Q6B8I1 (MDSP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity protein phosphatase 13 isoform MDSP
EC=3.1.3.16
EC=3.1.3.48

Alternative name(s):
Branching-enzyme interacting DSP
Muscle-restricted DSP

Gene names

Name:	DUSP13
Synonyms:	BEDP, MDSP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Enzyme regulation	Inhibited by vanadate. Ref.1
Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Skeletal muscle specific. Ref.1
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.
Biophysicochemical properties	Kinetic parameters: KM=7.5 mM for p-nitrophenol phosphate (at pH 6.0) Ref.1
Sequence caution	The sequence BAF84580.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence BAF84586.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence BAG54592.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative promoter usage Alternative splicing Polymorphism
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform 5 (identifier: Q6B8I1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Produced by alternative promoter usage.

Isoform 1 (identifier: Q9UII6-1)

The sequence of this isoform can be found in the external entry Q9UII6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative promoter usage.

Isoform 3 (identifier: Q9UII6-3)

The sequence of this isoform can be found in the external entry Q9UII6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative promoter usage and alternative splicing. No experimental confirmation available.

Isoform 4 (identifier: Q9UII6-4)

Also known as: TMDP-L2;

The sequence of this isoform can be found in the external entry Q9UII6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative promoter usage and alternative splicing. No experimental confirmation available.

Isoform 6 (identifier: Q6B8I1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     52-67: TANNRFELWKLGITHV → GPYSLPWGSATLPPWH
     68-188: Missing.

Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Isoform 7 (identifier: Q6B8I1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     51-92: ATANNRFELW...FYGSSVSYLG → RGPGTASLLV...SCGSWASPTC
     93-188: Missing.

Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Isoform 8 (identifier: Q6B8I1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     123-188: AKVLVHCVVG...DQQLRGAGQS → ELVLTPCHGA...DGGSPAWGRP

Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Dual specificity protein phosphatase 13 isoform MDSP		PRO_0000381973
Regions
	Domain	37 – 183	147	Tyrosine-protein phosphatase
Natural variations
	Alternative sequence	51 – 92	42	ATANN…VSYLG → RGPGTASLLVPWLGRHQVPF LPSPGPRQTTALSCGSWASP TC in isoform 7.		VSP_046445
	Alternative sequence	52 – 67	16	TANNR…GITHV → GPYSLPWGSATLPPWH in isoform 6.		VSP_046446
	Alternative sequence	68 – 188	121	Missing in isoform 6.		VSP_046447
	Alternative sequence	93 – 188	96	Missing in isoform 7.		VSP_046448
	Alternative sequence	123 – 188	66	AKVLV…GAGQS → ELVLTPCHGALPLCHPGTDP AGAAGGSGPGGHTEDGGSPA WGRP in isoform 8.		VSP_046449
	Natural variant	73	1	K → R. Ref.2 Corresponds to variant rs7912300 [ dbSNP | Ensembl ].		VAR_058495

Sequences

	Sequence		Length	Mass (Da)
	Isoform 5 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 88E604BD26E70EE5	FASTA	188	20,658
	10 20 30 40 50 60 MAETSLPELG GEDKATPCPS ILELEELLRA GKSSCSRVDE VWPNLFIGDA ATANNRFELW 70 80 90 100 110 120 KLGITHVLNA AHKGLYCQGG PDFYGSSVSY LGVPAHDLPD FDISAYFSSA ADFIHRALNT 130 140 150 160 170 180 PGAKVLVHCV VGVSRSATLV LAYLMLHQRL SLRQAVITVR QHRWVFPNRG FLHQLCRLDQ QLRGAGQS
	Isoform 1 [UniParc]. See Q9UII6.		–	–
	Isoform 3 [UniParc]. See Q9UII6.		–	–
	Isoform 4 (TMDP-L2) [UniParc]. See Q9UII6.		–	–
	Isoform 6 [UniParc]. Checksum: 5B6ED54212DA0242	FASTA	67	7,195
	10 20 30 40 50 60 MAETSLPELG GEDKATPCPS ILELEELLRA GKSSCSRVDE VWPNLFIGDA AGPYSLPWGS ATLPPWH
	Isoform 7 [UniParc]. Checksum: 4325575165B0055D	FASTA	92	9,746
	10 20 30 40 50 60 MAETSLPELG GEDKATPCPS ILELEELLRA GKSSCSRVDE VWPNLFIGDA RGPGTASLLV 70 80 90 PWLGRHQVPF LPSPGPRQTT ALSCGSWASP TC
	Isoform 8 [UniParc]. Checksum: 51BBCD025706F2A9	FASTA	166	17,283
	10 20 30 40 50 60 MAETSLPELG GEDKATPCPS ILELEELLRA GKSSCSRVDE VWPNLFIGDA ATANNRFELW 70 80 90 100 110 120 KLGITHVLNA AHKGLYCQGG PDFYGSSVSY LGVPAHDLPD FDISAYFSSA ADFIHRALNT 130 140 150 160 PGELVLTPCH GALPLCHPGT DPAGAAGGSG PGGHTEDGGS PAWGRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2." Chen H.-H., Luche R., Wei B., Tonks N.K. J. Biol. Chem. 279:41404-41413(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, ALTERNATIVE PROMOTER USAGE, ENZYME REGULATION, TISSUE SPECIFICITY.
[2]	"Identification of novel dual-specificity protein phosphatase which interacts with glycogen-branching enzyme." Skurat A.V., Dietrich A.D. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-73. Tissue: Skeletal muscle.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6; 7 AND 8). Tissue: Skeletal muscle.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY674051 mRNA. Translation: AAT79356.1. AY040091 mRNA. Translation: AAK77966.1. AK127886 mRNA. Translation: BAG54592.1. Sequence problems. AK291891 mRNA. Translation: BAF84580.1. Sequence problems. AK291897 mRNA. Translation: BAF84586.1. Sequence problems. CH471083 Genomic DNA. Translation: EAW54564.1.
IPI	IPI00465137.
RefSeq	NP_001007272.1. NM_001007271.1. NP_001007273.1. NM_001007272.1. NP_001007274.1. NM_001007273.1.
UniGene	Hs.178170.
3D structure databases
HSSP	HSSP built from PDB template 1VHR based on UniProtKB P51452.
ProteinModelPortal	Q6B8I1.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1448408.
Polymorphism databases
DMDM	74748394.
Proteomic databases
PRIDE	Q6B8I1.
Protocols and materials databases
DNASU	51207.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372702; ENSP00000361787; ENSG00000079393.
GeneID	51207.
KEGG	hsa:51207.
UCSC	uc001jws.3. human.
Organism-specific databases
CTD	51207.
GeneCards	GC10M076854.
HGNC	HGNC:19681. DUSP13.
MIM	613191. gene.
neXtProt	NX_Q6B8I1.
PharmGKB	PA134939640.
GenAtlas	Search...
Phylogenomic databases
KO	K14165.
OMA	FNISAYF.
Gene expression databases
ArrayExpress	Q6B8I1.
Bgee	Q6B8I1.
Genevestigator	Q6B8I1.
Family and domain databases
InterPro	IPR020417. Atypical_DUSP. IPR020405. Atypical_DUSP_famA. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51207.
NextBio	54264.
SOURCE	Search...

Entry information

Entry name

MDSP_HUMAN

Accession

Primary (citable) accession number: Q6B8I1
Secondary accession number(s): Q96J67

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	September 13, 2004
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.