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Q6BGW1

- GCN5_DEBHA

UniProt

Q6BGW1 - GCN5_DEBHA

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Protein
Histone acetyltransferase GCN5
Gene
GCN5, DEHA2G23474g
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei187 – 1871Important for catalytic activity By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase GCN5 (EC:2.3.1.48)
Gene namesi
Name:GCN5
Ordered Locus Names:DEHA2G23474g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome G

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Histone acetyltransferase GCN5
PRO_0000211197Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BGW1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 269156N-acetyltransferase
Add
BLAST
Domaini359 – 42971Bromo
Add
BLAST

Sequence similaritiesi

Contains 1 bromo domain.

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiCOG5076.
HOGENOMiHOG000192257.
KOiK06062.
OMAiDNCRKYN.
OrthoDBiEOG7XM37B.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BGW1-1 [UniParc]FASTAAdd to Basket

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MVDRKRNSSV ISDNEENGRV DKKTKIKDEI EGDEVERDVK NEEANGADTD    50
DKEEVRKDNE EENAENGGGE GDDDDDDDDE AEEEKKRTTT FNFDGVTYSF 100
KERPSVLEEK EGKIEFRVVN NDNTKESLMV LTGLKNIFQK QLPKMPREYI 150
SRLVYDRSHL SMAVVRKPLT VVGGITYRPF DNREFAEIVF CAISSTEQVR 200
GYGAHLMNHL KDYCRATSNV KYFLTYADNY AIGYFKKQGF NKEITLDKSV 250
WMGYIKDYEG GTLMQCSMLP PILRYLDSAK ILLLQKAAIE KKIKLRSKAH 300
VVRPGLQVFK TNKDAKLNPA KDIPGLAESG WSEEMDKLAQ KPKRGPHYNF 350
MVTLLSELTN HPSAWPFSTP VNKEEVGDYY DVIKEPMDLS TMESKLENDK 400
YDSFDQFLYD ARLIFNNCRS YNADSTTYFK NATKLEKFMN NKIKDSAEYS 450
HFLDQ 455
Length:455
Mass (Da):52,412
Last modified:December 16, 2008 - v2
Checksum:iBB3B6869D316C09D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382139 Genomic DNA. Translation: CAG91071.2.
RefSeqiXP_462560.2. XM_462560.1.

Genome annotation databases

GeneIDi2905516.
KEGGidha:DEHA2G23474g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382139 Genomic DNA. Translation: CAG91071.2 .
RefSeqi XP_462560.2. XM_462560.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 4959.Q6BGW1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2905516.
KEGGi dha:DEHA2G23474g.

Phylogenomic databases

eggNOGi COG5076.
HOGENOMi HOG000192257.
KOi K06062.
OMAi DNCRKYN.
OrthoDBi EOG7XM37B.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiGCN5_DEBHA
AccessioniPrimary (citable) accession number: Q6BGW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi