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Protein

Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial

Gene

ETR1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei59Proton donorBy similarity1
Binding sitei151NADPBy similarity1
Binding sitei372NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi180 – 183NADPBy similarity4
Nucleotide bindingi203 – 206NADPBy similarity4
Nucleotide bindingi284 – 287NADPBy similarity4
Nucleotide bindingi309 – 311NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial (EC:1.3.1.104)
Alternative name(s):
2-enoyl thioester reductase 1
Gene namesi
Name:ETR1
Ordered Locus Names:DEHA2F10362g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000000900? – 378Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PRIDEiQ6BLV6

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6BLV6
SMRiQ6BLV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000294683
InParanoidiQ6BLV6
KOiK07512
OMAiWLMTWIR
OrthoDBiEOG092C2NJA

Family and domain databases

InterProiView protein in InterPro
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BLV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKINASAIT YTKGGEISKI LSGTGFSIDT ETLGPKQVVI QALATPINPS
60 70 80 90 100
DLNQLAGTYA SKPNFTSELD TPVPVAIGGN EGLYKVIEVG SDVTSYKNGD
110 120 130 140 150
WVIPKMPSFG TWRTHALVTL DKPENPDPFI KVSSEDDKSI DLTQAATVSI
160 170 180 190 200
NPSTAYQLID QFIKDWDPKG NDWIIQNGGN SQVGKFVVQI AKIRNIKTIS
210 220 230 240 250
VIRDGKPDQD QIVKELLDLG ATKVITDKEA ESEEYINKIV PGWVNEGKVI
260 270 280 290 300
LALNCVCGKS GSALVSHLTG NHLADYRSPH LVTYGGMSGQ PLMYSSSESL
310 320 330 340 350
FKNVTSKAYW LTANTKRNPQ SKVDTVKKVL ALYKSGDIKP VPFNGKEFNI
360 370
KSTSDDYIKL FLKGIAESKT GKQVIVYN
Length:378
Mass (Da):41,163
Last modified:December 16, 2008 - v2
Checksum:iB5441D93474B0CAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382138 Genomic DNA Translation: CAR66313.1
RefSeqiXP_002770788.1, XM_002770742.1

Genome annotation databases

EnsemblFungiiCAR66313; CAR66313; DEHA2F10362g
GeneIDi8998934
KEGGidha:DEHA2F10362g

Similar proteinsi

Entry informationi

Entry nameiETR1_DEBHA
AccessioniPrimary (citable) accession number: Q6BLV6
Secondary accession number(s): B5RUD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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