Q6B8I0 (MDSP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity protein phosphatase isoform MDSP
EC=3.1.3.16
EC=3.1.3.48

Alternative name(s):
Muscle-restricted DSP

Gene names

Name:	Dusp13
Synonyms:	Mdsp

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Skeletal muscle-specific. Ref.1
Developmental stage	Expressed at very low levels in myotubes and early postnatal muscle. Expression markedly increases at approximately the 3rd week after birth and continues to increase gradually into adulthood. Ref.1
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative promoter usage
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from direct assay PubMed 11432789. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage. [Align] [Select]

Isoform 1 (identifier: Q6B8I0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9QYJ7-1)

The sequence of this isoform can be found in the external entry Q9QYJ7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative promoter usage.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Dual specificity protein phosphatase isoform MDSP		PRO_0000381974
Regions
	Domain	37 – 183	147	Tyrosine-protein phosphatase

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 340FA4CBB09FDCDE	FASTA	188	20,646
	10 20 30 40 50 60 MADASIPKPG EEKEATPCPS ILQLEELLRA GRASCSRVDE VWPNLFIGDA ATANNRFELW 70 80 90 100 110 120 KLGITHVLNA AHGGLYCQGG PDFYGSSVCY LGIPAHDLPD FNISPYFSSA ADFIHRALTV 130 140 150 160 170 180 PGAKVLVHCV VGVSRSATLV LAYLMLHQQL SLQQAIITVR ERRWIFPNRG FLRQLCQLDQ QLRGAGQS
	Isoform 2 [UniParc]. See Q9QYJ7.		–	–

References

[1]

"Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2." Chen H.-H., Luche R., Wei B., Tonks N.K. J. Biol. Chem. 279:41404-41413(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Skeletal muscle.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY674052 mRNA. Translation: AAT79357.1.
IPI	IPI00381698.
RefSeq	NP_001007269.1. NM_001007268.1.
UniGene	Mm.390674.
3D structure databases
ProteinModelPortal	Q6B8I0.
SMR	Q6B8I0. Positions 39-183.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000120977.
Proteomic databases
PRIDE	Q6B8I0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000075040; ENSMUSP00000074553; ENSMUSG00000021768.
GeneID	27389.
KEGG	mmu:27389.
UCSC	uc007slo.2. mouse.
Organism-specific databases
CTD	51207.
MGI	MGI:1351599. Dusp13.
Phylogenomic databases
GeneTree	ENSGT00550000074474.
HOGENOM	HOG000233767.
InParanoid	Q6B8I0.
KO	K14165.
OMA	FNISAYF.
Gene expression databases
ArrayExpress	Q6B8I0.
Bgee	Q6B8I0.
Genevestigator	Q6B8I0.
Family and domain databases
InterPro	IPR020417. Atypical_DUSP. IPR020405. Atypical_DUSP_famA. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	305348.
SOURCE	Search...

Entry information

Entry name

MDSP_MOUSE

Accession

Primary (citable) accession number: Q6B8I0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	September 13, 2004
Last modified:	May 29, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program