Q6BEX0 (YTFR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized ABC transporter ATP-binding protein YtfR

Gene names

Name:	ytfR
Synonyms:	ytfS
Ordered Locus Names:	b4485, JW5752

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities	Belongs to the ABC transporter superfamily. Contains 2 ABC transporter domains.
Sequence caution	The sequence AAA97126.1 differs from that shown. Reason: Frameshift at position 369.

Ontologies

Keywords
Biological process	Transport
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	galactose transport Inferred from direct assay PubMed 19744923. Source: EcoCyc
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW monosaccharide-transporting ATPase activity Inferred from direct assay PubMed 19744923. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Uncharacterized ABC transporter ATP-binding protein YtfR		PRO_0000093175
Regions
	Domain	10 – 245	236	ABC transporter 1
	Domain	259 – 497	239	ABC transporter 2
	Nucleotide binding	42 – 49	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6BEX0 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 251FE62D4FADF959	FASTA	500	55,260
	10 20 30 40 50 60 MTTDQHQEIL RTEGLSKFFP GVKALDNVDF SLRRGEIMAL LGENGAGKST LIKALTGVYH 70 80 90 100 110 120 ADRGTIWLEG QAISPKNTAH AQQLGIGTVY QEVNLLPNMS VADNLFIGRE PKRFGLLRRK 130 140 150 160 170 180 EMEKRATELM ASYGFSLDVR EPLNRFSVAM QQIVAICRAI DLSAKVLILD EPTASLDTQE 190 200 210 220 230 240 VELLFDLMRQ LRDRGVSLIF VTHFLDQVYQ VSDRITVLRN GSFVGCRETC ELPQIELVKM 250 260 270 280 290 300 MLGRELDTHA LQRAGRTLLS DKPVAAFKNY GKKGTIAPFD LEVRPGEIVG LAGLLGSGRT 310 320 330 340 350 360 ETAEVIFGIK PADSGTALIK GKPQNLRSPH QASVLGIGFC PEDRKTDGII AAASVRENII 370 380 390 400 410 420 LALQAQRGWL RPISRKEQQE IAERFIRQLG IRTPSTEQPI EFLSGGNQQK VLLSRWLLTR 430 440 450 460 470 480 PQFLILDEPT RGIDVGAHAE IIRLIETLCA DGLALLVISS ELEELVGYAD RVIIMRDRKQ 490 500 VAEIPLAELS VPAIMNAIAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R. Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005." Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R., Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T., Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H., Thomson N.R., Wishart D., Wanner B.L. Nucleic Acids Res. 34:1-9(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U14003 Genomic DNA. Translation: AAA97125.1. Frameshift. U14003 Genomic DNA. Translation: AAA97126.1. Frameshift. U00096 Genomic DNA. Translation: AAT48244.1. AP009048 Genomic DNA. Translation: BAE78229.1.
PIR	S56454. S56455.
RefSeq	YP_026286.1. NC_000913.2. YP_492370.1. NC_007779.1.
3D structure databases
ProteinModelPortal	Q6BEX0.
SMR	Q6BEX0. Positions 14-489.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48183N.
STRING	511145.b4485.
Proteomic databases
PaxDb	Q6BEX0.
PRIDE	Q6BEX0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAT48244; AAT48244; b4485. BAE78229; BAE78229; BAE78229.
GeneID	12932878. 2847725.
KEGG	ecj:Y75_p4114. eco:b4485.
PATRIC	32124031. VBIEscCol129921_4360.
Organism-specific databases
EchoBASE	EB2410.
EcoGene	EG12518. ytfR.
Phylogenomic databases
eggNOG	COG1129.
KO	K02056.
OMA	CAEGMSL.
ProtClustDB	CLSK880876.
Enzyme and pathway databases
BioCyc	EcoCyc:YTFR-MONOMER. ECOL316407:JW5752-MONOMER.
Gene expression databases
Genevestigator	Q6BEX0.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YTFR_ECOLI

Accession

Primary (citable) accession number: Q6BEX0
Secondary accession number(s): P39326, P39327, Q2M677

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program