ID   Q6B4S4_HUMAN            Unreviewed;       531 AA.
AC   Q6B4S4;
DT   13-SEP-2004, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2004, sequence version 1.
DT   24-JAN-2024, entry version 103.
DE   SubName: Full=Voltage-gated sodium channel Nav1.6 {ECO:0000313|EMBL:AAT85830.1};
DE   Flags: Fragment;
GN   Name=SCN8A {ECO:0000313|EMBL:AAT85830.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAT85830.1};
RN   [1] {ECO:0000313|EMBL:AAT85830.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Dorsal root ganglia {ECO:0000313|EMBL:AAT85830.1};
RX   PubMed=15302875; DOI=10.1074/jbc.M406387200;
RA   Raymond C.K., Castle J., Garrett-Engele P., Armour C.D., Kan Z.,
RA   Tsinoremas N., Johnson J.M.;
RT   "Expression of alternatively spliced sodium channel alpha-subunit genes:
RT   unique splicing patterns are observed in dorsal root ganglia.";
RL   J. Biol. Chem. 279:46234-46241(2004).
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DR   EMBL; AY682081; AAT85830.1; -; mRNA.
DR   RefSeq; NP_001317189.1; NM_001330260.1.
DR   AlphaFoldDB; Q6B4S4; -.
DR   SMR; Q6B4S4; -.
DR   PeptideAtlas; Q6B4S4; -.
DR   DNASU; 6334; -.
DR   GeneID; 6334; -.
DR   KEGG; hsa:6334; -.
DR   CTD; 6334; -.
DR   OrthoDB; 1110761at2759; -.
DR   BioGRID-ORCS; 6334; 13 hits in 1149 CRISPR screens.
DR   ChiTaRS; SCN8A; human.
DR   GenomeRNAi; 6334; -.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR043203; VGCC_Ca_Na.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF23; SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR01667; NACHANNEL8.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   2: Evidence at transcript level;
KW   Ion channel {ECO:0000313|EMBL:AAT85830.1};
KW   Ion transport {ECO:0000313|EMBL:AAT85830.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:AAT85830.1}.
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        81..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          6..270
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          396..520
FT                   /note="Voltage-gated Na+ ion channel cytoplasmic"
FT                   /evidence="ECO:0000259|Pfam:PF11933"
FT   REGION          296..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..453
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        350..380
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..453
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAT85830.1"
FT   NON_TER         531
FT                   /evidence="ECO:0000313|EMBL:AAT85830.1"
SQ   SEQUENCE   531 AA;  59709 MW;  44A31C1D45D18FD5 CRC64;
     FSNPPDWSKN VEYTFTGIYT FESLVKIIAR GFCIDGFTFL RDPWNWLDFS VIMMAYVTEF
     VDLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK LSDVMILTVF CLSVFALIGL
     QLFMGNLRNK CVVWPINFNE SYLENGTKGF DWEEYINNKT NFYTVPGMLE PLLCGNSSDA
     GQCPEGYQCM KAGRNPNYGY TSFDTFSWAF LALFRLMTQD YWENLYQLTL RAAGKTYMIF
     FVLVIFVGSF YLVNLILAVV AMAYEEQNQA TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA
     MATSAGTVSE DAIEEEGEEG GGSPRSSSEI SKLSSKSAKE RRNRRKKRKQ KELSEGEEKG
     DPEKVFKSES EDGMRRKAFR LPDNRIGRKF SIMNQSLLSI PGSPFLSRHN SKSSIFSFRG
     PGRFRDPGSE NEFADDEHST VEESEGRRDS LFIPIRARER RSSYSGYSGY SQGSRSSRIF
     PSLRRSVKRN STVDCNGVVS LIGGPGSHIG GRLLPEATTE VEIKKKGPGS L
//