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Protein

Scavenger receptor class A member 3

Gene

SCARA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.1 Publication

GO - Molecular functioni

  • scavenger receptor activity Source: ProtInc

GO - Biological processi

  • response to oxidative stress Source: ProtInc
  • UV protection Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor class A member 3
Alternative name(s):
Cellular stress response gene protein
Gene namesi
Name:SCARA3
Synonyms:CSR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:19000. SCARA3.

Subcellular locationi

  • Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication
  • Golgi apparatus membrane 1 Publication; Single-pass type II membrane protein 1 Publication

  • Note: Endoplasmic reticulum and/or Golgi.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656CytoplasmicSequence analysisAdd
BLAST
Transmembranei57 – 7721Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini78 – 606529ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38775.

Polymorphism and mutation databases

BioMutaiSCARA3.
DMDMi74736352.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 606606Scavenger receptor class A member 3PRO_0000181633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence analysis
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence analysis
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence analysis
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence analysis
Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence analysis
Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence analysis
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence analysis
Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence analysis
Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6AZY7.
MaxQBiQ6AZY7.
PaxDbiQ6AZY7.
PeptideAtlasiQ6AZY7.
PRIDEiQ6AZY7.

PTM databases

iPTMnetiQ6AZY7.
PhosphoSiteiQ6AZY7.

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

BgeeiQ6AZY7.
CleanExiHS_SCARA3.
GenevisibleiQ6AZY7. HS.

Organism-specific databases

HPAiHPA047386.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SYNGR2O437603EBI-8657660,EBI-2826419

Protein-protein interaction databases

BioGridi119539. 47 interactions.
IntActiQ6AZY7. 2 interactions.
STRINGi9606.ENSP00000301904.

Structurei

3D structure databases

ProteinModelPortaliQ6AZY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini455 – 51359Collagen-like 1Add
BLAST
Domaini544 – 60360Collagen-like 2Add
BLAST

Sequence similaritiesi

Contains 2 collagen-like domains.Curated

Keywords - Domaini

Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IER2. Eukaryota.
ENOG410Z17S. LUCA.
GeneTreeiENSGT00820000126981.
HOGENOMiHOG000154262.
HOVERGENiHBG093935.
InParanoidiQ6AZY7.
OMAiNNCSFCH.
OrthoDBiEOG7F24SR.
PhylomeDBiQ6AZY7.
TreeFamiTF332426.

Family and domain databases

InterProiIPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6AZY7-1) [UniParc]FASTAAdd to basket

Also known as: CSR1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVRSAGGDG DALCVTEEDL AGDDEDMPTF PCTQKGRPGP RCSRCQKNLS
60 70 80 90 100
LHTSVRILYL FLALLLVAVA VLASLVFRKV DSLSEDISLT QSIYDKKLVL
110 120 130 140 150
MQKNLQGLDP KALNNCSFCH EAGQLGPEIR KLQEELEGIQ KLLLAQEVQL
160 170 180 190 200
DQTLQAQEVL STTSRQISQE MGSCSFSIHQ VNQSLGLFLA QVRGWQATTA
210 220 230 240 250
GLDLSLKDLT QECYDVKAAV HQINFTVGQT SEWIHGIQRK TDEETLTLQK
260 270 280 290 300
IVTDWQNYTR LFSGLRTTST KTGEAVKNIQ ATLGASSQRI SQNSESMHDL
310 320 330 340 350
VLQVMGLQLQ LDNISSFLDD HEENMHDLQY HTHYAQNRTV ERFESLEGRM
360 370 380 390 400
ASHEIEIGTI FTNINATDNH VHSMLKYLDD VRLSCTLGFH THAEELYYLN
410 420 430 440 450
KSVSIMLGTT DLLRERFSLL SARLDLNVRN LSMIVEEMKA VDTQHGEILR
460 470 480 490 500
NVTILRGAPG PPGPRGFKGD MGVKGPVGGR GPKGDPGSLG PLGPQGPQGQ
510 520 530 540 550
PGEAGPVGER GPVGPRGFPG LKGSKGSFGT GGPRGQPGPK GDIGPPGPEG
560 570 580 590 600
PPGSPGPSGP QGKPGIAGKT GSPGQRGAMG PKGEPGIQGP PGLPGPPGPP

GSQSFY
Length:606
Mass (Da):65,137
Last modified:September 13, 2004 - v1
Checksum:i15EEC028AAF7762E
GO
Isoform 2 (identifier: Q6AZY7-2) [UniParc]FASTAAdd to basket

Also known as: CSR2

The sequence of this isoform differs from the canonical sequence as follows:
     458-466: APGPPGPRG → HTLFSHNRI
     467-606: Missing.

