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Q6BM98

- LYS4_DEBHA

UniProt

Q6BM98 - LYS4_DEBHA

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Protein

Homoaconitase, mitochondrial

Gene

LYS4

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.By similarity

Catalytic activityi

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O.

Cofactori

Binds 1 4Fe-4S cluster per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi346 – 3461Iron-sulfur (4Fe-4S)By similarity
Metal bindingi406 – 4061Iron-sulfur (4Fe-4S)By similarity
Metal bindingi409 – 4091Iron-sulfur (4Fe-4S)By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: InterPro
  2. homoaconitate hydratase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00033; UER01027.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoaconitase, mitochondrial (EC:4.2.1.36)
Alternative name(s):
Homoaconitate hydratase
Gene namesi
Name:LYS4
Ordered Locus Names:DEHA2F07238g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome F

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1919MitochondrionSequence AnalysisAdd
BLAST
Chaini20 – 688669Homoaconitase, mitochondrialPRO_0000247923Add
BLAST

Proteomic databases

PRIDEiQ6BM98.

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BM98.

Structurei

3D structure databases

ProteinModelPortaliQ6BM98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aconitase/IPM isomerase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1048.
HOGENOMiHOG000173778.
InParanoidiQ6BM98.
KOiK01705.
OMAiSWPVATK.
OrthoDBiEOG70CRGK.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR004418. Homoaconitase_mito.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF8. PTHR11670:SF8. 1 hit.
PfamiPF00330. Aconitase. 2 hits.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR00139. h_aconitase. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BM98-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALLYLSTRS SLKKTGARCL SSSSILYRGQ NLTEKIVQKY AVGLADDKKV
60 70 80 90 100
FSGDYVTIKP AHCMSHDNSW PVATKFMGLG ATNVHDNRQI VCTLDHDVQN
110 120 130 140 150
KSEKNLEKYH NIENFAKEQG IDFYPAGRGI GHQIMIEEGY AYPLNLTVAS
160 170 180 190 200
DSHSNTYGGI GSLGTPIVRT DAASIWATGQ TWWQIPPVAK VELVGQLPKG
210 220 230 240 250
ATGKDIIVAL CGIFNNDEVL NHAIEFTGEG VKNLSVDYRL TIANMTTEWG
260 270 280 290 300
ALSGLFPVDE TLVNFYDERV KKLPQPHPRV NENTVKNLSE NKVNSDNDAV
310 320 330 340 350
YAKHLVVDLS SLSPYISGPN SVKVSTSLHD LSKQNIKINK AYLVSCTNSR
360 370 380 390 400
LSDIKAAADI IKGHKVAEGV EFYVAAASSN VQKDAEAIGA WQDIIDAGAK
410 420 430 440 450
PLPAGCGPCI GLGTGLLEDG EVGISATNRN FKGRMGSKDA LAYLASPEVV
460 470 480 490 500
AASAVLGKIG GPEELQGNPV PTNPEIVRSI TSNESTETVD PDASGSSVDV
510 520 530 540 550
LDGFPQSIEG ELILCDADNI NTDGIYPGKY TYQDDIPRSK MAEVCMENYD
560 570 580 590 600
SEFKQKTKAG DIIISGYNFG TGSSREQAAT AILARDMKLV VAGSFGNIFS
610 620 630 640 650
RNSINNALLT LEIPALINKL REKYAQSNEL TIRTGWFLKW DVTKNQVTVS
660 670 680
DSEGNLILTQ KVGELGTNLQ DIIVKGGLEG WVKAQLKN
Length:688
Mass (Da):74,358
Last modified:August 16, 2004 - v1
Checksum:iB1E0A2C936163F89
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382138 Genomic DNA. Translation: CAG89007.1.
RefSeqiXP_460673.1. XM_460673.1.

Genome annotation databases

GeneIDi2903254.
KEGGidha:DEHA2F07238g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382138 Genomic DNA. Translation: CAG89007.1 .
RefSeqi XP_460673.1. XM_460673.1.

3D structure databases

ProteinModelPortali Q6BM98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BM98.

Proteomic databases

PRIDEi Q6BM98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2903254.
KEGGi dha:DEHA2F07238g.

Phylogenomic databases

eggNOGi COG1048.
HOGENOMi HOG000173778.
InParanoidi Q6BM98.
KOi K01705.
OMAi SWPVATK.
OrthoDBi EOG70CRGK.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER01027 .

Family and domain databases

Gene3Di 3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProi IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR004418. Homoaconitase_mito.
[Graphical view ]
PANTHERi PTHR11670. PTHR11670. 1 hit.
PTHR11670:SF8. PTHR11670:SF8. 1 hit.
Pfami PF00330. Aconitase. 2 hits.
PF00694. Aconitase_C. 1 hit.
[Graphical view ]
PRINTSi PR00415. ACONITASE.
SUPFAMi SSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsi TIGR00139. h_aconitase. 1 hit.
PROSITEi PS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiLYS4_DEBHA
AccessioniPrimary (citable) accession number: Q6BM98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3