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Protein

Zinc finger protein 660

Gene

ZNF660

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri50 – 7223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri78 – 10023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri106 – 12823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri134 – 15623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri162 – 18423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri190 – 21223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri218 – 24023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 660
Gene namesi
Name:ZNF660
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componentsi: Chromosome 3, Chromosome 6

Organism-specific databases

HGNCiHGNC:26720. ZNF660.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134920595.

Polymorphism and mutation databases

BioMutaiZNF660.
DMDMi74762291.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Zinc finger protein 660PRO_0000047701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AZW8.
PRIDEiQ6AZW8.

PTM databases

iPTMnetiQ6AZW8.
PhosphoSiteiQ6AZW8.

Expressioni

Gene expression databases

BgeeiQ6AZW8.
CleanExiHS_ZNF660.
ExpressionAtlasiQ6AZW8. baseline and differential.
GenevisibleiQ6AZW8. HS.

Organism-specific databases

HPAiHPA029705.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324605.

Structurei

3D structure databases

ProteinModelPortaliQ6AZW8.
SMRiQ6AZW8. Positions 44-213, 215-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri50 – 7223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri78 – 10023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri106 – 12823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri134 – 15623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri162 – 18423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri190 – 21223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri218 – 24023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6AZW8.
OMAiQRMHRGK.
PhylomeDBiQ6AZW8.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AZW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRKTRNFKH KTVKDNKVLT EGSDQESEKD NSQCCDPATN ERVQAEKRQY
60 70 80 90 100
VCTECGKAFS QSANLTVHER IHTGEKPYKC KECGKAFSHS SNLVVHRRIH
110 120 130 140 150
TGLKPYTCSE CGKSFSGKSH LIRHQGIHSG EKTYECKECG KAFSRSSGLI
160 170 180 190 200
SHHRVHTGEK PYSCIECGKA FSRSSNLTQH QRMHRGKKVY KCKECGKTCG
210 220 230 240 250
SNTKIMDHQR IHTGEKPYEC DECGKTFILR KTLNEHQRLH RREKPYKCNE
260 270 280 290 300
CGKAFTSNRN LVDHQRVHTG EKPYKCNECG KTFRQTSQVI LHLRTHTKEK
310 320 330
PYKCSECGKA YRYSSQLIQH QRKHNEEKET S
Length:331
Mass (Da):38,270
Last modified:September 13, 2004 - v1
Checksum:i0F78D1090AA32CB4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571K → N in BAC04303 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094189 mRNA. Translation: BAC04303.1.
BC075094 mRNA. Translation: AAH75094.1.
BC075095 mRNA. Translation: AAH75095.1.
BX538171 mRNA. Translation: CAD98047.1.
CCDSiCCDS2716.1.
RefSeqiNP_775929.2. NM_173658.2.
XP_005265147.1. XM_005265090.3.
XP_006713180.1. XM_006713117.2.
XP_011531924.1. XM_011533622.1.
XP_011547032.1. XM_011548730.1.
XP_011547033.1. XM_011548731.1.
XP_011547034.1. XM_011548732.1.
UniGeneiHs.733134.

Genome annotation databases

EnsembliENST00000322734; ENSP00000324605; ENSG00000144792.
ENST00000625494; ENSP00000487319; ENSG00000280661.
GeneIDi285349.
KEGGihsa:285349.
UCSCiuc003cnl.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094189 mRNA. Translation: BAC04303.1.
BC075094 mRNA. Translation: AAH75094.1.
BC075095 mRNA. Translation: AAH75095.1.
BX538171 mRNA. Translation: CAD98047.1.
CCDSiCCDS2716.1.
RefSeqiNP_775929.2. NM_173658.2.
XP_005265147.1. XM_005265090.3.
XP_006713180.1. XM_006713117.2.
XP_011531924.1. XM_011533622.1.
XP_011547032.1. XM_011548730.1.
XP_011547033.1. XM_011548731.1.
XP_011547034.1. XM_011548732.1.
UniGeneiHs.733134.

3D structure databases

ProteinModelPortaliQ6AZW8.
SMRiQ6AZW8. Positions 44-213, 215-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000324605.

PTM databases

iPTMnetiQ6AZW8.
PhosphoSiteiQ6AZW8.

Polymorphism and mutation databases

BioMutaiZNF660.
DMDMi74762291.

Proteomic databases

PaxDbiQ6AZW8.
PRIDEiQ6AZW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322734; ENSP00000324605; ENSG00000144792.
ENST00000625494; ENSP00000487319; ENSG00000280661.
GeneIDi285349.
KEGGihsa:285349.
UCSCiuc003cnl.2. human.

Organism-specific databases

CTDi285349.
GeneCardsiZNF660.
HGNCiHGNC:26720. ZNF660.
HPAiHPA029705.
neXtProtiNX_Q6AZW8.
PharmGKBiPA134920595.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6AZW8.
OMAiQRMHRGK.
PhylomeDBiQ6AZW8.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii285349.
NextBioi95463.
PROiQ6AZW8.

Gene expression databases

BgeeiQ6AZW8.
CleanExiHS_ZNF660.
ExpressionAtlasiQ6AZW8. baseline and differential.
GenevisibleiQ6AZW8. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Astrocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-331.
    Tissue: Uterus.
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN660_HUMAN
AccessioniPrimary (citable) accession number: Q6AZW8
Secondary accession number(s): Q7Z331, Q8N9M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.