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Protein

Dual specificity protein phosphatase 13 isoform A

Gene

DUSP13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Enzyme regulationi

Inhibited by vanadate.1 Publication

Kineticsi

  1. KM=7.5 mM for p-nitrophenol phosphate (at pH 6.0)1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 13 isoform A (EC:3.1.3.16, EC:3.1.3.48)
    Short name:
    DUSP13A
    Alternative name(s):
    Branching-enzyme interacting DSP
    Muscle-restricted DSP
    Short name:
    MDSP
    Gene namesi
    Name:DUSP13
    Synonyms:BEDP, DUSP13A, MDSP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640 Componenti: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:19681. DUSP13.

    Subcellular locationi

    • Cytoplasm 1 Publication

    GO - Cellular componenti

    • cytoplasm Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi97 – 971D → A: No effect on interaction with MAP3K5. 1 Publication
    Mutagenesisi129 – 1291C → S: No effect on interaction with MAP3K5. 1 Publication

    Organism-specific databases

    PharmGKBiPA134939640.

    Polymorphism and mutation databases

    BioMutaiGPR143.
    DMDMi74748394.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188Dual specificity protein phosphatase 13 isoform APRO_0000381973Add
    BLAST

    Proteomic databases

    PRIDEiQ6B8I1.

    PTM databases

    DEPODiQ6B8I1.

    Expressioni

    Tissue specificityi

    Skeletal muscle specific.1 Publication

    Gene expression databases

    BgeeiQ6B8I1.
    ExpressionAtlasiQ6B8I1. baseline and differential.
    GenevisibleiQ6B8I1. HS.

    Interactioni

    Subunit structurei

    Interacts with MAP3K5/ASK1; may compete with AKT1 preventing MAP3K5/ASK1 phosphorylation by AKT1.1 Publication

    Protein-protein interaction databases

    BioGridi119380. 5 interactions.
    MINTiMINT-1448408.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6B8I1.
    SMRiQ6B8I1. Positions 39-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 183147Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00760000118853.
    KOiK14165.
    OMAiSHVDEVW.
    PhylomeDBiQ6B8I1.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

    Isoform 5 (identifier: Q6B8I1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MAETSLPELG GEDKATPCPS ILELEELLRA GKSSCSRVDE VWPNLFIGDA
    60 70 80 90 100
    ATANNRFELW KLGITHVLNA AHKGLYCQGG PDFYGSSVSY LGVPAHDLPD
    110 120 130 140 150
    FDISAYFSSA ADFIHRALNT PGAKVLVHCV VGVSRSATLV LAYLMLHQRL
    160 170 180
    SLRQAVITVR QHRWVFPNRG FLHQLCRLDQ QLRGAGQS
    Note: Produced by alternative promoter usage.
    Length:188
    Mass (Da):20,658
    Last modified:September 13, 2004 - v1
    Checksum:i88E604BD26E70EE5
    GO
    Isoform 1 (identifier: Q9UII6-1) [UniParc]FASTAAdd to basket

    Also known as: TMDP

    The sequence of this isoform can be found in the external entry Q9UII6.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Note: Produced by alternative promoter usage.
    Length:198
    Mass (Da):22,149
    GO
    Isoform 2 (identifier: Q6B8I1-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         51-188: ATANNRFELW...DQQLRGAGQS → NSIKCAETGG

    Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    Show »
    Length:60
    Mass (Da):6,337
    Checksum:i83A12286F25BBE7C
    GO
    Isoform 4 (identifier: Q9UII6-4) [UniParc]FASTAAdd to basket

    Also known as: TMDP-L2

    The sequence of this isoform can be found in the external entry Q9UII6.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Note: Produced by alternative promoter usage and alternative splicing.
    Length:248
    Mass (Da):27,507
    GO
    Isoform 6 (identifier: Q6B8I1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-67: TANNRFELWKLGITHV → GPYSLPWGSATLPPWH
         68-188: Missing.

    Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
    Show »
    Length:67
    Mass (Da):7,195
    Checksum:i5B6ED54212DA0242
    GO
    Isoform 7 (identifier: Q6B8I1-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         51-92: ATANNRFELW...FYGSSVSYLG → RGPGTASLLV...SCGSWASPTC
         93-188: Missing.

    Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
    Show »
    Length:92
    Mass (Da):9,746
    Checksum:i4325575165B0055D
    GO
    Isoform 8 (identifier: Q6B8I1-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         123-188: AKVLVHCVVG...DQQLRGAGQS → ELVLTPCHGA...DGGSPAWGRP

    Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
    Show »
    Length:166
    Mass (Da):17,283
    Checksum:i51BBCD025706F2A9
    GO

    Sequence cautioni

    The sequence AAH09778.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
    The sequence BAF84580.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
    The sequence BAF84586.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
    The sequence BAG51843.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
    The sequence BAG54592.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
    The sequence BAG62362.1 differs from that shown. Reason: Erroneous termination at position 3. Translated as Glu.Curated
    The sequence BAG62362.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201S → G in AAH09778 (PubMed:15489334).Curated
    Sequence conflicti46 – 461F → S in BAG62362 (PubMed:14702039).Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti73 – 731K → R.1 Publication
    Corresponds to variant rs7912300 [ dbSNP | Ensembl ].
    VAR_058495

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei51 – 188138ATANN…GAGQS → NSIKCAETGG in isoform 2. 1 PublicationVSP_047819Add
    BLAST
    Alternative sequencei51 – 9242ATANN…VSYLG → RGPGTASLLVPWLGRHQVPF LPSPGPRQTTALSCGSWASP TC in isoform 7. 1 PublicationVSP_046445Add
    BLAST
    Alternative sequencei52 – 6716TANNR…GITHV → GPYSLPWGSATLPPWH in isoform 6. 1 PublicationVSP_046446Add
    BLAST
    Alternative sequencei68 – 188121Missing in isoform 6. 1 PublicationVSP_046447Add
    BLAST
    Alternative sequencei93 – 18896Missing in isoform 7. 1 PublicationVSP_046448Add
    BLAST
    Alternative sequencei123 – 18866AKVLV…GAGQS → ELVLTPCHGALPLCHPGTDP AGAAGGSGPGGHTEDGGSPA WGRP in isoform 8. 1 PublicationVSP_046449Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY674051 mRNA. Translation: AAT79356.1.
    AY040091 mRNA. Translation: AAK77966.1.
    AK057012 mRNA. Translation: BAG51843.1. Sequence problems.
    AK127886 mRNA. Translation: BAG54592.1. Sequence problems.
    AK291891 mRNA. Translation: BAF84580.1. Sequence problems.
    AK291897 mRNA. Translation: BAF84586.1. Sequence problems.
    AK300679 mRNA. Translation: BAG62362.1. Sequence problems.
    CH471083 Genomic DNA. Translation: EAW54564.1.
    BC009778 mRNA. Translation: AAH09778.1. Sequence problems.
    CCDSiCCDS53542.1. [Q6B8I1-1]
    RefSeqiNP_001007272.1. NM_001007271.1. [Q6B8I1-1]
    NP_001007273.1. NM_001007272.1.
    NP_001007274.1. NM_001007273.1.
    UniGeneiHs.178170.

    Genome annotation databases

    EnsembliENST00000308475; ENSP00000311051; ENSG00000079393. [Q6B8I1-5]
    ENST00000372702; ENSP00000361787; ENSG00000079393. [Q6B8I1-1]
    ENST00000394707; ENSP00000452702; ENSG00000079393. [Q6B8I1-2]
    ENST00000479884; ENSP00000474298; ENSG00000079393. [Q6B8I1-4]
    ENST00000494588; ENSP00000474689; ENSG00000079393. [Q6B8I1-3]
    GeneIDi51207.
    KEGGihsa:51207.
    UCSCiuc001jws.3. human. [Q6B8I1-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY674051 mRNA. Translation: AAT79356.1.
    AY040091 mRNA. Translation: AAK77966.1.
    AK057012 mRNA. Translation: BAG51843.1. Sequence problems.
    AK127886 mRNA. Translation: BAG54592.1. Sequence problems.
    AK291891 mRNA. Translation: BAF84580.1. Sequence problems.
    AK291897 mRNA. Translation: BAF84586.1. Sequence problems.
    AK300679 mRNA. Translation: BAG62362.1. Sequence problems.
    CH471083 Genomic DNA. Translation: EAW54564.1.
    BC009778 mRNA. Translation: AAH09778.1. Sequence problems.
    CCDSiCCDS53542.1. [Q6B8I1-1]
    RefSeqiNP_001007272.1. NM_001007271.1. [Q6B8I1-1]
    NP_001007273.1. NM_001007272.1.
    NP_001007274.1. NM_001007273.1.
    UniGeneiHs.178170.

    3D structure databases

    ProteinModelPortaliQ6B8I1.
    SMRiQ6B8I1. Positions 39-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi119380. 5 interactions.
    MINTiMINT-1448408.

    PTM databases

    DEPODiQ6B8I1.

    Polymorphism and mutation databases

    BioMutaiGPR143.
    DMDMi74748394.

    Proteomic databases

    PRIDEiQ6B8I1.

    Protocols and materials databases

    DNASUi51207.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000308475; ENSP00000311051; ENSG00000079393. [Q6B8I1-5]
    ENST00000372702; ENSP00000361787; ENSG00000079393. [Q6B8I1-1]
    ENST00000394707; ENSP00000452702; ENSG00000079393. [Q6B8I1-2]
    ENST00000479884; ENSP00000474298; ENSG00000079393. [Q6B8I1-4]
    ENST00000494588; ENSP00000474689; ENSG00000079393. [Q6B8I1-3]
    GeneIDi51207.
    KEGGihsa:51207.
    UCSCiuc001jws.3. human. [Q6B8I1-1]

    Organism-specific databases

    CTDi51207.
    GeneCardsiGC10M076854.
    HGNCiHGNC:19681. DUSP13.
    MIMi613191. gene.
    neXtProtiNX_Q6B8I1.
    PharmGKBiPA134939640.
    GenAtlasiSearch...

    Phylogenomic databases

    GeneTreeiENSGT00760000118853.
    KOiK14165.
    OMAiSHVDEVW.
    PhylomeDBiQ6B8I1.

    Miscellaneous databases

    GeneWikiiDUSP13.
    GenomeRNAii51207.
    NextBioi54264.
    SOURCEiSearch...

    Gene expression databases

    BgeeiQ6B8I1.
    ExpressionAtlasiQ6B8I1. baseline and differential.
    GenevisibleiQ6B8I1. HS.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2."
      Chen H.-H., Luche R., Wei B., Tonks N.K.
      J. Biol. Chem. 279:41404-41413(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, ALTERNATIVE PROMOTER USAGE, ENZYME REGULATION, TISSUE SPECIFICITY.
    2. "Identification of novel dual-specificity protein phosphatase which interacts with glycogen-branching enzyme."
      Skurat A.V., Dietrich A.D.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), VARIANT ARG-73.
      Tissue: Skeletal muscle.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 6; 7 AND 8).
      Tissue: Skeletal muscle.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Bone marrow.
    6. "Positive regulation of apoptosis signal-regulating kinase 1 by dual-specificity phosphatase 13A."
      Park J.E., Park B.C., Kim H.A., Song M., Park S.G., Lee D.H., Kim H.J., Choi H.K., Kim J.T., Cho S.
      Cell. Mol. Life Sci. 67:2619-2629(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN APOPTOSIS, INTERACTION WITH MAP3K5, MUTAGENESIS OF ASP-97 AND CYS-129.

    Entry informationi

    Entry nameiDS13A_HUMAN
    AccessioniPrimary (citable) accession number: Q6B8I1
    Secondary accession number(s): Q96J67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: September 13, 2004
    Last modified: June 24, 2015
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.