Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q6BGW1 (GCN5_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase GCN5
EC=2.3.1.48
Gene names
Name:GCN5
Ordered Locus Names:DEHA2G23474g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the GCN5 family.

Contains 1 bromo domain.

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainBromodomain
   Molecular functionActivator
Acyltransferase
Chromatin regulator
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhistone acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Histone acetyltransferase GCN5
PRO_0000211197

Regions

Domain114 – 269156N-acetyltransferase
Domain359 – 42971Bromo

Sites

Site1871Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BGW1 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: BB3B6869D316C09D

FASTA45552,412
        10         20         30         40         50         60 
MVDRKRNSSV ISDNEENGRV DKKTKIKDEI EGDEVERDVK NEEANGADTD DKEEVRKDNE 

        70         80         90        100        110        120 
EENAENGGGE GDDDDDDDDE AEEEKKRTTT FNFDGVTYSF KERPSVLEEK EGKIEFRVVN 

       130        140        150        160        170        180 
NDNTKESLMV LTGLKNIFQK QLPKMPREYI SRLVYDRSHL SMAVVRKPLT VVGGITYRPF 

       190        200        210        220        230        240 
DNREFAEIVF CAISSTEQVR GYGAHLMNHL KDYCRATSNV KYFLTYADNY AIGYFKKQGF 

       250        260        270        280        290        300 
NKEITLDKSV WMGYIKDYEG GTLMQCSMLP PILRYLDSAK ILLLQKAAIE KKIKLRSKAH 

       310        320        330        340        350        360 
VVRPGLQVFK TNKDAKLNPA KDIPGLAESG WSEEMDKLAQ KPKRGPHYNF MVTLLSELTN 

       370        380        390        400        410        420 
HPSAWPFSTP VNKEEVGDYY DVIKEPMDLS TMESKLENDK YDSFDQFLYD ARLIFNNCRS 

       430        440        450 
YNADSTTYFK NATKLEKFMN NKIKDSAEYS HFLDQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382139 Genomic DNA. Translation: CAG91071.2.
RefSeqXP_462560.2. XM_462560.1.

3D structure databases

ProteinModelPortalQ6BGW1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6BGW1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2905516.
GenomeReviewsGene locus DEHA2G23474g in contig CR382139_GR.
KEGGdha:DEHA2G23474g.

Phylogenomic databases

eggNOGfuNOG05844.
HOGENOMHBG749648.
OMALVYDRSH.
OrthoDBEOG412QF2.

Family and domain databases

InterProIPR000182. AcTrfase_GCN5-related_dom.
IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
[Graphical view]
Gene3DG3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
G3DSA:1.20.920.10. Bromodomain. 1 hit.
KOK06062.
PfamPF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSPR00503. BROMODOMAIN.
SMARTSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMSSF55729. Acyl_CoA_acyltransferase. 1 hit.
SSF47370. Bromodomain. 1 hit.
PROSITEPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCN5_DEBHA
AccessionPrimary (citable) accession number: Q6BGW1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 16, 2008
Last modified: November 16, 2011
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents