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Q6BM25

- SSN3_DEBHA

UniProt

Q6BM25 - SSN3_DEBHA

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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Magnesium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251ATPPROSITE-ProRule annotation
Active sitei237 – 2371Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 739ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:DEHA2F08844g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome F

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Serine/threonine-protein kinase SSN3PRO_0000312943Add
BLAST

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi4959.Q6BM25.

Structurei

3D structure databases

ProteinModelPortaliQ6BM25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 418360Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ6BM25.
KOiK02208.
OMAiRRVTHED.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BM25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSGYNPGNA NHITSHSNRT KNGVPTIPQP ALMASNAILT IGPYKHRKDL
60 70 80 90 100
IRESVLTKYQ IIGYIAAGTY GKVYKAKSKT NGNSNSNSAL MNDNVISIGN
110 120 130 140 150
GQKEAGLQKT NNESMEDKNQ LFAIKKFKSD NHSNKNNHDI NGNEVIHYTG
160 170 180 190 200
ISQSAIREMS LCRELSNKNI TKVVDILLEN KSIYMVFEYC EHDLLQIIQY
210 220 230 240 250
HSHPDVKPIP DFTIKSITWQ ILNGVTFLHK NWIFHRDLKP ANIMVSSSGV
260 270 280 290 300
VKIGDLGLAR KFNNPLQSLY TGDKVVVTIW YRAPELLLGA RHYTPSIDLW
310 320 330 340 350
AVGCILAELL SLRPIFKGEE AKIDMNNKKS VPFQKNQLQK IVEVLGTPTT
360 370 380 390 400
KNWPTITKYP EYSAFQQHFS NTYPPNLISW YKLIGRTSKQ CLNLLRCLLE
410 420 430 440 450
YDPTIRITAD DALTHAFFLE LPKMSENSFE GLSQKYPKRR IYTHENDIVS
460 470
NSQHVNNKRH GYDDNMTRKR QR
Length:472
Mass (Da):53,783
Last modified:December 16, 2008 - v2
Checksum:i0B4DE36D27A15AA2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382138 Genomic DNA. Translation: CAG89087.2.
RefSeqiXP_460746.2. XM_460746.1.

Genome annotation databases

GeneIDi2903762.
KEGGidha:DEHA2F08844g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382138 Genomic DNA. Translation: CAG89087.2 .
RefSeqi XP_460746.2. XM_460746.1.

3D structure databases

ProteinModelPortali Q6BM25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BM25.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2903762.
KEGGi dha:DEHA2F08844g.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q6BM25.
KOi K02208.
OMAi RRVTHED.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiSSN3_DEBHA
AccessioniPrimary (citable) accession number: Q6BM25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3