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Protein

Glutathione reductase

Gene

GLR1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Maintains high levels of reduced glutathione in the cytosol.By similarity

Miscellaneous

The active site is a redox-active disulfide bond.By similarity

Catalytic activityi

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei479Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 49FADBy similarityAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione reductase (EC:1.8.1.7)
Short name:
GR
Short name:
GRase
Gene namesi
Name:GLR1
Ordered Locus Names:DEHA2E13442g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome E

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000679671 – 490Glutathione reductaseAdd BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 54Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ6BPI1

Structurei

3D structure databases

ProteinModelPortaliQ6BPI1
SMRiQ6BPI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOGENOMiHOG000276712
InParanoidiQ6BPI1
KOiK00383
OrthoDBiEOG092C2ILO

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006322 Glutathione_Rdtase_euk/bac
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PANTHERiPTHR42737 PTHR42737, 1 hit
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01421 gluta_reduc_1, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q6BPI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLQAIRKY DYLVIGGGSG GVASARRAAS YGAKVLLIES KFNKMGGTCV
60 70 80 90 100
NVGCVPKKVM WYAGDLAEKR HHLKSYGLST TDDKVKYGDF DWSTFKDKRD
110 120 130 140 150
AYVKRLNGIY ERNLKNEGVD YIYGFAHFAN SNGDVEVTLT GDQELSFLEE
160 170 180 190 200
GKEFKKDEKL VFAGSKTLIA TGGYAINPPN VEGHELGTTS DGFFELQKQP
210 220 230 240 250
KSVAVVGAGY IGVELSGIFK ALGSETHLVI RGDTVLRSFD ESIQNSITDY
260 270 280 290 300
YTDKLGVNII KQSGSVSKVE KIDGDRKKIT LGNGQVLEVD ELIWTMGRKS
310 320 330 340 350
LINIGLDKVG VTLNDKQQVD VDQFQQTANP NIFSLGDVIG KVELTPVAIA
360 370 380 390 400
AGRRLSNRLF SGDKAFENDH LDYSNVPSVI FSHPEAGSIG LSCKEAKEKY
410 420 430 440 450
GEDQIKIYKS KFNAMYYAMM EDDSLKSPTS YKVVCAGEDE KVVGLHIVGD
460 470 480 490
SSAEILQGFG VAIKMGATKK DFDSCVAIHP TSAEELVTMK
Length:490
Mass (Da):53,520
Last modified:December 16, 2008 - v3
Checksum:i1076F6EDB4389EAE
GO

Sequence cautioni

The sequence CAG88130 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382137 Genomic DNA Translation: CAG88130.2 Different initiation.
RefSeqiXP_459889.2, XM_459889.2

Genome annotation databases

EnsemblFungiiCAG88130; CAG88130; DEHA2E13442g
GeneIDi2902393
KEGGidha:DEHA2E13442g

Similar proteinsi

Entry informationi

Entry nameiGSHR_DEBHA
AccessioniPrimary (citable) accession number: Q6BPI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 93 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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