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Q6B4S4 (Q6B4S4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:SCN8A EMBL AAT85830.1
OrganismHomo sapiens (Human) EMBL AAT85830.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length531 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS027359
   Molecular functionIon channel
Voltage-gated channel SAAS SAAS027359
Gene Ontology (GO)
   Cellular_componentvoltage-gated sodium channel complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionvoltage-gated sodium channel activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAT85830.1
Non-terminal residue5311 EMBL AAT85830.1

Sequences

Sequence LengthMass (Da)Tools
Q6B4S4 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 44A31C1D45D18FD5

FASTA53159,709
        10         20         30         40         50         60 
FSNPPDWSKN VEYTFTGIYT FESLVKIIAR GFCIDGFTFL RDPWNWLDFS VIMMAYVTEF 

        70         80         90        100        110        120 
VDLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK LSDVMILTVF CLSVFALIGL 

       130        140        150        160        170        180 
QLFMGNLRNK CVVWPINFNE SYLENGTKGF DWEEYINNKT NFYTVPGMLE PLLCGNSSDA 

       190        200        210        220        230        240 
GQCPEGYQCM KAGRNPNYGY TSFDTFSWAF LALFRLMTQD YWENLYQLTL RAAGKTYMIF 

       250        260        270        280        290        300 
FVLVIFVGSF YLVNLILAVV AMAYEEQNQA TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA 

       310        320        330        340        350        360 
MATSAGTVSE DAIEEEGEEG GGSPRSSSEI SKLSSKSAKE RRNRRKKRKQ KELSEGEEKG 

       370        380        390        400        410        420 
DPEKVFKSES EDGMRRKAFR LPDNRIGRKF SIMNQSLLSI PGSPFLSRHN SKSSIFSFRG 

       430        440        450        460        470        480 
PGRFRDPGSE NEFADDEHST VEESEGRRDS LFIPIRARER RSSYSGYSGY SQGSRSSRIF 

       490        500        510        520        530 
PSLRRSVKRN STVDCNGVVS LIGGPGSHIG GRLLPEATTE VEIKKKGPGS L 

« Hide

References

[1]"Expression of alternatively spliced sodium channel alpha-subunit genes: unique splicing patterns are observed in dorsal root ganglia."
Raymond C.K., Castle J., Garrett-Engele P., Armour C.D., Kan Z., Tsinoremas N., Johnson J.M.
J. Biol. Chem. 279:46234-46241(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Dorsal root ganglia EMBL AAT85830.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY682081 mRNA. Translation: AAT85830.1.
UniGeneHs.436550.
Hs.710638.

3D structure databases

ProteinModelPortalQ6B4S4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG091796.

Gene expression databases

ArrayExpressQ6B4S4.
BgeeQ6B4S4.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
InterProIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR008054. Na_channel_a8su.
[Graphical view]
PfamPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR01667. NACHANNEL8.
ProtoNetSearch...

Other

ChiTaRSSCN8A. human.

Entry information

Entry nameQ6B4S4_HUMAN
AccessionPrimary (citable) accession number: Q6B4S4
Entry history
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.