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Reviewed, UniProtKB/Swiss-Prot Q6B8I0 (MDSP_MOUSE)

Last modified November 24, 2009. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dual specificity protein phosphatase isoform MDSP
    EC=3.1.3.48
    EC=3.1.3.16
Alternative name(s):
    Muscle-restricted DSP
Gene names
Name: Dusp13
Synonyms: Mdsp
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

A phosphoprotein + H2O = a protein + phosphate.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Skeletal muscle-specific. Ref.1

Developmental stage

Expressed at very low levels in myotubes and early postnatal muscle. Expression markedly increases at approximately the 3rd week after birth and continues to increase gradually into adulthood. Ref.1

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative promoter usage
   Molecular functionHydrolase
Protein phosphatase
Gene Ontology (GO)
   Biological processprotein amino acid dephosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: EC

protein tyrosine/serine/threonine phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage. [Align] [Select]
Isoform 1 (identifier: Q6B8I0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9QYJ7-1)

The sequence of this isoform can be found in the external entry Q9QYJ7-1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by alternative promoter usage. Produced by use of an alternative open reading frames (ORFs).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188Dual specificity protein phosphatase isoform MDSP
PRO_0000381974

Regions

Domain37 – 183147Tyrosine-protein phosphatase

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 340FA4CBB09FDCDE

FASTA18820,646
        10         20         30         40         50         60 
MADASIPKPG EEKEATPCPS ILQLEELLRA GRASCSRVDE VWPNLFIGDA ATANNRFELW 

        70         80         90        100        110        120 
KLGITHVLNA AHGGLYCQGG PDFYGSSVCY LGIPAHDLPD FNISPYFSSA ADFIHRALTV 

       130        140        150        160        170        180 
PGAKVLVHCV VGVSRSATLV LAYLMLHQQL SLQQAIITVR ERRWIFPNRG FLRQLCQLDQ 


QLRGAGQS 

« Hide

Isoform 2.

See Q9QYJ7.

FASTA

References

[1]"Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2."
Chen H.-H., Luche R., Wei B., Tonks N.K.
J. Biol. Chem. 279:41404-41413(2004) [PubMed: 15252030] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Skeletal muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

AY674052 mRNA. Translation: AAT79357.1.
IPIIPI00381698.
RefSeqNP_001007269.1.
UniGeneMm.390674

3D structure databases

HSSPHSSP built from PDB template 1VHR based on UniProtKB P51452.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6B8I0.

Proteomic databases

PRIDEQ6B8I0.

Genome annotation databases

EnsemblENSMUST00000075040; ENSMUSP00000074553; ENSMUSG00000079337; Mus musculus. [Genome view]
GeneID27389.
KEGGmmu:27389.
NMPDRfig|10090.3.peg.28651.
UCSCuc007slo.1. mouse.

Organism-specific databases

CTD27389.
MGIMGI:1351599. Dusp13.

Phylogenomic databases

HOVERGENQ6B8I0.
OMAANNRFEL
OrthoDBEOG9R7XWX
PhylomeDBQ6B8I0.

Gene expression databases

BgeeQ6B8I0.
GenevestigatorQ6B8I0.

Family and domain databases

InterProIPR000387. Dual-sp/Tyr_phosphatase.
IPR020417. Dual-sp_phosphatase.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020405. Dual-sp_phosphatase_famA.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio305348.
SOURCESearch...

Entry information

Entry nameMDSP_MOUSE
AccessionPrimary (citable) accession number: Q6B8I0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 13, 2004
Last modified: November 24, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents