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Q6BM25 (SSN3_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:DEHA2F08844g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Serine/threonine-protein kinase SSN3
PRO_0000312943

Regions

Domain59 – 418360Protein kinase
Nucleotide binding65 – 739ATP By similarity

Sites

Active site2371Proton acceptor By similarity
Binding site1251ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BM25 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 0B4DE36D27A15AA2

FASTA47253,783
        10         20         30         40         50         60 
MNSGYNPGNA NHITSHSNRT KNGVPTIPQP ALMASNAILT IGPYKHRKDL IRESVLTKYQ 

        70         80         90        100        110        120 
IIGYIAAGTY GKVYKAKSKT NGNSNSNSAL MNDNVISIGN GQKEAGLQKT NNESMEDKNQ 

       130        140        150        160        170        180 
LFAIKKFKSD NHSNKNNHDI NGNEVIHYTG ISQSAIREMS LCRELSNKNI TKVVDILLEN 

       190        200        210        220        230        240 
KSIYMVFEYC EHDLLQIIQY HSHPDVKPIP DFTIKSITWQ ILNGVTFLHK NWIFHRDLKP 

       250        260        270        280        290        300 
ANIMVSSSGV VKIGDLGLAR KFNNPLQSLY TGDKVVVTIW YRAPELLLGA RHYTPSIDLW 

       310        320        330        340        350        360 
AVGCILAELL SLRPIFKGEE AKIDMNNKKS VPFQKNQLQK IVEVLGTPTT KNWPTITKYP 

       370        380        390        400        410        420 
EYSAFQQHFS NTYPPNLISW YKLIGRTSKQ CLNLLRCLLE YDPTIRITAD DALTHAFFLE 

       430        440        450        460        470 
LPKMSENSFE GLSQKYPKRR IYTHENDIVS NSQHVNNKRH GYDDNMTRKR QR 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382138 Genomic DNA. Translation: CAG89087.2.
RefSeqXP_460746.2. XM_460746.1.

3D structure databases

ProteinModelPortalQ6BM25.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.Q6BM25.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2903762.
KEGGdha:DEHA2F08844g.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK02208.
OMARRVTHED.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_DEBHA
AccessionPrimary (citable) accession number: Q6BM25
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families