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Q6BJ61

- PMIP_DEBHA

UniProt

Q6BJ61 - PMIP_DEBHA

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi581 – 5811Zinc; catalyticPROSITE-ProRule annotation
    Active sitei582 – 5821PROSITE-ProRule annotation
    Metal bindingi585 – 5851Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi588 – 5881Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    Ordered Locus Names:DEHA2G04928g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome G

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
    BLAST
    Chaini40 – 794755Mitochondrial intermediate peptidasePRO_0000338583Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4959.Q6BJ61.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6BJ61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    HOGENOMiHOG000076521.
    KOiK01410.
    OMAiVTEMNIE.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6BJ61-1 [UniParc]FASTAAdd to Basket

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    MRVTSSRLLQ GGSLVSRVLK RRLNNASRTK KGWFSTRTLA DSNEHLRRVF    50
    DDQAYFDNFT KSGAPEGAMN SLFGGNGVGL FRNRALISPQ GLVDFSEESL 100
    ERAKMLVSNM MAEVKTSEQG RLEYIKKLDQ LSDVLCRVID VAEFIRVSHP 150
    SQKWVDAAQR THEIMFEYMN QLNTNVELYE SLRDLLIDPA ITTKLSKEEI 200
    EVGEYLRQDF ERSGIHMDPN TRNNFVAITQ EISLLGSHFN NDIHSLESYW 250
    CNISRSEFDK ISDTVVKSEI YGYQSSSPAS QNKDSGNIYI PLAGHIPYTI 300
    LSKCEVESVR RKVWISLHNS PKEQIDTLNA FVKYRALLAK MLGYKSFAHY 350
    QLEHKMAKNP ENVLTLLRNL QQGLISKEYG VCEEVKKLHS FKNGDDAVMT 400
    DEEILEDVKP WDREYLLAQL QSQTLKDEEP LEDISEYFSV GTIVSGLSKL 450
    FYSIYNVNLI PEATLKGETW DSNQVRKLNV FDVTSNKKLG YLYLDFWSPK 500
    VLPSHFTIVC SRKLNTDIGS ESRDEMREMV QLDENEQHQL PVISLVCNLS 550
    KPQGTGVGRF TGMDSRKPTL LSLDQVDTIF HEMGHAMHSM IGKTDLHNLS 600
    GTRCVTDFVE LPSVLMESFS KDPRVLCKIA KHYRTKEPLS KETLAKHQSH 650
    RVLLEESETF MQSKMAMLDQ VLHNEDIINC GIKDFDSTAV YHHLESQLKV 700
    FADKWSTWHG KFPHLFSYGA VYYSYLLDRA IAEKIWHGLF KDDPWSREAG 750
    QKYKDSILKW GGTRDPWVCL ADALGDERLG KGDSKAMEII GQKV 794
    Length:794
    Mass (Da):90,794
    Last modified:December 16, 2008 - v2
    Checksum:iC4E8BCE83A403C84
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382139 Genomic DNA. Translation: CAG90217.2.
    RefSeqiXP_461760.2. XM_461760.1.

    Genome annotation databases

    GeneIDi2904636.
    KEGGidha:DEHA2G04928g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382139 Genomic DNA. Translation: CAG90217.2 .
    RefSeqi XP_461760.2. XM_461760.1.

    3D structure databases

    ProteinModelPortali Q6BJ61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BJ61.

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2904636.
    KEGGi dha:DEHA2G04928g.

    Phylogenomic databases

    eggNOGi COG0339.
    HOGENOMi HOG000076521.
    KOi K01410.
    OMAi VTEMNIE.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiPMIP_DEBHA
    AccessioniPrimary (citable) accession number: Q6BJ61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3