Q6BFF6 (PP2A3_PARTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit 3
Short name=PPN 3
EC=3.1.3.16

Gene names

Name:	Ppn3
ORF Names:	GSPATT00000061001, PTMB.417c

Organism

Paramecium tetraurelia [Reference proteome]

Taxonomic identifier

5888 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Peniculida › Parameciidae › Paramecium

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Sequence similarities	Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Keywords
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Serine/threonine-protein phosphatase PP2A catalytic subunit 3		PRO_0000307836
Sites
	Active site	123	1	Proton donor By similarity
	Metal binding	62	1	Iron By similarity
	Metal binding	64	1	Iron By similarity
	Metal binding	90	1	Iron By similarity
	Metal binding	90	1	Manganese By similarity
	Metal binding	122	1	Manganese By similarity
	Metal binding	172	1	Manganese By similarity
	Metal binding	247	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6BFF6 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 19AD3EAF9F1E392D	FASTA	315	36,080
	10 20 30 40 50 60 MASLNKLSSN DIGNIDRQIA KLKQGQILTE SEIKSLCIKA KEILSDEPNI IQVRAPLTIC 70 80 90 100 110 120 GDIHGQFHDL IELFQIGGNL PDTNYLFLGD YVDRGSQSVE TFSLMLSLKV RYKDRIVLLR 130 140 150 160 170 180 GNHENREINK VYGFYDECFR KYGNEIVWKQ FTEVFGYLPL SAIVEQQIFC AHGGLSPAME 190 200 210 220 230 240 SVDQIKQLNR VQDIPHEGLM CDLLWSDPEE TKNGWGISPR GAGWTWGCDI TEKFLHSNKL 250 260 270 280 290 300 KQIARAHQLV MEGIQKVHNQ KTITIFSAPN YCYRCGNQAC IVEVDEQLRM NQTQFEPAPR 310 ENEPHTTRRV PDYFL

References

[1]

"High coding density on the largest Paramecium tetraurelia somatic chromosome." Zagulski M., Nowak J.K., Le Mouel A., Nowacki M., Migdalski A., Gromadka R., Noel B., Blanc I., Dessen P., Wincker P., Keller A.-M., Cohen J., Meyer E., Sperling L. Curr. Biol. 14:1397-1404(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Stock d4-2.

[2]

"Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia." Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M., Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A., Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R. , Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F., Le Mouel A., Lepere G., Malinsky S., Nowacki M., Nowak J.K., Plattner H., Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M., Weissenbach J., Scarpelli C., Schaechter V., Sperling L., Meyer E., Cohen J., Wincker P. Nature 444:171-178(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Stock d4-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR548612 Genomic DNA. Translation: CAH03615.1. CT867985 Genomic DNA. Translation: CAK55626.1.
RefSeq	XP_001347241.1. XM_001347205.1. XP_001423024.1. XM_001422987.1.
UniGene	Pte.28113.
3D structure databases
HSSP	HSSP built from PDB template 1FJM based on UniProtKB P62139.
ProteinModelPortal	Q6BFF6.
SMR	Q6BFF6. Positions 15-315.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2898390. 5008828.
KEGG	ptm:GSPATT00000061001. ptm:PTMB.417c.
Phylogenomic databases
HOGENOM	HOG000172696.
KO	K04382.
ProtClustDB	CLSZ2446901.
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PP2A3_PARTE

Accession

Primary (citable) accession number: Q6BFF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)