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Q6B8I0

- DS13A_MOUSE

UniProt

Q6B8I0 - DS13A_MOUSE

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Protein
Dual specificity protein phosphatase 13 isoform A
Gene
Dusp13, Dusp13a, Mdsp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1 By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
  2. protein tyrosine/serine/threonine phosphatase activity Source: MGI

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 13 isoform A (EC:3.1.3.16, EC:3.1.3.48)
Short name:
DUSP13A
Alternative name(s):
Muscle-restricted DSP
Gene namesi
Name:Dusp13
Synonyms:Dusp13a, Mdsp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1351599. Dusp13.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Dual specificity protein phosphatase 13 isoform A
PRO_0000381974Add
BLAST

Proteomic databases

PRIDEiQ6B8I0.

Expressioni

Tissue specificityi

Skeletal muscle-specific.1 Publication

Developmental stagei

Expressed at very low levels in myotubes and early postnatal muscle. Expression markedly increases at approximately the 3rd week after birth and continues to increase gradually into adulthood.1 Publication

Gene expression databases

ArrayExpressiQ6B8I0.
BgeeiQ6B8I0.
GenevestigatoriQ6B8I0.

Interactioni

Subunit structurei

Interacts with MAP3K5/ASK1; may compete with AKT1 preventing MAP3K5/ASK1 phosphorylation by AKT1 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120977.

Structurei

3D structure databases

ProteinModelPortaliQ6B8I0.
SMRiQ6B8I0. Positions 39-183.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 183147Tyrosine-protein phosphatase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074474.
HOGENOMiHOG000233767.
InParanoidiQ6B8I0.
KOiK14165.
OMAiAEATPCP.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. Align

Isoform 1 (identifier: Q6B8I0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADASIPKPG EEKEATPCPS ILQLEELLRA GRASCSRVDE VWPNLFIGDA    50
ATANNRFELW KLGITHVLNA AHGGLYCQGG PDFYGSSVCY LGIPAHDLPD 100
FNISPYFSSA ADFIHRALTV PGAKVLVHCV VGVSRSATLV LAYLMLHQQL 150
SLQQAIITVR ERRWIFPNRG FLRQLCQLDQ QLRGAGQS 188
Length:188
Mass (Da):20,646
Last modified:September 13, 2004 - v1
Checksum:i340FA4CBB09FDCDE
GO
Isoform 2 (identifier: Q9QYJ7-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q9QYJ7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative promoter usage.

Length:198
Mass (Da):22,481
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY674052 mRNA. Translation: AAT79357.1.
CCDSiCCDS36821.1. [Q6B8I0-1]
RefSeqiNP_001007269.1. NM_001007268.1. [Q6B8I0-1]
UniGeneiMm.390674.

Genome annotation databases

EnsembliENSMUST00000075040; ENSMUSP00000074553; ENSMUSG00000021768. [Q6B8I0-1]
GeneIDi27389.
KEGGimmu:27389.
UCSCiuc007slo.2. mouse. [Q6B8I0-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY674052 mRNA. Translation: AAT79357.1 .
CCDSi CCDS36821.1. [Q6B8I0-1 ]
RefSeqi NP_001007269.1. NM_001007268.1. [Q6B8I0-1 ]
UniGenei Mm.390674.

3D structure databases

ProteinModelPortali Q6B8I0.
SMRi Q6B8I0. Positions 39-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000120977.

Proteomic databases

PRIDEi Q6B8I0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075040 ; ENSMUSP00000074553 ; ENSMUSG00000021768 . [Q6B8I0-1 ]
GeneIDi 27389.
KEGGi mmu:27389.
UCSCi uc007slo.2. mouse. [Q6B8I0-1 ]

Organism-specific databases

CTDi 51207.
MGIi MGI:1351599. Dusp13.

Phylogenomic databases

GeneTreei ENSGT00550000074474.
HOGENOMi HOG000233767.
InParanoidi Q6B8I0.
KOi K14165.
OMAi AEATPCP.

Miscellaneous databases

NextBioi 305348.
PROi Q6B8I0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6B8I0.
Bgeei Q6B8I0.
Genevestigatori Q6B8I0.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2."
    Chen H.-H., Luche R., Wei B., Tonks N.K.
    J. Biol. Chem. 279:41404-41413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiDS13A_MOUSE
AccessioniPrimary (citable) accession number: Q6B8I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 13, 2004
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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