Reviewed,
UniProtKB/Swiss-Prot Q6B8I1 (MDSP_HUMAN)
Last modified
November 24, 2009.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
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Names and origin
| Protein names | Recommended name: Dual specificity protein phosphatase 13 isoform MDSP EC=3.1.3.48 EC=3.1.3.16 Alternative name(s): Branching-enzyme interacting DSP Muscle-restricted DSP | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 188 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate. |
| Enzyme regulation | Inhibited by vanadate. Ref.1 |
| Subcellular location | |
| Tissue specificity | Skeletal muscle-specific. Ref.1 |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain. |
| Biophysicochemical properties | Kinetic parameters: KM=7.5 mM for p-nitrophenol phosphate (at pH 6.0) |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Alternative promoter usage Alternative splicing Polymorphism |
| Molecular function | Hydrolase Protein phosphatase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Ref.1 Inferred from direct assay. Source: UniProtKB |
| Molecular function | protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 5 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select] | ||||||
| Isoform 5 (identifier: Q6B8I1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 1 (identifier: Q9UII6-1) The sequence of this isoform can be found in the external entry Q9UII6-1. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: Produced by alternative promoter usage. Produced by use of an alternative open reading frames (ORFs). | ||||||
| Isoform 2 (identifier: Q9UII6-2) Also known as: TMDP-L1; The sequence of this isoform can be found in the external entry Q9UII6-2. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: Produced by alternative promoter usage and alternative splicing. No experimental confirmation available. Produced by use of an alternative open reading frames (ORFs). | ||||||
| Isoform 3 (identifier: Q9UII6-3) The sequence of this isoform can be found in the external entry Q9UII6-3. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: Produced by alternative promoter usage and alternative splicing. No experimental confirmation available. Produced by use of an alternative open reading frames (ORFs). | ||||||
| Isoform 4 (identifier: Q9UII6-4) Also known as: TMDP-L2; The sequence of this isoform can be found in the external entry Q9UII6-4. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: Produced by alternative promoter usage and alternative splicing. No experimental confirmation available. Produced by use of an alternative open reading frames (ORFs). |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 188 | 188 | Dual specificity protein phosphatase 13 isoform MDSP | PRO_0000381973 | |||||
Regions | |||||||||
| Domain | 37 – 183 | 147 | Tyrosine-protein phosphatase | ||||||
Natural variations | |||||||||
| Natural variant | 73 | 1 | K → R: dbSNP rs7912300. Ref.2 | VAR_058495 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2." Chen H.-H., Luche R., Wei B., Tonks N.K. J. Biol. Chem. 279:41404-41413(2004) [PubMed: 15252030] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, ALTERNATIVE PROMOTER USAGE, ENZYME REGULATION, TISSUE SPECIFICITY. |
| [2] | "Identification of novel dual-specificity protein phosphatase which interacts with glycogen-branching enzyme." Skurat A.V., Dietrich A.D. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-73. Tissue: Skeletal muscle. |
| [3] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AY674051 mRNA. Translation: AAT79356.1. AY040091 mRNA. Translation: AAK77966.1. CH471083 Genomic DNA. Translation: EAW54564.1. | |
| IPI | IPI00465137. |
| RefSeq | NP_001007272.1. NP_001007273.1. NP_001007274.1. |
| UniGene | Hs.178170 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1VHR based on UniProtKB P51452. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q6B8I1. |
Genome annotation databases | |
| GeneID | 51207. |
| KEGG | hsa:51207. |
| NMPDR | fig|9606.3.peg.4201. |
| UCSC | uc001jws.1. human. |
Organism-specific databases | |
| CTD | 51207. |
| HGNC | HGNC:19681. DUSP13. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q6B8I1. |
| PhylomeDB | Q6B8I1. |
Gene expression databases | |
| Genevestigator | Q6B8I1. |
Family and domain databases | |
| InterPro | IPR000387. Dual-sp/Tyr_phosphatase. IPR020417. Dual-sp_phosphatase. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020405. Dual-sp_phosphatase_famA. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR016130. Tyr_Pase_AS. [Graphical view] |
| Pfam | PF00782. DSPc. 1 hit. [Graphical view] |
| PRINTS | PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA. |
| SMART | SM00195. DSPc. 1 hit. [Graphical view] |
| PROSITE | PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 54264. |
Entry information
| Entry name | MDSP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6B8I1 Secondary accession number(s): Q96J67 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

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