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Protein

Protein S100-A11

Gene

S100a11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Facilitates the differentiation and the cornification of keratinocytes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinityPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi63 – 74122; high affinityPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
S100 calcium-binding protein A11
Gene namesi
Name:S100a11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1303295. S100a11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Protein S100-A11PRO_0000144013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51PhosphothreonineBy similarity
Disulfide bondi8 – 8InterchainBy similarity
Modified residuei22 – 221N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylation at Thr-5 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ6B345.
PRIDEiQ6B345.

Expressioni

Gene expression databases

GenevisibleiQ6B345. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

IntActiQ6B345. 1 interaction.
STRINGi10116.ENSRNOP00000013393.

Structurei

3D structure databases

ProteinModelPortaliQ6B345.
SMRiQ6B345. Positions 2-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1U7. Eukaryota.
ENOG410YYVE. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiQ6B345.
OMAiLIFMNTE.
OrthoDBiEOG7XH6SB.
PhylomeDBiQ6B345.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF60. PTHR11639:SF60. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6B345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTETERCIE SLIAVFQKYS GKDGNSCHLS KTEFLSFMNT ELAAFTKNQK
60 70 80 90
DPGVLDRMMK KLDLNSDGQL DFQEFLNLIG GLAIACHESF LQTSQKRI
Length:98
Mass (Da):11,065
Last modified:September 13, 2004 - v1
Checksum:i4693F1B07281DCBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY688465 mRNA. Translation: AAT91807.1.
RefSeqiNP_001004095.1. NM_001004095.1.
XP_006232867.1. XM_006232805.2.
UniGeneiRn.104930.

Genome annotation databases

EnsembliENSRNOT00000013393; ENSRNOP00000013393; ENSRNOG00000010105.
GeneIDi445415.
KEGGirno:445415.
UCSCiRGD:1303295. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY688465 mRNA. Translation: AAT91807.1.
RefSeqiNP_001004095.1. NM_001004095.1.
XP_006232867.1. XM_006232805.2.
UniGeneiRn.104930.

3D structure databases

ProteinModelPortaliQ6B345.
SMRiQ6B345. Positions 2-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6B345. 1 interaction.
STRINGi10116.ENSRNOP00000013393.

Proteomic databases

PaxDbiQ6B345.
PRIDEiQ6B345.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013393; ENSRNOP00000013393; ENSRNOG00000010105.
GeneIDi445415.
KEGGirno:445415.
UCSCiRGD:1303295. rat.

Organism-specific databases

CTDi6282.
RGDi1303295. S100a11.

Phylogenomic databases

eggNOGiENOG410J1U7. Eukaryota.
ENOG410YYVE. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiQ6B345.
OMAiLIFMNTE.
OrthoDBiEOG7XH6SB.
PhylomeDBiQ6B345.
TreeFamiTF332727.

Miscellaneous databases

PROiQ6B345.

Gene expression databases

GenevisibleiQ6B345. RN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF60. PTHR11639:SF60. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat S100 calcium-binding protein A11 (calgizzarin) mRNA."
    Hesse E.M.M., Wiehler W.B., Pho M.V.C., Walsh M.P.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Brown Norway.
    Tissue: Brain.

Entry informationi

Entry nameiS10AB_RAT
AccessioniPrimary (citable) accession number: Q6B345
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.