CLDN4

Functionⁱ

Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functionⁱ

chloride channel activity Source: UniProtKB
identical protein binding Source: UniProtKB
structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
establishment of skin barrier Source: Ensembl
renal absorption Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chloride channel, Ion channel
Biological process	Ion transport, Transport
Ligand	Chloride

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Claudin-4
Gene namesⁱ	Name:CLDN4
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 25

Organism-specific databases

VGNCⁱ	VGNC:27416 CLDN4

VGNCⁱ

VGNC:27416 CLDN4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 9	CytoplasmicSequence analysis	9
Transmembraneⁱ	10 – 30	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	31 – 81	ExtracellularSequence analysisAdd BLAST	51
Transmembraneⁱ	82 – 102	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	103 – 117	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	118 – 138	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	139 – 160	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	161 – 181	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	182 – 209	CytoplasmicSequence analysisAdd BLAST	28

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144741	1 – 209	Claudin-4Add BLAST		209

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	54 ↔ 64	By similarity
Modified residueⁱ	208	Phosphotyrosine; by EPHA2By similarity		1

Post-translational modificationⁱ

Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1 (By similarity).By similarity

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q6BBL6
PRIDEⁱ	Q6BBL6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSBTAG00000026278

Bgeeⁱ

ENSBTAG00000026278

Interactionⁱ

Subunit structureⁱ

Interacts with EPHA2; phosphorylates CLDN4 and may regulate tight junctions (By similarity). Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with CLDN1 (By similarity). Interacts with CLDN8 (By similarity).By similarity

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000037110

STRINGⁱ

9913.ENSBTAP00000037110

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 103	Interaction with EPHA2By similarityAdd BLAST		103
Regionⁱ	208 – 209	Interactions with TJP1, TJP2 and TJP3By similarity		2

Sequence similaritiesⁱ

Belongs to the claudin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IIJR Eukaryota ENOG410YA61 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118928
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG000643
InParanoidⁱ	Q6BBL6
KEGG Orthology (KO) More...KOⁱ	K06087
OMAⁱ	TAHNVIR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MMR
TreeFamⁱ	TF331936

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR003550 Claudin4 IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01379 CLAUDIN4
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6BBL6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASMGLQVMG IALAVLGWLG AILSCALPMW RVTAFIGSNI VTSQTIWEGL 
        60         70         80         90        100
WMNCVVQSTG QMQCKVYDSL LALPQDLQAA RALIVICIIL AVFGVLLSVV 
       110        120        130        140        150
GGKCTNCVDD ESSKAKIMIV AGVVFLLAGL LVMVPVSWTA NNVIRDFYNP 
       160        170        180        190        200
LVASGQKREM GASLYVGWAA AGLLILGGAL LCFNCPPRND KPYSAKYSAA 

RSAPASNYV

Length:209

Mass (Da):22,165

Last modified:September 13, 2004 - v1

Checksum:ⁱBB234586BBAEE1F2

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB185928 mRNA Translation: BAD34533.1 BC105534 mRNA Translation: AAI05535.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001014413.1, NM_001014391.2
UniGeneⁱ	Bt.12177

Genome annotation databases

Ensemblⁱ	ENSBTAT00000037275; ENSBTAP00000037110; ENSBTAG00000026278
GeneIDⁱ	414921
KEGGⁱ	bta:414921

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q6BBL6	Claudin-4	)	HUMAN		209
Claudin		PANTR		209
Claudin		PONAB		209
Claudin 4		PANPA		209
Claudin		NOMLE		209
+76

Protein	Similar proteins		Species	Score	Length
Q6BBL6	Claudin-4	)	HUMAN		209
Claudin		PANTR		209
Claudin		PONAB		209
Claudin 4		PANPA		209
Claudin		NOMLE		209
+332

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB185928 mRNA Translation: BAD34533.1 BC105534 mRNA Translation: AAI05535.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001014413.1, NM_001014391.2
UniGeneⁱ	Bt.12177

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000037110

STRINGⁱ

9913.ENSBTAP00000037110

Proteomic databases

PaxDbⁱ	Q6BBL6
PRIDEⁱ	Q6BBL6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000037275; ENSBTAP00000037110; ENSBTAG00000026278
GeneIDⁱ	414921
KEGGⁱ	bta:414921

Organism-specific databases

CTDⁱ	1364
VGNCⁱ	VGNC:27416 CLDN4

Phylogenomic databases

eggNOGⁱ	ENOG410IIJR Eukaryota ENOG410YA61 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118928
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG000643
InParanoidⁱ	Q6BBL6
KEGG Orthology (KO) More...KOⁱ	K06087
OMAⁱ	TAHNVIR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MMR
TreeFamⁱ	TF331936

Gene expression databases

Bgeeⁱ	ENSBTAG00000026278

Bgeeⁱ

ENSBTAG00000026278

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR003550 Claudin4 IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01379 CLAUDIN4
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLD4_BOVIN
Accessionⁱ	Q6BBL6Primary (citable) accession number: Q6BBL6 Secondary accession number(s): Q2KJ40
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
	Last sequence update:	September 13, 2004
	Last modified:	June 20, 2018
	This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6BBL6 (CLD4_BOVIN)

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Claudin-4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