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Q6B4S4

- Q6B4S4_HUMAN

UniProt

Q6B4S4 - Q6B4S4_HUMAN

Protein
Submitted name:

Voltage-gated sodium channel Nav1.6

Gene

SCN8A

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. voltage-gated sodium channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channelSAAS annotation

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Voltage-gated sodium channel Nav1.6Imported
    Gene namesi
    Name:SCN8AImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. voltage-gated sodium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiQ6B4S4.
    BgeeiQ6B4S4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6B4S4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG091796.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR008054. Na_channel_a8su.
    [Graphical view]
    PfamiPF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR01667. NACHANNEL8.

    Sequencei

    Sequence statusi: Fragment.

    Q6B4S4-1 [UniParc]FASTAAdd to Basket

    « Hide

    FSNPPDWSKN VEYTFTGIYT FESLVKIIAR GFCIDGFTFL RDPWNWLDFS    50
    VIMMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK 100
    LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVVWPINFNE SYLENGTKGF 150
    DWEEYINNKT NFYTVPGMLE PLLCGNSSDA GQCPEGYQCM KAGRNPNYGY 200
    TSFDTFSWAF LALFRLMTQD YWENLYQLTL RAAGKTYMIF FVLVIFVGSF 250
    YLVNLILAVV AMAYEEQNQA TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA 300
    MATSAGTVSE DAIEEEGEEG GGSPRSSSEI SKLSSKSAKE RRNRRKKRKQ 350
    KELSEGEEKG DPEKVFKSES EDGMRRKAFR LPDNRIGRKF SIMNQSLLSI 400
    PGSPFLSRHN SKSSIFSFRG PGRFRDPGSE NEFADDEHST VEESEGRRDS 450
    LFIPIRARER RSSYSGYSGY SQGSRSSRIF PSLRRSVKRN STVDCNGVVS 500
    LIGGPGSHIG GRLLPEATTE VEIKKKGPGS L 531
    Length:531
    Mass (Da):59,709
    Last modified:September 13, 2004 - v1
    Checksum:i44A31C1D45D18FD5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei531 – 5311Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY682081 mRNA. Translation: AAT85830.1.
    UniGeneiHs.436550.
    Hs.710638.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY682081 mRNA. Translation: AAT85830.1 .
    UniGenei Hs.436550.
    Hs.710638.

    3D structure databases

    ProteinModelPortali Q6B4S4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG091796.

    Miscellaneous databases

    ChiTaRSi SCN8A. human.

    Gene expression databases

    ArrayExpressi Q6B4S4.
    Bgeei Q6B4S4.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR008054. Na_channel_a8su.
    [Graphical view ]
    Pfami PF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR01667. NACHANNEL8.
    ProtoNeti Search...

    Publicationsi

    1. "Expression of alternatively spliced sodium channel alpha-subunit genes: unique splicing patterns are observed in dorsal root ganglia."
      Raymond C.K., Castle J., Garrett-Engele P., Armour C.D., Kan Z., Tsinoremas N., Johnson J.M.
      J. Biol. Chem. 279:46234-46241(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Dorsal root gangliaImported.

    Entry informationi

    Entry nameiQ6B4S4_HUMAN
    AccessioniPrimary (citable) accession number: Q6B4S4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 13, 2004
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.