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Q6BPI1 (GSHR_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutathione reductase
Short name=GR
Short name=GRase
EC=1.8.1.7
Gene names
Name:GLR1
Ordered Locus Names:DEHA2E13442g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces ›

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Maintains high levels of reduced glutathione in the cytosol By similarity.

Catalytic activity

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subcellular location

Cytoplasm By similarity.

Miscellaneous

The active site is a redox-active disulfide bond By similarity.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Sequence caution

The sequence CAG88130.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRedox-active center
   LigandFAD
Flavoprotein
NADP
   Molecular functionOxidoreductase
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

glutathione metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: InterPro

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

glutathione-disulfide reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Glutathione reductase
PRO_0000067967

Regions

Nucleotide binding39 – 4911FAD By similarity

Sites

Active site4791Proton acceptor By similarity

Amino acid modifications

Disulfide bond49 ↔ 54Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BPI1 [UniParc].

Last modified December 16, 2008. Version 3.
Checksum: 1076F6EDB4389EAE

FASTA49053,520
        10         20         30         40         50         60 
MAPLQAIRKY DYLVIGGGSG GVASARRAAS YGAKVLLIES KFNKMGGTCV NVGCVPKKVM 

        70         80         90        100        110        120 
WYAGDLAEKR HHLKSYGLST TDDKVKYGDF DWSTFKDKRD AYVKRLNGIY ERNLKNEGVD 

       130        140        150        160        170        180 
YIYGFAHFAN SNGDVEVTLT GDQELSFLEE GKEFKKDEKL VFAGSKTLIA TGGYAINPPN 

       190        200        210        220        230        240 
VEGHELGTTS DGFFELQKQP KSVAVVGAGY IGVELSGIFK ALGSETHLVI RGDTVLRSFD 

       250        260        270        280        290        300 
ESIQNSITDY YTDKLGVNII KQSGSVSKVE KIDGDRKKIT LGNGQVLEVD ELIWTMGRKS 

       310        320        330        340        350        360 
LINIGLDKVG VTLNDKQQVD VDQFQQTANP NIFSLGDVIG KVELTPVAIA AGRRLSNRLF 

       370        380        390        400        410        420 
SGDKAFENDH LDYSNVPSVI FSHPEAGSIG LSCKEAKEKY GEDQIKIYKS KFNAMYYAMM 

       430        440        450        460        470        480 
EDDSLKSPTS YKVVCAGEDE KVVGLHIVGD SSAEILQGFG VAIKMGATKK DFDSCVAIHP 

       490 
TSAEELVTMK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382137 Genomic DNA. Translation: CAG88130.2. Different initiation.
RefSeqXP_459889.2. XM_459889.2.

3D structure databases

ProteinModelPortalQ6BPI1.
ModBaseSearch...

Protein-protein interaction databases

STRING4959.Q6BPI1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2902393.
KEGGdha:DEHA2E13442g.

Phylogenomic databases

eggNOGCOG1249.
HOGENOMHOG000276712.
KOK00383.
OrthoDBEOG415KNX.

Family and domain databases

Gene3D3.30.390.30. 1 hit.
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
TIGRFAMsTIGR01421. gluta_reduc_1. 1 hit.
PROSITEPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSHR_DEBHA
AccessionPrimary (citable) accession number: Q6BPI1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 16, 2008
Last modified: May 1, 2013
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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