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Q6BJ08

- OS9_DEBHA

UniProt

Q6BJ08 - OS9_DEBHA

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Protein

Protein OS-9 homolog

Gene

YOS9

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei155 – 1551CarbohydrateBy similarity
Binding sitei241 – 2411CarbohydrateBy similarity
Binding sitei247 – 2471CarbohydrateBy similarity
Binding sitei270 – 2701CarbohydrateBy similarity
Binding sitei276 – 2761CarbohydrateBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein OS-9 homolog
Gene namesi
Name:YOS9
Ordered Locus Names:DEHA2G06116g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome G

Subcellular locationi

Endoplasmic reticulum membrane PROSITE-ProRule annotation; Peripheral membrane protein By similarity; Lumenal side By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 589568Protein OS-9 homologPRO_0000043269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi132 ↔ 148By similarity
Disulfide bondi240 ↔ 274By similarity
Disulfide bondi255 ↔ 286By similarity
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with missfolded ER lumenal proteins.By similarity

Protein-protein interaction databases

STRINGi4959.Q6BJ08.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 237105PRKCSHAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi586 – 5894Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the OS-9 family.Curated
Contains 1 PRKCSH domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240935.
HOGENOMiHOG000246696.
InParanoidiQ6BJ08.
KOiK10088.
OMAiYYHANIP.
OrthoDBiEOG7R2BVR.

Family and domain databases

InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BJ08-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSILNKLGI IWLALANISN CDNSKSGHKS IPKYNVKYYH ANIPKDFANR
60 70 80 90 100
FVELNDKIVE NGSFEILGID GQPSKNQYLC FTPNPNTAVN VSIESAQRNT
110 120 130 140 150
RSKEIENEPK SEAEIIQRGV EMIEKSFSRK DCVFAYGSNG GYWTLGYCYG
160 170 180 190 200
DKVVQFHENL QHFVATGKHK PEYPDYIYVL GRFKGSSKKP TNLDNQSPWA
210 220 230 240 250
SNNLDLSEFT IHESSIISDA TAKNEQSRFL QHTLYDGEIC DLTRKPRSID
260 270 280 290 300
IIYKCDPNHR GRIEILDQQE IKTCVYQMVI GVPKLCSLDE FRPNKVEDQI
310 320 330 340 350
IDIDCKLIDQ TNKVKADKLS YQDFFYYTDD IPSDNKIFPI PHSYKVSLNN
360 370 380 390 400
YNLSPCGHGF YLGQSKLPIN SPSVYFNFRH ILVFNDQYHS SSDLLEKLGK
410 420 430 440 450
MLKVCVGNKI LSPHIENKRQ SLLSWNDTFI LWFELYDFYG SFISLVKVSR
460 470 480 490 500
DGSKEELELK LRLINPETML DQDGDLVKVP EFDAPNNAWN FQKFSKGKGS
510 520 530 540 550
ALDSTNNDKN NKATAENDKQ YQSTSTDIVT VTVTESLETT SSEDGTEEVS
560 570 580
NEMVILKKLA DKLGMTDINE LHQAIEDLDI ELEVQHDEL
Length:589
Mass (Da):67,260
Last modified:December 16, 2008 - v2
Checksum:iAC51155A2F314EFD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382139 Genomic DNA. Translation: CAG90274.2.
RefSeqiXP_461813.2. XM_461813.1.

Genome annotation databases

GeneIDi2904692.
KEGGidha:DEHA2G06116g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382139 Genomic DNA. Translation: CAG90274.2 .
RefSeqi XP_461813.2. XM_461813.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BJ08.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2904692.
KEGGi dha:DEHA2G06116g.

Phylogenomic databases

eggNOGi NOG240935.
HOGENOMi HOG000246696.
InParanoidi Q6BJ08.
KOi K10088.
OMAi YYHANIP.
OrthoDBi EOG7R2BVR.

Family and domain databases

InterProi IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view ]
Pfami PF07915. PRKCSH. 1 hit.
[Graphical view ]
SUPFAMi SSF50911. SSF50911. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiOS9_DEBHA
AccessioniPrimary (citable) accession number: Q6BJ08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3