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Q6B0B8

- TIGD3_HUMAN

UniProt

Q6B0B8 - TIGD3_HUMAN

Protein

Tigger transposable element-derived protein 3

Gene

TIGD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi31 – 5121H-T-H motifBy similarityAdd
    BLAST
    DNA bindingi100 – 13031H-T-H motifBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tigger transposable element-derived protein 3
    Gene namesi
    Name:TIGD3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:18334. TIGD3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38527.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471Tigger transposable element-derived protein 3PRO_0000271090Add
    BLAST

    Proteomic databases

    PaxDbiQ6B0B8.
    PeptideAtlasiQ6B0B8.
    PRIDEiQ6B0B8.

    PTM databases

    PhosphoSiteiQ6B0B8.

    Expressioni

    Gene expression databases

    BgeeiQ6B0B8.
    CleanExiHS_TIGD3.
    GenevestigatoriQ6B0B8.

    Organism-specific databases

    HPAiHPA040016.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000308354.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6B0B8.
    SMRiQ6B0B8. Positions 8-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 5553HTH psq-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini67 – 13771HTH CENPB-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini167 – 360194DDEAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DDE domain.Curated
    Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG269582.
    HOGENOMiHOG000154579.
    HOVERGENiHBG094044.
    InParanoidiQ6B0B8.
    OMAiSFIQEGL.
    OrthoDBiEOG7RBZ8H.
    PhylomeDBiQ6B0B8.
    TreeFamiTF101131.

    Family and domain databases

    Gene3Di1.10.10.60. 2 hits.
    InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR007889. HTH_Psq.
    [Graphical view]
    PfamiPF04218. CENP-B_N. 1 hit.
    PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view]
    SMARTiSM00674. CENPB. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS51253. HTH_CENPB. 1 hit.
    PS50960. HTH_PSQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6B0B8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELSSKKKLH ALSLAEKIQV LELLDESKMS QSEVARRFQV SQPQISRICK    50
    NKEKLLADWC SGTANRERKR KRESKYSGID EALLCWYHIA RAKAWDVTGP 100
    MLLHKAKELA DIMGQDFVPS IGWLVRWKRR NNVGFGARHV LAPSFPPEPP 150
    PPGLTSQAQL PLSLKDFSPE DVFGCAELPL LYRAVPGSFG ACDQVQVLLC 200
    ANSRGTEKRR VLLGGLQAAP RCFFGIRSEA LPASYHPDLG IPWLEWLAQF 250
    DRDMGQQGRQ VALLLAARVV EELAGLPGLY HVKLLPLAAS STTPPLPSSV 300
    VRAFKAHYRH RLLGKLAAIQ SERDGTSLAE AGAGITVLDA LHVASAAWAK 350
    VPPQLIFSSF IQEGLAPGKT PPSSHKTSEM PPVPGGLSLE EFSRFVDLEG 400
    EEPRSGVCKE EIGTEDEKGD REGAFEPLPT KADALRALGT LRRWFECNST 450
    SPELFEKFYD CEEEVERLCC L 471
    Length:471
    Mass (Da):52,027
    Last modified:September 13, 2004 - v1
    Checksum:i82127423A95429B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074862 mRNA. Translation: AAH74862.1.
    CCDSiCCDS8101.1.
    RefSeqiNP_663771.1. NM_145719.2.
    UniGeneiHs.632121.

    Genome annotation databases

    EnsembliENST00000309880; ENSP00000308354; ENSG00000173825.
    GeneIDi220359.
    KEGGihsa:220359.
    UCSCiuc001odo.4. human.

    Polymorphism databases

    DMDMi74762295.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074862 mRNA. Translation: AAH74862.1 .
    CCDSi CCDS8101.1.
    RefSeqi NP_663771.1. NM_145719.2.
    UniGenei Hs.632121.

    3D structure databases

    ProteinModelPortali Q6B0B8.
    SMRi Q6B0B8. Positions 8-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000308354.

    PTM databases

    PhosphoSitei Q6B0B8.

    Polymorphism databases

    DMDMi 74762295.

    Proteomic databases

    PaxDbi Q6B0B8.
    PeptideAtlasi Q6B0B8.
    PRIDEi Q6B0B8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309880 ; ENSP00000308354 ; ENSG00000173825 .
    GeneIDi 220359.
    KEGGi hsa:220359.
    UCSCi uc001odo.4. human.

    Organism-specific databases

    CTDi 220359.
    GeneCardsi GC11P065122.
    HGNCi HGNC:18334. TIGD3.
    HPAi HPA040016.
    neXtProti NX_Q6B0B8.
    PharmGKBi PA38527.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG269582.
    HOGENOMi HOG000154579.
    HOVERGENi HBG094044.
    InParanoidi Q6B0B8.
    OMAi SFIQEGL.
    OrthoDBi EOG7RBZ8H.
    PhylomeDBi Q6B0B8.
    TreeFami TF101131.

    Miscellaneous databases

    GenomeRNAii 220359.
    NextBioi 91044.
    PROi Q6B0B8.

    Gene expression databases

    Bgeei Q6B0B8.
    CleanExi HS_TIGD3.
    Genevestigatori Q6B0B8.

    Family and domain databases

    Gene3Di 1.10.10.60. 2 hits.
    InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR007889. HTH_Psq.
    [Graphical view ]
    Pfami PF04218. CENP-B_N. 1 hit.
    PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view ]
    SMARTi SM00674. CENPB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS51253. HTH_CENPB. 1 hit.
    PS50960. HTH_PSQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiTIGD3_HUMAN
    AccessioniPrimary (citable) accession number: Q6B0B8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3