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Protein

NACHT, LRR and PYD domains-containing protein 14

Gene

Nlrp14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in inflammation and spermatogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi87 – 94ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 14
Short name:
NALP-iota
Alternative name(s):
Germ cell specific leucine-rich repeat NTPase
Gene namesi
Name:Nlrp14
Synonyms:Nalp14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1924108. Nlrp14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002863391 – 993NACHT, LRR and PYD domains-containing protein 14Add BLAST993

Proteomic databases

PaxDbiQ6B966.
PRIDEiQ6B966.

PTM databases

iPTMnetiQ6B966.
PhosphoSitePlusiQ6B966.

Expressioni

Gene expression databases

BgeeiENSMUSG00000016626.
CleanExiMM_NLRP14.
ExpressionAtlasiQ6B966. baseline and differential.
GenevisibleiQ6B966. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081819.

Structurei

3D structure databases

ProteinModelPortaliQ6B966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 403NACHTPROSITE-ProRule annotationAdd BLAST323
Repeati636 – 657LRR 1Add BLAST22
Repeati660 – 680LRR 2Add BLAST21
Repeati688 – 708LRR 3Add BLAST21
Repeati717 – 738LRR 4Add BLAST22
Repeati745 – 765LRR 5Add BLAST21
Repeati774 – 795LRR 6Add BLAST22
Repeati802 – 822LRR 7Add BLAST21
Repeati831 – 852LRR 8Add BLAST22
Repeati859 – 879LRR 9Add BLAST21

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 9 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00860000133669.
HOGENOMiHOG000294064.
HOVERGENiHBG063656.
InParanoidiQ6B966.
OMAiSERISHN.
OrthoDBiEOG091G01CG.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 5 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6B966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTEDDEMEY EASKEETVSE DKDFDDGIDY RTVIKENIFT MWYKTSLHGE
60 70 80 90 100
FATLNCVITP KDQNLLQHIF DEDIQTSEAP QTVVLQGAAG IGKTTLLKKA
110 120 130 140 150
VLEWADGNLY QQFTHVFYLN GKEISQVKEK SFAQLISKHW PSSEGPIEQV
160 170 180 190 200
LSKPSSLLFI IDSFDELDFS FEEPQFALCK DWTQISPVSF LISSLLRKVM
210 220 230 240 250
LPESYLLVAT RSTAWKRLVP LLQKPQRVKL SGLSKNARMD YIHHLLKDKA
260 270 280 290 300
WATSAIYSLR MNWRLFHMCH VCHMCQMICA VLKGQVEKGG RVEETCKTST
310 320 330 340 350
ALFTYYICSL FPRIPVGCVT LPNETLLRSL CKAAVEGIWT MKHVLYQQNL
360 370 380 390 400
RKHELTREDI LLFLDAKVLQ QDTEYENCYM FTHLHVQEFF AALFYLLREN
410 420 430 440 450
LEEQDYPSEP FENLYLLLES NHIHDPHLEQ MKCFLFGLLN KDRVRQLEET
460 470 480 490 500
FNLTISMEVR EELLACLEGL EKDDSSLSQL RFQDLLHCIY ETQDQEFITQ
510 520 530 540 550
ALMYFQKIIV RVDEEPQLRI YSFCLKHCHT LKTMRLTARA DLKNMLDTAE
560 570 580 590 600
MCLEGAAVQV IHYWQDLFSV LHTNESLIEM DLYESRLDES LMKILNEELS
610 620 630 640 650
HPKCKLQKLI FRAVDFLNGC QDFTFLASNK KVTHLDLKET DLGVNGLKTL
660 670 680 690 700
CEALKCKGCK LRVLRLASCD LNVARCQKLS NALQTNRSLV FLNLSLNNLS
710 720 730 740 750
NDGVKSLCEV LENPNSSLER LALASCGLTK AGCKVLSSAL TKSKRLTHLC
760 770 780 790 800
LSDNVLEDEG IKLLSHTLKH PQCTLQSLVL RSCSFTPIGS EHLSTALLHN
810 820 830 840 850
RSLVHLDLGQ NKLADNGVKL LCHSLQQPHC NLQELELMSC VLTSKACGDL
860 870 880 890 900
ASVLVNNSNL WSLDLGHNIL DDAGLNILCD ALRNPNCHVQ RLGLENCGLT
910 920 930 940 950
PGCCQDLLGI LSNNKSVIQM NLMKNALDHE SIKNLCKVLR SPTCKMEFLA
960 970 980 990
LDKKEILKKK IKKFLVDVRI NNPHLVIGPE CPNTESGCWW NYF
Length:993
Mass (Da):113,386
Last modified:July 27, 2011 - v2
Checksum:i0C48C366EF8015C3
GO

Sequence cautioni

The sequence AAT77542 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti669C → R in AAU06320 (PubMed:15317747).Curated1
Sequence conflicti689L → S in AAT77542 (PubMed:15590904).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY673647 mRNA. Translation: AAT77542.1. Different initiation.
BC141199 mRNA. Translation: AAI41200.1.
AY596199 mRNA. Translation: AAU06320.1.
CCDSiCCDS21688.1.
RefSeqiNP_001002894.2. NM_001002894.2.
XP_011240240.1. XM_011241938.1.
UniGeneiMm.35644.

Genome annotation databases

EnsembliENSMUST00000084763; ENSMUSP00000081819; ENSMUSG00000016626.
GeneIDi76858.
KEGGimmu:76858.
UCSCiuc009jax.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY673647 mRNA. Translation: AAT77542.1. Different initiation.
BC141199 mRNA. Translation: AAI41200.1.
AY596199 mRNA. Translation: AAU06320.1.
CCDSiCCDS21688.1.
RefSeqiNP_001002894.2. NM_001002894.2.
XP_011240240.1. XM_011241938.1.
UniGeneiMm.35644.

3D structure databases

ProteinModelPortaliQ6B966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081819.

PTM databases

iPTMnetiQ6B966.
PhosphoSitePlusiQ6B966.

Proteomic databases

PaxDbiQ6B966.
PRIDEiQ6B966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084763; ENSMUSP00000081819; ENSMUSG00000016626.
GeneIDi76858.
KEGGimmu:76858.
UCSCiuc009jax.2. mouse.

Organism-specific databases

CTDi338323.
MGIiMGI:1924108. Nlrp14.

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00860000133669.
HOGENOMiHOG000294064.
HOVERGENiHBG063656.
InParanoidiQ6B966.
OMAiSERISHN.
OrthoDBiEOG091G01CG.

Miscellaneous databases

PROiQ6B966.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016626.
CleanExiMM_NLRP14.
ExpressionAtlasiQ6B966. baseline and differential.
GenevisibleiQ6B966. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 5 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAL14_MOUSE
AccessioniPrimary (citable) accession number: Q6B966
Secondary accession number(s): B2RUL1, Q66X14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.