMVIT RLYKITMNTI HSYLGLTREI IRSEIQLNES EGAKDSLPSY 400
    LYDGVIEKFY GDKNNETLLN KTAESPSVSI NKTSSSSSSL PKKSTTSLRP 450
    LNRNQSSRYV VLDSRSKSTH PGDLLSSVPL SRRSDYYQTH TTIQPDPEEV 500
    RSQSRTKMTS PVLPKRQISS NGGPTLKGHS SSTTKFENIR DRTFSDEREE 550
    TEETSLRIAI IENIFKILGI NEVSNMIGSM SDLNSRSSSV NSSVVGLPSL 600
    MNNGNESKYP NGIFDFNTGK VRYDSISSFP TSLNKGANNN LKFYDTVNQS 650
    QLKDMDHEND KSSQVDINNL MFKRKSIPIQ SFESNFYDVK NEFSKHLNIK 700
    YFGPNTTLVE QESFNSGLYY VIDGTLDVFY KPASKESENL TPMNKKKLYT 750
    VKSGGLAGYL SSIIGVRSLV SISTPGDKGV IVAHIPKNEF SKLLDKFYFL 800
    QLPVASKLKS LLSSQILTID YALEWCHIPA GDVLCSQGDL ANGFHIVLSG 850
    RFRVVRYNNN KSSEVNPDDN TDIHDYNNNL IDESLSYKSR KKKDDITILG 900
    EYGHGETIGE VEVLTASRRT NSLIAVRDSE TARIPRTLFE MLSLRNPSIM 950
    VKVSRIVANK MAKKDNIGIP STISSNVPLI VTNTDSHISN DYKTITILPT 1000
    VSGLPVRDFA DKLVSALKNI GRNVIALDQA STLTHLGRHA FDERLAQLKL 1050
    SGYFAYLEEE YQTIVYVCDT PLKSNWTSTC ISQGDCILLL ADADDDDVAT 1100
    NIGEYERLLM KLKTTARTDL CLIHADKYVE PGSTSVWLKN RIWVQGHHHI 1150
    QMEIARDNSV QQGQKTSIIK NIAAKISSRT NTNIKSRLEN VKTKAILSLN 1200
    KFNNRLSRRT HSYKTVQAHK NDFLRLARIL SNESVGLVLG GGGSRGISHV 1250
    GVVMALEKHG IPIDLIGGTS IGSFVGGLYA KDYNIVSIYG RAKRFAKRVS 1300
    SWWRMVLDLT YPVTSYITGY EFNRGIWKIF GSSEIEDFWI RYFCNSTNIT 1350
    NSTMDIHESG FSWRFIRASM SLAGLLPPIT YGGSMLLDGG YLDNLPVMEM 1400
    KKKGAKYIIA VDVGSVDDRT PMNYGDTLSG FWVLFNRWNP FSRHPNVPNM 1450
    MDIQLRLAYV ASVNALELAK KTPGVIYLRP PIDDYATLDF AKFDEIYHVG 1500
    MAYADNLLTR WEQTGKIPPI AGMIDRSRIR NGEERKSLYR RSSI 1544
    Length:1,544
    Mass (Da):173,122
    Last modified:December 16, 2008 - v2
    Checksum:iB83771ADE5D86F30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382137 Genomic DNA. Translation: CAG87737.2.
    RefSeqiXP_459511.2. XM_459511.1.

    Genome annotation databases

    GeneIDi2902795.
    KEGGidha:DEHA2E04400g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382137 Genomic DNA. Translation: CAG87737.2 .
    RefSeqi XP_459511.2. XM_459511.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BQK9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2902795.
    KEGGi dha:DEHA2E04400g.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    KOi K14676.
    OMAi SPWTQTC.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiNTE1_DEBHA
    AccessioniPrimary (citable) accession number: Q6BQK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 63 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3