Q6B2U8 (TDA8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Topoisomerase I damage affected protein 8

Gene names

Name:	TDA8
Ordered Locus Names:	YAL064C-A

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	126 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Disruption phenotype	Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant. Ref.4
Sequence similarities	Belongs to the flocculin family.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 126	126	Topoisomerase I damage affected protein 8		PRO_0000268622

Sequences

	Sequence		Length	Mass (Da)
	Q6B2U8 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 7EA7549C4C0618D7	FASTA	126	13,886
	10 20 30 40 50 60 MTGYFLPPQT SSYTFRFAKV DDSAILSVGG DVAFGCCAQE QPPITSTNFT INGIKPWQGR 70 80 90 100 110 120 LPDNIAGTVY MYAGFYCPMK IVYSNAVSWH TLPVSVELPD VTTVSDDFAG HVYSFDDDLT AQLYYP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K. Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage." Reid R.J., Gonzalez-Barrera S., Sunjevaric I., Alvaro D., Ciccone S., Wagner M., Rothstein R. Genome Res. 21:477-486(2011) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U12980 Genomic DNA. No translation available. AY692632 Genomic DNA. Translation: AAT92651.1. BK006935 Genomic DNA. Translation: DAA06923.1.
RefSeq	NP_058136.1. NM_001180041.1.
3D structure databases
ProteinModelPortal	Q6B2U8.
SMR	Q6B2U8. Positions 1-120.
ModBase	Search...
Protein-protein interaction databases
STRING	4932.YAL064C-A.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YAL064C-A; YAL064C-A; YAL064C-A.
GeneID	851234.
KEGG	sce:YAL064C-A.
Organism-specific databases
CYGD	YAL064c-a.
SGD	S000002140. TDA8.
Phylogenomic databases
eggNOG	NOG12793.
GeneTree	ENSGT00660000095872.
OrthoDB	EOG43XZD2.
Gene expression databases
Genevestigator	Q6B2U8.
GermOnline	YAL064C-A. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR011658. PA14. [Graphical view]
Pfam	PF07691. PA14. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	968150.

Entry information

Entry name

TDA8_YEAST

Accession

Primary (citable) accession number: Q6B2U8
Secondary accession number(s): D6VPF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	September 13, 2004
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program