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Q6B2U8

- TDA8_YEAST

UniProt

Q6B2U8 - TDA8_YEAST

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Protein
Topoisomerase I damage affected protein 8
Gene
TDA8, YAL064C-A
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-28892-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Topoisomerase I damage affected protein 8
Gene namesi
Name:TDA8
Ordered Locus Names:YAL064C-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAL064c-a.
SGDiS000002140. TDA8.

Pathology & Biotechi

Disruption phenotypei

Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 126126Topoisomerase I damage affected protein 8
PRO_0000268622Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ6B2U8.

Interactioni

Protein-protein interaction databases

BioGridi31765. 7 interactions.
STRINGi4932.YAL064C-A.

Structurei

3D structure databases

ProteinModelPortaliQ6B2U8.
SMRiQ6B2U8. Positions 1-120.

Family & Domainsi

Sequence similaritiesi

Belongs to the flocculin family.

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00660000095872.
OrthoDBiEOG7H4F6F.

Family and domain databases

InterProiIPR011658. PA14.
[Graphical view]
PfamiPF07691. PA14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6B2U8-1 [UniParc]FASTAAdd to Basket

« Hide

MTGYFLPPQT SSYTFRFAKV DDSAILSVGG DVAFGCCAQE QPPITSTNFT    50
INGIKPWQGR LPDNIAGTVY MYAGFYCPMK IVYSNAVSWH TLPVSVELPD 100
VTTVSDDFAG HVYSFDDDLT AQLYYP 126
Length:126
Mass (Da):13,886
Last modified:September 13, 2004 - v1
Checksum:i7EA7549C4C0618D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12980 Genomic DNA. No translation available.
AY692632 Genomic DNA. Translation: AAT92651.1.
BK006935 Genomic DNA. Translation: DAA06923.1.
RefSeqiNP_058136.1. NM_001180041.1.

Genome annotation databases

EnsemblFungiiYAL064C-A; YAL064C-A; YAL064C-A.
GeneIDi851234.
KEGGisce:YAL064C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12980 Genomic DNA. No translation available.
AY692632 Genomic DNA. Translation: AAT92651.1 .
BK006935 Genomic DNA. Translation: DAA06923.1 .
RefSeqi NP_058136.1. NM_001180041.1.

3D structure databases

ProteinModelPortali Q6B2U8.
SMRi Q6B2U8. Positions 1-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31765. 7 interactions.
STRINGi 4932.YAL064C-A.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAL064C-A ; YAL064C-A ; YAL064C-A .
GeneIDi 851234.
KEGGi sce:YAL064C-A.

Organism-specific databases

CYGDi YAL064c-a.
SGDi S000002140. TDA8.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00660000095872.
OrthoDBi EOG7H4F6F.

Enzyme and pathway databases

BioCyci YEAST:G3O-28892-MONOMER.

Miscellaneous databases

NextBioi 968150.

Gene expression databases

Genevestigatori Q6B2U8.

Family and domain databases

InterProi IPR011658. PA14.
[Graphical view ]
Pfami PF07691. PA14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage."
    Reid R.J., Gonzalez-Barrera S., Sunjevaric I., Alvaro D., Ciccone S., Wagner M., Rothstein R.
    Genome Res. 21:477-486(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTDA8_YEAST
AccessioniPrimary (citable) accession number: Q6B2U8
Secondary accession number(s): D6VPF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3