Q6BF86 (LDRA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Small toxic polypeptide LdrA/LdrC

Gene names

Name:	ldrA
Ordered Locus Names:	b4419, JW5957
AND
Name:	ldrC
Ordered Locus Names:	b4423, JW5959

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	35 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Toxic peptide whose overexpression causes rapid cell killing and nucleoid condensation of the host cell By similarity.
Induction	A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA, in this case RdlA or RdlC. Only a few of these TA systems have been mechanistically characterized; the mechanisms used to control expression of the toxin gene are not necessarily the same Probable.
Sequence similarities	Belongs to the toxic peptide ldr family.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 35	35	Small toxic polypeptide LdrA/LdrC		PRO_0000230292

Sequences

	Sequence		Length	Mass (Da)
	Q6BF86 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 5C87B0B2BC271596	FASTA	35	4,014
	10 20 30 MTLAQFAMIF WHDLAAPILA GIITAAIVSW WRNRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli." Kawano M., Oshima T., Kasai H., Mori H. Mol. Microbiol. 45:333-349(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: AAT48126.1. U00096 Genomic DNA. Translation: AAT48128.1. AP009048 Genomic DNA. Translation: BAE76392.1. AP009048 Genomic DNA. Translation: BAE76394.1.
RefSeq	YP_025297.1. NC_000913.2. YP_025299.1. NC_000913.2. YP_489483.1. NC_007779.1. YP_489485.1. NC_007779.1.
3D structure databases
ProteinModelPortal	Q6BF86.
ModBase	Search...
Protein-protein interaction databases
STRING	511145.b4423.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAT48126; AAT48126; b4419. AAT48128; AAT48128; b4423. BAE76392; BAE76392; BAE76392. BAE76394; BAE76394; BAE76394.
GeneID	12934164. 12934194. 2847733. 2847775.
KEGG	ecj:Y75_p1188. ecj:Y75_p1190. eco:b4419. eco:b4423.
Organism-specific databases
EcoGene	EG14403. ldrA. EG14405. ldrC.
Phylogenomic databases
HOGENOM	HOG000125979.
ProtClustDB	CLSK2522513.
Enzyme and pathway databases
BioCyc	EcoCyc:MONOMER0-1601. EcoCyc:MONOMER0-1603. ECOL316407:JW5957-MONOMER. ECOL316407:JW5959-MONOMER.
Gene expression databases
Genevestigator	Q6BF86.
Family and domain databases
InterPro	IPR025253. Toxin_Ldr. [Graphical view]
Pfam	PF13940. Ldr_toxin. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LDRA_ECOLI

Accession

Primary (citable) accession number: Q6BF86
Secondary accession number(s): Q2MBG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program