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Protein

Fc receptor-like B

Gene

FCRLB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like B
Alternative name(s):
Fc receptor homolog expressed in B-cells protein 2
Short name:
FREB-2
Fc receptor-like and mucin-like protein 2
Fc receptor-like protein 2
Fc receptor-related protein Y
Short name:
FcRY
Gene namesi
Name:FCRLB
Synonyms:FCRL2, FCRLM2, FCRY, FREB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26431. FCRLB.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi127943.
OpenTargetsiENSG00000162746.
PharmGKBiPA162388195.

Polymorphism and mutation databases

BioMutaiFCRLB.
DMDMi74757430.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000033299218 – 426Fc receptor-like BAdd BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 85PROSITE-ProRule annotation
Disulfide bondi124 ↔ 168PROSITE-ProRule annotation
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6BAA4.
PeptideAtlasiQ6BAA4.
PRIDEiQ6BAA4.
TopDownProteomicsiQ6BAA4-5. [Q6BAA4-5]

PTM databases

iPTMnetiQ6BAA4.
PhosphoSitePlusiQ6BAA4.

Expressioni

Tissue specificityi

Expressed at low levels. Expressed in B-lymphocytes. Detected in tonsil, lung, kidney, spleen and placenta. Expressed by a small subset of germinal center B-cells in tonsils and by melanocytes (at protein level).4 Publications

Gene expression databases

BgeeiENSG00000162746.
CleanExiHS_FCRL2.
GenevisibleiQ6BAA4. HS.

Organism-specific databases

HPAiCAB026139.

Structurei

3D structure databases

ProteinModelPortaliQ6BAA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 101Ig-like C2-type 1Add BLAST79
Domaini103 – 189Ig-like C2-type 2Add BLAST87

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IDZ6. Eukaryota.
ENOG410ZPGM. LUCA.
GeneTreeiENSGT00760000119130.
HOVERGENiHBG096995.
InParanoidiQ6BAA4.
OMAiYQCSGTM.
OrthoDBiEOG091G0ETN.
PhylomeDBiQ6BAA4.
TreeFamiTF351107.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q6BAA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPLTALLLL VPSSGQAATL EKPILSLHPP WTTIFKGERV TLKCDGYHPL
60 70 80 90 100
LLELQPISTL WYLGHLLLPS HKKSIEVQTP GVYRCQTRGA PVSDPIHLSV
110 120 130 140 150
SNDWLILQVP YAPVFEGEPL VLRCRGWYDK VVYKLHYYHD GQAVRYFHSS
160 170 180 190 200
ANYTVLQARA SDSGRYQCSG TMRIPVESAP MFSAKVAVTV QELFRAPVLR
210 220 230 240 250
VMGPREARGA ALGGVVLRCD TRLHPQKRDT PLQFAFYKYS RAVRRFDWGA
260 270 280 290 300
EYTVPEPEVE ELESYWCEAA TATRSVRKRS PWLQLPGPGS PLDPASTTAP
310 320 330 340 350
APWAAALAPG NRPLSFRKPP VSRSVPLVTS VRNTTSTGLQ FPASGAPTAG
360 370 380 390 400
PPACAPPTPL EQSAGALKPD VDLLLREMQL LKGLLSRVVL ELKEPQALRE
410 420
LRGTPETPTS HFAVSPGTPE TTPVES
Length:426
Mass (Da):46,904
Last modified:September 13, 2004 - v1
Checksum:iD8AFD136B82D8962
GO
Isoform 2 (identifier: Q6BAA4-2) [UniParc]FASTAAdd to basket
Also known as: FCRL2c1

The sequence of this isoform differs from the canonical sequence as follows:
     193-275: LFRAPVLRVM...WCEAATATRS → ARHAAAVRVL...SSMGRSLGSW
     276-426: Missing.

Show »
Length:275
Mass (Da):30,301
Checksum:i3871C3F3481DF7B0
GO
Isoform 3 (identifier: Q6BAA4-3) [UniParc]FASTAAdd to basket
Also known as: FCRL2c2

The sequence of this isoform differs from the canonical sequence as follows:
     11-17: Missing.
     193-275: LFRAPVLRVM...WCEAATATRS → ARHAAAVRVL...SSMGRSLGSW
     276-426: Missing.

