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Q6BJ61

- PMIP_DEBHA

UniProt

Q6BJ61 - PMIP_DEBHA

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi581 – 5811Zinc; catalyticPROSITE-ProRule annotation
Active sitei582 – 5821PROSITE-ProRule annotation
Metal bindingi585 – 5851Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi588 – 5881Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Ordered Locus Names:DEHA2G04928g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome G

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
BLAST
Chaini40 – 794755Mitochondrial intermediate peptidasePRO_0000338583Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BJ61.

Structurei

3D structure databases

ProteinModelPortaliQ6BJ61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
InParanoidiQ6BJ61.
KOiK01410.
OMAiVTEMNIE.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BJ61-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVTSSRLLQ GGSLVSRVLK RRLNNASRTK KGWFSTRTLA DSNEHLRRVF
60 70 80 90 100
DDQAYFDNFT KSGAPEGAMN SLFGGNGVGL FRNRALISPQ GLVDFSEESL
110 120 130 140 150
ERAKMLVSNM MAEVKTSEQG RLEYIKKLDQ LSDVLCRVID VAEFIRVSHP
160 170 180 190 200
SQKWVDAAQR THEIMFEYMN QLNTNVELYE SLRDLLIDPA ITTKLSKEEI
210 220 230 240 250
EVGEYLRQDF ERSGIHMDPN TRNNFVAITQ EISLLGSHFN NDIHSLESYW
260 270 280 290 300
CNISRSEFDK ISDTVVKSEI YGYQSSSPAS QNKDSGNIYI PLAGHIPYTI
310 320 330 340 350
LSKCEVESVR RKVWISLHNS PKEQIDTLNA FVKYRALLAK MLGYKSFAHY
360 370 380 390 400
QLEHKMAKNP ENVLTLLRNL QQGLISKEYG VCEEVKKLHS FKNGDDAVMT
410 420 430 440 450
DEEILEDVKP WDREYLLAQL QSQTLKDEEP LEDISEYFSV GTIVSGLSKL
460 470 480 490 500
FYSIYNVNLI PEATLKGETW DSNQVRKLNV FDVTSNKKLG YLYLDFWSPK
510 520 530 540 550
VLPSHFTIVC SRKLNTDIGS ESRDEMREMV QLDENEQHQL PVISLVCNLS
560 570 580 590 600
KPQGTGVGRF TGMDSRKPTL LSLDQVDTIF HEMGHAMHSM IGKTDLHNLS
610 620 630 640 650
GTRCVTDFVE LPSVLMESFS KDPRVLCKIA KHYRTKEPLS KETLAKHQSH
660 670 680 690 700
RVLLEESETF MQSKMAMLDQ VLHNEDIINC GIKDFDSTAV YHHLESQLKV
710 720 730 740 750
FADKWSTWHG KFPHLFSYGA VYYSYLLDRA IAEKIWHGLF KDDPWSREAG
760 770 780 790
QKYKDSILKW GGTRDPWVCL ADALGDERLG KGDSKAMEII GQKV
Length:794
Mass (Da):90,794
Last modified:December 16, 2008 - v2
Checksum:iC4E8BCE83A403C84
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382139 Genomic DNA. Translation: CAG90217.2.
RefSeqiXP_461760.2. XM_461760.1.

Genome annotation databases

GeneIDi2904636.
KEGGidha:DEHA2G04928g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382139 Genomic DNA. Translation: CAG90217.2 .
RefSeqi XP_461760.2. XM_461760.1.

3D structure databases

ProteinModelPortali Q6BJ61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BJ61.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2904636.
KEGGi dha:DEHA2G04928g.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
InParanoidi Q6BJ61.
KOi K01410.
OMAi VTEMNIE.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiPMIP_DEBHA
AccessioniPrimary (citable) accession number: Q6BJ61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3