Q6B410 (LYSI_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Lysozyme C, intestinal isozyme EC=3.2.1.17 Alternative name(s): 1,4-beta-N-acetylmuramidase C
Organism	Bos taurus (Bovine) [Reference proteome]
Taxonomic identifier	9913 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 147	129	Lysozyme C, intestinal isozyme		PRO_0000246089
Sites
	Active site	53	1	By similarity
	Active site	71	1	By similarity
Amino acid modifications
	Disulfide bond	24 ↔ 145		By similarity
	Disulfide bond	48 ↔ 133		By similarity
	Disulfide bond	83 ↔ 99		By similarity
	Disulfide bond	95 ↔ 113		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6B410 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: C22DDA29D8889E22	FASTA	147	16,391
	10 20 30 40 50 60 MKAVLILGLL LLSVTVQGKK FEKCELARTL RRYGLDGYKG VSLANWMCLT YGESRYNTRV 70 80 90 100 110 120 TNYNPGSKST DYGIFQINSK WWCNDGKTPK AVNGCGVSCS AMLKDDITQA VACAKTIVSR 130 140 QGITAWVAWK NKCRNRDVSS YIRGCKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolution of cow nonstomach lysozyme genes." Irwin D.M. Genome 47:1082-1090(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY684065 mRNA. Translation: AAT92539.1. BC102281 mRNA. Translation: AAI02282.1.
IPI	IPI00705787.
RefSeq	NP_001007806.1. NM_001007805.1.
UniGene	Bt.49176.
3D structure databases
ProteinModelPortal	Q6B410.
SMR	Q6B410. Positions 19-147.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000027401.
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Proteomic databases
PRIDE	Q6B410.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000027401; ENSBTAP00000027401; ENSBTAG00000026323.
GeneID	493637.
KEGG	bta:493637.
Organism-specific databases
CTD	38125.
Phylogenomic databases
eggNOG	NOG85133.
GeneTree	ENSGT00550000074398.
HOGENOM	HOG000037357.
HOVERGEN	HBG052297.
InParanoid	Q6B410.
OMA	RVTNYNP.
OrthoDB	EOG48KRCP.
Enzyme and pathway databases
BioCyc	CATTLE:493637-MONOMER.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. IPR023346. Lysozyme-like_dom. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20865444.

Entry information

Entry name

LYSI_BOVIN

Accession

Primary (citable) accession number: Q6B410

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	September 13, 2004
Last modified:	May 29, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program