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Q6BLV6

- ETR1_DEBHA

UniProt

Q6BLV6 - ETR1_DEBHA

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Protein

Probable trans-2-enoyl-CoA reductase 1, mitochondrial

Gene

ETR1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.By similarity

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei151 – 1511NADPBy similarity
Binding sitei372 – 3721NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi180 – 1834NADPBy similarity
Nucleotide bindingi203 – 2064NADPBy similarity
Nucleotide bindingi284 – 2874NADPBy similarity
Nucleotide bindingi309 – 3113NADPBy similarity

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Probable trans-2-enoyl-CoA reductase 1, mitochondrial (EC:1.3.1.38)
Gene namesi
Name:ETR1
Ordered Locus Names:DEHA2F10362g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome F

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 378Probable trans-2-enoyl-CoA reductase 1, mitochondrialPRO_0000000900
Transit peptidei1 – ?MitochondrionSequence Analysis

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6BLV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
HOGENOMiHOG000294683.
InParanoidiQ6BLV6.
OMAiYWLTANT.
OrthoDBiEOG7PS1RH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BLV6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKINASAIT YTKGGEISKI LSGTGFSIDT ETLGPKQVVI QALATPINPS
60 70 80 90 100
DLNQLAGTYA SKPNFTSELD TPVPVAIGGN EGLYKVIEVG SDVTSYKNGD
110 120 130 140 150
WVIPKMPSFG TWRTHALVTL DKPENPDPFI KVSSEDDKSI DLTQAATVSI
160 170 180 190 200
NPSTAYQLID QFIKDWDPKG NDWIIQNGGN SQVGKFVVQI AKIRNIKTIS
210 220 230 240 250
VIRDGKPDQD QIVKELLDLG ATKVITDKEA ESEEYINKIV PGWVNEGKVI
260 270 280 290 300
LALNCVCGKS GSALVSHLTG NHLADYRSPH LVTYGGMSGQ PLMYSSSESL
310 320 330 340 350
FKNVTSKAYW LTANTKRNPQ SKVDTVKKVL ALYKSGDIKP VPFNGKEFNI
360 370
KSTSDDYIKL FLKGIAESKT GKQVIVYN
Length:378
Mass (Da):41,163
Last modified:December 16, 2008 - v2
Checksum:iB5441D93474B0CAF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382138 Genomic DNA. Translation: CAR66313.1.
RefSeqiXP_002770788.1. XM_002770742.1.

Genome annotation databases

GeneIDi8998934.
KEGGidha:DEHA2F10362g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382138 Genomic DNA. Translation: CAR66313.1 .
RefSeqi XP_002770788.1. XM_002770742.1.

3D structure databases

ProteinModelPortali Q6BLV6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8998934.
KEGGi dha:DEHA2F10362g.

Phylogenomic databases

eggNOGi COG0604.
HOGENOMi HOG000294683.
InParanoidi Q6BLV6.
OMAi YWLTANT.
OrthoDBi EOG7PS1RH.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiETR1_DEBHA
AccessioniPrimary (citable) accession number: Q6BLV6
Secondary accession number(s): B5RUD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3