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Protein

Tigger transposable element-derived protein 3

Gene

TIGD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi31 – 5121H-T-H motifBy similarityAdd
BLAST
DNA bindingi100 – 13031H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element-derived protein 3
Gene namesi
Name:TIGD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18334. TIGD3.

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38527.

Polymorphism and mutation databases

BioMutaiTIGD3.
DMDMi74762295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Tigger transposable element-derived protein 3PRO_0000271090Add
BLAST

Proteomic databases

PaxDbiQ6B0B8.
PeptideAtlasiQ6B0B8.
PRIDEiQ6B0B8.

PTM databases

PhosphoSiteiQ6B0B8.

Expressioni

Gene expression databases

BgeeiQ6B0B8.
CleanExiHS_TIGD3.
GenevestigatoriQ6B0B8.

Organism-specific databases

HPAiHPA040016.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308354.

Structurei

3D structure databases

ProteinModelPortaliQ6B0B8.
SMRiQ6B0B8. Positions 8-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 5553HTH psq-typePROSITE-ProRule annotationAdd
BLAST
Domaini67 – 13771HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST
Domaini167 – 360194DDEAdd
BLAST

Sequence similaritiesi

Contains 1 DDE domain.Curated
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG269582.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000154579.
HOVERGENiHBG094044.
InParanoidiQ6B0B8.
OMAiSFIQEGL.
OrthoDBiEOG7RBZ8H.
PhylomeDBiQ6B0B8.
TreeFamiTF101131.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6B0B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSSKKKLH ALSLAEKIQV LELLDESKMS QSEVARRFQV SQPQISRICK
60 70 80 90 100
NKEKLLADWC SGTANRERKR KRESKYSGID EALLCWYHIA RAKAWDVTGP
110 120 130 140 150
MLLHKAKELA DIMGQDFVPS IGWLVRWKRR NNVGFGARHV LAPSFPPEPP
160 170 180 190 200
PPGLTSQAQL PLSLKDFSPE DVFGCAELPL LYRAVPGSFG ACDQVQVLLC
210 220 230 240 250
ANSRGTEKRR VLLGGLQAAP RCFFGIRSEA LPASYHPDLG IPWLEWLAQF
260 270 280 290 300
DRDMGQQGRQ VALLLAARVV EELAGLPGLY HVKLLPLAAS STTPPLPSSV
310 320 330 340 350
VRAFKAHYRH RLLGKLAAIQ SERDGTSLAE AGAGITVLDA LHVASAAWAK
360 370 380 390 400
VPPQLIFSSF IQEGLAPGKT PPSSHKTSEM PPVPGGLSLE EFSRFVDLEG
410 420 430 440 450
EEPRSGVCKE EIGTEDEKGD REGAFEPLPT KADALRALGT LRRWFECNST
460 470
SPELFEKFYD CEEEVERLCC L
Length:471
Mass (Da):52,027
Last modified:September 13, 2004 - v1
Checksum:i82127423A95429B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074862 mRNA. Translation: AAH74862.1.
CCDSiCCDS8101.1.
RefSeqiNP_663771.1. NM_145719.2.
UniGeneiHs.632121.

Genome annotation databases

EnsembliENST00000309880; ENSP00000308354; ENSG00000173825.
GeneIDi220359.
KEGGihsa:220359.
UCSCiuc001odo.4. human.

Polymorphism and mutation databases

BioMutaiTIGD3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074862 mRNA. Translation: AAH74862.1.
CCDSiCCDS8101.1.
RefSeqiNP_663771.1. NM_145719.2.
UniGeneiHs.632121.

3D structure databases

ProteinModelPortaliQ6B0B8.
SMRiQ6B0B8. Positions 8-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308354.

PTM databases

PhosphoSiteiQ6B0B8.

Polymorphism and mutation databases

BioMutaiTIGD3.
DMDMi74762295.

Proteomic databases

PaxDbiQ6B0B8.
PeptideAtlasiQ6B0B8.
PRIDEiQ6B0B8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309880; ENSP00000308354; ENSG00000173825.
GeneIDi220359.
KEGGihsa:220359.
UCSCiuc001odo.4. human.

Organism-specific databases

CTDi220359.
GeneCardsiGC11P065122.
HGNCiHGNC:18334. TIGD3.
HPAiHPA040016.
neXtProtiNX_Q6B0B8.
PharmGKBiPA38527.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG269582.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000154579.
HOVERGENiHBG094044.
InParanoidiQ6B0B8.
OMAiSFIQEGL.
OrthoDBiEOG7RBZ8H.
PhylomeDBiQ6B0B8.
TreeFamiTF101131.

Miscellaneous databases

GenomeRNAii220359.
NextBioi91044.
PROiQ6B0B8.

Gene expression databases

BgeeiQ6B0B8.
CleanExiHS_TIGD3.
GenevestigatoriQ6B0B8.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiTIGD3_HUMAN
AccessioniPrimary (citable) accession number: Q6B0B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 13, 2004
Last modified: April 29, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.