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Q6B345 (S10AB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
S100 calcium-binding protein A11
Gene names
Name:S100a11
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Facilitates the differentiation and the cornification of keratinocytes By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Cytoplasm. Nucleus By similarity.

Post-translational modification

Phosphorylation at Thr-5 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation By similarity.

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins By similarity.

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   DomainRepeat
   LigandCalcium
Metal-binding
   PTMAcetylation
Disulfide bond
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9898Protein S100-A11
PRO_0000144013

Regions

Domain12 – 4736EF-hand 1
Domain50 – 8536EF-hand 2
Calcium binding20 – 33141; low affinity Potential
Calcium binding63 – 74122; high affinity Potential

Amino acid modifications

Modified residue51Phosphothreonine By similarity
Modified residue221N6-acetyllysine By similarity
Disulfide bond8Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6B345 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 4693F1B07281DCBD

FASTA9811,065
        10         20         30         40         50         60 
MPTETERCIE SLIAVFQKYS GKDGNSCHLS KTEFLSFMNT ELAAFTKNQK DPGVLDRMMK 

        70         80         90 
KLDLNSDGQL DFQEFLNLIG GLAIACHESF LQTSQKRI 

« Hide

References

[1]"Rat S100 calcium-binding protein A11 (calgizzarin) mRNA."
Hesse E.M.M., Wiehler W.B., Pho M.V.C., Walsh M.P.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Brown Norway.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY688465 mRNA. Translation: AAT91807.1.
RefSeqNP_001004095.1. NM_001004095.1.
XP_006232867.1. XM_006232805.1.
UniGeneRn.104930.

3D structure databases

ProteinModelPortalQ6B345.
SMRQ6B345. Positions 2-97.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6B345. 1 interaction.
STRING10116.ENSRNOP00000013393.

Proteomic databases

PaxDbQ6B345.
PRIDEQ6B345.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000013393; ENSRNOP00000013393; ENSRNOG00000010105.
GeneID445415.
KEGGrno:445415.
UCSCRGD:1303295. rat.

Organism-specific databases

CTD6282.
RGD1303295. S100a11.

Phylogenomic databases

eggNOGNOG29318.
GeneTreeENSGT00740000114954.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidQ6B345.
OMAIVPATIY.
OrthoDBEOG7XH6SB.
PhylomeDBQ6B345.
TreeFamTF332727.

Gene expression databases

GenevestigatorQ6B345.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERPTHR11639:SF68. PTHR11639:SF68. 1 hit.
PfamPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio697105.

Entry information

Entry nameS10AB_RAT
AccessionPrimary (citable) accession number: Q6B345
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families