Probable trans-2-enoyl-CoA reductase 1, mitochondrial precursor - Debaryomyces hansenii (Yeast)

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Reviewed, UniProtKB/Swiss-Prot Q6BLV6 (ETR1_DEBHA)

Last modified January 19, 2010. Version 40. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Probable trans-2-enoyl-CoA reductase 1, mitochondrial
EC=1.3.1.38

Gene names

Name:	ETR1
Ordered Locus Names:	DEHA2F10362g

Organism

Debaryomyces hansenii (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Debaryomyces

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA. May have a role in the mitochondrial synthesis of fatty acids By similarity.
Catalytic activity	Acyl-CoA + NADP⁺ = trans-2,3-dehydroacyl-CoA + NADPH.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	trans-2-enoyl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Molecule processing
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 378		Probable trans-2-enoyl-CoA reductase 1, mitochondrial		PRO_0000000900

Sequences

Sequence

Length

Mass (Da)

Tools

Q6BLV6-1 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: B5441D93474B0CAF
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378

41,163

        10         20         30         40         50         60 
MVKINASAIT YTKGGEISKI LSGTGFSIDT ETLGPKQVVI QALATPINPS DLNQLAGTYA 

        70         80         90        100        110        120 
SKPNFTSELD TPVPVAIGGN EGLYKVIEVG SDVTSYKNGD WVIPKMPSFG TWRTHALVTL 

       130        140        150        160        170        180 
DKPENPDPFI KVSSEDDKSI DLTQAATVSI NPSTAYQLID QFIKDWDPKG NDWIIQNGGN 

       190        200        210        220        230        240 
SQVGKFVVQI AKIRNIKTIS VIRDGKPDQD QIVKELLDLG ATKVITDKEA ESEEYINKIV 

       250        260        270        280        290        300 
PGWVNEGKVI LALNCVCGKS GSALVSHLTG NHLADYRSPH LVTYGGMSGQ PLMYSSSESL 

       310        320        330        340        350        360 
FKNVTSKAYW LTANTKRNPQ SKVDTVKKVL ALYKSGDIKP VPFNGKEFNI KSTSDDYIKL 

       370 
FLKGIAESKT GKQVIVYN

References

[1]

"Genome evolution in yeasts."
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.

expand/collapse author list

Souciet J.-L.
Nature 430:35-44(2004) [PubMed: 15229592] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 36239 / CBS 767 / IFO 0083 / IGC 2968 / JCM 1990.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382138 Genomic DNA. Translation: CAR66313.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GenomeReviews	Gene locus DEHA2F10362g in contig CR382138_GR.
Phylogenomic databases
eggNOG	fuNOG14266.
HOGENOM	HBG753318.
OMA	WLTANTK.
OrthoDB	EOG90P5R3.
Enzyme and pathway databases
BRENDA	1.3.1.38. 74267.
Family and domain databases
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ETR1_DEBHA

Accession

Primary (citable) accession number: Q6BLV6
Secondary accession number(s): B5RUD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	December 16, 2008
Last modified:	January 19, 2010
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents