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Protein

Hexokinase

Gene

CELE_F14B4.2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_273889. Regulation of gene expression in beta cells.
REACT_300789. Glucose transport.
REACT_339865. Glycolysis.
REACT_354295. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase (EC:2.7.1.1)
Gene namesi
ORF Names:CELE_F14B4.2Imported, F14B4.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF14B4.2b; CE36925; WBGene00008780.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ6BET1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ6BET1.
SMRiQ6BET1. Positions 32-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000017159.
HOGENOMiHOG000162670.
KOiK00844.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BET1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATGKCSKV RPRFEMLKSM SIQNSIDVSN NQMIQEACQR LVLSDQQLRR
60 70 80 90 100
IMQSMEKSME QGLATSTKKV AVKMLPTYVD SVPNGTESGD FLALDLGGTN
110 120 130 140 150
FRVLHIKLQG KETKMTGKIF RVPESIMRGT GEALFDHIAG CMAKFMGEND
160 170 180 190 200
LKDAQKLPLG FTFSFPCEQE GLTKGKLVTW TKGFKASGVE GVDVVTLLHE
210 220 230 240 250
ACHRRKDIDI DVVALLNDTV GTLMACAFQE NSCQIGVIVG TGTNACYMER
260 270 280 290 300
LDRIPKLAGY VDEHGVTPEE MIINTEWGAF GDDGALDFLR TEWDEVVDRE
310 320 330 340 350
SINPGQHLYE KMISGMYMGE CARVVLEDLA KQGLLFGGNS DAISVPHCFP
360 370 380 390 400
TKFVSEIDSD LLEDDDRTFQ KTYQILEDIG VEMITANDCA NVAYVCSLIS
410 420 430 440 450
TRAAHLTAAG IAMLLNRMNK KHVTVGVDGS VYRFHPTYPT LLDAKIGELI
460 470 480 490
VGDIEYKLML SEDGSGRGAA LVAAVATRLK EEKLAASLSS SSSNQ
Length:495
Mass (Da):54,234
Last modified:August 16, 2004 - v1
Checksum:i5110D0935E94FD6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAH04733.1.
RefSeqiNP_001021107.1. NM_001025936.3.
UniGeneiCel.7424.

Genome annotation databases

EnsemblMetazoaiF14B4.2b; F14B4.2b; WBGene00008780.
GeneIDi172751.
KEGGicel:CELE_F14B4.2.
UCSCiF14B4.2b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAH04733.1.
RefSeqiNP_001021107.1. NM_001025936.3.
UniGeneiCel.7424.

3D structure databases

ProteinModelPortaliQ6BET1.
SMRiQ6BET1. Positions 32-485.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF14B4.2b; F14B4.2b; WBGene00008780.
GeneIDi172751.
KEGGicel:CELE_F14B4.2.
UCSCiF14B4.2b. c. elegans.

Organism-specific databases

CTDi172751.
WormBaseiF14B4.2b; CE36925; WBGene00008780.

Phylogenomic databases

GeneTreeiENSGT00390000017159.
HOGENOMiHOG000162670.
KOiK00844.

Enzyme and pathway databases

ReactomeiREACT_273889. Regulation of gene expression in beta cells.
REACT_300789. Glucose transport.
REACT_339865. Glycolysis.
REACT_354295. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Miscellaneous databases

NextBioi876865.

Gene expression databases

ExpressionAtlasiQ6BET1. baseline and differential.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ6BET1_CAEEL
AccessioniPrimary (citable) accession number: Q6BET1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 27, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.