Show »
Length:268
Mass (Da):29,674
Checksum:i0297F0D641FAED60
GO
Isoform 4 (identifier: Q6BAA4-4) [UniParc]FASTAAdd to basket
Also known as: FCRL2b1

The sequence of this isoform differs from the canonical sequence as follows:
     192-318: ELFRAPVLRV...PGNRPLSFRK → AARCAASTGA...RRPWNNRLEP
     319-426: Missing.

Show »
Length:318
Mass (Da):35,250
Checksum:i115A94BA61CF9012
GO
Isoform 5 (identifier: Q6BAA4-5) [UniParc]FASTAAdd to basket
Also known as: FCRL2b2

The sequence of this isoform differs from the canonical sequence as follows:
     11-17: Missing.
     192-318: ELFRAPVLRV...PGNRPLSFRK → AARCAASTGA...RRPWNNRLEP
     319-426: Missing.

Show »
Length:311
Mass (Da):34,623
Checksum:iC6A64A847EBD9008
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18 – 19AT → VP in AAT77989 (PubMed:15676285).Curated2
Sequence conflicti18 – 19AT → VP in AAT77990 (PubMed:15676285).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03341911 – 17Missing in isoform 3 and isoform 5. 1 Publication7
Alternative sequenceiVSP_033420192 – 318ELFRA…LSFRK → AARCAASTGAPSTQSRSPRS RSSNRTGARRLPPPAVSGNA VRGCSSRGRVLPWTRPPPPP QLHGPQPWLLVIGRFPSESP RCPDRSRWSPPSGTPPPPGC SSRRAAPRLRGHPPALRRRP WNNRLEP in isoform 4 and isoform 5. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_033421193 – 275LFRAP…TATRS → ARHAAAVRVLQVQPRGAPLR LGRRVHSPGARGRGARIVLV RGGYRHPQCPETQSVAAAPG AGFSPGPGLHHRPSSMGRSL GSW in isoform 2 and isoform 3. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_033422276 – 426Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_033423319 – 426Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ021957 mRNA. Translation: AAY42534.1.
AY786314 mRNA. Translation: AAX11390.1.
AY670683 mRNA. Translation: AAT77987.1.
AY670684 mRNA. Translation: AAT77988.1.
AY670685 mRNA. Translation: AAT77989.1.
AY670686 mRNA. Translation: AAT77990.1.
AY670687 mRNA. Translation: AAT77991.1.
EF064728 Genomic DNA. Translation: ABK41911.1.
AK290733 mRNA. Translation: BAF83422.1.
AL359541 Genomic DNA. Translation: CAH74155.2.
AL359541 Genomic DNA. Translation: CAM20340.1.
AL359541 Genomic DNA. Translation: CAM20341.1.
AL359541 Genomic DNA. Translation: CAM20342.1.
AL359541 Genomic DNA. Translation: CAM20343.1.
BC038564 mRNA. Translation: AAH38564.2.
CCDSiCCDS30927.1. [Q6BAA4-1]
CCDS72962.1. [Q6BAA4-2]
CCDS72963.1. [Q6BAA4-4]
CCDS72964.1. [Q6BAA4-3]
CCDS72965.1. [Q6BAA4-5]
RefSeqiNP_001002901.1. NM_001002901.3. [Q6BAA4-1]
NP_001275758.1. NM_001288829.1. [Q6BAA4-4]
NP_001275759.1. NM_001288830.1. [Q6BAA4-5]
NP_001275760.1. NM_001288831.1. [Q6BAA4-2]
NP_001275761.1. NM_001288832.1. [Q6BAA4-3]
NP_001307170.1. NM_001320241.1. [Q6BAA4-1]
UniGeneiHs.517422.

