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Q6B0B8

- TIGD3_HUMAN

UniProt

Q6B0B8 - TIGD3_HUMAN

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Protein

Tigger transposable element-derived protein 3

Gene

TIGD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi31 – 5121H-T-H motifBy similarityAdd
BLAST
DNA bindingi100 – 13031H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element-derived protein 3
Gene namesi
Name:TIGD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:18334. TIGD3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38527.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Tigger transposable element-derived protein 3PRO_0000271090Add
BLAST

Proteomic databases

PaxDbiQ6B0B8.
PeptideAtlasiQ6B0B8.
PRIDEiQ6B0B8.

PTM databases

PhosphoSiteiQ6B0B8.

Expressioni

Gene expression databases

BgeeiQ6B0B8.
CleanExiHS_TIGD3.
GenevestigatoriQ6B0B8.

Organism-specific databases

HPAiHPA040016.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308354.

Structurei

3D structure databases

ProteinModelPortaliQ6B0B8.
SMRiQ6B0B8. Positions 8-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 5553HTH psq-typePROSITE-ProRule annotationAdd
BLAST
Domaini67 – 13771HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST
Domaini167 – 360194DDEAdd
BLAST

Sequence similaritiesi

Contains 1 DDE domain.Curated
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG269582.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000154579.
HOVERGENiHBG094044.
InParanoidiQ6B0B8.
OMAiSFIQEGL.
OrthoDBiEOG7RBZ8H.
PhylomeDBiQ6B0B8.
TreeFamiTF101131.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6B0B8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELSSKKKLH ALSLAEKIQV LELLDESKMS QSEVARRFQV SQPQISRICK
60 70 80 90 100
NKEKLLADWC SGTANRERKR KRESKYSGID EALLCWYHIA RAKAWDVTGP
110 120 130 140 150
MLLHKAKELA DIMGQDFVPS IGWLVRWKRR NNVGFGARHV LAPSFPPEPP
160 170 180 190 200
PPGLTSQAQL PLSLKDFSPE DVFGCAELPL LYRAVPGSFG ACDQVQVLLC
210 220 230 240 250
ANSRGTEKRR VLLGGLQAAP RCFFGIRSEA LPASYHPDLG IPWLEWLAQF
260 270 280 290 300
DRDMGQQGRQ VALLLAARVV EELAGLPGLY HVKLLPLAAS STTPPLPSSV
310 320 330 340 350
VRAFKAHYRH RLLGKLAAIQ SERDGTSLAE AGAGITVLDA LHVASAAWAK
360 370 380 390 400
VPPQLIFSSF IQEGLAPGKT PPSSHKTSEM PPVPGGLSLE EFSRFVDLEG
410 420 430 440 450
EEPRSGVCKE EIGTEDEKGD REGAFEPLPT KADALRALGT LRRWFECNST
460 470
SPELFEKFYD CEEEVERLCC L
Length:471
Mass (Da):52,027
Last modified:September 13, 2004 - v1
Checksum:i82127423A95429B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC074862 mRNA. Translation: AAH74862.1.
CCDSiCCDS8101.1.
RefSeqiNP_663771.1. NM_145719.2.
UniGeneiHs.632121.

Genome annotation databases

EnsembliENST00000309880; ENSP00000308354; ENSG00000173825.
GeneIDi220359.
KEGGihsa:220359.
UCSCiuc001odo.4. human.

Polymorphism databases

DMDMi74762295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC074862 mRNA. Translation: AAH74862.1 .
CCDSi CCDS8101.1.
RefSeqi NP_663771.1. NM_145719.2.
UniGenei Hs.632121.

3D structure databases

ProteinModelPortali Q6B0B8.
SMRi Q6B0B8. Positions 8-132.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000308354.

PTM databases

PhosphoSitei Q6B0B8.

Polymorphism databases

DMDMi 74762295.

Proteomic databases

PaxDbi Q6B0B8.
PeptideAtlasi Q6B0B8.
PRIDEi Q6B0B8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309880 ; ENSP00000308354 ; ENSG00000173825 .
GeneIDi 220359.
KEGGi hsa:220359.
UCSCi uc001odo.4. human.

Organism-specific databases

CTDi 220359.
GeneCardsi GC11P065122.
HGNCi HGNC:18334. TIGD3.
HPAi HPA040016.
neXtProti NX_Q6B0B8.
PharmGKBi PA38527.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG269582.
GeneTreei ENSGT00760000119149.
HOGENOMi HOG000154579.
HOVERGENi HBG094044.
InParanoidi Q6B0B8.
OMAi SFIQEGL.
OrthoDBi EOG7RBZ8H.
PhylomeDBi Q6B0B8.
TreeFami TF101131.

Miscellaneous databases

GenomeRNAii 220359.
NextBioi 91044.
PROi Q6B0B8.

Gene expression databases

Bgeei Q6B0B8.
CleanExi HS_TIGD3.
Genevestigatori Q6B0B8.

Family and domain databases

Gene3Di 1.10.10.60. 2 hits.
InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view ]
Pfami PF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view ]
SMARTi SM00674. CENPB. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiTIGD3_HUMAN
AccessioniPrimary (citable) accession number: Q6B0B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3