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Q6B8I0

- DS13A_MOUSE

UniProt

Q6B8I0 - DS13A_MOUSE

Protein

Dual specificity protein phosphatase 13 isoform A

Gene

Dusp13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1 By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: MGI
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 13 isoform A (EC:3.1.3.16, EC:3.1.3.48)
    Short name:
    DUSP13A
    Alternative name(s):
    Muscle-restricted DSP
    Gene namesi
    Name:Dusp13
    Synonyms:Dusp13a, Mdsp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1351599. Dusp13.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188Dual specificity protein phosphatase 13 isoform APRO_0000381974Add
    BLAST

    Proteomic databases

    PRIDEiQ6B8I0.

    Expressioni

    Tissue specificityi

    Skeletal muscle-specific.1 Publication

    Developmental stagei

    Expressed at very low levels in myotubes and early postnatal muscle. Expression markedly increases at approximately the 3rd week after birth and continues to increase gradually into adulthood.1 Publication

    Gene expression databases

    ArrayExpressiQ6B8I0.
    BgeeiQ6B8I0.
    GenevestigatoriQ6B8I0.

    Interactioni

    Subunit structurei

    Interacts with MAP3K5/ASK1; may compete with AKT1 preventing MAP3K5/ASK1 phosphorylation by AKT1.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000120977.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6B8I0.
    SMRiQ6B8I0. Positions 39-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 183147Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00550000074474.
    HOGENOMiHOG000233767.
    InParanoidiQ6B8I0.
    KOiK14165.
    OMAiAEATPCP.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative promoter usage. Align

    Isoform 1 (identifier: Q6B8I0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADASIPKPG EEKEATPCPS ILQLEELLRA GRASCSRVDE VWPNLFIGDA    50
    ATANNRFELW KLGITHVLNA AHGGLYCQGG PDFYGSSVCY LGIPAHDLPD 100
    FNISPYFSSA ADFIHRALTV PGAKVLVHCV VGVSRSATLV LAYLMLHQQL 150
    SLQQAIITVR ERRWIFPNRG FLRQLCQLDQ QLRGAGQS 188
    Length:188
    Mass (Da):20,646
    Last modified:September 13, 2004 - v1
    Checksum:i340FA4CBB09FDCDE
    GO
    Isoform 2 (identifier: Q9QYJ7-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q9QYJ7.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Produced by alternative promoter usage.

    Length:198
    Mass (Da):22,481
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY674052 mRNA. Translation: AAT79357.1.
    CCDSiCCDS36821.1. [Q6B8I0-1]
    RefSeqiNP_001007269.1. NM_001007268.1. [Q6B8I0-1]
    UniGeneiMm.390674.

    Genome annotation databases

    EnsembliENSMUST00000075040; ENSMUSP00000074553; ENSMUSG00000021768. [Q6B8I0-1]
    GeneIDi27389.
    KEGGimmu:27389.
    UCSCiuc007slo.2. mouse. [Q6B8I0-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY674052 mRNA. Translation: AAT79357.1 .
    CCDSi CCDS36821.1. [Q6B8I0-1 ]
    RefSeqi NP_001007269.1. NM_001007268.1. [Q6B8I0-1 ]
    UniGenei Mm.390674.

    3D structure databases

    ProteinModelPortali Q6B8I0.
    SMRi Q6B8I0. Positions 39-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000120977.

    Proteomic databases

    PRIDEi Q6B8I0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075040 ; ENSMUSP00000074553 ; ENSMUSG00000021768 . [Q6B8I0-1 ]
    GeneIDi 27389.
    KEGGi mmu:27389.
    UCSCi uc007slo.2. mouse. [Q6B8I0-1 ]

    Organism-specific databases

    CTDi 51207.
    MGIi MGI:1351599. Dusp13.

    Phylogenomic databases

    GeneTreei ENSGT00550000074474.
    HOGENOMi HOG000233767.
    InParanoidi Q6B8I0.
    KOi K14165.
    OMAi AEATPCP.

    Miscellaneous databases

    NextBioi 305348.
    PROi Q6B8I0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6B8I0.
    Bgeei Q6B8I0.
    Genevestigatori Q6B8I0.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2."
      Chen H.-H., Luche R., Wei B., Tonks N.K.
      J. Biol. Chem. 279:41404-41413(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiDS13A_MOUSE
    AccessioniPrimary (citable) accession number: Q6B8I0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3