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Protein

Small toxic polypeptide LdrB

Gene

ldrB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes rapid cell killing, probably by disrupting the cell inner membrane and disruption of ATP synthesis.By similarity

Keywordsi

Biological processToxin-antitoxin system

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1602.

Names & Taxonomyi

Protein namesi
Recommended name:
Small toxic polypeptide LdrB
Gene namesi
Name:ldrB
Ordered Locus Names:b4421, JW5958
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14404. ldrB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00002302931 – 35Small toxic polypeptide LdrBAdd BLAST35

Proteomic databases

PaxDbiQ6BF87.
PRIDEiQ6BF87.

Expressioni

Inductioni

Expression of the proteinaceous toxin is probably controlled by an antisense sRNA, in this case rdlB. Only a few of these TA systems have been mechanistically characterized; the mechanisms used to control expression of the toxin gene are not necessarily the same (Probable).Curated

Structurei

3D structure databases

SMRiQ6BF87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ldr toxic peptide family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000125979.
KOiK18862.
PhylomeDBiQ6BF87.

Family and domain databases

InterProiView protein in InterPro
IPR025253. Toxin_Ldr.
PfamiView protein in Pfam
PF13940. Ldr_toxin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6BF87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MTLAQFAMTF WHDLAAPILA GIITAAIVGW WRNRK
Length:35
Mass (Da):3,972
Last modified:August 16, 2004 - v1
Checksum:i5C87AC6371270856
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAT48127.1.
AP009048 Genomic DNA. Translation: BAE76393.1.
RefSeqiWP_000170963.1. NZ_LN832404.1.
YP_025298.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48127; AAT48127; b4421.
BAE76393; BAE76393; BAE76393.
GeneIDi2847735.
KEGGiecj:JW5958.
eco:b4421.
PATRICifig|511145.12.peg.1265.

Similar proteinsi

Entry informationi

Entry nameiLDRB_ECOLI
AccessioniPrimary (citable) accession number: Q6BF87
Secondary accession number(s): Q2MBG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 16, 2004
Last modified: January 31, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families