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Protein

Alcohol dehydrogenase [NADP(+)] A

Gene

akr1a1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity).By similarity

Catalytic activityi

An alcohol + NADP+ = an aldehyde + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Proton donorBy similarity1
Sitei79Lowers pKa of active site TyrBy similarity1
Binding sitei112SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 272NADPBy similarityAdd BLAST63

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase [NADP(+)] A (EC:1.1.1.2)
Alternative name(s):
Aldehyde reductase-A
Aldo-keto reductase family 1 member A1-A
Gene namesi
Name:akr1a1a
ORF Names:si:ch211-113n10.1, zgc:100940
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-040808-44 akr1a1a

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003841521 – 324Alcohol dehydrogenase [NADP(+)] AAdd BLAST324

Proteomic databases

PaxDbiQ6AZW2
PRIDEiQ6AZW2

Expressioni

Gene expression databases

BgeeiENSDARG00000035257

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000051081

Structurei

3D structure databases

ProteinModelPortaliQ6AZW2
SMRiQ6AZW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
GeneTreeiENSGT00760000119041
HOGENOMiHOG000250272
InParanoidiQ6AZW2
KOiK00002
OMAiWNTFHDG
OrthoDBiEOG091G0D69
PhylomeDBiQ6AZW2
TreeFamiTF106492

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AZW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATITLSTG QRMPTVGLGT WKSAPGQVKQ AVLAALDCGY RHIDCAAAYS
60 70 80 90 100
NEREVGEALT ERLGPGKSLR RDDIFVTSKL WNTKHHPDDV EEACRRSLSD
110 120 130 140 150
LRLSYLDLYL IHWPMAFGRG DELIPRHPDG TIQYDDTHYR DTWAAMEKLV
160 170 180 190 200
DQGLAKAIGL SNFNAKQIDD ILSIAKHKPV VNQVECHPYL VQAELVSHCW
210 220 230 240 250
SRNLTVTAYS PLGSPDRPWV TPGEALLLDD PRVVGIAKSY NKTPAQVIIR
260 270 280 290 300
WHIQRGVVCI PKSVTPSRIK QNIEVFDFKL SDEDMRLIES FNRNERFIIP
310 320
TVIKDGQKIW RDAKHPHFPF IEPY
Length:324
Mass (Da):36,762
Last modified:September 22, 2009 - v2
Checksum:i74BAFFE5775EE624
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196V → A in AAH77140 (Ref. 2) Curated1
Sequence conflicti309I → V in AAH77140 (Ref. 2) Curated1
Sequence conflicti314K → N in AAH77140 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR318632, CR753867 Genomic DNA Translation: CAM13142.1
CR753867, CR318632 Genomic DNA Translation: CAN88791.1
BC077140 mRNA Translation: AAH77140.1
RefSeqiNP_001003783.1, NM_001003783.2
UniGeneiDr.91252

Genome annotation databases

EnsembliENSDART00000051082; ENSDARP00000051081; ENSDARG00000035257
ENSDART00000163905; ENSDARP00000135248; ENSDARG00000035257
GeneIDi445326
KEGGidre:445326

Similar proteinsi

Entry informationi

Entry nameiA1A1A_DANRE
AccessioniPrimary (citable) accession number: Q6AZW2
Secondary accession number(s): A2CE54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: March 28, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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