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Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei187Proton donor/acceptorBy similarity1
Sitei187Important for catalytic activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Acyltransferase, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase GCN5 (EC:2.3.1.48)
Gene namesi
Name:GCN5
Ordered Locus Names:DEHA2G23474g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome G

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002111971 – 455Histone acetyltransferase GCN5Add BLAST455

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6BGW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 269N-acetyltransferasePROSITE-ProRule annotationAdd BLAST156
Domaini359 – 429BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 193Acetyl-CoA bindingBy similarity3
Regioni198 – 204Acetyl-CoA bindingBy similarity7
Regioni230 – 233Acetyl-CoA bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Bromodomain

Phylogenomic databases

HOGENOMiHOG000192257.
InParanoidiQ6BGW1.
KOiK06062.
OMAiDVMHFLT.
OrthoDBiEOG092C0SVC.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
PfamiView protein in Pfam
PF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiView protein in SMART
SM00297. BROMO. 1 hit.
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiView protein in PROSITE
PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6BGW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDRKRNSSV ISDNEENGRV DKKTKIKDEI EGDEVERDVK NEEANGADTD
60 70 80 90 100
DKEEVRKDNE EENAENGGGE GDDDDDDDDE AEEEKKRTTT FNFDGVTYSF
110 120 130 140 150
KERPSVLEEK EGKIEFRVVN NDNTKESLMV LTGLKNIFQK QLPKMPREYI
160 170 180 190 200
SRLVYDRSHL SMAVVRKPLT VVGGITYRPF DNREFAEIVF CAISSTEQVR
210 220 230 240 250
GYGAHLMNHL KDYCRATSNV KYFLTYADNY AIGYFKKQGF NKEITLDKSV
260 270 280 290 300
WMGYIKDYEG GTLMQCSMLP PILRYLDSAK ILLLQKAAIE KKIKLRSKAH
310 320 330 340 350
VVRPGLQVFK TNKDAKLNPA KDIPGLAESG WSEEMDKLAQ KPKRGPHYNF
360 370 380 390 400
MVTLLSELTN HPSAWPFSTP VNKEEVGDYY DVIKEPMDLS TMESKLENDK
410 420 430 440 450
YDSFDQFLYD ARLIFNNCRS YNADSTTYFK NATKLEKFMN NKIKDSAEYS

HFLDQ
Length:455
Mass (Da):52,412
Last modified:December 16, 2008 - v2
Checksum:iBB3B6869D316C09D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382139 Genomic DNA. Translation: CAG91071.2.
RefSeqiXP_462560.2. XM_462560.1.

Genome annotation databases

EnsemblFungiiCAG91071; CAG91071; DEHA2G23474g.
GeneIDi2905516.
KEGGidha:DEHA2G23474g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382139 Genomic DNA. Translation: CAG91071.2.
RefSeqiXP_462560.2. XM_462560.1.

3D structure databases

SMRiQ6BGW1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG91071; CAG91071; DEHA2G23474g.
GeneIDi2905516.
KEGGidha:DEHA2G23474g.

Phylogenomic databases

HOGENOMiHOG000192257.
InParanoidiQ6BGW1.
KOiK06062.
OMAiDVMHFLT.
OrthoDBiEOG092C0SVC.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
PfamiView protein in Pfam
PF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiView protein in SMART
SM00297. BROMO. 1 hit.
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiView protein in PROSITE
PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGCN5_DEBHA
AccessioniPrimary (citable) accession number: Q6BGW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 16, 2008
Last modified: May 10, 2017
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.