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Protein

Protein N-terminal and lysine N-methyltransferase EFM7

Gene

EFM7

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei106S-adenosyl-L-methionineUniRule annotation1
Binding sitei138S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei165S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein N-terminal and lysine N-methyltransferase EFM7UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
Elongation factor methyltransferase 7UniRule annotation
Gene namesi
Name:EFM7UniRule annotation
Synonyms:NNT1
Ordered Locus Names:DEHA2F21604g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome F

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968941 – 254Protein N-terminal and lysine N-methyltransferase EFM7Add BLAST254

Structurei

3D structure databases

ProteinModelPortaliQ6BKI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 86S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000199189.
InParanoidiQ6BKI8.
KOiK17878.
OMAiVVFSPHR.
OrthoDBiEOG092C4ME2.

Family and domain databases

HAMAPiMF_03223. Methyltr_EFM7. 1 hit.
InterProiView protein in InterPro
IPR019410. Methyltransf_16.
IPR025784. Nicotinamide_N-MeTfrase_put.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF10294. Methyltransf_16. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS51560. SAM_MT_NNT1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6BKI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDEFIDTG LFAEPEGFTP PPPPPHFAKY QRKNKTDPAE LNLRLVGKSP
60 70 80 90 100
LWGHLLWNAG VFTADYLDKH ADELVTGKDV LELGAAAGLP SLICGINKCN
110 120 130 140 150
RVVCTDYPDP DLISNIQHNF DHCQGLDLSK TVVKGFIWGA DAKPLMDDSE
160 170 180 190 200
KEIQNEDKFD LVILSDLVFN HTEHLKLLKT CRDTVKKNGK CLVVFSPHRP
210 220 230 240 250
KLLENDLEFF RTCEDFQFKA EKIDLVTWKP MFEEDDESID IRARVYSFFL

VPQW
Length:254
Mass (Da):28,982
Last modified:August 16, 2004 - v1
Checksum:iC3D3D58C40F28EDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382138 Genomic DNA. Translation: CAG89682.1.
RefSeqiXP_461283.1. XM_461283.1.

Genome annotation databases

EnsemblFungiiCAG89682; CAG89682; DEHA2F21604g.
GeneIDi2903085.
KEGGidha:DEHA2F21604g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382138 Genomic DNA. Translation: CAG89682.1.
RefSeqiXP_461283.1. XM_461283.1.

3D structure databases

ProteinModelPortaliQ6BKI8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG89682; CAG89682; DEHA2F21604g.
GeneIDi2903085.
KEGGidha:DEHA2F21604g.

Phylogenomic databases

HOGENOMiHOG000199189.
InParanoidiQ6BKI8.
KOiK17878.
OMAiVVFSPHR.
OrthoDBiEOG092C4ME2.

Family and domain databases

HAMAPiMF_03223. Methyltr_EFM7. 1 hit.
InterProiView protein in InterPro
IPR019410. Methyltransf_16.
IPR025784. Nicotinamide_N-MeTfrase_put.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF10294. Methyltransf_16. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS51560. SAM_MT_NNT1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEFM7_DEBHA
AccessioniPrimary (citable) accession number: Q6BKI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 16, 2004
Last modified: May 10, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.