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Q6AZZ1

- TRI68_HUMAN

UniProt

Q6AZZ1 - TRI68_HUMAN

Protein

E3 ubiquitin-protein ligase TRIM68

Gene

TRIM68

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.1 Publication

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 6146RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri93 – 13442B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. androgen receptor binding Source: UniProtKB
    2. histone acetyltransferase binding Source: UniProtKB
    3. ligase activity Source: UniProtKB-KW
    4. ubiquitin-protein transferase activity Source: UniProtKB
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein autoubiquitination Source: UniProtKB
    2. regulation of androgen receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase TRIM68 (EC:6.3.2.-)
    Alternative name(s):
    RING finger protein 137
    SSA protein SS-56
    Short name:
    SS-56
    Tripartite motif-containing protein 68
    Gene namesi
    Name:TRIM68
    Synonyms:GC109, RNF137, SS56
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:21161. TRIM68.

    Subcellular locationi

    Cytoplasmperinuclear region. Nucleus
    Note: Colocalized with AR in nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: LIFEdb
    2. Golgi apparatus Source: HPA
    3. nucleolus Source: HPA
    4. nucleus Source: UniProtKB
    5. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134939870.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485E3 ubiquitin-protein ligase TRIM68PRO_0000249437Add
    BLAST

    Post-translational modificationi

    Auto-ubiquitinated.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ6AZZ1.
    PaxDbiQ6AZZ1.
    PRIDEiQ6AZZ1.

    PTM databases

    PhosphoSiteiQ6AZZ1.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells.3 Publications

    Inductioni

    Up-regulated in prostate cancer.

    Gene expression databases

    ArrayExpressiQ6AZZ1.
    BgeeiQ6AZZ1.
    CleanExiHS_TRIM68.
    GenevestigatoriQ6AZZ1.

    Organism-specific databases

    HPAiHPA023455.

    Interactioni

    Subunit structurei

    Interacts with AR/androgen receptor (via ligand-binding domain). Interacts with KAT5/TIP60.1 Publication

    Protein-protein interaction databases

    BioGridi120434. 5 interactions.
    IntActiQ6AZZ1. 1 interaction.
    STRINGi9606.ENSP00000300747.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AZZ1.
    SMRiQ6AZZ1. Positions 10-80, 92-133, 305-481.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini285 – 481197B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili207 – 23933Sequence AnalysisAdd
    BLAST

    Domaini

    The RING domain is essential for ubiquitin E3 ligase activity.1 Publication

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 6146RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri93 – 13442B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG252602.
    HOVERGENiHBG001357.
    InParanoidiQ6AZZ1.
    KOiK12033.
    OMAiCYSIGTN.
    OrthoDBiEOG72ZCDQ.
    PhylomeDBiQ6AZZ1.
    TreeFamiTF338674.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6AZZ1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPTALVEAI VEEVACPICM TFLREPMSID CGHSFCHSCL SGLWEIPGES    50
    QNWGYTCPLC RAPVQPRNLR PNWQLANVVE KVRLLRLHPG MGLKGDLCER 100
    HGEKLKMFCK EDVLIMCEAC SQSPEHEAHS VVPMEDVAWE YKWELHEALE 150
    HLKKEQEEAW KLEVGERKRT ATWKIQVETR KQSIVWEFEK YQRLLEKKQP 200
    PHRQLGAEVA AALASLQREA AETMQKLELN HSELIQQSQV LWRMIAELKE 250
    RSQRPVRWML QDIQEVLNRS KSWSLQQPEP ISLELKTDCR VLGLREILKT 300
    YAADVRLDPD TAYSRLIVSE DRKRVHYGDT NQKLPDNPER FYRYNIVLGS 350
    QCISSGRHYW EVEVGDRSEW GLGVCKQNVD RKEVVYLSPH YGFWVIRLRK 400
    GNEYRAGTDE YPILSLPVPP RRVGIFVDYE AHDISFYNVT DCGSHIFTFP 450
    RYPFPGRLLP YFSPCYSIGT NNTAPLAICS LDGED 485
    Length:485
    Mass (Da):56,259
    Last modified:September 13, 2004 - v1
    Checksum:iFCB9A6076382E2A5
    GO
    Isoform 2 (identifier: Q6AZZ1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-3: MDP → MQK
         4-282: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:206
    Mass (Da):23,798
    Checksum:i8D38B44D58737F7B
    GO

    Sequence cautioni

    The sequence BAA91569.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB14309.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441W → R in BAG51737. (PubMed:14702039)Curated
    Sequence conflicti109 – 1146CKEDVL → RGNSLQ in AAF91075. (PubMed:11597395)Curated
    Sequence conflicti175 – 1751I → V in AAF91075. (PubMed:11597395)Curated
    Sequence conflicti303 – 3031A → G in AAL31641. 1 PublicationCurated
    Sequence conflicti304 – 3041D → V in BAG62716. (PubMed:14702039)Curated
    Sequence conflicti314 – 3141S → P in BAB14309. (PubMed:14702039)Curated
    Sequence conflicti376 – 3761K → Y in AAF91075. (PubMed:11597395)Curated
    Sequence conflicti399 – 3991R → K in AAF91075. (PubMed:11597395)Curated
    Sequence conflicti411 – 4111Y → V in AAF91075. (PubMed:11597395)Curated
    Sequence conflicti422 – 4221R → P in AAF91075. (PubMed:11597395)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti442 – 4421C → Y.1 Publication
    Corresponds to variant rs2231975 [ dbSNP | Ensembl ].
    VAR_027415
    Natural varianti457 – 4571R → H.
    Corresponds to variant rs2231976 [ dbSNP | Ensembl ].
    VAR_063007
    Natural varianti466 – 4661Y → S.
    Corresponds to variant rs7109316 [ dbSNP | Ensembl ].
    VAR_063008

