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Q6BFF6 (PP2A3_PARTE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit 3

Short name=PPN 3
EC=3.1.3.16
Gene names
Name:Ppn3
ORF Names:GSPATT00000061001, PTMB.417c
OrganismParamecium tetraurelia [Reference proteome]
Taxonomic identifier5888 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Post-translational modification

Reversibly methyl esterified on Leu-315 by leucine carboxyl methyltransferase 1 (PPM1) and protein phosphatase methylesterase 1 (PPE1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.

Sequence similarities

Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Serine/threonine-protein phosphatase PP2A catalytic subunit 3
PRO_0000307836

Sites

Active site1231Proton donor By similarity
Metal binding621Manganese 1 By similarity
Metal binding641Manganese 1 By similarity
Metal binding901Manganese 1 By similarity
Metal binding901Manganese 2 By similarity
Metal binding1221Manganese 2 By similarity
Metal binding1721Manganese 2 By similarity
Metal binding2471Manganese 2 By similarity

Amino acid modifications

Modified residue3151Leucine methyl ester By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BFF6 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 19AD3EAF9F1E392D

FASTA31536,080
        10         20         30         40         50         60 
MASLNKLSSN DIGNIDRQIA KLKQGQILTE SEIKSLCIKA KEILSDEPNI IQVRAPLTIC 

        70         80         90        100        110        120 
GDIHGQFHDL IELFQIGGNL PDTNYLFLGD YVDRGSQSVE TFSLMLSLKV RYKDRIVLLR 

       130        140        150        160        170        180 
GNHENREINK VYGFYDECFR KYGNEIVWKQ FTEVFGYLPL SAIVEQQIFC AHGGLSPAME 

       190        200        210        220        230        240 
SVDQIKQLNR VQDIPHEGLM CDLLWSDPEE TKNGWGISPR GAGWTWGCDI TEKFLHSNKL 

       250        260        270        280        290        300 
KQIARAHQLV MEGIQKVHNQ KTITIFSAPN YCYRCGNQAC IVEVDEQLRM NQTQFEPAPR 

       310 
ENEPHTTRRV PDYFL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR548612 Genomic DNA. Translation: CAH03615.1.
CT867985 Genomic DNA. Translation: CAK55626.1.
RefSeqXP_001347241.1. XM_001347205.1.
XP_001423024.1. XM_001422987.1.
UniGenePte.28113.

3D structure databases

ProteinModelPortalQ6BFF6.
SMRQ6BFF6. Positions 15-315.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsCAK55626; CAK55626; GSPATT00000061001.
GeneID2898390.
5008828.
KEGGptm:GSPATT00000061001.
ptm:PTMB.417c.

Phylogenomic databases

HOGENOMHOG000172696.
KOK04382.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP2A3_PARTE
AccessionPrimary (citable) accession number: Q6BFF6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families