Genome annotation databases

EnsembliENST00000336830; ENSP00000338598; ENSG00000162746. [Q6BAA4-2]
ENST00000367944; ENSP00000356921; ENSG00000162746. [Q6BAA4-3]
ENST00000367945; ENSP00000356922; ENSG00000162746. [Q6BAA4-5]
ENST00000367946; ENSP00000356923; ENSG00000162746. [Q6BAA4-4]
ENST00000367948; ENSP00000356925; ENSG00000162746. [Q6BAA4-1]
GeneIDi127943.
KEGGihsa:127943.
UCSCiuc001gbh.4. human. [Q6BAA4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ021957 mRNA. Translation: AAY42534.1.
AY786314 mRNA. Translation: AAX11390.1.
AY670683 mRNA. Translation: AAT77987.1.
AY670684 mRNA. Translation: AAT77988.1.
AY670685 mRNA. Translation: AAT77989.1.
AY670686 mRNA. Translation: AAT77990.1.
AY670687 mRNA. Translation: AAT77991.1.
EF064728 Genomic DNA. Translation: ABK41911.1.
AK290733 mRNA. Translation: BAF83422.1.
AL359541 Genomic DNA. Translation: CAH74155.2.
AL359541 Genomic DNA. Translation: CAM20340.1.
AL359541 Genomic DNA. Translation: CAM20341.1.
AL359541 Genomic DNA. Translation: CAM20342.1.
AL359541 Genomic DNA. Translation: CAM20343.1.
BC038564 mRNA. Translation: AAH38564.2.
CCDSiCCDS30927.1. [Q6BAA4-1]
CCDS72962.1. [Q6BAA4-2]
CCDS72963.1. [Q6BAA4-4]
CCDS72964.1. [Q6BAA4-3]
CCDS72965.1. [Q6BAA4-5]
RefSeqiNP_001002901.1. NM_001002901.3. [Q6BAA4-1]
NP_001275758.1. NM_001288829.1. [Q6BAA4-4]
NP_001275759.1. NM_001288830.1. [Q6BAA4-5]
NP_001275760.1. NM_001288831.1. [Q6BAA4-2]
NP_001275761.1. NM_001288832.1. [Q6BAA4-3]
NP_001307170.1. NM_001320241.1. [Q6BAA4-1]
UniGeneiHs.517422.

3D structure databases

ProteinModelPortaliQ6BAA4.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6BAA4.
PhosphoSitePlusiQ6BAA4.

Polymorphism and mutation databases

BioMutaiFCRLB.
DMDMi74757430.

Proteomic databases

PaxDbiQ6BAA4.
PeptideAtlasiQ6BAA4.
PRIDEiQ6BAA4.
TopDownProteomicsiQ6BAA4-5. [Q6BAA4-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336830; ENSP00000338598; ENSG00000162746. [Q6BAA4-2]
ENST00000367944; ENSP00000356921; ENSG00000162746. [Q6BAA4-3]
ENST00000367945; ENSP00000356922; ENSG00000162746. [Q6BAA4-5]
ENST00000367946; ENSP00000356923; ENSG00000162746. [Q6BAA4-4]
ENST00000367948; ENSP00000356925; ENSG00000162746. [Q6BAA4-1]
GeneIDi127943.
KEGGihsa:127943.
UCSCiuc001gbh.4. human. [Q6BAA4-1]

Organism-specific databases

CTDi127943.
DisGeNETi127943.
GeneCardsiFCRLB.
HGNCiHGNC:26431. FCRLB.
HPAiCAB026139.
MIMi609251. gene.
neXtProtiNX_Q6BAA4.
OpenTargetsiENSG00000162746.
PharmGKBiPA162388195.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDZ6. Eukaryota.
ENOG410ZPGM. LUCA.
GeneTreeiENSGT00760000119130.
HOVERGENiHBG096995.
InParanoidiQ6BAA4.
OMAiYQCSGTM.
OrthoDBiEOG091G0ETN.
PhylomeDBiQ6BAA4.
TreeFamiTF351107.

Miscellaneous databases

GenomeRNAii127943.
PROiQ6BAA4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162746.
CleanExiHS_FCRL2.
GenevisibleiQ6BAA4. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCRLB_HUMAN
AccessioniPrimary (citable) accession number: Q6BAA4
Secondary accession number(s): A2A3J5
, A2A3J7, Q5VXA6, Q6BAA0, Q6BAA1, Q6BAA2, Q6BAA3, Q8IXZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2004
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.