Reviewed, UniProtKB/Swiss-Prot Q6BKW1 (ACH1_DEBHA)

Names and origin

Protein names

Recommended name:
    Acetyl-CoA hydrolase
    EC=3.1.2.1
Alternative name(s):
    Acetyl-CoA deacylase
      Short name=Acetyl-CoA acylase

Gene names

Name:	ACH1
Ordered Locus Names:	DEHA2F18744g

Organism

Debaryomyces hansenii (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

4959 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Debaryomyces

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.
Catalytic activity	Acetyl-CoA + H2O = CoA + acetate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetyl-CoA hydrolase/transferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 523	523	Acetyl-CoA hydrolase		PRO_0000215519

Sequences

	Sequence		Length	Mass (Da)
	Q6BKW1-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 9EED942E19750768	FASTA	523	58,294
	10 20 30 40 50 60 MSSILKQRVR YAPYLQKLRT AEQCVELFKH GQYLGWSGFT GVGAPKVVPD AIADHVEKNN 70 80 90 100 110 120 LQGKLGFNLF VGASAGPEEG RWAENDMLLR RSPHQVGKPI AKAINTGKTK FFDKHLSMFP 130 140 150 160 170 180 QDLTYGFYTR EKENDLLDYT IIEATAITED GSIVPGPAVG ASPEMISVSD KIIIEVNTVT 190 200 210 220 230 240 PSFEGLHDID MPVNPPFRQP YPHTTVDYRT GLTAIPVDPS KVVAIVESQT RDKVPPNTPS 250 260 270 280 290 300 DETSRNIANN LLEFFEHEAK LGRLPENLHP LQSGIGNIAN AVVEGLADSK FKNLTVWTEV 310 320 330 340 350 360 LQDSFLDFFE SGSLDFATAT SIRLTEAGFD KFYENWDTYS KKLCLRSQVV SNSPEIIRRL 370 380 390 400 410 420 GTIAMNTPVE VDIYAHANST NVMGSRMLNG LGGSADFLRN SKLSVMHTPS ARPSKTDKTG 430 440 450 460 470 480 VSCIVPFATH VDQTEHDLDI VVTDQGLADL RGLSPKERAR EIITKTSHPD YRDQLTDYLD 490 500 510 520 RATFYAEKSK CLHEPHILQD AFKMHLNFQE NGTMKLDSWD KKF

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / IFO 0083 / IGC 2968 / JCM 1990.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382138 Genomic DNA. Translation: CAG89543.1.
RefSeq	XP_461160.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2903722.
GenomeReviews	Gene locus DEHA2F18744g in contig CR382138_GR.
KEGG	dha:DEHA0F19954g.
Phylogenomic databases
HOGENOM	Q6BKW1.
OMA	DEALSWH.
Enzyme and pathway databases
BRENDA	3.1.2.1. 74267.
Family and domain databases
InterPro	IPR003702. ActCoA_hydro. [Graphical view]
PANTHER	PTHR21432. ActCoA_hydro. 1 hit.
Pfam	PF02550. AcetylCoA_hydro. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACH1_DEBHA

Accession

Primary (citable) accession number: Q6BKW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	August 16, 2004
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)