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 33MDP → MQK in isoform 2. 1 PublicationVSP_055444
    Alternative sequencei4 – 282279Missing in isoform 2. 1 PublicationVSP_055445Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF360739 mRNA. Translation: AAL11501.1.
    AF439153 mRNA. Translation: AAL31641.1.
    AK001231 mRNA. Translation: BAA91569.1. Different initiation.
    AK022923 mRNA. Translation: BAB14309.1. Different initiation.
    AK291166 mRNA. Translation: BAF83855.1.
    AK301120 mRNA. Translation: BAG62716.1.
    AK056523 mRNA. Translation: BAG51737.1.
    AC090719 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68835.1.
    BC075058 mRNA. Translation: AAH75058.1.
    BC109063 mRNA. Translation: AAI09064.1.
    AY005802 mRNA. Translation: AAF91075.1.
    CCDSiCCDS31356.1.
    RefSeqiNP_060543.5. NM_018073.6.
    UniGeneiHs.523438.
    Hs.738828.

    Genome annotation databases

    EnsembliENST00000300747; ENSP00000300747; ENSG00000167333. [Q6AZZ1-1]
    GeneIDi55128.
    KEGGihsa:55128.
    UCSCiuc001lzf.2. human.

    Polymorphism databases

    DMDMi74748376.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF360739 mRNA. Translation: AAL11501.1 .
    AF439153 mRNA. Translation: AAL31641.1 .
    AK001231 mRNA. Translation: BAA91569.1 . Different initiation.
    AK022923 mRNA. Translation: BAB14309.1 . Different initiation.
    AK291166 mRNA. Translation: BAF83855.1 .
    AK301120 mRNA. Translation: BAG62716.1 .
    AK056523 mRNA. Translation: BAG51737.1 .
    AC090719 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68835.1 .
    BC075058 mRNA. Translation: AAH75058.1 .
    BC109063 mRNA. Translation: AAI09064.1 .
    AY005802 mRNA. Translation: AAF91075.1 .
    CCDSi CCDS31356.1.
    RefSeqi NP_060543.5. NM_018073.6.
    UniGenei Hs.523438.
    Hs.738828.

    3D structure databases

    ProteinModelPortali Q6AZZ1.
    SMRi Q6AZZ1. Positions 10-80, 92-133, 305-481.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120434. 5 interactions.
    IntActi Q6AZZ1. 1 interaction.
    STRINGi 9606.ENSP00000300747.

    PTM databases

    PhosphoSitei Q6AZZ1.

    Polymorphism databases

    DMDMi 74748376.

    Proteomic databases

    MaxQBi Q6AZZ1.
    PaxDbi Q6AZZ1.
    PRIDEi Q6AZZ1.

    Protocols and materials databases

    DNASUi 55128.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300747 ; ENSP00000300747 ; ENSG00000167333 . [Q6AZZ1-1 ]
    GeneIDi 55128.
    KEGGi hsa:55128.
    UCSCi uc001lzf.2. human.

    Organism-specific databases

    CTDi 55128.
    GeneCardsi GC11M004577.
    HGNCi HGNC:21161. TRIM68.
    HPAi HPA023455.
    MIMi 613184. gene.
    neXtProti NX_Q6AZZ1.
    PharmGKBi PA134939870.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG252602.
    HOVERGENi HBG001357.
    InParanoidi Q6AZZ1.
    KOi K12033.
    OMAi CYSIGTN.
    OrthoDBi EOG72ZCDQ.
    PhylomeDBi Q6AZZ1.
    TreeFami TF338674.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi TRIM68. human.
    GeneWikii TRIM68.
    GenomeRNAii 55128.
    NextBioi 58790.
    PROi Q6AZZ1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6AZZ1.
    Bgeei Q6AZZ1.
    CleanExi HS_TRIM68.
    Genevestigatori Q6AZZ1.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SS-56, a novel cellular target of autoantibody responses in Sjogren syndrome and systemic lupus erythematosus."
      Billaut-Mulot O., Cocude C., Kolesnitchenko V., Truong M.-J., Chan E.K.L., Hachulla E., de La Tribonniere X., Capron A., Bahr G.M.
      J. Clin. Invest. 108:861-869(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, IDENTIFICATION AS AUTOANTIGEN IN AUTOIMMUNE DISEASES, VARIANT TYR-442.
    2. "Cloning and characterization of FLJ10369, a novel Ro/SSA1-related gene on human chromosome 11p15.5."
      Rhodes D.A., Allcock R.J.N., Trowsdale J.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Spleen and Teratocarcinoma.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells."
      Chang G.T., Steenbeek M., Schippers E., Blok L.J., van Weerden W.M., van Alewijk D.C., Eussen B.H., van Steenbrugge G.J., Brinkmann A.O.
      Eur. J. Cancer 37:2129-2134(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 109-427 (ISOFORM 1), TISSUE SPECIFICITY.
    8. "TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells."
      Miyajima N., Maruyama S., Bohgaki M., Kano S., Shigemura M., Shinohara N., Nonomura K., Hatakeyama S.
      Cancer Res. 68:3486-3494(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH KAT5 AND AR, DOMAIN RING, AUTOUBIQUITINATION.

    Entry informationi

    Entry nameiTRI68_HUMAN
    AccessioniPrimary (citable) accession number: Q6AZZ1
    Secondary accession number(s): A6NI19
    , A8K551, B3KPM5, B4DVK4, Q8WZ70, Q96LE5, Q96PF7, Q9H9C2, Q9NW18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Antibodies against TRIM68 are found in patients with systemic lupus erythematosus (SLE) and primary Sjoegren syndrome.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3