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Protein

Small toxic polypeptide LdrD

Gene

ldrD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Toxic peptide whose overexpression causes rapid cell killing and nucleoid condensation of the host cell. Overexpression induces stress-response and a number of membrane protein genes.2 Publications

GO - Biological processi

  • cell death Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-921.
ECOL316407:JW5966-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small toxic polypeptide LdrD
Gene namesi
Name:ldrD
Ordered Locus Names:b4453, JW5966
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14406. ldrD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3535Small toxic polypeptide LdrDPRO_0000230294Add
BLAST

Proteomic databases

PaxDbiQ6BF25.

Expressioni

Inductioni

A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA, in this case RdlD. Only a few of these TA systems have been mechanistically characterized; the mechanisms used to control expression of the toxin gene are not necessarily the same (Probable).Curated

Interactioni

Protein-protein interaction databases

BioGridi4260912. 12 interactions.
STRINGi511145.b4453.

Structurei

3D structure databases

ProteinModelPortaliQ6BF25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the toxic peptide ldr family.Curated

Phylogenomic databases

HOGENOMiHOG000125979.
KOiK18862.
OrthoDBiEOG6TR0N6.
PhylomeDBiQ6BF25.

Family and domain databases

InterProiIPR025253. Toxin_Ldr.
[Graphical view]
PfamiPF13940. Ldr_toxin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BF25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MTFAELGMAF WHDLAAPVIA GILASMIVNW LNKRK
Length:35
Mass (Da):3,917
Last modified:August 16, 2004 - v1
Checksum:i25E6A9A8634CD78D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAT48189.1.
AP009048 Genomic DNA. Translation: BAE77756.1.
RefSeqiWP_000141634.1. NZ_LN832404.1.
YP_026227.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48189; AAT48189; b4453.
BAE77756; BAE77756; BAE77756.
GeneIDi2847730.
KEGGiecj:JW5966.
eco:b4453.
PATRICi48667006. VBIEscCol107702_3769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAT48189.1.
AP009048 Genomic DNA. Translation: BAE77756.1.
RefSeqiWP_000141634.1. NZ_LN832404.1.
YP_026227.1. NC_000913.3.

3D structure databases

ProteinModelPortaliQ6BF25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260912. 12 interactions.
STRINGi511145.b4453.

Proteomic databases

PaxDbiQ6BF25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48189; AAT48189; b4453.
BAE77756; BAE77756; BAE77756.
GeneIDi2847730.
KEGGiecj:JW5966.
eco:b4453.
PATRICi48667006. VBIEscCol107702_3769.

Organism-specific databases

EcoGeneiEG14406. ldrD.

Phylogenomic databases

HOGENOMiHOG000125979.
KOiK18862.
OrthoDBiEOG6TR0N6.
PhylomeDBiQ6BF25.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-921.
ECOL316407:JW5966-MONOMER.

Miscellaneous databases

PROiQ6BF25.

Family and domain databases

InterProiIPR025253. Toxin_Ldr.
[Graphical view]
PfamiPF13940. Ldr_toxin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli."
    Kawano M., Oshima T., Kasai H., Mori H.
    Mol. Microbiol. 45:333-349(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, PROBABLE INDUCTION.
  4. "Repression of small toxic protein synthesis by the Sib and OhsC small RNAs."
    Fozo E.M., Kawano M., Fontaine F., Kaya Y., Mendieta K.S., Jones K.L., Ocampo A., Rudd K.E., Storz G.
    Mol. Microbiol. 70:1076-1093(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiLDRD_ECOLI
AccessioniPrimary (citable) accession number: Q6BF25
Secondary accession number(s): Q2M7K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 16, 2004
Last modified: January 20, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.