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Protein

UHRF1-binding protein 1

Gene

UHRF1BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a negative regulator of cell growth.1 Publication

GO - Molecular functioni

  • histone deacetylase binding Source: BHF-UCL
  • identical protein binding Source: BHF-UCL

Names & Taxonomyi

Protein namesi
Recommended name:
UHRF1-binding protein 1
Alternative name(s):
ICBP90-binding protein 1
Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1
Gene namesi
Name:UHRF1BP1
Synonyms:C6orf107
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000065060.16
HGNCiHGNC:21216 UHRF1BP1
neXtProtiNX_Q6BDS2

Pathology & Biotechi

Organism-specific databases

DisGeNETi54887
OpenTargetsiENSG00000065060
PharmGKBiPA162408530

Polymorphism and mutation databases

BioMutaiUHRF1BP1
DMDMi67462038

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000657231 – 1440UHRF1-binding protein 1Add BLAST1440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei444PhosphoserineCombined sources1
Modified residuei446PhosphoserineCombined sources1
Modified residuei755PhosphoserineCombined sources1
Modified residuei758PhosphoserineCombined sources1
Modified residuei988PhosphoserineCombined sources1
Modified residuei1103PhosphoserineCombined sources1
Modified residuei1106PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6BDS2
MaxQBiQ6BDS2
PaxDbiQ6BDS2
PeptideAtlasiQ6BDS2
PRIDEiQ6BDS2

PTM databases

iPTMnetiQ6BDS2
PhosphoSitePlusiQ6BDS2

Expressioni

Gene expression databases

BgeeiENSG00000065060
CleanExiHS_UHRF1BP1
ExpressionAtlasiQ6BDS2 baseline and differential
GenevisibleiQ6BDS2 HS

Organism-specific databases

HPAiHPA032099
HPA032100

Interactioni

Subunit structurei

Homodimer (Potential). Interacts with UHRF1.Curated1 Publication

GO - Molecular functioni

  • histone deacetylase binding Source: BHF-UCL
  • identical protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi120235, 37 interactors
IntActiQ6BDS2, 22 interactors
MINTiQ6BDS2
STRINGi9606.ENSP00000192788

Structurei

3D structure databases

ProteinModelPortaliQ6BDS2
SMRiQ6BDS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili837 – 860Sequence analysisAdd BLAST24
Coiled coili1401 – 1435Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2955 Eukaryota
ENOG410XQGP LUCA
GeneTreeiENSGT00600000084428
HOGENOMiHOG000154771
HOVERGENiHBG061128
InParanoidiQ6BDS2
OMAiRFFSMKR
OrthoDBiEOG091G00DN
PhylomeDBiQ6BDS2
TreeFamiTF314874

