Q6B0K9 (HBM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemoglobin subunit mu

Alternative name(s):
Hemoglobin mu chain
Mu-globin

Gene names

Name:	HBM
Synonyms:	HBAP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	141 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Expressed in erythroid tissues. Ref.1
Developmental stage	Maximal expression during the erythroblast terminal differentiation. Ref.1
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 141	141	Hemoglobin subunit mu		PRO_0000282855
Sites
	Metal binding	58	1	Iron (heme distal ligand) By similarity
	Metal binding	87	1	Iron (heme proximal ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6B0K9 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 6864266BBE841516	FASTA	141	15,618
	10 20 30 40 50 60 MLSAQERAQI AQVWDLIAGH EAQFGAELLL RLFTVYPSTK VYFPHLSACQ DATQLLSHGQ 70 80 90 100 110 120 RMLAAVGAAV QHVDNLRAAL SPLADLHALV LRVDPANFPL LIQCFHVVLA SHLQDEFTVQ 130 140 MQAAWDKFLT GVAVVLTEKY R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A newly discovered human alpha-globin gene." Goh S.-H., Lee Y.T., Bhanu N.V., Cam M.C., Desper R., Martin B.M., Moharram R., Gherman R.B., Miller J.L. Blood 106:1466-1472(2005) [PubMed: 15855277] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Blood.
[2]	"A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter." De Gobbi M., Viprakasit V., Hughes J.R., Fisher C., Buckle V.J., Ayyub H., Gibbons R.J., Vernimmen D., Yoshinaga Y., de Jong P., Cheng J.-F., Rubin E.M., Wood W.G., Bowden D., Higgs D.R. Science 312:1215-1217(2006) [PubMed: 16728641] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY698022 mRNA. Translation: AAT92513.1. DQ431198 Genomic DNA. Translation: ABD95909.1. BC035682 mRNA. Translation: AAH35682.1.
IPI	IPI00456238.
RefSeq	NP_001003938.1. NM_001003938.3.
UniGene	Hs.647389.
3D structure databases
HSSP	HSSP built from PDB template 1Y01 based on UniProtKB P69905.
ProteinModelPortal	Q6B0K9.
SMR	Q6B0K9. Positions 1-141.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6B0K9.
Polymorphism databases
DMDM	74748384.
Proteomic databases
PRIDE	Q6B0K9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356815; ENSP00000349270; ENSG00000206177.
GeneID	3042.
KEGG	hsa:3042.
UCSC	uc002cfu.1. human.
Organism-specific databases
CTD	3042.
GeneCards	GC16P000203.
H-InvDB	HIX0059565.
HGNC	HGNC:4826. HBM.
MIM	609639. gene.
neXtProt	NX_Q6B0K9.
PharmGKB	PA29201.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12459.
GeneTree	ENSGT00550000074190.
HOGENOM	HBG715197.
HOVERGEN	HBG009709.
InParanoid	Q6B0K9.
OMA	QVWDLIA.
OrthoDB	EOG47M209.
Gene expression databases
ArrayExpress	Q6B0K9.
Bgee	Q6B0K9.
Genevestigator	Q6B0K9.
Family and domain databases
InterPro	IPR009050. Globin-like. IPR012292. Globin_dom. IPR000971. Globin_subset. IPR002338. Haemoglobin_a. [Graphical view]
Gene3D	G3DSA:1.10.490.10. Globin_related. 1 hit.
KO	K13828.
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00612. ALPHAHAEM.
SUPFAM	SSF46458. Globin_like. 1 hit.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	12044.
SOURCE	Search...

Entry information

Entry name

HBM_HUMAN

Accession

Primary (citable) accession number: Q6B0K9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.