Q6B8I1 (MDSP_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 76.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Dual specificity protein phosphatase 13 isoform MDSP EC=3.1.3.16 EC=3.1.3.48 Alternative name(s): Branching-enzyme interacting DSP Muscle-restricted DSP | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 188 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate. |
| Enzyme regulation | Inhibited by vanadate. Ref.1 |
| Subcellular location | |
| Tissue specificity | Skeletal muscle specific. Ref.1 |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain. |
| Biophysicochemical properties | Kinetic parameters: KM=7.5 mM for p-nitrophenol phosphate (at pH 6.0) Ref.1 |
| Sequence caution | The sequence BAF84580.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence BAF84586.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence BAG54592.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Alternative promoter usage Alternative splicing Polymorphism |
| Molecular function | Hydrolase Protein phosphatase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC |
| Cellular_component | cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB |
| Molecular_function | protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 7 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select] | ||||||
| Isoform 5 (identifier: Q6B8I1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: Produced by alternative promoter usage. | ||||||
| Isoform 1 (identifier: Q9UII6-1) The sequence of this isoform can be found in the external entry Q9UII6. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: Produced by alternative promoter usage. | ||||||
| Isoform 3 (identifier: Q9UII6-3) The sequence of this isoform can be found in the external entry Q9UII6. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: Produced by alternative promoter usage and alternative splicing. No experimental confirmation available. | ||||||
| Isoform 4 (identifier: Q9UII6-4) Also known as: TMDP-L2; The sequence of this isoform can be found in the external entry Q9UII6. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: Produced by alternative promoter usage and alternative splicing. No experimental confirmation available. | ||||||
| Isoform 6 (identifier: Q6B8I1-2) The sequence of this isoform differs from the canonical sequence as follows: 52-67: TANNRFELWKLGITHV → GPYSLPWGSATLPPWH 68-188: Missing. | ||||||
| Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available. | ||||||
| Isoform 7 (identifier: Q6B8I1-3) The sequence of this isoform differs from the canonical sequence as follows: 51-92: ATANNRFELW...FYGSSVSYLG → RGPGTASLLV...SCGSWASPTC 93-188: Missing. | ||||||
| Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available. | ||||||
| Isoform 8 (identifier: Q6B8I1-4) The sequence of this isoform differs from the canonical sequence as follows: 123-188: AKVLVHCVVG...DQQLRGAGQS → ELVLTPCHGA...DGGSPAWGRP | ||||||
| Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 188 | 188 | Dual specificity protein phosphatase 13 isoform MDSP | PRO_0000381973 | |||||
Regions | |||||||||
| Domain | 37 – 183 | 147 | Tyrosine-protein phosphatase | ||||||
Natural variations | |||||||||
| Alternative sequence | 51 – 92 | 42 | ATANN…VSYLG → RGPGTASLLVPWLGRHQVPF LPSPGPRQTTALSCGSWASP TC in isoform 7. | VSP_046445 | |||||
| Alternative sequence | 52 – 67 | 16 | TANNR…GITHV → GPYSLPWGSATLPPWH in isoform 6. | VSP_046446 | |||||
| Alternative sequence | 68 – 188 | 121 | Missing in isoform 6. | VSP_046447 | |||||
| Alternative sequence | 93 – 188 | 96 | Missing in isoform 7. | VSP_046448 | |||||
| Alternative sequence | 123 – 188 | 66 | AKVLV…GAGQS → ELVLTPCHGALPLCHPGTDP AGAAGGSGPGGHTEDGGSPA WGRP in isoform 8. | VSP_046449 | |||||
| Natural variant | 73 | 1 | K → R. Ref.2 Corresponds to variant rs7912300 [ dbSNP | Ensembl ]. | VAR_058495 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2." Chen H.-H., Luche R., Wei B., Tonks N.K. J. Biol. Chem. 279:41404-41413(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, ALTERNATIVE PROMOTER USAGE, ENZYME REGULATION, TISSUE SPECIFICITY. |
| [2] | "Identification of novel dual-specificity protein phosphatase which interacts with glycogen-branching enzyme." Skurat A.V., Dietrich A.D. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-73. Tissue: Skeletal muscle. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6; 7 AND 8). Tissue: Skeletal muscle. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY674051 mRNA. Translation: AAT79356.1. AY040091 mRNA. Translation: AAK77966.1. AK127886 mRNA. Translation: BAG54592.1. Sequence problems. AK291891 mRNA. Translation: BAF84580.1. Sequence problems. AK291897 mRNA. Translation: BAF84586.1. Sequence problems. CH471083 Genomic DNA. Translation: EAW54564.1. |
| IPI | IPI00465137. |
| RefSeq | NP_001007272.1. NM_001007271.1. NP_001007273.1. NM_001007272.1. NP_001007274.1. NM_001007273.1. |
| UniGene | Hs.178170. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1VHR based on UniProtKB P51452. |
| ProteinModelPortal | Q6B8I1. |
| ModBase | Search... |
Protein-protein interaction databases | |
| MINT | MINT-1448408. |
Polymorphism databases | |
| DMDM | 74748394. |
Proteomic databases | |
| PRIDE | Q6B8I1. |
Protocols and materials databases | |
| DNASU | 51207. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000372702; ENSP00000361787; ENSG00000079393. |
| GeneID | 51207. |
| KEGG | hsa:51207. |
| UCSC | uc001jws.3. human. |
Organism-specific databases | |
| CTD | 51207. |
| GeneCards | GC10M076854. |
| HGNC | HGNC:19681. DUSP13. |
| MIM | 613191. gene. |
| neXtProt | NX_Q6B8I1. |
| PharmGKB | PA134939640. |
| GenAtlas | Search... |
Phylogenomic databases | |
| KO | K14165. |
| OMA | FNISAYF. |
Gene expression databases | |
| ArrayExpress | Q6B8I1. |
| Bgee | Q6B8I1. |
| Genevestigator | Q6B8I1. |
Family and domain databases | |
| InterPro | IPR020417. Atypical_DUSP. IPR020405. Atypical_DUSP_famA. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view] |
| PANTHER | PTHR10159. PTHR10159. 1 hit. |
| Pfam | PF00782. DSPc. 1 hit. [Graphical view] |
| PRINTS | PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA. |
| SMART | SM00195. DSPc. 1 hit. [Graphical view] |
| PROSITE | PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 51207. |
| NextBio | 54264. |
| SOURCE | Search... |
Entry information
| Entry name | MDSP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6B8I1 Secondary accession number(s): Q96J67 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