Show »
Length:466
Mass (Da):52,434
Checksum:iCE3F14DCBF5CDF31
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti488 – 4881S → I in BAA86201 (PubMed:9580669).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301R → Q.1 Publication
Corresponds to variant rs34791518 [ dbSNP | Ensembl ].
VAR_025228
Natural varianti325 – 3251M → T.1 Publication
Corresponds to variant rs33930667 [ dbSNP | Ensembl ].
VAR_025229
Natural varianti423 – 4231R → Q.1 Publication
Corresponds to variant rs3735754 [ dbSNP | Ensembl ].
VAR_025230
Natural varianti428 – 4281V → I.1 Publication
Corresponds to variant rs34086286 [ dbSNP | Ensembl ].
VAR_025231
Natural varianti467 – 4671F → L.1 Publication
Corresponds to variant rs17057523 [ dbSNP | Ensembl ].
VAR_025232
Natural varianti551 – 5511P → S.1 Publication
Corresponds to variant rs35928641 [ dbSNP | Ensembl ].
VAR_025233

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei458 – 4669APGPPGPRG → HTLFSHNRI in isoform 2. 2 PublicationsVSP_017135
Alternative sequencei467 – 606140Missing in isoform 2. 2 PublicationsVSP_017136Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007829 mRNA. Translation: BAA86201.1.
AB007830 mRNA. Translation: BAA86202.1.
DQ205185 Genomic DNA. Translation: ABA27098.1.
BC060811 mRNA. Translation: AAH60811.1.
BC075067 mRNA. Translation: AAH75067.1.
BC075068 mRNA. Translation: AAH75068.1.
CCDSiCCDS34870.1. [Q6AZY7-2]
CCDS34871.1. [Q6AZY7-1]
RefSeqiNP_057324.2. NM_016240.2. [Q6AZY7-1]
NP_878185.1. NM_182826.1. [Q6AZY7-2]
UniGeneiHs.128856.

Genome annotation databases

EnsembliENST00000301904; ENSP00000301904; ENSG00000168077. [Q6AZY7-1]
ENST00000337221; ENSP00000337985; ENSG00000168077. [Q6AZY7-2]
GeneIDi51435.
KEGGihsa:51435.
UCSCiuc003xga.2. human. [Q6AZY7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007829 mRNA. Translation: BAA86201.1.
AB007830 mRNA. Translation: BAA86202.1.
DQ205185 Genomic DNA. Translation: ABA27098.1.
BC060811 mRNA. Translation: AAH60811.1.
BC075067 mRNA. Translation: AAH75067.1.
BC075068 mRNA. Translation: AAH75068.1.
CCDSiCCDS34870.1. [Q6AZY7-2]
CCDS34871.1. [Q6AZY7-1]
RefSeqiNP_057324.2. NM_016240.2. [Q6AZY7-1]
NP_878185.1. NM_182826.1. [Q6AZY7-2]
UniGeneiHs.128856.

3D structure databases

ProteinModelPortaliQ6AZY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119539. 47 interactions.
IntActiQ6AZY7. 2 interactions.
STRINGi9606.ENSP00000301904.

PTM databases

iPTMnetiQ6AZY7.
PhosphoSiteiQ6AZY7.

Polymorphism and mutation databases

BioMutaiSCARA3.
DMDMi74736352.

Proteomic databases

EPDiQ6AZY7.
MaxQBiQ6AZY7.
PaxDbiQ6AZY7.
PeptideAtlasiQ6AZY7.
PRIDEiQ6AZY7.

Protocols and materials databases

DNASUi51435.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301904; ENSP00000301904; ENSG00000168077. [Q6AZY7-1]
ENST00000337221; ENSP00000337985; ENSG00000168077. [Q6AZY7-2]
GeneIDi51435.
KEGGihsa:51435.
UCSCiuc003xga.2. human. [Q6AZY7-1]

Organism-specific databases

CTDi51435.
GeneCardsiSCARA3.
HGNCiHGNC:19000. SCARA3.
HPAiHPA047386.
MIMi602728. gene.
neXtProtiNX_Q6AZY7.
PharmGKBiPA38775.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IER2. Eukaryota.
ENOG410Z17S. LUCA.
GeneTreeiENSGT00820000126981.
HOGENOMiHOG000154262.
HOVERGENiHBG093935.
InParanoidiQ6AZY7.
OMAiNNCSFCH.
OrthoDBiEOG7F24SR.
PhylomeDBiQ6AZY7.
TreeFamiTF332426.

Miscellaneous databases

ChiTaRSiSCARA3. human.
GenomeRNAii51435.
PROiQ6AZY7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6AZY7.
CleanExiHS_SCARA3.
GenevisibleiQ6AZY7. HS.

Family and domain databases

InterProiIPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CSR, a scavenger receptor-like protein with a protective role against cellular damage caused by UV irradiation and oxidative stress."
    Han H.-J., Tokino T., Nakamura Y.
    Hum. Mol. Genet. 7:1039-1046(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. NIEHS SNPs program
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-130; THR-325; GLN-423; ILE-428; LEU-467 AND SER-551.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Placenta.

Entry informationi

Entry nameiSCAR3_HUMAN
AccessioniPrimary (citable) accession number: Q6AZY7
Secondary accession number(s): Q9UM15, Q9UM16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: September 13, 2004
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.