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Protein

Protein N-methyltransferase NNT1

Gene

NNT1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein methyltransferase. Involved in rDNA silencing and in lifespan determination.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei106 – 1061S-adenosyl-L-methionineBy similarity
Binding sitei138 – 1381S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei165 – 1651S-adenosyl-L-methionine; via carbonyl oxygenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein N-methyltransferase NNT1By similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Nicotinamide N-methyltransferase-like protein 1By similarity
Gene namesi
Name:NNT1
Ordered Locus Names:DEHA2F21604g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome F

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Protein N-methyltransferase NNT1PRO_0000096894Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6BKI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 863S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. NNT1 family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000199189.
InParanoidiQ6BKI8.
KOiK17878.
OMAiVVFSPHR.
OrthoDBiEOG092C4ME2.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Methyltransf_16.
IPR025784. Nicotinamide_N-MeTfrase_put.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51560. SAM_MT_NNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BKI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDEFIDTG LFAEPEGFTP PPPPPHFAKY QRKNKTDPAE LNLRLVGKSP
60 70 80 90 100
LWGHLLWNAG VFTADYLDKH ADELVTGKDV LELGAAAGLP SLICGINKCN
110 120 130 140 150
RVVCTDYPDP DLISNIQHNF DHCQGLDLSK TVVKGFIWGA DAKPLMDDSE
160 170 180 190 200
KEIQNEDKFD LVILSDLVFN HTEHLKLLKT CRDTVKKNGK CLVVFSPHRP
210 220 230 240 250
KLLENDLEFF RTCEDFQFKA EKIDLVTWKP MFEEDDESID IRARVYSFFL

VPQW
Length:254
Mass (Da):28,982
Last modified:August 16, 2004 - v1
Checksum:iC3D3D58C40F28EDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382138 Genomic DNA. Translation: CAG89682.1.
RefSeqiXP_461283.1. XM_461283.1.

Genome annotation databases

EnsemblFungiiCAG89682; CAG89682; DEHA2F21604g.
GeneIDi2903085.
KEGGidha:DEHA2F21604g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382138 Genomic DNA. Translation: CAG89682.1.
RefSeqiXP_461283.1. XM_461283.1.

3D structure databases

ProteinModelPortaliQ6BKI8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG89682; CAG89682; DEHA2F21604g.
GeneIDi2903085.
KEGGidha:DEHA2F21604g.

Phylogenomic databases

HOGENOMiHOG000199189.
InParanoidiQ6BKI8.
KOiK17878.
OMAiVVFSPHR.
OrthoDBiEOG092C4ME2.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Methyltransf_16.
IPR025784. Nicotinamide_N-MeTfrase_put.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51560. SAM_MT_NNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNNT1_DEBHA
AccessioniPrimary (citable) accession number: Q6BKI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.