UniProtKB - Q6BBL6 (CLD4_BOVIN)
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Protein
Claudin-4
Gene
CLDN4
Organism
Bos taurus (Bovine)
Status
Functioni
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity
GO - Molecular functioni
- chloride channel activity Source: UniProtKB
- identical protein binding Source: UniProtKB
- structural molecule activity Source: InterPro
GO - Biological processi
- calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
- establishment of skin barrier Source: Ensembl
- renal absorption Source: UniProtKB
Keywordsi
Molecular function | Chloride channel, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Names & Taxonomyi
Protein namesi | Recommended name: Claudin-4 |
Gene namesi | Name:CLDN4 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:27416. CLDN4. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 31 – 81 | ExtracellularSequence analysisAdd BLAST | 51 | |
Transmembranei | 82 – 102 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 117 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 118 – 138 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 160 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 161 – 181 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 182 – 209 | CytoplasmicSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Tight junctionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144741 | 1 – 209 | Claudin-4Add BLAST | 209 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 198 | PhosphoserineBy similarity | 1 | |
Modified residuei | 208 | Phosphotyrosine; by EPHA2By similarity | 1 |
Post-translational modificationi
Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1 (By similarity).By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q6BBL6. |
PRIDEi | Q6BBL6. |
Interactioni
Subunit structurei
Interacts with EPHA2; phosphorylates CLDN4 and may regulate tight junctions (By similarity). Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with CLDN1 (By similarity). Interacts with CLDN4 (By similarity).By similarity
GO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000037110. |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 103 | Interaction with EPHA2By similarityAdd BLAST | 103 | |
Regioni | 208 – 209 | Interactions with TJP1, TJP2 and TJP3By similarity | 2 |
Sequence similaritiesi
Belongs to the claudin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IIJR. Eukaryota. ENOG410YA61. LUCA. |
GeneTreei | ENSGT00760000118928. |
HOGENOMi | HOG000220937. |
HOVERGENi | HBG000643. |
InParanoidi | Q6BBL6. |
KOi | K06087. |
OMAi | TAHNVIR. |
OrthoDBi | EOG091G0MMR. |
TreeFami | TF331936. |
Family and domain databases
InterProi | View protein in InterPro IPR006187. Claudin. IPR003550. Claudin4. IPR017974. Claudin_CS. IPR004031. PMP22/EMP/MP20/Claudin. |
PANTHERi | PTHR12002. PTHR12002. 1 hit. |
Pfami | View protein in Pfam PF00822. PMP22_Claudin. 1 hit. |
PRINTSi | PR01379. CLAUDIN4. |
PROSITEi | View protein in PROSITE PS01346. CLAUDIN. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q6BBL6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASMGLQVMG IALAVLGWLG AILSCALPMW RVTAFIGSNI VTSQTIWEGL
60 70 80 90 100
WMNCVVQSTG QMQCKVYDSL LALPQDLQAA RALIVICIIL AVFGVLLSVV
110 120 130 140 150
GGKCTNCVDD ESSKAKIMIV AGVVFLLAGL LVMVPVSWTA NNVIRDFYNP
160 170 180 190 200
LVASGQKREM GASLYVGWAA AGLLILGGAL LCFNCPPRND KPYSAKYSAA
RSAPASNYV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB185928 mRNA. Translation: BAD34533.1. BC105534 mRNA. Translation: AAI05535.1. |
RefSeqi | NP_001014413.1. NM_001014391.2. |
UniGenei | Bt.12177. |
Genome annotation databases
Ensembli | ENSBTAT00000037275; ENSBTAP00000037110; ENSBTAG00000026278. |
GeneIDi | 414921. |
KEGGi | bta:414921. |
Similar proteinsi
Entry informationi
Entry namei | CLD4_BOVIN | |
Accessioni | Q6BBL6Primary (citable) accession number: Q6BBL6 Secondary accession number(s): Q2KJ40 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | September 13, 2004 | |
Last modified: | March 28, 2018 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |