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Q6AZZ1

- TRI68_HUMAN

UniProt

Q6AZZ1 - TRI68_HUMAN

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Protein

E3 ubiquitin-protein ligase TRIM68

Gene

TRIM68

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6146RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri93 – 13442B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. androgen receptor binding Source: UniProtKB
  2. histone acetyltransferase binding Source: UniProtKB
  3. ligase activity Source: UniProtKB-KW
  4. ubiquitin-protein transferase activity Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein autoubiquitination Source: UniProtKB
  2. regulation of androgen receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM68 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 137
SSA protein SS-56
Short name:
SS-56
Tripartite motif-containing protein 68
Gene namesi
Name:TRIM68
Synonyms:GC109, RNF137, SS56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:21161. TRIM68.

Subcellular locationi

Cytoplasmperinuclear region. Nucleus
Note: Colocalized with AR in nucleus.

GO - Cellular componenti

  1. cytoplasm Source: LIFEdb
  2. Golgi apparatus Source: HPA
  3. nucleolus Source: HPA
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485E3 ubiquitin-protein ligase TRIM68PRO_0000249437Add
BLAST

Post-translational modificationi

Auto-ubiquitinated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ6AZZ1.
PaxDbiQ6AZZ1.
PRIDEiQ6AZZ1.

PTM databases

PhosphoSiteiQ6AZZ1.

Expressioni

Tissue specificityi

Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells.3 Publications

Inductioni

Up-regulated in prostate cancer.

Gene expression databases

BgeeiQ6AZZ1.
CleanExiHS_TRIM68.
ExpressionAtlasiQ6AZZ1. baseline and differential.
GenevestigatoriQ6AZZ1.

Organism-specific databases

HPAiHPA023455.

Interactioni

Subunit structurei

Interacts with AR/androgen receptor (via ligand-binding domain). Interacts with KAT5/TIP60.1 Publication

Protein-protein interaction databases

BioGridi120434. 25 interactions.
IntActiQ6AZZ1. 1 interaction.
STRINGi9606.ENSP00000300747.

Structurei

3D structure databases

ProteinModelPortaliQ6AZZ1.
SMRiQ6AZZ1. Positions 10-80, 92-133, 305-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 481197B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili207 – 23933Sequence AnalysisAdd
BLAST

Domaini

The RING domain is essential for ubiquitin E3 ligase activity.1 Publication

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6146RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri93 – 13442B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG252602.
GeneTreeiENSGT00760000118893.
HOVERGENiHBG001357.
InParanoidiQ6AZZ1.
KOiK12033.
OMAiCYSIGTN.
OrthoDBiEOG72ZCDQ.
PhylomeDBiQ6AZZ1.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6AZZ1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPTALVEAI VEEVACPICM TFLREPMSID CGHSFCHSCL SGLWEIPGES
60 70 80 90 100
QNWGYTCPLC RAPVQPRNLR PNWQLANVVE KVRLLRLHPG MGLKGDLCER
110 120 130 140 150
HGEKLKMFCK EDVLIMCEAC SQSPEHEAHS VVPMEDVAWE YKWELHEALE
160 170 180 190 200
HLKKEQEEAW KLEVGERKRT ATWKIQVETR KQSIVWEFEK YQRLLEKKQP
210 220 230 240 250
PHRQLGAEVA AALASLQREA AETMQKLELN HSELIQQSQV LWRMIAELKE
260 270 280 290 300
RSQRPVRWML QDIQEVLNRS KSWSLQQPEP ISLELKTDCR VLGLREILKT
310 320 330 340 350
YAADVRLDPD TAYSRLIVSE DRKRVHYGDT NQKLPDNPER FYRYNIVLGS
360 370 380 390 400
QCISSGRHYW EVEVGDRSEW GLGVCKQNVD RKEVVYLSPH YGFWVIRLRK
410 420 430 440 450
GNEYRAGTDE YPILSLPVPP RRVGIFVDYE AHDISFYNVT DCGSHIFTFP
460 470 480
RYPFPGRLLP YFSPCYSIGT NNTAPLAICS LDGED
Length:485
Mass (Da):56,259
Last modified:September 13, 2004 - v1
Checksum:iFCB9A6076382E2A5
GO
Isoform 2 (identifier: Q6AZZ1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MDP → MQK
     4-282: Missing.

