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Q6B0B8 (TIGD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tigger transposable element-derived protein 3
Gene names
Name:TIGD3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the tigger transposable element derived protein family.

Contains 1 DDE domain.

Contains 1 HTH CENPB-type DNA-binding domain.

Contains 1 HTH psq-type DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Tigger transposable element-derived protein 3
PRO_0000271090

Regions

Domain3 – 5553HTH psq-type
Domain67 – 13771HTH CENPB-type
Domain167 – 360194DDE
DNA binding31 – 5121H-T-H motif By similarity
DNA binding100 – 13031H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6B0B8 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 82127423A95429B7

FASTA47152,027
        10         20         30         40         50         60 
MELSSKKKLH ALSLAEKIQV LELLDESKMS QSEVARRFQV SQPQISRICK NKEKLLADWC 

        70         80         90        100        110        120 
SGTANRERKR KRESKYSGID EALLCWYHIA RAKAWDVTGP MLLHKAKELA DIMGQDFVPS 

       130        140        150        160        170        180 
IGWLVRWKRR NNVGFGARHV LAPSFPPEPP PPGLTSQAQL PLSLKDFSPE DVFGCAELPL 

       190        200        210        220        230        240 
LYRAVPGSFG ACDQVQVLLC ANSRGTEKRR VLLGGLQAAP RCFFGIRSEA LPASYHPDLG 

       250        260        270        280        290        300 
IPWLEWLAQF DRDMGQQGRQ VALLLAARVV EELAGLPGLY HVKLLPLAAS STTPPLPSSV 

       310        320        330        340        350        360 
VRAFKAHYRH RLLGKLAAIQ SERDGTSLAE AGAGITVLDA LHVASAAWAK VPPQLIFSSF 

       370        380        390        400        410        420 
IQEGLAPGKT PPSSHKTSEM PPVPGGLSLE EFSRFVDLEG EEPRSGVCKE EIGTEDEKGD 

       430        440        450        460        470 
REGAFEPLPT KADALRALGT LRRWFECNST SPELFEKFYD CEEEVERLCC L 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC074862 mRNA. Translation: AAH74862.1.
RefSeqNP_663771.1. NM_145719.2.
UniGeneHs.632121.

3D structure databases

ProteinModelPortalQ6B0B8.
SMRQ6B0B8. Positions 8-132.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000308354.

PTM databases

PhosphoSiteQ6B0B8.

Polymorphism databases

DMDM74762295.

Proteomic databases

PaxDbQ6B0B8.
PeptideAtlasQ6B0B8.
PRIDEQ6B0B8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309880; ENSP00000308354; ENSG00000173825.
GeneID220359.
KEGGhsa:220359.
UCSCuc001odo.4. human.

Organism-specific databases

CTD220359.
GeneCardsGC11P065122.
HGNCHGNC:18334. TIGD3.
HPAHPA040016.
neXtProtNX_Q6B0B8.
PharmGKBPA38527.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG269582.
HOGENOMHOG000154579.
HOVERGENHBG094044.
InParanoidQ6B0B8.
OMASFIQEGL.
OrthoDBEOG7RBZ8H.
PhylomeDBQ6B0B8.
TreeFamTF101131.

Gene expression databases

BgeeQ6B0B8.
CleanExHS_TIGD3.
GenevestigatorQ6B0B8.

Family and domain databases

Gene3D1.10.10.60. 2 hits.
InterProIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 2 hits.
PROSITEPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi220359.
NextBio91044.
PROQ6B0B8.

Entry information

Entry nameTIGD3_HUMAN
AccessionPrimary (citable) accession number: Q6B0B8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 13, 2004
Last modified: February 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM