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Q6B2U8

- TDA8_YEAST

UniProt

Q6B2U8 - TDA8_YEAST

Protein

Topoisomerase I damage affected protein 8

Gene

TDA8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28892-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Topoisomerase I damage affected protein 8
    Gene namesi
    Name:TDA8
    Ordered Locus Names:YAL064C-A
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL064c-a.
    SGDiS000002140. TDA8.

    Pathology & Biotechi

    Disruption phenotypei

    Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 126126Topoisomerase I damage affected protein 8PRO_0000268622Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ6B2U8.

    Interactioni

    Protein-protein interaction databases

    BioGridi31765. 7 interactions.
    STRINGi4932.YAL064C-A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6B2U8.
    SMRiQ6B2U8. Positions 1-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the flocculin family.Curated

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00660000095872.
    OrthoDBiEOG7H4F6F.

    Family and domain databases

    InterProiIPR011658. PA14.
    [Graphical view]
    PfamiPF07691. PA14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6B2U8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGYFLPPQT SSYTFRFAKV DDSAILSVGG DVAFGCCAQE QPPITSTNFT    50
    INGIKPWQGR LPDNIAGTVY MYAGFYCPMK IVYSNAVSWH TLPVSVELPD 100
    VTTVSDDFAG HVYSFDDDLT AQLYYP 126
    Length:126
    Mass (Da):13,886
    Last modified:September 13, 2004 - v1
    Checksum:i7EA7549C4C0618D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. No translation available.
    AY692632 Genomic DNA. Translation: AAT92651.1.
    BK006935 Genomic DNA. Translation: DAA06923.1.
    RefSeqiNP_058136.1. NM_001180041.1.

    Genome annotation databases

    EnsemblFungiiYAL064C-A; YAL064C-A; YAL064C-A.
    GeneIDi851234.
    KEGGisce:YAL064C-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. No translation available.
    AY692632 Genomic DNA. Translation: AAT92651.1 .
    BK006935 Genomic DNA. Translation: DAA06923.1 .
    RefSeqi NP_058136.1. NM_001180041.1.

    3D structure databases

    ProteinModelPortali Q6B2U8.
    SMRi Q6B2U8. Positions 1-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31765. 7 interactions.
    STRINGi 4932.YAL064C-A.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL064C-A ; YAL064C-A ; YAL064C-A .
    GeneIDi 851234.
    KEGGi sce:YAL064C-A.

    Organism-specific databases

    CYGDi YAL064c-a.
    SGDi S000002140. TDA8.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00660000095872.
    OrthoDBi EOG7H4F6F.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28892-MONOMER.

    Miscellaneous databases

    NextBioi 968150.

    Gene expression databases

    Genevestigatori Q6B2U8.

    Family and domain databases

    InterProi IPR011658. PA14.
    [Graphical view ]
    Pfami PF07691. PA14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage."
      Reid R.J., Gonzalez-Barrera S., Sunjevaric I., Alvaro D., Ciccone S., Wagner M., Rothstein R.
      Genome Res. 21:477-486(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiTDA8_YEAST
    AccessioniPrimary (citable) accession number: Q6B2U8
    Secondary accession number(s): D6VPF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3