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Q6B410

- LYSI_BOVIN

UniProt

Q6B410 - LYSI_BOVIN

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Protein
Lysozyme C, intestinal isozyme
Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei53 – 531 By similarity
Active sitei71 – 711 By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_206540. Amyloids.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme C, intestinal isozyme (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 147129Lysozyme C, intestinal isozyme
PRO_0000246089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 145 By similarity
Disulfide bondi48 ↔ 133 By similarity
Disulfide bondi83 ↔ 99 By similarity
Disulfide bondi95 ↔ 113 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ6B410.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027401.

Structurei

3D structure databases

ProteinModelPortaliQ6B410.
SMRiQ6B410. Positions 19-147.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG85133.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiQ6B410.
KOiK01185.
OMAiNTTATHY.
OrthoDBiEOG7BW0M5.
TreeFamiTF324882.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6B410-1 [UniParc]FASTAAdd to Basket

« Hide

MKAVLILGLL LLSVTVQGKK FEKCELARTL RRYGLDGYKG VSLANWMCLT    50
YGESRYNTRV TNYNPGSKST DYGIFQINSK WWCNDGKTPK AVNGCGVSCS 100
AMLKDDITQA VACAKTIVSR QGITAWVAWK NKCRNRDVSS YIRGCKL 147
Length:147
Mass (Da):16,391
Last modified:September 13, 2004 - v1
Checksum:iC22DDA29D8889E22
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY684065 mRNA. Translation: AAT92539.1.
BC102281 mRNA. Translation: AAI02282.1.
RefSeqiNP_001007806.1. NM_001007805.1.
UniGeneiBt.49176.

Genome annotation databases

EnsembliENSBTAT00000027401; ENSBTAP00000027401; ENSBTAG00000026323.
GeneIDi493637.
KEGGibta:493637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY684065 mRNA. Translation: AAT92539.1 .
BC102281 mRNA. Translation: AAI02282.1 .
RefSeqi NP_001007806.1. NM_001007805.1.
UniGenei Bt.49176.

3D structure databases

ProteinModelPortali Q6B410.
SMRi Q6B410. Positions 19-147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000027401.

Protein family/group databases

CAZyi GH22. Glycoside Hydrolase Family 22.

Proteomic databases

PRIDEi Q6B410.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000027401 ; ENSBTAP00000027401 ; ENSBTAG00000026323 .
GeneIDi 493637.
KEGGi bta:493637.

Organism-specific databases

CTDi 38125.

Phylogenomic databases

eggNOGi NOG85133.
GeneTreei ENSGT00550000074398.
HOGENOMi HOG000037357.
HOVERGENi HBG052297.
InParanoidi Q6B410.
KOi K01185.
OMAi NTTATHY.
OrthoDBi EOG7BW0M5.
TreeFami TF324882.

Enzyme and pathway databases

Reactomei REACT_206540. Amyloids.

Miscellaneous databases

NextBioi 20865444.

Family and domain databases

InterProi IPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view ]
Pfami PF00062. Lys. 1 hit.
[Graphical view ]
PRINTSi PR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTi SM00263. LYZ1. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolution of cow nonstomach lysozyme genes."
    Irwin D.M.
    Genome 47:1082-1090(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiLYSI_BOVIN
AccessioniPrimary (citable) accession number: Q6B410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: September 13, 2004
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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