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Protein

Protein S100-A11

Gene

S100a11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Facilitates the differentiation and the cornification of keratinocytes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinityPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi63 – 74122; high affinityPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
S100 calcium-binding protein A11
Gene namesi
Name:S100a11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1303295. S100a11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Protein S100-A11PRO_0000144013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51PhosphothreonineBy similarity
Disulfide bondi8 – 8InterchainBy similarity
Modified residuei22 – 221N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylation at Thr-5 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ6B345.
PRIDEiQ6B345.

Expressioni

Gene expression databases

GenevisibleiQ6B345. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

IntActiQ6B345. 1 interaction.
STRINGi10116.ENSRNOP00000013393.

Structurei

3D structure databases

ProteinModelPortaliQ6B345.
SMRiQ6B345. Positions 2-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG29318.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiQ6B345.
OMAiLIFMNTE.
OrthoDBiEOG7XH6SB.
PhylomeDBiQ6B345.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF68. PTHR11639:SF68. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6B345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTETERCIE SLIAVFQKYS GKDGNSCHLS KTEFLSFMNT ELAAFTKNQK
60 70 80 90
DPGVLDRMMK KLDLNSDGQL DFQEFLNLIG GLAIACHESF LQTSQKRI
Length:98
Mass (Da):11,065
Last modified:September 13, 2004 - v1
Checksum:i4693F1B07281DCBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY688465 mRNA. Translation: AAT91807.1.
RefSeqiNP_001004095.1. NM_001004095.1.
XP_006232867.1. XM_006232805.2.
UniGeneiRn.104930.

Genome annotation databases

EnsembliENSRNOT00000013393; ENSRNOP00000013393; ENSRNOG00000010105.
GeneIDi445415.
KEGGirno:445415.
UCSCiRGD:1303295. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY688465 mRNA. Translation: AAT91807.1.
RefSeqiNP_001004095.1. NM_001004095.1.
XP_006232867.1. XM_006232805.2.
UniGeneiRn.104930.

3D structure databases

ProteinModelPortaliQ6B345.
SMRiQ6B345. Positions 2-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6B345. 1 interaction.
STRINGi10116.ENSRNOP00000013393.

Proteomic databases

PaxDbiQ6B345.
PRIDEiQ6B345.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013393; ENSRNOP00000013393; ENSRNOG00000010105.
GeneIDi445415.
KEGGirno:445415.
UCSCiRGD:1303295. rat.

Organism-specific databases

CTDi6282.
RGDi1303295. S100a11.

Phylogenomic databases

eggNOGiNOG29318.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiQ6B345.
OMAiLIFMNTE.
OrthoDBiEOG7XH6SB.
PhylomeDBiQ6B345.
TreeFamiTF332727.

Miscellaneous databases

NextBioi697105.
PROiQ6B345.

Gene expression databases

GenevisibleiQ6B345. RN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF68. PTHR11639:SF68. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat S100 calcium-binding protein A11 (calgizzarin) mRNA."
    Hesse E.M.M., Wiehler W.B., Pho M.V.C., Walsh M.P.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Brown Norway.
    Tissue: Brain.

Entry informationi

Entry nameiS10AB_RAT
AccessioniPrimary (citable) accession number: Q6B345
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: September 13, 2004
Last modified: July 22, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.