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Q6BJ08

- OS9_DEBHA

UniProt

Q6BJ08 - OS9_DEBHA

Protein

Protein OS-9 homolog

Gene

YOS9

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei155 – 1551CarbohydrateBy similarity
    Binding sitei241 – 2411CarbohydrateBy similarity
    Binding sitei247 – 2471CarbohydrateBy similarity
    Binding sitei270 – 2701CarbohydrateBy similarity
    Binding sitei276 – 2761CarbohydrateBy similarity

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein OS-9 homolog
    Gene namesi
    Name:YOS9
    Ordered Locus Names:DEHA2G06116g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome G

    Subcellular locationi

    Endoplasmic reticulum membrane PROSITE-ProRule annotation; Peripheral membrane protein By similarity; Lumenal side By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 589568Protein OS-9 homologPRO_0000043269Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi132 ↔ 148By similarity
    Disulfide bondi240 ↔ 274By similarity
    Disulfide bondi255 ↔ 286By similarity
    Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with missfolded ER lumenal proteins.By similarity

    Protein-protein interaction databases

    STRINGi4959.Q6BJ08.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini133 – 237105PRKCSHAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi586 – 5894Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the OS-9 family.Curated
    Contains 1 PRKCSH domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG240935.
    HOGENOMiHOG000246696.
    KOiK10088.
    OMAiYYHANIP.
    OrthoDBiEOG7R2BVR.

    Family and domain databases

    InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
    IPR012913. PRKCSH.
    [Graphical view]
    PfamiPF07915. PRKCSH. 1 hit.
    [Graphical view]
    SUPFAMiSSF50911. SSF50911. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6BJ08-1 [UniParc]FASTAAdd to Basket

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    MFSILNKLGI IWLALANISN CDNSKSGHKS IPKYNVKYYH ANIPKDFANR    50
    FVELNDKIVE NGSFEILGID GQPSKNQYLC FTPNPNTAVN VSIESAQRNT 100
    RSKEIENEPK SEAEIIQRGV EMIEKSFSRK DCVFAYGSNG GYWTLGYCYG 150
    DKVVQFHENL QHFVATGKHK PEYPDYIYVL GRFKGSSKKP TNLDNQSPWA 200
    SNNLDLSEFT IHESSIISDA TAKNEQSRFL QHTLYDGEIC DLTRKPRSID 250
    IIYKCDPNHR GRIEILDQQE IKTCVYQMVI GVPKLCSLDE FRPNKVEDQI 300
    IDIDCKLIDQ TNKVKADKLS YQDFFYYTDD IPSDNKIFPI PHSYKVSLNN 350
    YNLSPCGHGF YLGQSKLPIN SPSVYFNFRH ILVFNDQYHS SSDLLEKLGK 400
    MLKVCVGNKI LSPHIENKRQ SLLSWNDTFI LWFELYDFYG SFISLVKVSR 450
    DGSKEELELK LRLINPETML DQDGDLVKVP EFDAPNNAWN FQKFSKGKGS 500
    ALDSTNNDKN NKATAENDKQ YQSTSTDIVT VTVTESLETT SSEDGTEEVS 550
    NEMVILKKLA DKLGMTDINE LHQAIEDLDI ELEVQHDEL 589
    Length:589
    Mass (Da):67,260
    Last modified:December 16, 2008 - v2
    Checksum:iAC51155A2F314EFD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382139 Genomic DNA. Translation: CAG90274.2.
    RefSeqiXP_461813.2. XM_461813.1.

    Genome annotation databases

    GeneIDi2904692.
    KEGGidha:DEHA2G06116g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382139 Genomic DNA. Translation: CAG90274.2 .
    RefSeqi XP_461813.2. XM_461813.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BJ08.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2904692.
    KEGGi dha:DEHA2G06116g.

    Phylogenomic databases

    eggNOGi NOG240935.
    HOGENOMi HOG000246696.
    KOi K10088.
    OMAi YYHANIP.
    OrthoDBi EOG7R2BVR.

    Family and domain databases

    InterProi IPR009011. Man6P_isomerase_rcpt-bd_dom.
    IPR012913. PRKCSH.
    [Graphical view ]
    Pfami PF07915. PRKCSH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50911. SSF50911. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiOS9_DEBHA
    AccessioniPrimary (citable) accession number: Q6BJ08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3