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Q6B8T1 (ODPB_GRATL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component subunit beta

EC=1.2.4.1
Gene names
Name:pdhB
Synonyms:odpB
Ordered Locus Names:Grc000123
Encoded onPlastid; Chloroplast
OrganismGracilaria tenuistipitata var. liui (Red alga)
Taxonomic identifier285951 [NCBI]
Taxonomic lineageEukaryotaRhodophytaFlorideophyceaeGracilarialesGracilariaceaeGracilaria

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Heterodimer of an alpha and a beta chain By similarity.

Subcellular location

Plastidchloroplast.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentChloroplast
Plastid
   LigandPyruvate
Thiamine pyrophosphate
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpyruvate dehydrogenase (acetyl-transferring) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Pyruvate dehydrogenase E1 component subunit beta
PRO_0000280108

Sites

Binding site601Thiamine pyrophosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6B8T1 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: EF7821FA426BFEED

FASTA32335,742
        10         20         30         40         50         60 
MTEVLMFDAL REATDEEMQN DSSVFILGED VGHYGGSYKV TKDLHSKYGD LRVLDTPIAE 

        70         80         90        100        110        120 
NSFMGMAIGA AITGLRPIVE GMNMSFLLLA FNQISNNAGM LRYTSGGNFQ IPIVIRGPGG 

       130        140        150        160        170        180 
VGRQLGAEHS QRLEAYFQAI PGLKIVACST PYNAKGLLKS AIRDNNPVIF FEHVLLYNLK 

       190        200        210        220        230        240 
DELPNDEYFL PLDKAELVRD GLDVTILTYS RMRHHVMQAV VDLVNDGYNP EVIDLISLKP 

       250        260        270        280        290        300 
LDITSIAQSL MKTHKLIIVE ECMKTGGIGA EIIAQINDNY FDFLDAPIVR LSSQDIPTPY 

       310        320 
NGKLEKATVI YPQQIIEAVK SIV 

« Hide

References

[1]"Comparative analysis of the complete plastid genome sequence of the red alga Gracilaria tenuistipitata var. liui provides insights into the evolution of rhodoplasts and their relationship to other plastids."
Hagopian J.C., Reis M., Kitajima J.P., Bhattacharya D., de Oliveira M.C.
J. Mol. Evol. 59:464-477(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY673996 Genomic DNA. Translation: AAT79704.1.
RefSeqYP_063629.1. NC_006137.1.

3D structure databases

ProteinModelPortalQ6B8T1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2943994.

Family and domain databases

Gene3D3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProIPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
PfamPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODPB_GRATL
AccessionPrimary (citable) accession number: Q6B8T1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)