Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6BGW1

- GCN5_DEBHA

UniProt

Q6BGW1 - GCN5_DEBHA

Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei187 – 1871Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase GCN5 (EC:2.3.1.48)
    Gene namesi
    Name:GCN5
    Ordered Locus Names:DEHA2G23474g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome G

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Histone acetyltransferase GCN5PRO_0000211197Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4959.Q6BGW1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini114 – 269156N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST
    Domaini359 – 42971BromoPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bromo domain.PROSITE-ProRule annotation
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Bromodomain

    Phylogenomic databases

    eggNOGiCOG5076.
    HOGENOMiHOG000192257.
    KOiK06062.
    OMAiDNCRKYN.
    OrthoDBiEOG7XM37B.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF13508. Acetyltransf_7. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6BGW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDRKRNSSV ISDNEENGRV DKKTKIKDEI EGDEVERDVK NEEANGADTD    50
    DKEEVRKDNE EENAENGGGE GDDDDDDDDE AEEEKKRTTT FNFDGVTYSF 100
    KERPSVLEEK EGKIEFRVVN NDNTKESLMV LTGLKNIFQK QLPKMPREYI 150
    SRLVYDRSHL SMAVVRKPLT VVGGITYRPF DNREFAEIVF CAISSTEQVR 200
    GYGAHLMNHL KDYCRATSNV KYFLTYADNY AIGYFKKQGF NKEITLDKSV 250
    WMGYIKDYEG GTLMQCSMLP PILRYLDSAK ILLLQKAAIE KKIKLRSKAH 300
    VVRPGLQVFK TNKDAKLNPA KDIPGLAESG WSEEMDKLAQ KPKRGPHYNF 350
    MVTLLSELTN HPSAWPFSTP VNKEEVGDYY DVIKEPMDLS TMESKLENDK 400
    YDSFDQFLYD ARLIFNNCRS YNADSTTYFK NATKLEKFMN NKIKDSAEYS 450
    HFLDQ 455
    Length:455
    Mass (Da):52,412
    Last modified:December 16, 2008 - v2
    Checksum:iBB3B6869D316C09D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382139 Genomic DNA. Translation: CAG91071.2.
    RefSeqiXP_462560.2. XM_462560.1.

    Genome annotation databases

    GeneIDi2905516.
    KEGGidha:DEHA2G23474g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382139 Genomic DNA. Translation: CAG91071.2 .
    RefSeqi XP_462560.2. XM_462560.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BGW1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2905516.
    KEGGi dha:DEHA2G23474g.

    Phylogenomic databases

    eggNOGi COG5076.
    HOGENOMi HOG000192257.
    KOi K06062.
    OMAi DNCRKYN.
    OrthoDBi EOG7XM37B.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF13508. Acetyltransf_7. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiGCN5_DEBHA
    AccessioniPrimary (citable) accession number: Q6BGW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3