Q6B0B8 (TIGD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tigger transposable element-derived protein 3

Gene names

Name:

TIGD3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the tigger transposable element derived protein family. Contains 1 DDE domain. Contains 1 HTH CENPB-type DNA-binding domain. Contains 1 HTH psq-type DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	Tigger transposable element-derived protein 3		PRO_0000271090
Regions
	Domain	3 – 55	53	HTH psq-type
	Domain	67 – 137	71	HTH CENPB-type
	Domain	167 – 360	194	DDE
	DNA binding	31 – 51	21	H-T-H motif By similarity
	DNA binding	100 – 130	31	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6B0B8 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 82127423A95429B7	FASTA	471	52,027
	10 20 30 40 50 60 MELSSKKKLH ALSLAEKIQV LELLDESKMS QSEVARRFQV SQPQISRICK NKEKLLADWC 70 80 90 100 110 120 SGTANRERKR KRESKYSGID EALLCWYHIA RAKAWDVTGP MLLHKAKELA DIMGQDFVPS 130 140 150 160 170 180 IGWLVRWKRR NNVGFGARHV LAPSFPPEPP PPGLTSQAQL PLSLKDFSPE DVFGCAELPL 190 200 210 220 230 240 LYRAVPGSFG ACDQVQVLLC ANSRGTEKRR VLLGGLQAAP RCFFGIRSEA LPASYHPDLG 250 260 270 280 290 300 IPWLEWLAQF DRDMGQQGRQ VALLLAARVV EELAGLPGLY HVKLLPLAAS STTPPLPSSV 310 320 330 340 350 360 VRAFKAHYRH RLLGKLAAIQ SERDGTSLAE AGAGITVLDA LHVASAAWAK VPPQLIFSSF 370 380 390 400 410 420 IQEGLAPGKT PPSSHKTSEM PPVPGGLSLE EFSRFVDLEG EEPRSGVCKE EIGTEDEKGD 430 440 450 460 470 REGAFEPLPT KADALRALGT LRRWFECNST SPELFEKFYD CEEEVERLCC L

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC074862 mRNA. Translation: AAH74862.1.
IPI	IPI00170550.
RefSeq	NP_663771.1. NM_145719.2.
UniGene	Hs.632121.
3D structure databases
HSSP	HSSP built from PDB template 1HLV based on UniProtKB P07199.
ProteinModelPortal	Q6B0B8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000308354.
PTM databases
PhosphoSite	Q6B0B8.
Polymorphism databases
DMDM	74762295.
Proteomic databases
PaxDb	Q6B0B8.
PeptideAtlas	Q6B0B8.
PRIDE	Q6B0B8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309880; ENSP00000308354; ENSG00000173825.
GeneID	220359.
KEGG	hsa:220359.
UCSC	uc001odo.4. human.
Organism-specific databases
CTD	220359.
GeneCards	GC11P065122.
HGNC	HGNC:18334. TIGD3.
HPA	HPA040016.
neXtProt	NX_Q6B0B8.
PharmGKB	PA38527.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG269582.
HOGENOM	HOG000154579.
HOVERGEN	HBG094044.
InParanoid	Q6B0B8.
OMA	SFIQEGL.
OrthoDB	EOG4QNMW6.
PhylomeDB	Q6B0B8.
Gene expression databases
Bgee	Q6B0B8.
CleanEx	HS_TIGD3.
Genevestigator	Q6B0B8.
Family and domain databases
Gene3D	1.10.10.60. 2 hits.
InterPro	IPR004875. DDE_SF_endonuclease_CENPB-like. IPR009057. Homeodomain-like. IPR006600. HTH_CenpB_DNA-bd_dom. IPR007889. HTH_Psq. [Graphical view]
Pfam	PF04218. CENP-B_N. 1 hit. PF03184. DDE_1. 1 hit. PF03221. HTH_Tnp_Tc5. 1 hit. [Graphical view]
SMART	SM00674. CENPB. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 2 hits.
PROSITE	PS51253. HTH_CENPB. 1 hit. PS50960. HTH_PSQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	220359.
NextBio	91044.

Entry information

Entry name

TIGD3_HUMAN

Accession

Primary (citable) accession number: Q6B0B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	September 13, 2004
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.