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Q6BLS3 (GUAA_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing]
EC=6.3.5.2
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene names
Name:GUA1
Ordered Locus Names:DEHA2F11110g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.

Ontologies

Keywords
   Biological processGMP biosynthesis
Purine biosynthesis
   Cellular componentCytoplasm
   DomainGlutamine amidotransferase
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processGMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

glutamine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GMP synthase (glutamine-hydrolyzing) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529GMP synthase [glutamine-hydrolyzing]
PRO_0000286148

Regions

Domain17 – 206190Glutamine amidotransferase type-1
Domain207 – 404198GMPS ATP-PPase
Nucleotide binding235 – 2417ATP By similarity

Sites

Active site931For GATase activity By similarity
Active site1801For GATase activity By similarity
Active site1821For GATase activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BLS3 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 9233BB0713F860DC

FASTA52958,792
        10         20         30         40         50         60 
MVNPADVPIE VSKVFDTILV LDFGSQYSHL ITRRLREFNV YAEMLPCTQK ISELTWKPKG 

        70         80         90        100        110        120 
IILSGGPYSV YEDGSPHVDH DIFKLNVPIL GICYGMQELA WINGKGVARG DKREYGPATL 

       130        140        150        160        170        180 
NVEDSSCSLF KGVDHSQVWM SHGDKLHALP TGFKVVATSD NSPFAAISNE KENIFGIQFH 

       190        200        210        220        230        240 
PEVTHTKQGK VLLRNFAIDI CQASNNWTME NFIDTEIARI QKLVGPTAEV IGAVSGGVDS 

       250        260        270        280        290        300 
TVGAKIMKEA IGDRFHAIYV DNGLMRLNET EQVYKTLTEG LGINLTVVDA TDLFLGKLQG 

       310        320        330        340        350        360 
VTDPEKKRKI IGNNFIHVFE AEAAKIKPAS GQEIEYLLQG TLYPDVIESI SFKGPSQTIK 

       370        380        390        400        410        420 
THHNVGGLLE DMKLKLIEPL RELFKDEVRH LGEIMGVPHD LVWRHPFPGP GLAIRVLGEV 

       430        440        450        460        470        480 
TREQLKIARE ADNIFIEEIR KAGLYKDISQ AFAALLPVKS VGVMGDQRTY EQVIALRAIE 

       490        500        510        520 
TTDFMTADWF VFEAAFLKKT ASRIVNEVDG VARVTYDITS KPPATVEWE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382138 Genomic DNA. Translation: CAG89193.1.
RefSeqXP_460848.1. XM_460848.1.

3D structure databases

HSSPHSSP built from PDB template 1GPM based on UniProtKB P04079.
ProteinModelPortalQ6BLS3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6BLS3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2903588.
GenomeReviewsGene locus DEHA2F11110g in contig CR382138_GR.
KEGGdha:DEHA2F11110g.

Phylogenomic databases

eggNOGfuNOG07551.
HOGENOMHBG391775.
OMADGRTYEY.
OrthoDBEOG4WWVST.

Family and domain databases

InterProIPR017926. GATASE_1.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01951.
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. GuaA_Cterm. 1 hit.
TIGR00888. GuaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAA_DEBHA
AccessionPrimary (citable) accession number: Q6BLS3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: August 16, 2004
Last modified: January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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