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Protein

Small toxic polypeptide LdrD

Gene

ldrD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes rapid cell killing and nucleoid condensation of the host cell (PubMed:12123448). Overexpression induces stress-response and a number of membrane protein genes. May inhibit ATP synthesis due to its insertion in the cell inner membrane (By similarity).By similarity2 Publications

GO - Biological processi

  • cell death Source: EcoCyc

Keywordsi

Biological processToxin-antitoxin system

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-921

Names & Taxonomyi

Protein namesi
Recommended name:
Small toxic polypeptide LdrD
Gene namesi
Name:ldrD
Ordered Locus Names:b4453, JW5966
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14406 ldrD

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 32HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00002302941 – 35Small toxic polypeptide LdrDAdd BLAST35

Proteomic databases

PaxDbiQ6BF25
PRIDEiQ6BF25

Expressioni

Inductioni

Expression of the proteinaceous toxin is controlled by an antisense sRNA, in this case RdlD. Only a few of these TA systems have been mechanistically characterized; the mechanisms used to control expression of the toxin gene are not necessarily the same (Probable).Curated

Interactioni

Protein-protein interaction databases

BioGridi4260912, 12 interactors

Structurei

Secondary structure

135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 34Combined sources32

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LBJNMR-A1-35[»]
ProteinModelPortaliQ6BF25
SMRiQ6BF25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ldr toxic peptide family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000125979
KOiK18862
PhylomeDBiQ6BF25

Family and domain databases

InterProiView protein in InterPro
IPR025253 Toxin_Ldr
PfamiView protein in Pfam
PF13940 Ldr_toxin, 1 hit

Sequencei

Sequence statusi: Complete.

Q6BF25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MTFAELGMAF WHDLAAPVIA GILASMIVNW LNKRK
Length:35
Mass (Da):3,917
Last modified:August 16, 2004 - v1
Checksum:i25E6A9A8634CD78D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAT48189.1
AP009048 Genomic DNA Translation: BAE77756.1
RefSeqiWP_000141634.1, NZ_LN832404.1
YP_026227.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48189; AAT48189; b4453
BAE77756; BAE77756; BAE77756
GeneIDi2847730
KEGGiecj:JW5966
eco:b4453
PATRICifig|1411691.4.peg.3177

Similar proteinsi

Entry informationi

Entry nameiLDRD_ECOLI
AccessioniPrimary (citable) accession number: Q6BF25
Secondary accession number(s): Q2M7K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 16, 2004
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health