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Q6BLV6

- ETR1_DEBHA

UniProt

Q6BLV6 - ETR1_DEBHA

Protein

Probable trans-2-enoyl-CoA reductase 1, mitochondrial

Gene

ETR1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei151 – 1511NADPBy similarity
    Binding sitei372 – 3721NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi180 – 1834NADPBy similarity
    Nucleotide bindingi203 – 2064NADPBy similarity
    Nucleotide bindingi284 – 2874NADPBy similarity
    Nucleotide bindingi309 – 3113NADPBy similarity

    GO - Molecular functioni

    1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable trans-2-enoyl-CoA reductase 1, mitochondrial (EC:1.3.1.38)
    Gene namesi
    Name:ETR1
    Ordered Locus Names:DEHA2F10362g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome F

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 378Probable trans-2-enoyl-CoA reductase 1, mitochondrialPRO_0000000900
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6BLV6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0604.
    HOGENOMiHOG000294683.
    OMAiYWLTANT.
    OrthoDBiEOG7PS1RH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6BLV6-1 [UniParc]FASTAAdd to Basket

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    MVKINASAIT YTKGGEISKI LSGTGFSIDT ETLGPKQVVI QALATPINPS    50
    DLNQLAGTYA SKPNFTSELD TPVPVAIGGN EGLYKVIEVG SDVTSYKNGD 100
    WVIPKMPSFG TWRTHALVTL DKPENPDPFI KVSSEDDKSI DLTQAATVSI 150
    NPSTAYQLID QFIKDWDPKG NDWIIQNGGN SQVGKFVVQI AKIRNIKTIS 200
    VIRDGKPDQD QIVKELLDLG ATKVITDKEA ESEEYINKIV PGWVNEGKVI 250
    LALNCVCGKS GSALVSHLTG NHLADYRSPH LVTYGGMSGQ PLMYSSSESL 300
    FKNVTSKAYW LTANTKRNPQ SKVDTVKKVL ALYKSGDIKP VPFNGKEFNI 350
    KSTSDDYIKL FLKGIAESKT GKQVIVYN 378
    Length:378
    Mass (Da):41,163
    Last modified:December 16, 2008 - v2
    Checksum:iB5441D93474B0CAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382138 Genomic DNA. Translation: CAR66313.1.
    RefSeqiXP_002770788.1. XM_002770742.1.

    Genome annotation databases

    GeneIDi8998934.
    KEGGidha:DEHA2F10362g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382138 Genomic DNA. Translation: CAR66313.1 .
    RefSeqi XP_002770788.1. XM_002770742.1.

    3D structure databases

    ProteinModelPortali Q6BLV6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8998934.
    KEGGi dha:DEHA2F10362g.

    Phylogenomic databases

    eggNOGi COG0604.
    HOGENOMi HOG000294683.
    OMAi YWLTANT.
    OrthoDBi EOG7PS1RH.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    ProtoNeti Search...

    Entry informationi

    Entry nameiETR1_DEBHA
    AccessioniPrimary (citable) accession number: Q6BLV6
    Secondary accession number(s): B5RUD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3