Reviewed, UniProtKB/Swiss-Prot Q6BMH4 (MCES_DEBHA)

Names and origin

Protein names

Recommended name:
    mRNA cap guanine-N7 methyltransferase
    EC=2.1.1.56
Alternative name(s):
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase

Gene names

Name:	ABD1
Ordered Locus Names:	DEHA0F05940g

Organism

Debaryomyces hansenii (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

4959 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Debaryomyces

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Responsible for methylating the 5'-cap structure of mRNAs By similarity.
Catalytic activity	S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
Subcellular location	NucleusBy similarity.
Sequence similarities	Belongs to the mRNA cap methyltransferase family.

Ontologies

Keywords
Biological process	mRNA capping mRNA processing
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA capping Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (guanine-N7-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	mRNA cap guanine-N7 methyltransferase		PRO_0000303908

Sequences

	Sequence		Length	Mass (Da)
	Q6BMH4-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 4920354B62CEBBA6	FASTA	487	55,553
	10 20 30 40 50 60 MTVPGIPIRY YYHHDGIDIS DSFSRRENKG NNKVISSVYN DENKKTPAWM KSKTTDKYDK 70 80 90 100 110 120 YGSRSTPIAT PTAPVNNPDE RYSKYMTNSV NSNDRVRRPP TETTSSQYDK KRAHDEAEDD 130 140 150 160 170 180 VVAPYSNLAV ANPSSNLYQT FQSHINNREG KDINSIVRSH YNQRTQQSKF QGSRTKSPIY 190 200 210 220 230 240 KLRNFNNAIK YILLGNWVKP NPDSNRPTVI LDLCCGKGGD LNKCEFVSVD QYIGIDISDA 250 260 270 280 290 300 SIKEAFSRYS RNKARFIPQT AESKKERDTR RYNFEACFAT GDCFSSSIPE ILEPNFPGII 310 320 330 340 350 360 DGLFPVDCVS LQFAMHYAFE TEEKVHQLLT NVTKSLRAGG TLIGTIPSSD FIRDKIVNRA 370 380 390 400 410 420 FIDQENRKFG NDLYSVTFHK DPPDEGVFRP PFGNGYNYSL KDAIDDVPEY VVPFEVFRGL 430 440 450 460 470 480 CEEYGLVLKY KKNFIDIFNQ EIPKYFSKLN KNLIEGMKRS DGKYGAEGLE KEAVGFYIGF VFEKLGN

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / IFO 0083 / IGC 2968 / JCM 1990.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382138 Genomic DNA. Translation: CAG88922.1.
RefSeq	XP_460598.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2903540.
KEGG	dha:DEHA0F05940g.
Phylogenomic databases
HOGENOM	Q6BMH4.
Family and domain databases
InterPro	IPR016899. mRNA_G-N7_MeTrfase. IPR004971. Pox_MCEL. [Graphical view]
Pfam	PF03291. Pox_MCEL. 1 hit. [Graphical view]
PIRSF	PIRSF028762. ABD1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCES_DEBHA

Accession

Primary (citable) accession number: Q6BMH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	August 16, 2004
Last modified:	November 25, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)