Q6B3N0 (HXA5_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A5

Gene names

Name:

HOXA5

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Homeobox protein Hox-A5		PRO_0000200061
Regions
	DNA binding	195 – 254	60	Homeobox
	Motif	176 – 181	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q6B3N0 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 1A9F8EC9E740B1CC	FASTA	270	29,742
	10 20 30 40 50 60 MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQYRDSASM HSGRYGYGYN GMDLSVGRSA 70 80 90 100 110 120 STHFGASERA RTYPANSTSA STEPRYSQSA AASHSPPPDP LPCTAVAASP VSESHHGVKN 130 140 150 160 170 180 SLGNSSSTSS NSSSSTHISR DGVGTSSGTE EDTPASSEQA SAPSDQSTAQ PSQPQIYPWM 190 200 210 220 230 240 RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK 250 260 270 IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP

References

[1]	"Expression and regulation of HOXA5, HOXA6 and HOXA7 during chick wing development." Oberg K.C., Pira C.U., Creamer D.H., Revelli J.-P., Eichele G. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY686640 mRNA. Translation: AAT90845.1.
IPI	IPI00602185.
3D structure databases
ProteinModelPortal	Q6B3N0.
SMR	Q6B3N0. Positions 174-255.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6B3N0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG016849.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA5_CHICK

Accession

Primary (citable) accession number: Q6B3N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	September 13, 2004
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program