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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei125ATPPROSITE-ProRule annotation1
Active sitei237Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 73ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:DEHA2F08844g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129431 – 472Serine/threonine-protein kinase SSN3Add BLAST472

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6BM25
SMRiQ6BM25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 418Protein kinasePROSITE-ProRule annotationAdd BLAST360

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024
InParanoidiQ6BM25
KOiK02208
OMAiKSIYMVF
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q6BM25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSGYNPGNA NHITSHSNRT KNGVPTIPQP ALMASNAILT IGPYKHRKDL
60 70 80 90 100
IRESVLTKYQ IIGYIAAGTY GKVYKAKSKT NGNSNSNSAL MNDNVISIGN
110 120 130 140 150
GQKEAGLQKT NNESMEDKNQ LFAIKKFKSD NHSNKNNHDI NGNEVIHYTG
160 170 180 190 200
ISQSAIREMS LCRELSNKNI TKVVDILLEN KSIYMVFEYC EHDLLQIIQY
210 220 230 240 250
HSHPDVKPIP DFTIKSITWQ ILNGVTFLHK NWIFHRDLKP ANIMVSSSGV
260 270 280 290 300
VKIGDLGLAR KFNNPLQSLY TGDKVVVTIW YRAPELLLGA RHYTPSIDLW
310 320 330 340 350
AVGCILAELL SLRPIFKGEE AKIDMNNKKS VPFQKNQLQK IVEVLGTPTT
360 370 380 390 400
KNWPTITKYP EYSAFQQHFS NTYPPNLISW YKLIGRTSKQ CLNLLRCLLE
410 420 430 440 450
YDPTIRITAD DALTHAFFLE LPKMSENSFE GLSQKYPKRR IYTHENDIVS
460 470
NSQHVNNKRH GYDDNMTRKR QR
Length:472
Mass (Da):53,783
Last modified:December 16, 2008 - v2
Checksum:i0B4DE36D27A15AA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382138 Genomic DNA Translation: CAG89087.2
RefSeqiXP_460746.2, XM_460746.1

Genome annotation databases

EnsemblFungiiCAG89087; CAG89087; DEHA2F08844g
GeneIDi2903762
KEGGidha:DEHA2F08844g

Similar proteinsi

Entry informationi

Entry nameiSSN3_DEBHA
AccessioniPrimary (citable) accession number: Q6BM25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 16, 2008
Last modified: March 28, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health