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Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2995-glutamyl coenzyme A thioester intermediateBy similarity1
Binding sitei389Coenzyme ABy similarity1
Binding sitei393Coenzyme A; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ACH1
Ordered Locus Names:DEHA2F18744g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155191 – 523Acetyl-CoA hydrolaseAdd BLAST523

Structurei

3D structure databases

ProteinModelPortaliQ6BKW1
SMRiQ6BKW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni274 – 278Coenzyme A bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172597
InParanoidiQ6BKW1
KOiK01067
OMAiDEALSWH
OrthoDBiEOG092C1EVJ

Family and domain databases

Gene3Di3.40.1080.20, 1 hit
InterProiView protein in InterPro
IPR026888 AcetylCoA_hyd_C
IPR038460 AcetylCoA_hyd_C_sf
IPR003702 ActCoA_hydro
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF13336 AcetylCoA_hyd_C, 1 hit
PF02550 AcetylCoA_hydro, 1 hit
SUPFAMiSSF100950 SSF100950, 2 hits

Sequencei

Sequence statusi: Complete.

Q6BKW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSILKQRVR YAPYLQKLRT AEQCVELFKH GQYLGWSGFT GVGAPKVVPD
60 70 80 90 100
AIADHVEKNN LQGKLGFNLF VGASAGPEEG RWAENDMLLR RSPHQVGKPI
110 120 130 140 150
AKAINTGKTK FFDKHLSMFP QDLTYGFYTR EKENDLLDYT IIEATAITED
160 170 180 190 200
GSIVPGPAVG ASPEMISVSD KIIIEVNTVT PSFEGLHDID MPVNPPFRQP
210 220 230 240 250
YPHTTVDYRT GLTAIPVDPS KVVAIVESQT RDKVPPNTPS DETSRNIANN
260 270 280 290 300
LLEFFEHEAK LGRLPENLHP LQSGIGNIAN AVVEGLADSK FKNLTVWTEV
310 320 330 340 350
LQDSFLDFFE SGSLDFATAT SIRLTEAGFD KFYENWDTYS KKLCLRSQVV
360 370 380 390 400
SNSPEIIRRL GTIAMNTPVE VDIYAHANST NVMGSRMLNG LGGSADFLRN
410 420 430 440 450
SKLSVMHTPS ARPSKTDKTG VSCIVPFATH VDQTEHDLDI VVTDQGLADL
460 470 480 490 500
RGLSPKERAR EIITKTSHPD YRDQLTDYLD RATFYAEKSK CLHEPHILQD
510 520
AFKMHLNFQE NGTMKLDSWD KKF
Length:523
Mass (Da):58,294
Last modified:August 16, 2004 - v1
Checksum:i9EED942E19750768
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382138 Genomic DNA Translation: CAG89543.1
RefSeqiXP_461160.1, XM_461160.1

Genome annotation databases

EnsemblFungiiCAG89543; CAG89543; DEHA2F18744g
GeneIDi2903722
KEGGidha:DEHA2F18744g

Similar proteinsi

Entry informationi

Entry nameiACH1_DEBHA
AccessioniPrimary (citable) accession number: Q6BKW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health