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Q6BJG4 (CARA_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Carbamoyl-phosphate synthase arginine-specific small chain
Short name=CPS-A
EC=6.3.5.5
Alternative name(s):
Arginine-specific carbamoyl-phosphate synthetase, glutamine chain
Gene names
Name:CPA1
Ordered Locus Names:DEHA2G02618g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.

Subunit structure

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the CarA family.

Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   DomainGlutamine amidotransferase
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

glutamine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Carbamoyl-phosphate synthase arginine-specific small chain
PRO_0000290594

Regions

Domain218 – 406189Glutamine amidotransferase type-1

Sites

Active site2951Nucleophile By similarity
Active site3791 By similarity
Active site3811 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BJG4 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 5B8B9DDEE57A3C18

FASTA42947,132
        10         20         30         40         50         60 
MIRVIQPPLI ASKQLFRRYL ATGGTFTNKT SQLDRATLTI KDGPVFSGYS FGANKNISGE 

        70         80         90        100        110        120 
AVFTTSLVGY PESMTDPSYK GQILCFTQPL IGNYGVPSST LKDEFNLLKH MESPSVQCIG 

       130        140        150        160        170        180 
IVVADVALEY SHWTAVESLQ QWCQRSGVAA ISGVDTRQLV SYLREKGSSL AKITIGEEYD 

       190        200        210        220        230        240 
ADEDAAFEDP GSVNLVHKVS TKAPFHISCP EKYAKGLHIA VLDCGAKENI LRCLVERGAS 

       250        260        270        280        290        300 
LTVFPYNYPI DKIANKFDGI FISNGPGDPT HCSSTTENLA KTMEKYHDLP IFGICLGHQL 

       310        320        330        340        350        360 
LALASGARTI KMKYGNRAHN IPALDLTTGK CHITSQNHGY SVDAETLDSD WEPYFTNLND 

       370        380        390        400        410        420 
LSNEGMKHKS RPIFSTQFHP EAKGGPLDTA FLFDKFFENI EQYRATNGLN LGNVDDSLLV 


DILPKGRVL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382139 Genomic DNA. Translation: CAG90105.1.
RefSeqXP_461657.1. XM_461657.1.

3D structure databases

HSSPHSSP built from PDB template 1M6V based on UniProtKB P0A6F1.
ProteinModelPortalQ6BJG4.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6BJG4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2904523.
GenomeReviewsGene locus DEHA2G02618g in contig CR382139_GR.
KEGGdha:DEHA2G02618g.

Phylogenomic databases

eggNOGfuNOG04647.
HOGENOMHBG286341.
OMAFTYPELG.
OrthoDBEOG4N8VDH.

Family and domain databases

InterProIPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR017926. GATASE_1.
[Graphical view]
Gene3DG3DSA:3.50.30.20. G3DSA:3.50.30.20. 1 hit.
KOK01956.
PfamPF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SMARTSM01097. CPSase_sm_chain. 1 hit.
[Graphical view]
SUPFAMSSF52021. CP_synthsmall. 1 hit.
TIGRFAMsTIGR01368. CPSaseIIsmall. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCARA_DEBHA
AccessionPrimary (citable) accession number: Q6BJG4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: August 16, 2004
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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