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Q6BLV6 (ETR1_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable trans-2-enoyl-CoA reductase 1, mitochondrial

EC=1.3.1.38
Gene names
Name:ETR1
Ordered Locus Names:DEHA2F10362g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontrans-2-enoyl-CoA reductase (NADPH) activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 378Probable trans-2-enoyl-CoA reductase 1, mitochondrialPRO_0000000900

Regions

Nucleotide binding180 – 1834NADP By similarity
Nucleotide binding203 – 2064NADP By similarity
Nucleotide binding284 – 2874NADP By similarity
Nucleotide binding309 – 3113NADP By similarity

Sites

Binding site1511NADP By similarity
Binding site3721NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BLV6 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: B5441D93474B0CAF

FASTA37841,163
        10         20         30         40         50         60 
MVKINASAIT YTKGGEISKI LSGTGFSIDT ETLGPKQVVI QALATPINPS DLNQLAGTYA 

        70         80         90        100        110        120 
SKPNFTSELD TPVPVAIGGN EGLYKVIEVG SDVTSYKNGD WVIPKMPSFG TWRTHALVTL 

       130        140        150        160        170        180 
DKPENPDPFI KVSSEDDKSI DLTQAATVSI NPSTAYQLID QFIKDWDPKG NDWIIQNGGN 

       190        200        210        220        230        240 
SQVGKFVVQI AKIRNIKTIS VIRDGKPDQD QIVKELLDLG ATKVITDKEA ESEEYINKIV 

       250        260        270        280        290        300 
PGWVNEGKVI LALNCVCGKS GSALVSHLTG NHLADYRSPH LVTYGGMSGQ PLMYSSSESL 

       310        320        330        340        350        360 
FKNVTSKAYW LTANTKRNPQ SKVDTVKKVL ALYKSGDIKP VPFNGKEFNI KSTSDDYIKL 

       370 
FLKGIAESKT GKQVIVYN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382138 Genomic DNA. Translation: CAR66313.1.
RefSeqXP_002770788.1. XM_002770742.1.

3D structure databases

ProteinModelPortalQ6BLV6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8998934.
KEGGdha:DEHA2F10362g.

Phylogenomic databases

eggNOGCOG0604.
HOGENOMHOG000294683.
OMAYWLTANT.
OrthoDBEOG7PS1RH.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
ProtoNetSearch...

Entry information

Entry nameETR1_DEBHA
AccessionPrimary (citable) accession number: Q6BLV6
Secondary accession number(s): B5RUD5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 16, 2008
Last modified: March 19, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families