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Q6BP84 (FKBP2_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FK506-binding protein 2

EC=5.2.1.8
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name=PPIase
Rotamase
Gene names
Name:FPR2
Ordered Locus Names:DEHA2E15708g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length135 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by both FK506 and rapamycin By similarity.

Subcellular location

Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the FKBP-type PPIase family. FKBP2 subfamily.

Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionIsomerase
Rotamase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 135118FK506-binding protein 2
PRO_0000233067

Regions

Domain40 – 12788PPIase FKBP-type
Motif132 – 1354Prevents secretion from ER Potential

Sequences

Sequence LengthMass (Da)Tools
Q6BP84 [UniParc].

Last modified April 18, 2006. Version 2.
Checksum: 08B9E39E0D025F1E

FASTA13514,605
        10         20         30         40         50         60 
MLLKSLFLLF LTAIAFASEL QIGILTSVPD DKCKVKSKPG DLISVHYEGK LEDGTVFDSS 

        70         80         90        100        110        120 
YSRGQPISFQ LGIGQVIQGW DQGLTRMCIG EKRKLTIPSH LAYGDRGVGP IPAKATLVFV 

       130 
AELVDIAGSS KHDEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382137 Genomic DNA. Translation: CAG88239.2.
RefSeqXP_459986.2. XM_459986.2.

3D structure databases

ProteinModelPortalQ6BP84.
SMRQ6BP84. Positions 35-126.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.Q6BP84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2902171.
KEGGdha:DEHA2E15708g.

Phylogenomic databases

eggNOGCOG0545.
HOGENOMHOG000154887.
KOK09569.
OMAKRVENCT.
OrthoDBEOG77WWQ3.

Family and domain databases

InterProIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFKBP2_DEBHA
AccessionPrimary (citable) accession number: Q6BP84
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: April 16, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families