Q6BKI8 (NNT1_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative nicotinamide N-methyltransferase
EC=2.1.1.1

Gene names

Name:	NNT1
Ordered Locus Names:	DEHA2F21604g

Organism

Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

284592 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination By similarity.
Catalytic activity	S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NNT1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinamide N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Putative nicotinamide N-methyltransferase		PRO_0000096894

Sequences

	Sequence		Length	Mass (Da)
	Q6BKI8 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: C3D3D58C40F28EDD	FASTA	254	28,982
	10 20 30 40 50 60 MSDDEFIDTG LFAEPEGFTP PPPPPHFAKY QRKNKTDPAE LNLRLVGKSP LWGHLLWNAG 70 80 90 100 110 120 VFTADYLDKH ADELVTGKDV LELGAAAGLP SLICGINKCN RVVCTDYPDP DLISNIQHNF 130 140 150 160 170 180 DHCQGLDLSK TVVKGFIWGA DAKPLMDDSE KEIQNEDKFD LVILSDLVFN HTEHLKLLKT 190 200 210 220 230 240 CRDTVKKNGK CLVVFSPHRP KLLENDLEFF RTCEDFQFKA EKIDLVTWKP MFEEDDESID 250 IRARVYSFFL VPQW

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382138 Genomic DNA. Translation: CAG89682.1.
RefSeq	XP_461283.1. XM_461283.1.
3D structure databases
ProteinModelPortal	Q6BKI8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6BKI8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2903085.
GenomeReviews	Gene locus DEHA2F21604g in contig CR382138_GR.
KEGG	dha:DEHA2F21604g.
Phylogenomic databases
eggNOG	fuNOG05731.
HOGENOM	HBG397955.
OMA	HLLWNAG.
OrthoDB	EOG4MKRRQ.
Family and domain databases
InterPro	IPR019410. Nicotinamide_N-MeTfrase_put. [Graphical view]
Pfam	PF10294. Methyltransf_16. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NNT1_DEBHA

Accession

Primary (citable) accession number: Q6BKI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	August 16, 2004
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program