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Protein

RuvB-like helicase 1

Gene

RBV1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 798ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RuvB-like helicase 1 (EC:3.6.4.12)
Gene namesi
Name:RBV1
Ordered Locus Names:DEHA2G13200g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome G

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457RuvB-like helicase 1PRO_0000165653Add
BLAST

Interactioni

Subunit structurei

May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6BI60.
SMRiQ6BI60. Positions 12-452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.Curated

Phylogenomic databases

HOGENOMiHOG000190885.
InParanoidiQ6BI60.
KOiK04499.
OMAiTPVAHNA.
OrthoDBiEOG7FBRT0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR027238. RuvB-like.
IPR010339. TIP49_C.
[Graphical view]
PANTHERiPTHR11093. PTHR11093. 1 hit.
PfamiPF06068. TIP49. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6BI60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQINEVKDT QTRESRTAAH THIKGLGLDE HGIAKRVEGG FVGQSDAREA
60 70 80 90 100
CGIIVDLIKS KRMSGKAILL AGAPGTGKTA LALAISQELG PKVPFCPIVG
110 120 130 140 150
SELFSAEIKK TAALMENFRR AIGLRIKETK EVYEGEVIEL TPEEAENPLG
160 170 180 190 200
GYGKTISHVI VGLKTAKGTK SLRLDPSIYE SIQKERVSVG DVIYIEANTG
210 220 230 240 250
SVKRVGRSDA YATEFDLEAE EYVPLPKGEV HKKKEIVQDV TLHDLDVANA
260 270 280 290 300
RPQGGQDVLS MMGQLLKPRK TEITDKLRSE VNKVVSKYID QGVAELIPGV
310 320 330 340 350
LFIDEVNMLD IECFTYLNRA LESSIAPIVV LASNRGMTTI RGTDDDKKSP
360 370 380 390 400
HGCPADLIDR LLIVRTLPYN QEEIKIIISK RATLENLIVT PDALDKLSLH
410 420 430 440 450
GINNSLRYAL QLLAPAGVLS KTAGRNEITS EDIEECEILF LDSRRSIKIL

EETKGYL
Length:457
Mass (Da):50,077
Last modified:August 16, 2004 - v1
Checksum:i600D4183A07C3E0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382139 Genomic DNA. Translation: CAG90597.1.
RefSeqiXP_462111.1. XM_462111.1.

Genome annotation databases

EnsemblFungiiCAG90597; CAG90597; DEHA2G13200g.
GeneIDi2905025.
KEGGidha:DEHA2G13200g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382139 Genomic DNA. Translation: CAG90597.1.
RefSeqiXP_462111.1. XM_462111.1.

3D structure databases

ProteinModelPortaliQ6BI60.
SMRiQ6BI60. Positions 12-452.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG90597; CAG90597; DEHA2G13200g.
GeneIDi2905025.
KEGGidha:DEHA2G13200g.

Phylogenomic databases

HOGENOMiHOG000190885.
InParanoidiQ6BI60.
KOiK04499.
OMAiTPVAHNA.
OrthoDBiEOG7FBRT0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR027238. RuvB-like.
IPR010339. TIP49_C.
[Graphical view]
PANTHERiPTHR11093. PTHR11093. 1 hit.
PfamiPF06068. TIP49. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRUVB1_DEBHA
AccessioniPrimary (citable) accession number: Q6BI60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.