Q6B345 (S10AB_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein S100-A11

Alternative name(s):
Calgizzarin
S100 calcium-binding protein A11

Gene names

Name:

S100a11

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Facilitates the differentiation and the cornification of keratinocytes By similarity.
Subunit structure	Homodimer; disulfide-linked By similarity.
Subcellular location	Cytoplasm. Nucleus By similarity.
Post-translational modification	Phosphorylation at Thr-5 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation By similarity.
Miscellaneous	Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins By similarity.
Sequence similarities	Belongs to the S-100 family. Contains 2 EF-hand domains.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Repeat
Ligand	Calcium Metal-binding
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 98	98	Protein S100-A11		PRO_0000144013
Regions
	Domain	12 – 47	36	EF-hand 1
	Domain	50 – 85	36	EF-hand 2
	Calcium binding	20 – 33	14	1; low affinity Potential
	Calcium binding	63 – 74	12	2; high affinity Potential
Amino acid modifications
	Modified residue	5	1	Phosphothreonine By similarity
	Disulfide bond	8		Interchain By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6B345 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 4693F1B07281DCBD	FASTA	98	11,065
	10 20 30 40 50 60 MPTETERCIE SLIAVFQKYS GKDGNSCHLS KTEFLSFMNT ELAAFTKNQK DPGVLDRMMK 70 80 90 KLDLNSDGQL DFQEFLNLIG GLAIACHESF LQTSQKRI

References

[1]	"Rat S100 calcium-binding protein A11 (calgizzarin) mRNA." Hesse E.M.M., Wiehler W.B., Pho M.V.C., Walsh M.P. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Brown Norway. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY688465 mRNA. Translation: AAT91807.1.
IPI	IPI00554148.
RefSeq	NP_001004095.1. NM_001004095.1.
UniGene	Rn.104930.
3D structure databases
ProteinModelPortal	Q6B345.
SMR	Q6B345. Positions 2-97.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6B345. 1 interaction.
STRING	10116.ENSRNOP00000013393.
Proteomic databases
PaxDb	Q6B345.
PRIDE	Q6B345.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000013393; ENSRNOP00000013393; ENSRNOG00000010105.
GeneID	445415.
KEGG	rno:445415.
UCSC	RGD:1303295. rat.
Organism-specific databases
CTD	6282.
RGD	1303295. S100a11.
Phylogenomic databases
eggNOG	NOG29318.
GeneTree	ENSGT00660000095419.
HOGENOM	HOG000246968.
HOVERGEN	HBG001479.
InParanoid	Q6B345.
OMA	MSSPTET.
OrthoDB	EOG4BG8XN.
Gene expression databases
Genevestigator	Q6B345.
GermOnline	ENSRNOG00000010105. Rattus norvegicus.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR001751. S100/CaBP-9k_CS. IPR013787. S100_Ca-bd_sub. [Graphical view]
Pfam	PF00036. efhand. 1 hit. PF01023. S_100. 1 hit. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 1 hit. PS00303. S100_CABP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	697105.

Entry information

Entry name

S10AB_RAT

Accession

Primary (citable) accession number: Q6B345

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	September 13, 2004
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program