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Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit 3

Gene

Ppn3

Organism
Paramecium tetraurelia
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Manganese 1By similarity1
Metal bindingi64Manganese 1By similarity1
Metal bindingi90Manganese 1By similarity1
Metal bindingi90Manganese 2By similarity1
Metal bindingi122Manganese 2By similarity1
Active sitei123Proton donorBy similarity1
Metal bindingi172Manganese 2By similarity1
Metal bindingi247Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit 3 (EC:3.1.3.16)
Short name:
PPN 3
Gene namesi
Name:Ppn3
ORF Names:GSPATT00000061001, PTMB.417c
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
Proteomesi
  • UP000000600 Componentsi: Chromosome, Partially assembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078361 – 315Serine/threonine-protein phosphatase PP2A catalytic subunit 3Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei315Leucine methyl esterBy similarity1

Post-translational modificationi

Reversibly methyl esterified on Leu-315 by leucine carboxyl methyltransferase 1 (PPM1) and protein phosphatase methylesterase 1 (PPE1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.

Keywords - PTMi

Methylation

Interactioni

Protein-protein interaction databases

STRINGi412030.XP_001423024.1

Structurei

3D structure databases

ProteinModelPortaliQ6BFF6
SMRiQ6BFF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiKOG0371 Eukaryota
COG0639 LUCA
HOGENOMiHOG000172696
InParanoidiQ6BFF6
KOiK04382

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6BFF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLNKLSSN DIGNIDRQIA KLKQGQILTE SEIKSLCIKA KEILSDEPNI
60 70 80 90 100
IQVRAPLTIC GDIHGQFHDL IELFQIGGNL PDTNYLFLGD YVDRGSQSVE
110 120 130 140 150
TFSLMLSLKV RYKDRIVLLR GNHENREINK VYGFYDECFR KYGNEIVWKQ
160 170 180 190 200
FTEVFGYLPL SAIVEQQIFC AHGGLSPAME SVDQIKQLNR VQDIPHEGLM
210 220 230 240 250
CDLLWSDPEE TKNGWGISPR GAGWTWGCDI TEKFLHSNKL KQIARAHQLV
260 270 280 290 300
MEGIQKVHNQ KTITIFSAPN YCYRCGNQAC IVEVDEQLRM NQTQFEPAPR
310
ENEPHTTRRV PDYFL
Length:315
Mass (Da):36,080
Last modified:August 16, 2004 - v1
Checksum:i19AD3EAF9F1E392D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR548612 Genomic DNA Translation: CAH03615.1
CT867985 Genomic DNA Translation: CAK55626.1
RefSeqiXP_001347241.1, XM_001347205.1
XP_001423024.1, XM_001422987.1
UniGeneiPte.28113

Genome annotation databases

EnsemblProtistsiCAK55626; CAK55626; GSPATT00000061001
GeneIDi2898390
5008828
KEGGiptm:GSPATT00000061001
ptm:PTMB.417c

Similar proteinsi

Entry informationi

Entry nameiPP2A3_PARTE
AccessioniPrimary (citable) accession number: Q6BFF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 16, 2004
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health