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Protein

Mitochondrial thiamine pyrophosphate carrier 1

Gene

TPC1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier 1
Gene namesi
Name:TPC1
Ordered Locus Names:DEHA2E10428g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome E

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 44Helical; Name=1Sequence analysisAdd BLAST19
Transmembranei89 – 105Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei129 – 149Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei183 – 200Helical; Name=4Sequence analysisAdd BLAST18
Transmembranei215 – 231Helical; Name=5Sequence analysisAdd BLAST17
Transmembranei280 – 297Helical; Name=6Sequence analysisAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003204641 – 316Mitochondrial thiamine pyrophosphate carrier 1Add BLAST316

Structurei

3D structure databases

ProteinModelPortaliQ6BPW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 108Solcar 1Add BLAST88
Repeati123 – 208Solcar 2Add BLAST86
Repeati215 – 305Solcar 3Add BLAST91

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000165726.
InParanoidiQ6BPW0.
KOiK15108.
OMAiWKGNVPA.
OrthoDBiEOG092C3KDM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q6BPW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAASDTSSG RENHLKKGSK VSPYEALIAG SLSGAIARGI IAPLDTIKIR
60 70 80 90 100
LQLQIQGYDT YKGASKTFVS ICKNEGVKAL WKGNVPAEIL YILYGAIQFT
110 120 130 140 150
SYSALSKALS EFEKNNRNLF TISNSTHSLI AGSGSGLAST FFTYPFDLLR
160 170 180 190 200
TRLAANSEAH FLSMSSTIKS IYEMHGIGGF CKGLTPGLLS VASSTGLMFW
210 220 230 240 250
SYELAREFSN NYKDVIPFLE GFCGFIAGAT AKGLTFPLDT LRKRIQMLSK
260 270 280 290 300
TRDIDQNSIK AIQLCKTILK NEGIFGFYKG FSISILKSAP TSAISLFTYE
310
YSLSAIKEFT SKHKKL
Length:316
Mass (Da):34,522
Last modified:December 16, 2008 - v3
Checksum:i28E014BCF781C17B
GO

Sequence cautioni

The sequence CAG87999 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382137 Genomic DNA. Translation: CAG87999.2. Sequence problems.
RefSeqiXP_459760.2. XM_459760.2.

Genome annotation databases

EnsemblFungiiCAG87999; CAG87999; DEHA2E10428g.
GeneIDi2902694.
KEGGidha:DEHA2E10428g.

Similar proteinsi

Entry informationi

Entry nameiTPC1_DEBHA
AccessioniPrimary (citable) accession number: Q6BPW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 16, 2008
Last modified: June 7, 2017
This is version 73 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families