Reviewed, UniProtKB/Swiss-Prot Q6BMH4 (MCES_DEBHA)

Names and origin

Protein names

Recommended name:
    mRNA cap guanine-N7 methyltransferase
    EC=2.1.1.56
Alternative name(s):
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase

Gene names

Name:	ABD1
Ordered Locus Names:	DEHA2F05434g

Organism

Debaryomyces hansenii (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

4959 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Debaryomyces

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Responsible for methylating the 5'-cap structure of mRNAs By similarity.
Catalytic activity	S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the mRNA cap methyltransferase family.

Ontologies

Keywords
Biological process	mRNA capping mRNA processing
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA capping Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (guanine-N7-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 524	524	mRNA cap guanine-N7 methyltransferase		PRO_0000303908

Sequences

	Sequence		Length	Mass (Da)
	Q6BMH4-1 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: F062DD77414E822E	FASTA	524	59,331
	10 20 30 40 50 60 MSDKEAGVAS SLGSNSPINK DEVDVKNTEE HSKQESKSDI NKPPLKKIKA DDGIDISDSF 70 80 90 100 110 120 SRRENKGNNK VISSVYNDEN KKTPAWMKSK TTDKYDKYGS RSTPIATPTA PVNNPDERYS 130 140 150 160 170 180 KYMTNSVNSN DRVRRPPTET TSSQYDKKRA HDEAEDDVVA PYSNLAVANP SSNLYQTFQS 190 200 210 220 230 240 HINNREGKDI NSIVRSHYNQ RTQQSKFQGS RTKSPIYKLR NFNNAIKYIL LGNWVKPNPD 250 260 270 280 290 300 SNRPTVILDL CCGKGGDLNK CEFVSVDQYI GIDISDASIK EAFSRYSRNK ARFIPQTAES 310 320 330 340 350 360 KKERDTRRYN FEACFATGDC FSSSIPEILE PNFPGIIDGL FPVDCVSLQF AMHYAFETEE 370 380 390 400 410 420 KVHQLLTNVT KSLRAGGTLI GTIPSSDFIR DKIVNRAFID QENRKFGNDL YSVTFHKDPP 430 440 450 460 470 480 DEGVFRPPFG NGYNYSLKDA IDDVPEYVVP FEVFRGLCEE YGLVLKYKKN FIDIFNQEIP 490 500 510 520 KYFSKLNKNL IEGMKRSDGK YGAEGLEKEA VGFYIGFVFE KLGN

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / IFO 0083 / IGC 2968 / JCM 1990.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382138 Genomic DNA. Translation: CAG88922.2.
RefSeq	XP_460598.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2903540.
KEGG	dha:DEHA0F05940g.
Phylogenomic databases
HOGENOM	Q6BMH4.
OMA	Q6BMH4. WLEDAID.
Enzyme and pathway databases
BRENDA	2.1.1.56. 74267.
Family and domain databases
InterPro	IPR016899. mRNA_G-N7_MeTrfase. IPR004971. Pox_MCEL. [Graphical view]
Pfam	PF03291. Pox_MCEL. 1 hit. [Graphical view]
PIRSF	PIRSF028762. ABD1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCES_DEBHA

Accession

Primary (citable) accession number: Q6BMH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 16, 2008
Last modified:	June 16, 2009
This is version 26 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)