CLDN4

Functionⁱ

Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functionⁱ

chloride channel activity Source: UniProtKB
identical protein binding Source: UniProtKB
structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
establishment of skin barrier Source: Ensembl
renal absorption Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chloride channel, Ion channel
Biological process	Ion transport, Transport
Ligand	Chloride

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Claudin-4
Gene namesⁱ	Name:CLDN4
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 25

Organism-specific databases

VGNCⁱ	VGNC:27416. CLDN4.

VGNCⁱ

VGNC:27416. CLDN4.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 9	CytoplasmicSequence analysis	9
Transmembraneⁱ	10 – 30	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	31 – 81	ExtracellularSequence analysisAdd BLAST	51
Transmembraneⁱ	82 – 102	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	103 – 117	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	118 – 138	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	139 – 160	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	161 – 181	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	182 – 209	CytoplasmicSequence analysisAdd BLAST	28

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144741	1 – 209	Claudin-4Add BLAST		209

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	198	PhosphoserineBy similarity		1
Modified residueⁱ	208	Phosphotyrosine; by EPHA2By similarity		1

Post-translational modificationⁱ

Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1 (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q6BBL6.
PRIDEⁱ	Q6BBL6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSBTAG00000026278.

Bgeeⁱ

ENSBTAG00000026278.

Interactionⁱ

Subunit structureⁱ

Interacts with EPHA2; phosphorylates CLDN4 and may regulate tight junctions (By similarity). Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with CLDN1 (By similarity). Interacts with CLDN4 (By similarity).By similarity

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000037110.

STRINGⁱ

9913.ENSBTAP00000037110.

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 103	Interaction with EPHA2By similarityAdd BLAST		103
Regionⁱ	208 – 209	Interactions with TJP1, TJP2 and TJP3By similarity		2

Sequence similaritiesⁱ

Belongs to the claudin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IIJR. Eukaryota. ENOG410YA61. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118928.
HOGENOMⁱ	HOG000220937.
HOVERGENⁱ	HBG000643.
InParanoidⁱ	Q6BBL6.
KEGG Orthology (KO) More...KOⁱ	K06087.
OMAⁱ	TAHNVIR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MMR.
TreeFamⁱ	TF331936.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187. Claudin. IPR003550. Claudin4. IPR017974. Claudin_CS. IPR004031. PMP22/EMP/MP20/Claudin.
PANTHERⁱ	PTHR12002. PTHR12002. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822. PMP22_Claudin. 1 hit.
PRINTSⁱ	PR01379. CLAUDIN4.
PROSITEⁱ	View protein in PROSITE PS01346. CLAUDIN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6BBL6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASMGLQVMG IALAVLGWLG AILSCALPMW RVTAFIGSNI VTSQTIWEGL 
        60         70         80         90        100
WMNCVVQSTG QMQCKVYDSL LALPQDLQAA RALIVICIIL AVFGVLLSVV 
       110        120        130        140        150
GGKCTNCVDD ESSKAKIMIV AGVVFLLAGL LVMVPVSWTA NNVIRDFYNP 
       160        170        180        190        200
LVASGQKREM GASLYVGWAA AGLLILGGAL LCFNCPPRND KPYSAKYSAA 

RSAPASNYV

Length:209

Mass (Da):22,165

Last modified:September 13, 2004 - v1

Checksum:ⁱBB234586BBAEE1F2

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB185928 mRNA. Translation: BAD34533.1. BC105534 mRNA. Translation: AAI05535.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001014413.1. NM_001014391.2.
UniGeneⁱ	Bt.12177.

Genome annotation databases

Ensemblⁱ	ENSBTAT00000037275; ENSBTAP00000037110; ENSBTAG00000026278.
GeneIDⁱ	414921.
KEGGⁱ	bta:414921.

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6BBL6	L8ITH0 Q6L707	Bos mutus (wild yak) Bos taurus (Bovine)	209	UniRef100_Q6BBL6	Cluster: Claudin-4	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6BBL6	O14493 Q75L80 H2QUQ3 H2PLX4 A0A2I2ZD15 G1SAN1 UPI000812F2B6 E2RNC2 L8ITH0 Q6L707 +70	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Gorilla gorilla gorilla (Western lowland gorilla) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Manis javanica (Malayan pangolin) (Sunda pangolin) Canis lupus familiaris (Dog) (Canis familiaris) Bos mutus (wild yak) Bos taurus (Bovine) Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) And more	209	UniRef90_O14493	Cluster: Claudin-4	81

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6BBL6	O14493 Q75L80 H2QUQ3 H2PLX4 A0A2I2ZD15 G1SAN1 UPI000812F2B6 E2RNC2 UPI000BB4A7AC A0A2K5C5J2 +309	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Gorilla gorilla gorilla (Western lowland gorilla) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Manis javanica (Malayan pangolin) (Sunda pangolin) Canis lupus familiaris (Dog) (Canis familiaris) Enhydra lutris kenyoni Aotus nancymaae (Ma's night monkey) Delphinapterus leucas (Beluga whale) And more	209	UniRef50_O14493	Cluster: Claudin-4	320

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB185928 mRNA. Translation: BAD34533.1. BC105534 mRNA. Translation: AAI05535.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001014413.1. NM_001014391.2.
UniGeneⁱ	Bt.12177.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000037110.

STRINGⁱ

9913.ENSBTAP00000037110.

Proteomic databases

PaxDbⁱ	Q6BBL6.
PRIDEⁱ	Q6BBL6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000037275; ENSBTAP00000037110; ENSBTAG00000026278.
GeneIDⁱ	414921.
KEGGⁱ	bta:414921.

Organism-specific databases

CTDⁱ	1364.
VGNCⁱ	VGNC:27416. CLDN4.

Phylogenomic databases

eggNOGⁱ	ENOG410IIJR. Eukaryota. ENOG410YA61. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118928.
HOGENOMⁱ	HOG000220937.
HOVERGENⁱ	HBG000643.
InParanoidⁱ	Q6BBL6.
KEGG Orthology (KO) More...KOⁱ	K06087.
OMAⁱ	TAHNVIR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MMR.
TreeFamⁱ	TF331936.

Gene expression databases

Bgeeⁱ	ENSBTAG00000026278.

Bgeeⁱ

ENSBTAG00000026278.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187. Claudin. IPR003550. Claudin4. IPR017974. Claudin_CS. IPR004031. PMP22/EMP/MP20/Claudin.
PANTHERⁱ	PTHR12002. PTHR12002. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822. PMP22_Claudin. 1 hit.
PRINTSⁱ	PR01379. CLAUDIN4.
PROSITEⁱ	View protein in PROSITE PS01346. CLAUDIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLD4_BOVIN
Accessionⁱ	Q6BBL6Primary (citable) accession number: Q6BBL6 Secondary accession number(s): Q2KJ40
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
	Last sequence update:	September 13, 2004
	Last modified:	March 28, 2018
	This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6BBL6 (CLD4_BOVIN)

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Claudin-4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