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Protein

Transcription factor Sp5

Gene

SP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri296 – 32025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 35025C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp5
Gene namesi
Name:SP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14529. SP5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875843.

Polymorphism and mutation databases

BioMutaiSP5.
DMDMi74762296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Transcription factor Sp5PRO_0000047146Add
BLAST

Proteomic databases

MaxQBiQ6BEB4.
PaxDbiQ6BEB4.
PRIDEiQ6BEB4.

PTM databases

iPTMnetiQ6BEB4.
PhosphoSiteiQ6BEB4.

Expressioni

Gene expression databases

BgeeiQ6BEB4.
CleanExiHS_SP5.
GenevisibleiQ6BEB4. HS.

Interactioni

Protein-protein interaction databases

BioGridi132951. 1 interaction.
STRINGi9606.ENSP00000364430.

Structurei

3D structure databases

ProteinModelPortaliQ6BEB4.
SMRiQ6BEB4. Positions 264-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi164 – 17310Poly-Pro
Compositional biasi224 – 23512Poly-AlaAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri296 – 32025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 35025C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000231067.
HOVERGENiHBG014797.
InParanoidiQ6BEB4.
KOiK09195.
OMAiAYVPYAT.
OrthoDBiEOG76HQ15.
PhylomeDBiQ6BEB4.
TreeFamiTF350150.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BEB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVAVLRND SLQAFLQDRT PSASPDLGKH SPLALLAATC SRIGQPGAAA
60 70 80 90 100
PPDFLQVPYD PALGSPSRLF HPWTADMPAH SPGALPPPHP SLGLTPQKTH
110 120 130 140 150
LQPSFGAAHE LPLTPPADPS YPYEFSPVKM LPSSMAALPA SCAPAYVPYA
160 170 180 190 200
AQAALPPGYS NLLPPPPPPP PPPTCRQLSP NPAPDDLPWW SIPQAGAGPG
210 220 230 240 250
ASGVPGSGLS GACAGAPHAP RFPASAAAAA AAAAALQRGL VLGPSDFAQY
260 270 280 290 300
QSQIAALLQT KAPLAATARR CRRCRCPNCQ AAGGAPEAEP GKKKQHVCHV
310 320 330 340 350
PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKSFTRS DELQRHLRTH
360 370 380 390
TGEKRFACPE CGKRFMRSDH LAKHVKTHQN KKLKVAEAGV KREDARDL
Length:398
Mass (Da):41,964
Last modified:September 13, 2004 - v1
Checksum:iBC2C27EE3ED499FA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751A → T.
Corresponds to variant rs3749036 [ dbSNP | Ensembl ].
VAR_052713

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096175 mRNA. Translation: BAD34944.1.
CCDSiCCDS33322.1.
RefSeqiNP_001003845.1. NM_001003845.2.
UniGeneiHs.368802.

Genome annotation databases

EnsembliENST00000375281; ENSP00000364430; ENSG00000204335.
GeneIDi389058.
KEGGihsa:389058.
UCSCiuc002uge.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096175 mRNA. Translation: BAD34944.1.
CCDSiCCDS33322.1.
RefSeqiNP_001003845.1. NM_001003845.2.
UniGeneiHs.368802.

3D structure databases

ProteinModelPortaliQ6BEB4.
SMRiQ6BEB4. Positions 264-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132951. 1 interaction.
STRINGi9606.ENSP00000364430.

PTM databases

iPTMnetiQ6BEB4.
PhosphoSiteiQ6BEB4.

Polymorphism and mutation databases

BioMutaiSP5.
DMDMi74762296.

Proteomic databases

MaxQBiQ6BEB4.
PaxDbiQ6BEB4.
PRIDEiQ6BEB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375281; ENSP00000364430; ENSG00000204335.
GeneIDi389058.
KEGGihsa:389058.
UCSCiuc002uge.4. human.

Organism-specific databases

CTDi389058.
GeneCardsiSP5.
HGNCiHGNC:14529. SP5.
MIMi609391. gene.
neXtProtiNX_Q6BEB4.
PharmGKBiPA134875843.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000231067.
HOVERGENiHBG014797.
InParanoidiQ6BEB4.
KOiK09195.
OMAiAYVPYAT.
OrthoDBiEOG76HQ15.
PhylomeDBiQ6BEB4.
TreeFamiTF350150.

Miscellaneous databases

GenomeRNAii389058.
PROiQ6BEB4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6BEB4.
CleanExiHS_SP5.
GenevisibleiQ6BEB4. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of human Sp5 as a direct target of the b-catenin/T-cell factor 4 complex and its frequent elevated expression in colon cancers."
    Takahashi M., Furukawa Y., Nakamura Y.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSP5_HUMAN
AccessioniPrimary (citable) accession number: Q6BEB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.