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Protein

Phosphoglycerate kinase

Gene

PGK1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei169SubstrateBy similarity1
Binding sitei218ATPBy similarity1
Binding sitei311ATP; via carbonyl oxygenBy similarity1
Binding sitei342ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi371 – 374ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK1
Ordered Locus Names:DEHA2F15202g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome F

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458791 – 416Phosphoglycerate kinaseAdd BLAST416

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6BLA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni63 – 66Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000227107.
InParanoidiQ6BLA0.
KOiK00927.
OMAiFPVDYVT.
OrthoDBiEOG092C2GKC.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BLA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSNKLSVK DLDVSGKRVF IRVDFNVPLD GKTITNNQRI VAALPTIKYV
60 70 80 90 100
LENKPKAVIL ASHLGRPNGE KVDKFSLAPV ASELEKLLGK KVNFLDDCVG
110 120 130 140 150
DNVEKAVNGG SDGEVFLLEN LRFHIEEEGS QKKDGEKVKA SGEDVKKFRQ
160 170 180 190 200
QLTNLADVYV NDAFGTAHRA HSSMVGLELP QKAAGFLMAK ELEYFAKALE
210 220 230 240 250
NPVRPFLAIL GGAKVSDKIQ LIDNLLDKVD LLIVGGGMSF TFKKVLDNMP
260 270 280 290 300
IGDSLFDEAG AKNVENLVAK AKKNNVKIVL PVDFITADKF DKDAKTSTAT
310 320 330 340 350
EDEGIPDNWM GLDAGPKSNE LFAKTVAEAK TIVWNGPPGV FEFDNFAKGT
360 370 380 390 400
KSLLDAAVKS AESGNTVIIG GGDTATVAKK YGVVDKLSHV STGGGASLEL
410
LEGKELPGVV AISDKK
Length:416
Mass (Da):44,614
Last modified:August 16, 2004 - v1
Checksum:i443C791E3E129A9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382138 Genomic DNA. Translation: CAG89391.1.
RefSeqiXP_461021.1. XM_461021.1.

Genome annotation databases

EnsemblFungiiCAG89391; CAG89391; DEHA2F15202g.
GeneIDi2904142.
KEGGidha:DEHA2F15202g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382138 Genomic DNA. Translation: CAG89391.1.
RefSeqiXP_461021.1. XM_461021.1.

3D structure databases

ProteinModelPortaliQ6BLA0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG89391; CAG89391; DEHA2F15202g.
GeneIDi2904142.
KEGGidha:DEHA2F15202g.

Phylogenomic databases

HOGENOMiHOG000227107.
InParanoidiQ6BLA0.
KOiK00927.
OMAiFPVDYVT.
OrthoDBiEOG092C2GKC.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGK_DEBHA
AccessioniPrimary (citable) accession number: Q6BLA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.