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Q6BKW1

- ACH1_DEBHA

UniProt

Q6BKW1 - ACH1_DEBHA

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Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei299 – 29915-glutamyl coenzyme A thioester intermediateBy similarity
Binding sitei389 – 3891Coenzyme ABy similarity
Binding sitei393 – 3931Coenzyme A; via amide nitrogenBy similarity

GO - Molecular functioni

  1. acetyl-CoA hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetyl-CoA metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ACH1
Ordered Locus Names:DEHA2F18744g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome F

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Acetyl-CoA hydrolasePRO_0000215519Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BKW1.

Structurei

3D structure databases

ProteinModelPortaliQ6BKW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni274 – 2785Coenzyme A bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0427.
HOGENOMiHOG000172597.
InParanoidiQ6BKW1.
KOiK01067.
OMAiDYQPILT.
OrthoDBiEOG7TQV8M.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BKW1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSILKQRVR YAPYLQKLRT AEQCVELFKH GQYLGWSGFT GVGAPKVVPD
60 70 80 90 100
AIADHVEKNN LQGKLGFNLF VGASAGPEEG RWAENDMLLR RSPHQVGKPI
110 120 130 140 150
AKAINTGKTK FFDKHLSMFP QDLTYGFYTR EKENDLLDYT IIEATAITED
160 170 180 190 200
GSIVPGPAVG ASPEMISVSD KIIIEVNTVT PSFEGLHDID MPVNPPFRQP
210 220 230 240 250
YPHTTVDYRT GLTAIPVDPS KVVAIVESQT RDKVPPNTPS DETSRNIANN
260 270 280 290 300
LLEFFEHEAK LGRLPENLHP LQSGIGNIAN AVVEGLADSK FKNLTVWTEV
310 320 330 340 350
LQDSFLDFFE SGSLDFATAT SIRLTEAGFD KFYENWDTYS KKLCLRSQVV
360 370 380 390 400
SNSPEIIRRL GTIAMNTPVE VDIYAHANST NVMGSRMLNG LGGSADFLRN
410 420 430 440 450
SKLSVMHTPS ARPSKTDKTG VSCIVPFATH VDQTEHDLDI VVTDQGLADL
460 470 480 490 500
RGLSPKERAR EIITKTSHPD YRDQLTDYLD RATFYAEKSK CLHEPHILQD
510 520
AFKMHLNFQE NGTMKLDSWD KKF
Length:523
Mass (Da):58,294
Last modified:August 16, 2004 - v1
Checksum:i9EED942E19750768
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382138 Genomic DNA. Translation: CAG89543.1.
RefSeqiXP_461160.1. XM_461160.1.

Genome annotation databases

GeneIDi2903722.
KEGGidha:DEHA2F18744g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382138 Genomic DNA. Translation: CAG89543.1 .
RefSeqi XP_461160.1. XM_461160.1.

3D structure databases

ProteinModelPortali Q6BKW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BKW1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2903722.
KEGGi dha:DEHA2F18744g.

Phylogenomic databases

eggNOGi COG0427.
HOGENOMi HOG000172597.
InParanoidi Q6BKW1.
KOi K01067.
OMAi DYQPILT.
OrthoDBi EOG7TQV8M.

Family and domain databases

InterProi IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view ]
Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiACH1_DEBHA
AccessioniPrimary (citable) accession number: Q6BKW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3