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Q6BJ08

- OS9_DEBHA

UniProt

Q6BJ08 - OS9_DEBHA

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Protein
Protein OS-9 homolog
Gene
YOS9, DEHA2G06116g
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei155 – 1551Carbohydrate By similarity
Binding sitei241 – 2411Carbohydrate By similarity
Binding sitei247 – 2471Carbohydrate By similarity
Binding sitei270 – 2701Carbohydrate By similarity
Binding sitei276 – 2761Carbohydrate By similarity

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein OS-9 homolog
Gene namesi
Name:YOS9
Ordered Locus Names:DEHA2G06116g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome G

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 589568Protein OS-9 homolog
PRO_0000043269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi17 – 171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi61 – 611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi132 ↔ 148 By similarity
Disulfide bondi240 ↔ 274 By similarity
Disulfide bondi255 ↔ 286 By similarity
Glycosylationi426 – 4261N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with missfolded ER lumenal proteins By similarity.

Protein-protein interaction databases

STRINGi4959.Q6BJ08.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 237105PRKCSH
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi586 – 5894Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the OS-9 family.
Contains 1 PRKCSH domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240935.
HOGENOMiHOG000246696.
KOiK10088.
OMAiYYHANIP.
OrthoDBiEOG7R2BVR.

Family and domain databases

InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BJ08-1 [UniParc]FASTAAdd to Basket

« Hide

MFSILNKLGI IWLALANISN CDNSKSGHKS IPKYNVKYYH ANIPKDFANR    50
FVELNDKIVE NGSFEILGID GQPSKNQYLC FTPNPNTAVN VSIESAQRNT 100
RSKEIENEPK SEAEIIQRGV EMIEKSFSRK DCVFAYGSNG GYWTLGYCYG 150
DKVVQFHENL QHFVATGKHK PEYPDYIYVL GRFKGSSKKP TNLDNQSPWA 200
SNNLDLSEFT IHESSIISDA TAKNEQSRFL QHTLYDGEIC DLTRKPRSID 250
IIYKCDPNHR GRIEILDQQE IKTCVYQMVI GVPKLCSLDE FRPNKVEDQI 300
IDIDCKLIDQ TNKVKADKLS YQDFFYYTDD IPSDNKIFPI PHSYKVSLNN 350
YNLSPCGHGF YLGQSKLPIN SPSVYFNFRH ILVFNDQYHS SSDLLEKLGK 400
MLKVCVGNKI LSPHIENKRQ SLLSWNDTFI LWFELYDFYG SFISLVKVSR 450
DGSKEELELK LRLINPETML DQDGDLVKVP EFDAPNNAWN FQKFSKGKGS 500
ALDSTNNDKN NKATAENDKQ YQSTSTDIVT VTVTESLETT SSEDGTEEVS 550
NEMVILKKLA DKLGMTDINE LHQAIEDLDI ELEVQHDEL 589
Length:589
Mass (Da):67,260
Last modified:December 16, 2008 - v2
Checksum:iAC51155A2F314EFD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382139 Genomic DNA. Translation: CAG90274.2.
RefSeqiXP_461813.2. XM_461813.1.

Genome annotation databases

GeneIDi2904692.
KEGGidha:DEHA2G06116g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382139 Genomic DNA. Translation: CAG90274.2 .
RefSeqi XP_461813.2. XM_461813.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 4959.Q6BJ08.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2904692.
KEGGi dha:DEHA2G06116g.

Phylogenomic databases

eggNOGi NOG240935.
HOGENOMi HOG000246696.
KOi K10088.
OMAi YYHANIP.
OrthoDBi EOG7R2BVR.

Family and domain databases

InterProi IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view ]
Pfami PF07915. PRKCSH. 1 hit.
[Graphical view ]
SUPFAMi SSF50911. SSF50911. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiOS9_DEBHA
AccessioniPrimary (citable) accession number: Q6BJ08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 16, 2008
Last modified: March 19, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi