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Q6BM98

- LYS4_DEBHA

UniProt

Q6BM98 - LYS4_DEBHA

Protein

Homoaconitase, mitochondrial

Gene

LYS4

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.By similarity

    Catalytic activityi

    (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O.

    Cofactori

    Binds 1 4Fe-4S cluster per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi346 – 3461Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi406 – 4061Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi409 – 4091Iron-sulfur (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: InterPro
    2. homoaconitate hydratase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Keywords - Ligandi

    Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00033; UER01027.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homoaconitase, mitochondrial (EC:4.2.1.36)
    Alternative name(s):
    Homoaconitate hydratase
    Gene namesi
    Name:LYS4
    Ordered Locus Names:DEHA2F07238g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome F

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1919MitochondrionSequence AnalysisAdd
    BLAST
    Chaini20 – 688669Homoaconitase, mitochondrialPRO_0000247923Add
    BLAST

    Proteomic databases

    PRIDEiQ6BM98.

    Interactioni

    Protein-protein interaction databases

    STRINGi4959.Q6BM98.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6BM98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aconitase/IPM isomerase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1048.
    HOGENOMiHOG000173778.
    KOiK01705.
    OMAiSWPVATK.
    OrthoDBiEOG70CRGK.

    Family and domain databases

    Gene3Di3.20.19.10. 1 hit.
    3.30.499.10. 2 hits.
    3.40.1060.10. 1 hit.
    InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
    IPR015937. Acoase/IPM_deHydtase.
    IPR001030. Acoase/IPM_deHydtase_lsu_aba.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
    IPR018136. Aconitase_4Fe-4S_BS.
    IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
    IPR004418. Homoaconitase_mito.
    [Graphical view]
    PANTHERiPTHR11670. PTHR11670. 1 hit.
    PTHR11670:SF8. PTHR11670:SF8. 1 hit.
    PfamiPF00330. Aconitase. 2 hits.
    PF00694. Aconitase_C. 1 hit.
    [Graphical view]
    PRINTSiPR00415. ACONITASE.
    SUPFAMiSSF52016. SSF52016. 1 hit.
    SSF53732. SSF53732. 1 hit.
    TIGRFAMsiTIGR00139. h_aconitase. 1 hit.
    PROSITEiPS00450. ACONITASE_1. 1 hit.
    PS01244. ACONITASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6BM98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLYLSTRS SLKKTGARCL SSSSILYRGQ NLTEKIVQKY AVGLADDKKV    50
    FSGDYVTIKP AHCMSHDNSW PVATKFMGLG ATNVHDNRQI VCTLDHDVQN 100
    KSEKNLEKYH NIENFAKEQG IDFYPAGRGI GHQIMIEEGY AYPLNLTVAS 150
    DSHSNTYGGI GSLGTPIVRT DAASIWATGQ TWWQIPPVAK VELVGQLPKG 200
    ATGKDIIVAL CGIFNNDEVL NHAIEFTGEG VKNLSVDYRL TIANMTTEWG 250
    ALSGLFPVDE TLVNFYDERV KKLPQPHPRV NENTVKNLSE NKVNSDNDAV 300
    YAKHLVVDLS SLSPYISGPN SVKVSTSLHD LSKQNIKINK AYLVSCTNSR 350
    LSDIKAAADI IKGHKVAEGV EFYVAAASSN VQKDAEAIGA WQDIIDAGAK 400
    PLPAGCGPCI GLGTGLLEDG EVGISATNRN FKGRMGSKDA LAYLASPEVV 450
    AASAVLGKIG GPEELQGNPV PTNPEIVRSI TSNESTETVD PDASGSSVDV 500
    LDGFPQSIEG ELILCDADNI NTDGIYPGKY TYQDDIPRSK MAEVCMENYD 550
    SEFKQKTKAG DIIISGYNFG TGSSREQAAT AILARDMKLV VAGSFGNIFS 600
    RNSINNALLT LEIPALINKL REKYAQSNEL TIRTGWFLKW DVTKNQVTVS 650
    DSEGNLILTQ KVGELGTNLQ DIIVKGGLEG WVKAQLKN 688
    Length:688
    Mass (Da):74,358
    Last modified:August 16, 2004 - v1
    Checksum:iB1E0A2C936163F89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382138 Genomic DNA. Translation: CAG89007.1.
    RefSeqiXP_460673.1. XM_460673.1.

    Genome annotation databases

    GeneIDi2903254.
    KEGGidha:DEHA2F07238g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382138 Genomic DNA. Translation: CAG89007.1 .
    RefSeqi XP_460673.1. XM_460673.1.

    3D structure databases

    ProteinModelPortali Q6BM98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BM98.

    Proteomic databases

    PRIDEi Q6BM98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2903254.
    KEGGi dha:DEHA2F07238g.

    Phylogenomic databases

    eggNOGi COG1048.
    HOGENOMi HOG000173778.
    KOi K01705.
    OMAi SWPVATK.
    OrthoDBi EOG70CRGK.

    Enzyme and pathway databases

    UniPathwayi UPA00033 ; UER01027 .

    Family and domain databases

    Gene3Di 3.20.19.10. 1 hit.
    3.30.499.10. 2 hits.
    3.40.1060.10. 1 hit.
    InterProi IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
    IPR015937. Acoase/IPM_deHydtase.
    IPR001030. Acoase/IPM_deHydtase_lsu_aba.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
    IPR018136. Aconitase_4Fe-4S_BS.
    IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
    IPR004418. Homoaconitase_mito.
    [Graphical view ]
    PANTHERi PTHR11670. PTHR11670. 1 hit.
    PTHR11670:SF8. PTHR11670:SF8. 1 hit.
    Pfami PF00330. Aconitase. 2 hits.
    PF00694. Aconitase_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00415. ACONITASE.
    SUPFAMi SSF52016. SSF52016. 1 hit.
    SSF53732. SSF53732. 1 hit.
    TIGRFAMsi TIGR00139. h_aconitase. 1 hit.
    PROSITEi PS00450. ACONITASE_1. 1 hit.
    PS01244. ACONITASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiLYS4_DEBHA
    AccessioniPrimary (citable) accession number: Q6BM98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3