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Protein

Insulin growth factor-like family member 4

Gene

IGFL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin growth factor-like family member 4
Gene namesi
Name:IGFL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32931. IGFL4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147357961.

Polymorphism and mutation databases

BioMutaiIGFL4.
DMDMi74709209.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 124105Insulin growth factor-like family member 4PRO_0000045062Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6B9Z1.
PRIDEiQ6B9Z1.

Expressioni

Tissue specificityi

Detected in the cerebellum.1 Publication

Gene expression databases

BgeeiQ6B9Z1.
CleanExiHS_IGFL4.
ExpressionAtlasiQ6B9Z1. baseline and differential.

Organism-specific databases

HPAiHPA047655.

Structurei

3D structure databases

ProteinModelPortaliQ6B9Z1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IGFL family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JE04. Eukaryota.
ENOG41117SS. LUCA.
GeneTreeiENSGT00390000009557.
HOGENOMiHOG000113010.
HOVERGENiHBG081785.
InParanoidiQ6B9Z1.
OMAiTRICAQE.
OrthoDBiEOG7SXW5M.
PhylomeDBiQ6B9Z1.
TreeFamiTF343427.

Family and domain databases

InterProiIPR032744. IGFL.
[Graphical view]
PANTHERiPTHR34827. PTHR34827. 1 hit.
PfamiPF14653. IGFL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6B9Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPRISAAIF IFELLGSNSE GVTDLRLWLC QPAPRCGEWT YNPLEQCCDD
60 70 80 90 100
GVILDLNQTR LCGSSCTFWP CFQHCCLESL GSQNQTVVRF KVPGMKPDCK
110 120
SSPITRICAQ EYHPKSPVSR SDLI
Length:124
Mass (Da):13,885
Last modified:September 13, 2004 - v1
Checksum:iFBBFB971350A330E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251L → P.
Corresponds to variant rs10412490 [ dbSNP | Ensembl ].
VAR_049571
Natural varianti60 – 601R → Q.
Corresponds to variant rs17271272 [ dbSNP | Ensembl ].
VAR_049572

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY672114 mRNA. Translation: AAT77788.1.
AC007785 Genomic DNA. No translation available.
CCDSiCCDS33057.1.
RefSeqiNP_001002923.1. NM_001002923.1.
UniGeneiHs.531310.

Genome annotation databases

EnsembliENST00000377697; ENSP00000366926; ENSG00000204869.
GeneIDi444882.
KEGGihsa:444882.
UCSCiuc002pdy.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY672114 mRNA. Translation: AAT77788.1.
AC007785 Genomic DNA. No translation available.
CCDSiCCDS33057.1.
RefSeqiNP_001002923.1. NM_001002923.1.
UniGeneiHs.531310.

3D structure databases

ProteinModelPortaliQ6B9Z1.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiIGFL4.
DMDMi74709209.

Proteomic databases

PaxDbiQ6B9Z1.
PRIDEiQ6B9Z1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377697; ENSP00000366926; ENSG00000204869.
GeneIDi444882.
KEGGihsa:444882.
UCSCiuc002pdy.1. human.

Organism-specific databases

CTDi444882.
GeneCardsiIGFL4.
HGNCiHGNC:32931. IGFL4.
HPAiHPA047655.
MIMi610547. gene.
neXtProtiNX_Q6B9Z1.
PharmGKBiPA147357961.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JE04. Eukaryota.
ENOG41117SS. LUCA.
GeneTreeiENSGT00390000009557.
HOGENOMiHOG000113010.
HOVERGENiHBG081785.
InParanoidiQ6B9Z1.
OMAiTRICAQE.
OrthoDBiEOG7SXW5M.
PhylomeDBiQ6B9Z1.
TreeFamiTF343427.

Miscellaneous databases

GenomeRNAii444882.
NextBioi111360.
PROiQ6B9Z1.
SOURCEiSearch...

Gene expression databases

BgeeiQ6B9Z1.
CleanExiHS_IGFL4.
ExpressionAtlasiQ6B9Z1. baseline and differential.

Family and domain databases

InterProiIPR032744. IGFL.
[Graphical view]
PANTHERiPTHR34827. PTHR34827. 1 hit.
PfamiPF14653. IGFL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily."
    Emtage P., Vatta P., Arterburn M., Muller M.W., Park E., Boyle B., Hazell S., Polizotto R., Funk W.D., Tang Y.T.
    Genomics 88:513-520(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiIGFL4_HUMAN
AccessioniPrimary (citable) accession number: Q6B9Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: September 13, 2004
Last modified: January 20, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.