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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi581Zinc; catalyticPROSITE-ProRule annotation1
Active sitei582PROSITE-ProRule annotation1
Metal bindingi585Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi588Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Ordered Locus Names:DEHA2G04928g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome G

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionSequence analysisAdd BLAST39
ChainiPRO_000033858340 – 794Mitochondrial intermediate peptidaseAdd BLAST755

Proteomic databases

PRIDEiQ6BJ61

Structurei

3D structure databases

ProteinModelPortaliQ6BJ61
SMRiQ6BJ61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076521
InParanoidiQ6BJ61
KOiK01410
OMAiVENTAWQ
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BJ61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTSSRLLQ GGSLVSRVLK RRLNNASRTK KGWFSTRTLA DSNEHLRRVF
60 70 80 90 100
DDQAYFDNFT KSGAPEGAMN SLFGGNGVGL FRNRALISPQ GLVDFSEESL
110 120 130 140 150
ERAKMLVSNM MAEVKTSEQG RLEYIKKLDQ LSDVLCRVID VAEFIRVSHP
160 170 180 190 200
SQKWVDAAQR THEIMFEYMN QLNTNVELYE SLRDLLIDPA ITTKLSKEEI
210 220 230 240 250
EVGEYLRQDF ERSGIHMDPN TRNNFVAITQ EISLLGSHFN NDIHSLESYW
260 270 280 290 300
CNISRSEFDK ISDTVVKSEI YGYQSSSPAS QNKDSGNIYI PLAGHIPYTI
310 320 330 340 350
LSKCEVESVR RKVWISLHNS PKEQIDTLNA FVKYRALLAK MLGYKSFAHY
360 370 380 390 400
QLEHKMAKNP ENVLTLLRNL QQGLISKEYG VCEEVKKLHS FKNGDDAVMT
410 420 430 440 450
DEEILEDVKP WDREYLLAQL QSQTLKDEEP LEDISEYFSV GTIVSGLSKL
460 470 480 490 500
FYSIYNVNLI PEATLKGETW DSNQVRKLNV FDVTSNKKLG YLYLDFWSPK
510 520 530 540 550
VLPSHFTIVC SRKLNTDIGS ESRDEMREMV QLDENEQHQL PVISLVCNLS
560 570 580 590 600
KPQGTGVGRF TGMDSRKPTL LSLDQVDTIF HEMGHAMHSM IGKTDLHNLS
610 620 630 640 650
GTRCVTDFVE LPSVLMESFS KDPRVLCKIA KHYRTKEPLS KETLAKHQSH
660 670 680 690 700
RVLLEESETF MQSKMAMLDQ VLHNEDIINC GIKDFDSTAV YHHLESQLKV
710 720 730 740 750
FADKWSTWHG KFPHLFSYGA VYYSYLLDRA IAEKIWHGLF KDDPWSREAG
760 770 780 790
QKYKDSILKW GGTRDPWVCL ADALGDERLG KGDSKAMEII GQKV
Length:794
Mass (Da):90,794
Last modified:December 16, 2008 - v2
Checksum:iC4E8BCE83A403C84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382139 Genomic DNA Translation: CAG90217.2
RefSeqiXP_461760.2, XM_461760.1

Genome annotation databases

EnsemblFungiiCAG90217; CAG90217; DEHA2G04928g
GeneIDi2904636
KEGGidha:DEHA2G04928g

Similar proteinsi

Entry informationi

Entry nameiPMIP_DEBHA
AccessioniPrimary (citable) accession number: Q6BJ61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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