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Protein

RuvB-like helicase 1

Gene

RBV1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 79ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Helicase, Hydrolase
Biological processDNA damage, DNA repair, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RuvB-like helicase 1 (EC:3.6.4.12)
Gene namesi
Name:RBV1
Ordered Locus Names:DEHA2G13200g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome G

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001656531 – 457RuvB-like helicase 1Add BLAST457

Proteomic databases

PRIDEiQ6BI60

Interactioni

Subunit structurei

May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6BI60
SMRiQ6BI60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.Curated

Phylogenomic databases

HOGENOMiHOG000190885
InParanoidiQ6BI60
KOiK04499
OMAiDVHKRKE
OrthoDBiEOG092C2Z17

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR027238 RuvB-like
IPR037938 RUVBL1
IPR010339 TIP49_C
PANTHERiPTHR11093 PTHR11093, 1 hit
PTHR11093:SF6 PTHR11093:SF6, 1 hit
PfamiView protein in Pfam
PF06068 TIP49, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

Q6BI60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQINEVKDT QTRESRTAAH THIKGLGLDE HGIAKRVEGG FVGQSDAREA
60 70 80 90 100
CGIIVDLIKS KRMSGKAILL AGAPGTGKTA LALAISQELG PKVPFCPIVG
110 120 130 140 150
SELFSAEIKK TAALMENFRR AIGLRIKETK EVYEGEVIEL TPEEAENPLG
160 170 180 190 200
GYGKTISHVI VGLKTAKGTK SLRLDPSIYE SIQKERVSVG DVIYIEANTG
210 220 230 240 250
SVKRVGRSDA YATEFDLEAE EYVPLPKGEV HKKKEIVQDV TLHDLDVANA
260 270 280 290 300
RPQGGQDVLS MMGQLLKPRK TEITDKLRSE VNKVVSKYID QGVAELIPGV
310 320 330 340 350
LFIDEVNMLD IECFTYLNRA LESSIAPIVV LASNRGMTTI RGTDDDKKSP
360 370 380 390 400
HGCPADLIDR LLIVRTLPYN QEEIKIIISK RATLENLIVT PDALDKLSLH
410 420 430 440 450
GINNSLRYAL QLLAPAGVLS KTAGRNEITS EDIEECEILF LDSRRSIKIL

EETKGYL
Length:457
Mass (Da):50,077
Last modified:August 16, 2004 - v1
Checksum:i600D4183A07C3E0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382139 Genomic DNA Translation: CAG90597.1
RefSeqiXP_462111.1, XM_462111.1

Genome annotation databases

EnsemblFungiiCAG90597; CAG90597; DEHA2G13200g
GeneIDi2905025
KEGGidha:DEHA2G13200g

Similar proteinsi

Entry informationi

Entry nameiRUVB1_DEBHA
AccessioniPrimary (citable) accession number: Q6BI60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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