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Protein

Hemoglobin subunit mu

Gene

HBM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi58Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi87Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:G66-30684-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit mu
Alternative name(s):
Hemoglobin mu chain
Mu-globin
Gene namesi
Name:HBM
Synonyms:HBAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:4826. HBM.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • hemoglobin complex Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi3042.
OpenTargetsiENSG00000206177.
PharmGKBiPA29201.

Polymorphism and mutation databases

BioMutaiHBM.
DMDMi74748384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828551 – 141Hemoglobin subunit muAdd BLAST141

Proteomic databases

PaxDbiQ6B0K9.
PeptideAtlasiQ6B0K9.
PRIDEiQ6B0K9.

Expressioni

Tissue specificityi

Expressed in erythroid tissues.1 Publication

Developmental stagei

Maximal expression during the erythroblast terminal differentiation.1 Publication

Gene expression databases

BgeeiENSG00000206177.
GenevisibleiQ6B0K9. HS.

Interactioni

Protein-protein interaction databases

BioGridi109292. 20 interactors.
STRINGi9606.ENSP00000349270.

Structurei

3D structure databases

ProteinModelPortaliQ6B0K9.
SMRiQ6B0K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiQ6B0K9.
KOiK13828.
OMAiAGHEAPF.
OrthoDBiEOG091G0S0X.
PhylomeDBiQ6B0K9.
TreeFamiTF332328.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6B0K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAQERAQI AQVWDLIAGH EAQFGAELLL RLFTVYPSTK VYFPHLSACQ
60 70 80 90 100
DATQLLSHGQ RMLAAVGAAV QHVDNLRAAL SPLADLHALV LRVDPANFPL
110 120 130 140
LIQCFHVVLA SHLQDEFTVQ MQAAWDKFLT GVAVVLTEKY R
Length:141
Mass (Da):15,618
Last modified:September 13, 2004 - v1
Checksum:i6864266BBE841516
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY698022 mRNA. Translation: AAT92513.1.
DQ431198 Genomic DNA. Translation: ABD95909.1.
BC035682 mRNA. Translation: AAH35682.1.
CCDSiCCDS32347.1.
RefSeqiNP_001003938.1. NM_001003938.3.
UniGeneiHs.647389.

Genome annotation databases

EnsembliENST00000356815; ENSP00000349270; ENSG00000206177.
GeneIDi3042.
KEGGihsa:3042.
UCSCiuc002cfu.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY698022 mRNA. Translation: AAT92513.1.
DQ431198 Genomic DNA. Translation: ABD95909.1.
BC035682 mRNA. Translation: AAH35682.1.
CCDSiCCDS32347.1.
RefSeqiNP_001003938.1. NM_001003938.3.
UniGeneiHs.647389.

3D structure databases

ProteinModelPortaliQ6B0K9.
SMRiQ6B0K9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109292. 20 interactors.
STRINGi9606.ENSP00000349270.

Polymorphism and mutation databases

BioMutaiHBM.
DMDMi74748384.

Proteomic databases

PaxDbiQ6B0K9.
PeptideAtlasiQ6B0K9.
PRIDEiQ6B0K9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356815; ENSP00000349270; ENSG00000206177.
GeneIDi3042.
KEGGihsa:3042.
UCSCiuc002cfu.2. human.

Organism-specific databases

CTDi3042.
DisGeNETi3042.
GeneCardsiHBM.
HGNCiHGNC:4826. HBM.
MIMi609639. gene.
neXtProtiNX_Q6B0K9.
OpenTargetsiENSG00000206177.
PharmGKBiPA29201.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiQ6B0K9.
KOiK13828.
OMAiAGHEAPF.
OrthoDBiEOG091G0S0X.
PhylomeDBiQ6B0K9.
TreeFamiTF332328.

Enzyme and pathway databases

BioCyciZFISH:G66-30684-MONOMER.

Miscellaneous databases

ChiTaRSiHBM. human.
GenomeRNAii3042.
PROiQ6B0K9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000206177.
GenevisibleiQ6B0K9. HS.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBM_HUMAN
AccessioniPrimary (citable) accession number: Q6B0K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.