Reviewed, UniProtKB/Swiss-Prot Q6BLV6 (ETR1_DEBHA)

Names and origin

Protein names

Recommended name:
    Probable trans-2-enoyl-CoA reductase 1, mitochondrial
    EC=1.3.1.38

Gene names

Name:	ETR1
Ordered Locus Names:	DEHA0F11319g

Organism

Debaryomyces hansenii (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

4959 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Debaryomyces

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA. May have a role in the mitochondrial synthesis of fatty acids By similarity.
Catalytic activity	Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
Subunit structure	Homodimer By similarity.
Subcellular location	MitochondrionBy similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	trans-2-enoyl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 378		Probable trans-2-enoyl-CoA reductase 1, mitochondrial		PRO_0000000900

Sequences

	Sequence		Length	Mass (Da)
	Q6BLV6-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: CA83C11C8D31FB2F	FASTA	378	41,243
	10 20 30 40 50 60 MVKINASAIT YTKGGEISKI LLGTGFSIDT ETLGPKQVVI QALATPINPS DLNQLAGTYA 70 80 90 100 110 120 SKPNFTSELD TPVPVAIGGN EGLYKVIEVG SDVTSYKNGD WVIPKMPSFG TWRTHALVTL 130 140 150 160 170 180 DKPENPDPFI KVSSEDDKSI DLTQAATVSI NPSTAYQLID QFIKDWDPKG NDWIIQNGGN 190 200 210 220 230 240 SQVGKFVVQI AKIRNIKTIS VIRDGKPDQD QIVKELLDLG ATKVITDKEA ESEEYINKIV 250 260 270 280 290 300 PGWVNEGKVI LALNCVCGKS GSALVSHLTG NHLADYRSPH LVTYGGMLGQ PLMYSSSESL 310 320 330 340 350 360 FKNVTSKAYW LTANTKRNPQ SKVDTVKKVL ALYKSGDIKP VPFNGKEFNI KSTSDDYIKL 370 FLRGIAESKT GKQVIVYN

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / IFO 0083 / IGC 2968 / JCM 1990.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382138 Genomic DNA. Translation: CAG89156.1.
RefSeq	XP_460815.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2904327.
KEGG	dha:DEHA0F11319g.
Phylogenomic databases
HOGENOM	Q6BLV6.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ETR1_DEBHA

Accession

Primary (citable) accession number: Q6BLV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	August 16, 2004
Last modified:	November 25, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)