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Q6B345

- S10AB_RAT

UniProt

Q6B345 - S10AB_RAT

Protein

Protein S100-A11

Gene

S100a11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Facilitates the differentiation and the cornification of keratinocytes.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi20 – 33141; low affinityPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi63 – 74122; high affinityPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. regulation of cell proliferation Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A11
    Alternative name(s):
    Calgizzarin
    S100 calcium-binding protein A11
    Gene namesi
    Name:S100a11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi1303295. S100a11.

    Subcellular locationi

    Cytoplasm. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9898Protein S100-A11PRO_0000144013Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei5 – 51PhosphothreonineBy similarity
    Disulfide bondi8 – 8InterchainBy similarity
    Modified residuei22 – 221N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylation at Thr-5 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.By similarity

    Keywords - PTMi

    Acetylation, Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiQ6B345.
    PRIDEiQ6B345.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6B345.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    IntActiQ6B345. 1 interaction.
    STRINGi10116.ENSRNOP00000013393.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6B345.
    SMRiQ6B345. Positions 2-97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG29318.
    GeneTreeiENSGT00740000114954.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    InParanoidiQ6B345.
    OMAiIVPATIY.
    OrthoDBiEOG7XH6SB.
    PhylomeDBiQ6B345.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    IPR028482. S100A11.
    [Graphical view]
    PANTHERiPTHR11639:SF68. PTHR11639:SF68. 1 hit.
    PfamiPF00036. EF-hand_1. 1 hit.
    PF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6B345-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTETERCIE SLIAVFQKYS GKDGNSCHLS KTEFLSFMNT ELAAFTKNQK   50
    DPGVLDRMMK KLDLNSDGQL DFQEFLNLIG GLAIACHESF LQTSQKRI 98
    Length:98
    Mass (Da):11,065
    Last modified:September 13, 2004 - v1
    Checksum:i4693F1B07281DCBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY688465 mRNA. Translation: AAT91807.1.
    RefSeqiNP_001004095.1. NM_001004095.1.
    XP_006232867.1. XM_006232805.1.
    UniGeneiRn.104930.

    Genome annotation databases

    EnsembliENSRNOT00000013393; ENSRNOP00000013393; ENSRNOG00000010105.
    GeneIDi445415.
    KEGGirno:445415.
    UCSCiRGD:1303295. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY688465 mRNA. Translation: AAT91807.1 .
    RefSeqi NP_001004095.1. NM_001004095.1.
    XP_006232867.1. XM_006232805.1.
    UniGenei Rn.104930.

    3D structure databases

    ProteinModelPortali Q6B345.
    SMRi Q6B345. Positions 2-97.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6B345. 1 interaction.
    STRINGi 10116.ENSRNOP00000013393.

    Proteomic databases

    PaxDbi Q6B345.
    PRIDEi Q6B345.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013393 ; ENSRNOP00000013393 ; ENSRNOG00000010105 .
    GeneIDi 445415.
    KEGGi rno:445415.
    UCSCi RGD:1303295. rat.

    Organism-specific databases

    CTDi 6282.
    RGDi 1303295. S100a11.

    Phylogenomic databases

    eggNOGi NOG29318.
    GeneTreei ENSGT00740000114954.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    InParanoidi Q6B345.
    OMAi IVPATIY.
    OrthoDBi EOG7XH6SB.
    PhylomeDBi Q6B345.
    TreeFami TF332727.

    Miscellaneous databases

    NextBioi 697105.

    Gene expression databases

    Genevestigatori Q6B345.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    IPR028482. S100A11.
    [Graphical view ]
    PANTHERi PTHR11639:SF68. PTHR11639:SF68. 1 hit.
    Pfami PF00036. EF-hand_1. 1 hit.
    PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat S100 calcium-binding protein A11 (calgizzarin) mRNA."
      Hesse E.M.M., Wiehler W.B., Pho M.V.C., Walsh M.P.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Brown Norway.
      Tissue: Brain.

    Entry informationi

    Entry nameiS10AB_RAT
    AccessioniPrimary (citable) accession number: Q6B345
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3