Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vitamin K epoxide reductase complex subunit 1

Gene

VKORC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development (By similarity).By similarity

Miscellaneous

The location of two cysteine active-site residues within a proposed transmembrane is consistent both with the known hydrophobic environment of the thiol redox site of the enzyme and with the lipophilicity of vitamin K and warfarin (coumadin).By similarity

Catalytic activityi

Phylloquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

ReactomeiR-BTA-6806664 Metabolism of vitamin K

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin K epoxide reductase complex subunit 1 (EC:1.17.4.4)
Alternative name(s):
Vitamin K1 2,3-epoxide reductase subunit 1
Gene namesi
Name:VKORC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8LumenalSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 81CytoplasmicSequence analysisAdd BLAST52
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103LumenalSequence analysis1
Transmembranei104 – 122HelicalSequence analysisAdd BLAST19
Transmembranei128 – 150HelicalSequence analysisAdd BLAST23
Topological domaini151 – 163CytoplasmicBy similarityAdd BLAST13

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3212

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916671 – 163Vitamin K epoxide reductase complex subunit 1Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi132 ↔ 135Redox-activeBy similarity

Keywords - PTMi

Disulfide bond, Quinone

Proteomic databases

PaxDbiQ6B4J2
PRIDEiQ6B4J2

Expressioni

Gene expression databases

BgeeiENSBTAG00000000405

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000519

Chemistry databases

BindingDBiQ6B4J2

Family & Domainsi

Domaini

The number of transmembrane domains and the membrane topology are controversial; supporting evidence is available both for models with three transmembrane domains and four transmembrane domains.By similarity

Sequence similaritiesi

Belongs to the VKOR family.Curated

Keywords - Domaini

Redox-active center, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0HT Eukaryota
ENOG4111UX7 LUCA
GeneTreeiENSGT00390000002103
HOGENOMiHOG000230752
HOVERGENiHBG076672
InParanoidiQ6B4J2
KOiK05357
OMAiQGKVKGH
OrthoDBiEOG091G0QTR
TreeFamiTF328467

Family and domain databases

Gene3Di1.20.1440.130, 1 hit
InterProiView protein in InterPro
IPR012932 VKOR
IPR038354 VKOR_sf
PfamiView protein in Pfam
PF07884 VKOR, 1 hit
SMARTiView protein in SMART
SM00756 VKc, 1 hit

Sequencei

Sequence statusi: Complete.

Q6B4J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGATWRSPGW VRLALCLAGL VLSLYALHVK AARARDRDYR ALCDVGTAIS
60 70 80 90 100
CSRVFSSRWG RGFGLVEHVL GKDSILNQSN SIFGCIFYTL QLLLGCLQGR
110 120 130 140 150
WASVLLRLSC LVSLAGSVYL AWILFFVLYD FCIVCITTYA INVGLTVLSF
160
REVQGPQGKV KGH
Length:163
Mass (Da):17,967
Last modified:September 13, 2004 - v1
Checksum:i7C8A7A5057908F20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY682746 mRNA Translation: AAT85856.1
BC133442 mRNA Translation: AAI33443.1
RefSeqiNP_001003903.1, NM_001003903.3
UniGeneiBt.1707

Genome annotation databases

EnsembliENSBTAT00000000519; ENSBTAP00000000519; ENSBTAG00000000405
GeneIDi445422
KEGGibta:445422

Similar proteinsi

Entry informationi

Entry nameiVKOR1_BOVIN
AccessioniPrimary (citable) accession number: Q6B4J2
Secondary accession number(s): A2VDX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health