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Q6BJ08 (OS9_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation By similarity.

Subunit structure

Interacts with missfolded ER lumenal proteins By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side By similarity.

Sequence similarities

Belongs to the OS-9 family.

Contains 1 PRKCSH domain.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
   DomainSignal
   LigandLectin
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 589568Protein OS-9 homolog
PRO_0000043269

Regions

Domain133 – 237105PRKCSH
Motif586 – 5894Prevents secretion from ER Potential

Sites

Binding site1551Carbohydrate By similarity
Binding site2411Carbohydrate By similarity
Binding site2471Carbohydrate By similarity
Binding site2701Carbohydrate By similarity
Binding site2761Carbohydrate By similarity

Amino acid modifications

Glycosylation171N-linked (GlcNAc...) Potential
Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation4261N-linked (GlcNAc...) Potential
Disulfide bond132 ↔ 148 By similarity
Disulfide bond240 ↔ 274 By similarity
Disulfide bond255 ↔ 286 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BJ08 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: AC51155A2F314EFD

FASTA58967,260
        10         20         30         40         50         60 
MFSILNKLGI IWLALANISN CDNSKSGHKS IPKYNVKYYH ANIPKDFANR FVELNDKIVE 

        70         80         90        100        110        120 
NGSFEILGID GQPSKNQYLC FTPNPNTAVN VSIESAQRNT RSKEIENEPK SEAEIIQRGV 

       130        140        150        160        170        180 
EMIEKSFSRK DCVFAYGSNG GYWTLGYCYG DKVVQFHENL QHFVATGKHK PEYPDYIYVL 

       190        200        210        220        230        240 
GRFKGSSKKP TNLDNQSPWA SNNLDLSEFT IHESSIISDA TAKNEQSRFL QHTLYDGEIC 

       250        260        270        280        290        300 
DLTRKPRSID IIYKCDPNHR GRIEILDQQE IKTCVYQMVI GVPKLCSLDE FRPNKVEDQI 

       310        320        330        340        350        360 
IDIDCKLIDQ TNKVKADKLS YQDFFYYTDD IPSDNKIFPI PHSYKVSLNN YNLSPCGHGF 

       370        380        390        400        410        420 
YLGQSKLPIN SPSVYFNFRH ILVFNDQYHS SSDLLEKLGK MLKVCVGNKI LSPHIENKRQ 

       430        440        450        460        470        480 
SLLSWNDTFI LWFELYDFYG SFISLVKVSR DGSKEELELK LRLINPETML DQDGDLVKVP 

       490        500        510        520        530        540 
EFDAPNNAWN FQKFSKGKGS ALDSTNNDKN NKATAENDKQ YQSTSTDIVT VTVTESLETT 

       550        560        570        580 
SSEDGTEEVS NEMVILKKLA DKLGMTDINE LHQAIEDLDI ELEVQHDEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382139 Genomic DNA. Translation: CAG90274.2.
RefSeqXP_461813.2. XM_461813.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.Q6BJ08.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2904692.
KEGGdha:DEHA2G06116g.

Phylogenomic databases

eggNOGNOG240935.
HOGENOMHOG000246696.
KOK10088.
OMAYYHANIP.
OrthoDBEOG7R2BVR.

Family and domain databases

InterProIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamPF07915. PRKCSH. 1 hit.
[Graphical view]
SUPFAMSSF50911. SSF50911. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOS9_DEBHA
AccessionPrimary (citable) accession number: Q6BJ08
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 16, 2008
Last modified: March 19, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families