Q6BDI9 (REP15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rab15 effector protein

Gene names

Name:

REP15

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates transferrin receptor recycling from the endocytic recycling compartment. Ref.3
Subunit structure	Interacts with the GTP-bound form of RAB15. Ref.3
Subcellular location	Early endosome membrane. Note: Colocalizes with RAB11 and RAB15 to the endocytic recycling compartment. Ref.3
Sequence caution	The sequence AAT76304.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

Ontologies

Keywords
Cellular component	Endosome Membrane
Coding sequence diversity	Polymorphism
PTM	Lipoprotein Myristate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	early endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Potential
	Chain	2 – 236	235	Rab15 effector protein		PRO_0000323587
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine Potential
Natural variations
	Natural variant	101	1	N → D. Ref.2 Ref.3 Corresponds to variant rs929949 [ dbSNP | Ensembl ].		VAR_039548
	Natural variant	206	1	E → D. Corresponds to variant rs12819160 [ dbSNP | Ensembl ].		VAR_039549
Experimental info
	Sequence conflict	88	1	L → P in AAT76304. Ref.3
	Sequence conflict	114	1	Q → R in AAT76304. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q6BDI9 [UniParc]. Last modified January 11, 2011. Version 4. Checksum: BE81DA3B710C25DC	FASTA	236	26,571
	10 20 30 40 50 60 MGQKASQQLA LKDSKEVPVV CEVVSEAIVH AAQKLKEYLG FEYPPSKLCP AANTLNEIFL 70 80 90 100 110 120 IHFITFCQEK GVDEWLTTTK MTKHQAFLFG ADWIWTFWGS NKQIKLQLAV QTLQMSSPPP 130 140 150 160 170 180 VESKPCDLSN PESRVEESSW KKSRFDKLEE FCNLIGEDCL GLFIIFGMPG KPKDIRGVVL 190 200 210 220 230 DSVKSQMVRS HLPGGKAVAQ FVLETEDCVF IKELLRNCLS KKDGLREVGK VYISIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-101. Tissue: Testis.
[3]	"Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment." Strick D.J., Elferink L.A. Mol. Biol. Cell 16:5699-5709(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-236, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH THE GTP-BOUND FORM OF RAB15, VARIANT ASP-101.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC009509 Genomic DNA. No translation available. BC140921 mRNA. Translation: AAI40922.1. AY662682 mRNA. Translation: AAT76304.1. Sequence problems.
IPI	IPI00465270.
RefSeq	NP_001025045.1. NM_001029874.1.
UniGene	Hs.269836.
3D structure databases
ProteinModelPortal	Q6BDI9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000310335.
Polymorphism databases
DMDM	205371860.
Proteomic databases
PaxDb	Q6BDI9.
PRIDE	Q6BDI9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000310791; ENSP00000310335; ENSG00000174236.
GeneID	387849.
KEGG	hsa:387849.
UCSC	uc001rig.1. human.
Organism-specific databases
CTD	387849.
GeneCards	GC12P027849.
H-InvDB	HIX0036773.
HGNC	HGNC:33748. REP15.
HPA	HPA040448.
MIM	610848. gene.
neXtProt	NX_Q6BDI9.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG26651.
HOGENOM	HOG000154091.
HOVERGEN	HBG108401.
InParanoid	Q6BDI9.
OMA	FGADWIW.
OrthoDB	EOG4933JR.
PhylomeDB	Q6BDI9.
Gene expression databases
Bgee	Q6BDI9.
Genevestigator	Q6BDI9.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	387849.
NextBio	101671.
SOURCE	Search...

Entry information

Entry name

REP15_HUMAN

Accession

Primary (citable) accession number: Q6BDI9
Secondary accession number(s): B2RU16

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	January 11, 2011
Last modified:	April 3, 2013
This is version 48 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.