Family and domain databases

InterProiView protein in InterPro
IPR026728 UHRF1BP1-like
IPR026854 VPS13_N
PANTHERiPTHR22774 PTHR22774, 1 hit
PfamiView protein in Pfam
PF12624 Chorein_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q6BDS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGIIKKQIL KHLSRFTKNL SPDKINLSTL KGEGQLTNLE LDEEVLQNVL
60 70 80 90 100
ELPTWLAITR VYCNRASIRI QWTKLKTHPI CLCLDKVEVE MKTCEDPRPP
110 120 130 140 150
NGQSPIALAS GQSEYGFAEK VVEGMFIIVN SITIKIHSKA FHASFELWQL
160 170 180 190 200
QGYSVNPNWQ QSDLRLTRIT DPCRGEVLTF KEITWQTLRI EADATDNGDQ
210 220 230 240 250
DPVTTPLRLI TNQGRIQIAL KRRTKDCNVI SSKLMFLLDD LLWVLTDSQL
260 270 280 290 300
KAMMKYAESL SEAMEKSAHQ RKSLAPEPVQ ITPPAPSAQQ SWAQAFGGSQ
310 320 330 340 350
GNSNSSSSRL SQYFEKFDVK ESSYHLLISR LDLHICDDSQ SREPGVSANR
360 370 380 390 400
LMGGAMQLTF RKMAFDYYPF HWAGDSCKHW VRHCEAMETR GQWAQKLVME
410 420 430 440 450
FQSKMEKWHE ETGLKPPWHL GVDSLFRRKA DSLSSPRKNP LERSPSQGRQ
460 470 480 490 500
PAFQPPAWNR LRSSCMVVRV DDLDIHQVST AGQPSKKPST LLSCSRKLHN
510 520 530 540 550
LPTQVSAIHI EFTEYYFPDN QELPVPCPNL YIQLNGLTFT MDPVSLLWGN
560 570 580 590 600
LFCLDLYRSL EQFKAIYKLE DSSQKDEHLD IRLDAFWLKV SFPLEKRERA
610 620 630 640 650
ELHRPQALVF SASGMIATNT RHAPHCSCSD LQSLFRGFAA AEFFHSNYDH
660 670 680 690 700
FPKVPGGFSL LHMLFLHHAF QMDSCLPQPN TLPPQRPKAS WDLWSVHFTQ
710 720 730 740 750
ISLDFEGTEN FKGHTLNFVA PFPLSIWACL PLRWQQAQAR KLLLASEGRL
760 770 780 790 800
KPSASFGSPV QSEALAPDSM SHPRSKTEHD LKSLSGLTEV MEILKEGSSG
810 820 830 840 850
MDNKGPLTEL EDVADVHMLV HSPAHVRVRL DHYQYLALLR LKEVLQRLQE
860 870 880 890 900
QLTKDTESMT GSPLQNQTAC IGVLFPSAEV ALLMHPAPGA VDADSAGSDS
910 920 930 940 950
TSLVDSELSP SEDRELKSDA SSDQGPASPE KVLEESSIEN QDVSQERPHS
960 970 980 990 1000
NGELQDSGPL AQQLAGKGHE AVESLQAKKL SRTQASSSPA ALKPPAGRET
1010 1020 1030 1040 1050
AVNGQGELIP LKNIEGELSS AIHMTKDATK EALHATMDLT KEAVSLTKDA
1060 1070 1080 1090 1100
FSLGRDRMTS TMHKMLSLPP AKEPMAKTDE GVAAPVSGGA ARLRFFSMKR
1110 1120 1130 1140 1150
TVSQQSFDGV SLDSSGPEDR ISVDSDGSDS FVMLLESESG PESVPPGSLS
1160 1170 1180 1190 1200
NVSDNAGVQG SPLVNNYGQG SPAANSSVSP SGEDLIFHPV SVLVLKVNEV
1210 1220 1230 1240 1250
SFGIEVRGED LTVALQAEEL TLQQLGTVGL WQFLHGQCPG TCFQESSTLK
1260 1270 1280 1290 1300
TGHIRPAVGL RFEVGPGAAV HSPLASQNGF LHLLLHGCDL ELLTSVLSGL
1310 1320 1330 1340 1350
GPFLEDEEIP VVVPMQIELL NSSITLKDDI PPIYPTSPGP IPITLAMEHV
1360 1370 1380 1390 1400
VLKRSDDGVF HIGAAAQDKP SAEVLKSEKR QPPKEQVFLV PTGEVFEQQV
1410 1420 1430 1440
KELPILQKEL IETKQALANA NQDKEKLLQE IRKYNPFFEL
Length:1,440
Mass (Da):159,485
Last modified:September 13, 2004 - v1
Checksum:iF6A5585274C33FA9
GO

Sequence cautioni

The sequence BAA91074 differs from that shown. Chimeric cDNA.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051474404K → N. Corresponds to variant dbSNP:rs16894945Ensembl.1
Natural variantiVAR_051475454Q → R. Corresponds to variant dbSNP:rs11755393Ensembl.1
Natural variantiVAR_051476854K → E. Corresponds to variant dbSNP:rs3734265Ensembl.1
Natural variantiVAR_051477984Q → H. Corresponds to variant dbSNP:rs9469913Ensembl.1
Natural variantiVAR_0514781098M → T. Corresponds to variant dbSNP:rs13205210Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126777 mRNA Translation: BAD32740.1
AL139100 Genomic DNA No translation available.
AL033520 Genomic DNA No translation available.
AK000309 mRNA Translation: BAA91074.1 Sequence problems.
CCDSiCCDS43455.1
RefSeqiNP_060224.3, NM_017754.3
UniGeneiHs.700656

Genome annotation databases

EnsembliENST00000192788; ENSP00000192788; ENSG00000065060
GeneIDi54887
KEGGihsa:54887
UCSCiuc003oju.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiURFB1_HUMAN
AccessioniPrimary (citable) accession number: Q6BDS2
Secondary accession number(s): Q9NXE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health