Note: No experimental confirmation available.

Show »
Length:206
Mass (Da):23,798
Checksum:i8D38B44D58737F7B
GO

Sequence cautioni

The sequence BAA91569.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB14309.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441W → R in BAG51737. (PubMed:14702039)Curated
Sequence conflicti109 – 1146CKEDVL → RGNSLQ in AAF91075. (PubMed:11597395)Curated
Sequence conflicti175 – 1751I → V in AAF91075. (PubMed:11597395)Curated
Sequence conflicti303 – 3031A → G in AAL31641. 1 PublicationCurated
Sequence conflicti304 – 3041D → V in BAG62716. (PubMed:14702039)Curated
Sequence conflicti314 – 3141S → P in BAB14309. (PubMed:14702039)Curated
Sequence conflicti376 – 3761K → Y in AAF91075. (PubMed:11597395)Curated
Sequence conflicti399 – 3991R → K in AAF91075. (PubMed:11597395)Curated
Sequence conflicti411 – 4111Y → V in AAF91075. (PubMed:11597395)Curated
Sequence conflicti422 – 4221R → P in AAF91075. (PubMed:11597395)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti442 – 4421C → Y.1 Publication
Corresponds to variant rs2231975 [ dbSNP | Ensembl ].
VAR_027415
Natural varianti457 – 4571R → H.
Corresponds to variant rs2231976 [ dbSNP | Ensembl ].
VAR_063007
Natural varianti466 – 4661Y → S.
Corresponds to variant rs7109316 [ dbSNP | Ensembl ].
VAR_063008

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 33MDP → MQK in isoform 2. 1 PublicationVSP_055444
Alternative sequencei4 – 282279Missing in isoform 2. 1 PublicationVSP_055445Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF360739 mRNA. Translation: AAL11501.1.
AF439153 mRNA. Translation: AAL31641.1.
AK001231 mRNA. Translation: BAA91569.1. Different initiation.
AK022923 mRNA. Translation: BAB14309.1. Different initiation.
AK291166 mRNA. Translation: BAF83855.1.
AK301120 mRNA. Translation: BAG62716.1.
AK056523 mRNA. Translation: BAG51737.1.
AC090719 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68835.1.
BC075058 mRNA. Translation: AAH75058.1.
BC109063 mRNA. Translation: AAI09064.1.
AY005802 mRNA. Translation: AAF91075.1.
CCDSiCCDS31356.1. [Q6AZZ1-1]
RefSeqiNP_060543.5. NM_018073.6. [Q6AZZ1-1]
UniGeneiHs.523438.
Hs.738828.

Genome annotation databases

EnsembliENST00000300747; ENSP00000300747; ENSG00000167333. [Q6AZZ1-1]
GeneIDi55128.
KEGGihsa:55128.
UCSCiuc001lzf.2. human. [Q6AZZ1-1]

Polymorphism databases

DMDMi74748376.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF360739 mRNA. Translation: AAL11501.1 .
AF439153 mRNA. Translation: AAL31641.1 .
AK001231 mRNA. Translation: BAA91569.1 . Different initiation.
AK022923 mRNA. Translation: BAB14309.1 . Different initiation.
AK291166 mRNA. Translation: BAF83855.1 .
AK301120 mRNA. Translation: BAG62716.1 .
AK056523 mRNA. Translation: BAG51737.1 .
AC090719 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68835.1 .
BC075058 mRNA. Translation: AAH75058.1 .
BC109063 mRNA. Translation: AAI09064.1 .
AY005802 mRNA. Translation: AAF91075.1 .
CCDSi CCDS31356.1. [Q6AZZ1-1 ]
RefSeqi NP_060543.5. NM_018073.6. [Q6AZZ1-1 ]
UniGenei Hs.523438.
Hs.738828.

