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Q6B411

- LYSM_BOVIN

UniProt

Q6B411 - LYSM_BOVIN

Protein

Lysozyme C, milk isozyme

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei53 – 531PROSITE-ProRule annotation
    Active sitei71 – 711PROSITE-ProRule annotation

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_206540. Amyloids.

    Protein family/group databases

    CAZyiGH22. Glycoside Hydrolase Family 22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme C, milk isozyme (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase C
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 5

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 148130Lysozyme C, milk isozymePRO_0000246090Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 146PROSITE-ProRule annotation
    Disulfide bondi48 ↔ 134PROSITE-ProRule annotation
    Disulfide bondi83 ↔ 99PROSITE-ProRule annotation
    Disulfide bondi95 ↔ 113PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ6B411.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000015846.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6B411.
    SMRiQ6B411. Positions 18-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG85133.
    GeneTreeiENSGT00550000074398.
    HOGENOMiHOG000037357.
    HOVERGENiHBG052297.
    InParanoidiQ6B411.
    KOiK13915.
    OMAiWESSFNT.
    OrthoDBiEOG7BW0M5.
    TreeFamiTF324882.

    Family and domain databases

    InterProiIPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view]
    PfamiPF00062. Lys. 1 hit.
    [Graphical view]
    PRINTSiPR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTiSM00263. LYZ1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6B411-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKALLIVGLL LLSVAVQGKK FQRCELARTL KKLGLDGYRG VSLANWVCLA    50
    RWESNYNTRA TNYNRGDKST DYGIFQINSR WWCNDGKTPK AVNACRIPCS 100
    ALLKDDITQA VACAKRVVRD PQGIKAWVAW RNKCQNRDLR SYVQGCRV 148
    Length:148
    Mass (Da):16,783
    Last modified:September 13, 2004 - v1
    Checksum:iD8BF07EF7C668027
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY684064 mRNA. Translation: AAT92538.1.
    BC103297 mRNA. Translation: AAI03298.1.
    RefSeqiNP_001071297.1. NM_001077829.1.
    UniGeneiBt.67194.

    Genome annotation databases

    EnsembliENSBTAT00000015846; ENSBTAP00000015846; ENSBTAG00000011941.
    GeneIDi281287.
    KEGGibta:281287.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY684064 mRNA. Translation: AAT92538.1 .
    BC103297 mRNA. Translation: AAI03298.1 .
    RefSeqi NP_001071297.1. NM_001077829.1.
    UniGenei Bt.67194.

    3D structure databases

    ProteinModelPortali Q6B411.
    SMRi Q6B411. Positions 18-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000015846.

    Protein family/group databases

    CAZyi GH22. Glycoside Hydrolase Family 22.

    Proteomic databases

    PRIDEi Q6B411.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000015846 ; ENSBTAP00000015846 ; ENSBTAG00000011941 .
    GeneIDi 281287.
    KEGGi bta:281287.

    Organism-specific databases

    CTDi 17110.

    Phylogenomic databases

    eggNOGi NOG85133.
    GeneTreei ENSGT00550000074398.
    HOGENOMi HOG000037357.
    HOVERGENi HBG052297.
    InParanoidi Q6B411.
    KOi K13915.
    OMAi WESSFNT.
    OrthoDBi EOG7BW0M5.
    TreeFami TF324882.

    Enzyme and pathway databases

    Reactomei REACT_206540. Amyloids.

    Miscellaneous databases

    NextBioi 20805318.

    Family and domain databases

    InterProi IPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view ]
    Pfami PF00062. Lys. 1 hit.
    [Graphical view ]
    PRINTSi PR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTi SM00263. LYZ1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of cow nonstomach lysozyme genes."
      Irwin D.M.
      Genome 47:1082-1090(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Ascending colon.

    Entry informationi

    Entry nameiLYSM_BOVIN
    AccessioniPrimary (citable) accession number: Q6B411
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3