Q6BQF2 (ACS1_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 1
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase 1
Acyl-activating enzyme 1

Gene names

Name:	ACS1
Ordered Locus Names:	DEHA2E05676g

Organism

Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

284592 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces

Protein attributes

Sequence length	671 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 671	671	Acetyl-coenzyme A synthetase 1		PRO_0000208411

Sequences

	Sequence		Length	Mass (Da)
	Q6BQF2 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: E42BB91905E81966	FASTA	671	74,416
	10 20 30 40 50 60 MTPHSTHVTL DHEGIIQPPA EFKERSKSKP NLADFETYSK MYKESIENPS KFFGEQALEH 70 80 90 100 110 120 LSWDRPFDEA RYPVSSEQDF ADGDIASWFV NGQLNASYNA VDRWAIKNPN KPAIIYEADE 130 140 150 160 170 180 ENEGRIITYG QLLKDVCKLA QCLTKLGIRK GDSVAVYLPM IPEALVTLLA IVRIGAVHSV 190 200 210 220 230 240 VFAGFSSSSL KDRILDASSK IVITTDESKR GGKTIETKKI VDDALKNCPD VTNVLLFKRT 250 260 270 280 290 300 GNAHIPFTEG RDLWWHEEMA KYGPYFPPVP VNSEDPLFLL YTSGSTGKPK GIQHSTAGYL 310 320 330 340 350 360 LGAAMTSKYT FDVHEDDVLF TAGDVGWITG HTYVVYGPLL CGATTVVFEG TPAHPNYSRY 370 380 390 400 410 420 WEIVDKYQVT QFYVAPTALR LLKRAGTKYI ENYKLDSLRV LGSVGEPIAA EIWHWYNDNI 430 440 450 460 470 480 GRRKCHIVDT YWQTESGSHM LAPLAGITPT KPGSASLPCF GIDAKILDPV SGKELKENDV 490 500 510 520 530 540 EGVLCVKSCW PSISRGIYND YARFIETYLK PYPNHYFSGD GAARDVDGFY WILGRVDDVV 550 560 570 580 590 600 NVSGHRLSTA EIEAALILHE SVAECAVVGY ADELTGQAVA AYVSLKSNVS EDLEVIKKEL 610 620 630 640 650 660 ILTVRKEIGP FATPKTILLV DDLPKTRSGK IMRRILRKVL AGEEDQLGDI STLSNPGVVA 670 QIIDVVKATR K

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382137 Genomic DNA. Translation: CAG87795.1.
RefSeq	XP_459568.1. XM_459568.1.
3D structure databases
ProteinModelPortal	Q6BQF2.
SMR	Q6BQF2. Positions 36-667.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6BQF2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2901869.
GenomeReviews	Gene locus DEHA2E05676g in contig CR382137_GR.
KEGG	dha:DEHA2E05676g.
Phylogenomic databases
eggNOG	fuNOG05220.
HOGENOM	HBG547964.
OMA	DGFYWIL.
OrthoDB	EOG4M0J8W.
Family and domain databases
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACS1_DEBHA

Accession

Primary (citable) accession number: Q6BQF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	August 16, 2004
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program