3D structure databases

ProteinModelPortali Q6AZZ1.
SMRi Q6AZZ1. Positions 10-80, 92-133, 305-481.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120434. 25 interactions.
IntActi Q6AZZ1. 1 interaction.
STRINGi 9606.ENSP00000300747.

PTM databases

PhosphoSitei Q6AZZ1.

Polymorphism databases

DMDMi 74748376.

Proteomic databases

MaxQBi Q6AZZ1.
PaxDbi Q6AZZ1.
PRIDEi Q6AZZ1.

Protocols and materials databases

DNASUi 55128.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300747 ; ENSP00000300747 ; ENSG00000167333 . [Q6AZZ1-1 ]
GeneIDi 55128.
KEGGi hsa:55128.
UCSCi uc001lzf.2. human. [Q6AZZ1-1 ]

Organism-specific databases

CTDi 55128.
GeneCardsi GC11M004577.
HGNCi HGNC:21161. TRIM68.
HPAi HPA023455.
MIMi 613184. gene.
neXtProti NX_Q6AZZ1.
PharmGKBi PA134939870.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG252602.
GeneTreei ENSGT00760000118893.
HOVERGENi HBG001357.
InParanoidi Q6AZZ1.
KOi K12033.
OMAi CYSIGTN.
OrthoDBi EOG72ZCDQ.
PhylomeDBi Q6AZZ1.
TreeFami TF338674.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi TRIM68. human.
GeneWikii TRIM68.
GenomeRNAii 55128.
NextBioi 35475481.
PROi Q6AZZ1.
SOURCEi Search...

Gene expression databases

Bgeei Q6AZZ1.
CleanExi HS_TRIM68.
ExpressionAtlasi Q6AZZ1. baseline and differential.
Genevestigatori Q6AZZ1.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SS-56, a novel cellular target of autoantibody responses in Sjogren syndrome and systemic lupus erythematosus."
    Billaut-Mulot O., Cocude C., Kolesnitchenko V., Truong M.-J., Chan E.K.L., Hachulla E., de La Tribonniere X., Capron A., Bahr G.M.
    J. Clin. Invest. 108:861-869(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, IDENTIFICATION AS AUTOANTIGEN IN AUTOIMMUNE DISEASES, VARIANT TYR-442.
  2. "Cloning and characterization of FLJ10369, a novel Ro/SSA1-related gene on human chromosome 11p15.5."
    Rhodes D.A., Allcock R.J.N., Trowsdale J.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Spleen and Teratocarcinoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells."
    Chang G.T., Steenbeek M., Schippers E., Blok L.J., van Weerden W.M., van Alewijk D.C., Eussen B.H., van Steenbrugge G.J., Brinkmann A.O.
    Eur. J. Cancer 37:2129-2134(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 109-427 (ISOFORM 1), TISSUE SPECIFICITY.
  8. "TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells."
    Miyajima N., Maruyama S., Bohgaki M., Kano S., Shigemura M., Shinohara N., Nonomura K., Hatakeyama S.
    Cancer Res. 68:3486-3494(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH KAT5 AND AR, DOMAIN RING, AUTOUBIQUITINATION.

Entry informationi

Entry nameiTRI68_HUMAN
AccessioniPrimary (citable) accession number: Q6AZZ1
Secondary accession number(s): A6NI19
, A8K551, B3KPM5, B4DVK4, Q8WZ70, Q96LE5, Q96PF7, Q9H9C2, Q9NW18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against TRIM68 are found in patients with systemic lupus erythematosus (SLE) and primary Sjoegren syndrome.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3