Reviewed, UniProtKB/Swiss-Prot Q6B4J2 (VKOR1_BOVIN)

Names and origin

Protein names

Recommended name:
    Vitamin K epoxide reductase complex subunit 1
    EC=1.1.4.1
Alternative name(s):
    Vitamin K1 2,3-epoxide reductase subunit 1

Gene names

Name:

VKORC1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K By similarity.
Catalytic activity	2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane proteinBy similarity.
Miscellaneous	The location of two cysteine active-site residues within a proposed transmembrane is consistent both with the known hydrophobic environment of the thiol redox site of the enzyme and with the lipophilicity of vitamin K and warfarin By similarity.
Sequence similarities	Belongs to the VKOR family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Redox-active center Transmembrane
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	vitamin-K-epoxide reductase (warfarin-sensitive) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 163	163	Vitamin K epoxide reductase complex subunit 1		PRO_0000191667
Regions
	Topological domain	1 – 8	8	Lumenal Potential
	Transmembrane	9 – 29	21	Potential
	Topological domain	30 – 81	52	Cytoplasmic Potential
	Transmembrane	82 – 102	21	Potential
	Topological domain	103 – 113	11	Lumenal Potential
	Transmembrane	114 – 134	21	Potential
	Topological domain	135 – 163	29	Cytoplasmic Potential
Amino acid modifications
	Disulfide bond	132 ↔ 135		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6B4J2-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 7C8A7A5057908F20	FASTA	163	17,967
	10 20 30 40 50 60 MGATWRSPGW VRLALCLAGL VLSLYALHVK AARARDRDYR ALCDVGTAIS CSRVFSSRWG 70 80 90 100 110 120 RGFGLVEHVL GKDSILNQSN SIFGCIFYTL QLLLGCLQGR WASVLLRLSC LVSLAGSVYL 130 140 150 160 AWILFFVLYD FCIVCITTYA INVGLTVLSF REVQGPQGKV KGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bovine vitamin K epoxide reductase cDNA." Jin D.-Y., Tie J.-K., Stafford D.W. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY682746 mRNA. Translation: AAT85856.1. BC133442 mRNA. Translation: AAI33443.1.
RefSeq	NP_001003903.1.
UniGene	Bt.1707
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000000405. Bos taurus. [Contig view]
GeneID	445422.
KEGG	bta:445422.
Phylogenomic databases
HOVERGEN	Q6B4J2.
Family and domain databases
InterPro	IPR012932. VKOR. [Graphical view]
Pfam	PF07884. VKOR. 1 hit. [Graphical view]
SMART	SM00756. VKc. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VKOR1_BOVIN

Accession

Primary (citable) accession number: Q6B4J2
Secondary accession number(s): A2VDX1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	September 13, 2004
Last modified:	November 4, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)