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Q6B2U8 (TDA8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Topoisomerase I damage affected protein 8
Gene names
Name:TDA8
Ordered Locus Names:YAL064C-A
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length126 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Disruption phenotype

Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant. Ref.4

Sequence similarities

Belongs to the flocculin family.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 126126Topoisomerase I damage affected protein 8
PRO_0000268622

Sequences

Sequence LengthMass (Da)Tools
Q6B2U8 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 7EA7549C4C0618D7

FASTA12613,886
        10         20         30         40         50         60 
MTGYFLPPQT SSYTFRFAKV DDSAILSVGG DVAFGCCAQE QPPITSTNFT INGIKPWQGR 

        70         80         90        100        110        120 
LPDNIAGTVY MYAGFYCPMK IVYSNAVSWH TLPVSVELPD VTTVSDDFAG HVYSFDDDLT 


AQLYYP 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage."
Reid R.J., Gonzalez-Barrera S., Sunjevaric I., Alvaro D., Ciccone S., Wagner M., Rothstein R.
Genome Res. 21:477-486(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12980 Genomic DNA. No translation available.
AY692632 Genomic DNA. Translation: AAT92651.1.
BK006935 Genomic DNA. Translation: DAA06923.1.
RefSeqNP_058136.1. NM_001180041.1.

3D structure databases

ProteinModelPortalQ6B2U8.
SMRQ6B2U8. Positions 1-120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31765. 7 interactions.
STRING4932.YAL064C-A.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL064C-A; YAL064C-A; YAL064C-A.
GeneID851234.
KEGGsce:YAL064C-A.

Organism-specific databases

CYGDYAL064c-a.
SGDS000002140. TDA8.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00660000095872.
OrthoDBEOG7H4F6F.

Enzyme and pathway databases

BioCycYEAST:G3O-28892-MONOMER.

Gene expression databases

GenevestigatorQ6B2U8.

Family and domain databases

InterProIPR011658. PA14.
[Graphical view]
PfamPF07691. PA14. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968150.

Entry information

Entry nameTDA8_YEAST
AccessionPrimary (citable) accession number: Q6B2U8
Secondary accession number(s): D6VPF3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families