Reviewed, UniProtKB/Swiss-Prot Q6B8I1 (MDSP_HUMAN)

Names and origin

Protein names

Recommended name:
    Dual specificity protein phosphatase 13 isoform MDSP
    EC=3.1.3.48
    EC=3.1.3.16
Alternative name(s):
    Branching-enzyme interacting DSP
    Muscle-restricted DSP

Gene names

Name:	DUSP13
Synonyms:	BEDP, MDSP

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Enzyme regulation	Inhibited by vanadate. Ref.1
Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Skeletal muscle-specific. Ref.1
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.
Biophysicochemical properties	Kinetic parameters: KM=7.5 mM for p-nitrophenol phosphate (at pH 6.0)

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative promoter usage Alternative splicing Polymorphism
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform 5 (identifier: Q6B8I1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q9UII6-1)

The sequence of this isoform can be found in the external entry Q9UII6-1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative promoter usage. Produced by use of an alternative open reading frames (ORFs).

Isoform 2 (identifier: Q9UII6-2)

Also known as: TMDP-L1;

The sequence of this isoform can be found in the external entry Q9UII6-2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative promoter usage and alternative splicing. No experimental confirmation available. Produced by use of an alternative open reading frames (ORFs).

Isoform 3 (identifier: Q9UII6-3)

The sequence of this isoform can be found in the external entry Q9UII6-3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative promoter usage and alternative splicing. No experimental confirmation available. Produced by use of an alternative open reading frames (ORFs).

Isoform 4 (identifier: Q9UII6-4)

Also known as: TMDP-L2;

The sequence of this isoform can be found in the external entry Q9UII6-4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative promoter usage and alternative splicing. No experimental confirmation available. Produced by use of an alternative open reading frames (ORFs).

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Dual specificity protein phosphatase 13 isoform MDSP		PRO_0000381973
Regions
	Domain	37 – 183	147	Tyrosine-protein phosphatase
Natural variations
	Natural variant	73	1	K → R: dbSNP rs7912300. Ref.2		VAR_058495

Sequences

	Sequence		Length	Mass (Da)
	Isoform 5 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 88E604BD26E70EE5	FASTA	188	20,658
	10 20 30 40 50 60 MAETSLPELG GEDKATPCPS ILELEELLRA GKSSCSRVDE VWPNLFIGDA ATANNRFELW 70 80 90 100 110 120 KLGITHVLNA AHKGLYCQGG PDFYGSSVSY LGVPAHDLPD FDISAYFSSA ADFIHRALNT 130 140 150 160 170 180 PGAKVLVHCV VGVSRSATLV LAYLMLHQRL SLRQAVITVR QHRWVFPNRG FLHQLCRLDQ QLRGAGQS
	Isoform 1. See Q9UII6.	FASTA	–	–
	Isoform 2 (TMDP-L1). See Q9UII6.	FASTA	–	–
	Isoform 3. See Q9UII6.	FASTA	–	–
	Isoform 4 (TMDP-L2). See Q9UII6.	FASTA	–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2." Chen H.-H., Luche R., Wei B., Tonks N.K. J. Biol. Chem. 279:41404-41413(2004) [PubMed: 15252030] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, ALTERNATIVE PROMOTER USAGE, ENZYME REGULATION, TISSUE SPECIFICITY.
[2]	"Identification of novel dual-specificity protein phosphatase which interacts with glycogen-branching enzyme." Skurat A.V., Dietrich A.D. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-73. Tissue: Skeletal muscle.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY674051 mRNA. Translation: AAT79356.1. AY040091 mRNA. Translation: AAK77966.1. CH471083 Genomic DNA. Translation: EAW54564.1.
IPI	IPI00465137.
RefSeq	NP_001007272.1. NP_001007273.1. NP_001007274.1.
UniGene	Hs.178170
3D structure databases
HSSP	HSSP built from PDB template 1VHR based on UniProtKB P51452.
ModBase	Search...
Proteomic databases
PRIDE	Q6B8I1.
Genome annotation databases
GeneID	51207.
KEGG	hsa:51207.
NMPDR	fig|9606.3.peg.4201.
UCSC	uc001jws.1. human.
Organism-specific databases
CTD	51207.
HGNC	HGNC:19681. DUSP13.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q6B8I1.
PhylomeDB	Q6B8I1.
Gene expression databases
Genevestigator	Q6B8I1.
Family and domain databases
InterPro	IPR000387. Dual-sp/Tyr_phosphatase. IPR020417. Dual-sp_phosphatase. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020405. Dual-sp_phosphatase_famA. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR016130. Tyr_Pase_AS. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	54264.

Entry information

Entry name

MDSP_HUMAN

Accession

Primary (citable) accession number: Q6B8I1
Secondary accession number(s): Q96J67

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	September 13, 2004
Last modified:	November 24, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.