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Protein

Tigger transposable element-derived protein 3

Gene

TIGD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi31 – 51H-T-H motifBy similarityAdd BLAST21
DNA bindingi100 – 130H-T-H motifBy similarityAdd BLAST31

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element-derived protein 3
Gene namesi
Name:TIGD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000173825.6.
HGNCiHGNC:18334. TIGD3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173825.
PharmGKBiPA38527.

Polymorphism and mutation databases

BioMutaiTIGD3.
DMDMi74762295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710901 – 471Tigger transposable element-derived protein 3Add BLAST471

Proteomic databases

PaxDbiQ6B0B8.
PRIDEiQ6B0B8.

Expressioni

Gene expression databases

BgeeiENSG00000173825.
CleanExiHS_TIGD3.
GenevisibleiQ6B0B8. HS.

Organism-specific databases

HPAiHPA040016.

Interactioni

Protein-protein interaction databases

BioGridi128641. 4 interactors.
IntActiQ6B0B8. 4 interactors.
STRINGi9606.ENSP00000308354.

Structurei

3D structure databases

ProteinModelPortaliQ6B0B8.
SMRiQ6B0B8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 55HTH psq-typePROSITE-ProRule annotationAdd BLAST53
Domaini67 – 137HTH CENPB-typePROSITE-ProRule annotationAdd BLAST71
Domaini167 – 360DDE-1Sequence analysisAdd BLAST194

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3105. Eukaryota.
ENOG4110CDI. LUCA.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000154579.
HOVERGENiHBG094044.
InParanoidiQ6B0B8.
OMAiIPWSEWL.
OrthoDBiEOG091G079U.
PhylomeDBiQ6B0B8.
TreeFamiTF101131.

Family and domain databases

InterProiView protein in InterPro
IPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeobox-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
PfamiView protein in Pfam
PF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
SMARTiView protein in SMART
SM00674. CENPB. 1 hit.
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiView protein in PROSITE
PS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6B0B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSSKKKLH ALSLAEKIQV LELLDESKMS QSEVARRFQV SQPQISRICK
60 70 80 90 100
NKEKLLADWC SGTANRERKR KRESKYSGID EALLCWYHIA RAKAWDVTGP
110 120 130 140 150
MLLHKAKELA DIMGQDFVPS IGWLVRWKRR NNVGFGARHV LAPSFPPEPP
160 170 180 190 200
PPGLTSQAQL PLSLKDFSPE DVFGCAELPL LYRAVPGSFG ACDQVQVLLC
210 220 230 240 250
ANSRGTEKRR VLLGGLQAAP RCFFGIRSEA LPASYHPDLG IPWLEWLAQF
260 270 280 290 300
DRDMGQQGRQ VALLLAARVV EELAGLPGLY HVKLLPLAAS STTPPLPSSV
310 320 330 340 350
VRAFKAHYRH RLLGKLAAIQ SERDGTSLAE AGAGITVLDA LHVASAAWAK
360 370 380 390 400
VPPQLIFSSF IQEGLAPGKT PPSSHKTSEM PPVPGGLSLE EFSRFVDLEG
410 420 430 440 450
EEPRSGVCKE EIGTEDEKGD REGAFEPLPT KADALRALGT LRRWFECNST
460 470
SPELFEKFYD CEEEVERLCC L
Length:471
Mass (Da):52,027
Last modified:September 13, 2004 - v1
Checksum:i82127423A95429B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074862 mRNA. Translation: AAH74862.1.
CCDSiCCDS8101.1.
RefSeqiNP_663771.1. NM_145719.2.
UniGeneiHs.632121.

Genome annotation databases

EnsembliENST00000309880; ENSP00000308354; ENSG00000173825.
GeneIDi220359.
KEGGihsa:220359.
UCSCiuc001odo.5. human.

Similar proteinsi

Entry informationi

Entry nameiTIGD3_HUMAN
AccessioniPrimary (citable) accession number: Q6B0B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 13, 2004
Last modified: September 27, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families